Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 512-525

  Dring, Ann M ^a   Anderson, Linnea E ^a   Qamar, Saima ^a   Stoner, Matthew A ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

CAR; Isoform specific activity; Mid throughput screening; Nuclear receptor; PXR; QSAR

Indexed keywords

ALKYLPHENOL; BIPHENYL DERIVATIVE; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR 1; CONSTITUTIVE ANDROSTANE RECEPTOR 3; ISOPROTEIN; LUCIFERASE; PHTHALEIN; PREGNANE X RECEPTOR; STILBENE DERIVATIVE; TRIPHENYLMETHANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN VARIANT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSACTIVATION; TRANSIENT TRANSFECTION;

ANTIFUNGAL AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HISTAMINE ANTAGONISTS; HUMANS; LIGANDS; PHENOLPHTHALEIN; PROTEIN BINDING; PROTEIN ISOFORMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STILBENES; SUBSTRATE SPECIFICITY; TERPHENYL COMPOUNDS;

EID: 78149468556     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.018     Document Type: Article

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