Direct functionalization of (Un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: Two metals, two mechanisms

Journal of Organic Chemistry

Volumn 76, Issue 21, 2011, Pages 8781-8793

  Ghobrial, Michael ^a   Schnürch, Michael ^a   Mihovilovic, Marko D ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER CATALYSIS; ELECTRON-RICH ARENES; FUNCTIONALIZATIONS; IRON CATALYST; TETRAHYDROISOQUINOLINES;

AROMATIC COMPOUNDS; CATALYSIS; CATALYSTS; COPPER;

IRON;

1 (1 METHYL 1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (1H INDOL 3 YL) 2 (PYRIDIN 2 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (2 METHYL 1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3 INDOLYL)TETRAHYDROISOQUINOLINE; 1 (5 METHOXY 1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (5 METHOXYCARBONYL 1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (5 NITRO 1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 [1 (1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL]ETHANONE; 1,1 DIMETHYLETHYL 1 (1 METHYL 1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 (1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 (2 METHYL 1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 (5 AMINO 1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 (5 CHLORO 1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 [1H PYRROLO(2,3 B)PYRIDIN 3 YL] 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 [4 CHLORO 7H PYRROLO(2,3 D)PYRIMIDIN 5 YL] 2(1H)CARBOXYLATE; 1,1 DIMETHYLETHYL 1 [5 (METHOXYCARBONYL) 1H INDOL 3 YL] 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; 2 PHENYLMETHYL 1 (1H INDOL 3 YL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 2,2 DIMETHYL 1 [1 (1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL]PROPAN 1 ONE; [1 (1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHENYL)METHANONE; COPPER; INDOLE DERIVATIVE; IRON; ISOCHROMAN DERIVATIVE; NUCLEOPHILE; PHENYLMETHYL 1 (1H INDOL 3 YL) 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOXYLATE; POLYCYCLIC AROMATIC HYDROCARBON; PYRROLE; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG SYNTHESIS; ELECTRON TRANSPORT;

CATALYSIS; CHROMANS; COPPER; IRON; LIGANDS; METALS; MOLECULAR STRUCTURE; TETRAHYDROISOQUINOLINES;

EID: 80055077308     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201511d     Document Type: Article

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