SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2513-2528

  Berglund, Magnus ^a   Dalence Guzmán, María F ^a,b   Skogvall, Staffan ^c   Sterner, Olov ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSIDAD MAYOR DE SAN SIMÓN   (Bolivia)

^c Respiratorius AB   (Sweden)

Author keywords

1,2,3,4 Tetrahydroisoquinoline; 2,3,4,5 Tetrahydro 1H 2 azepine; 2,3,4,5 Tetrahydro 1H 3 benzazepine; A ring catechol; Asthma; B ring; Bronchodilator; Capsazepine; COPD; Isoindoline; SAR; Small human airways

Indexed keywords

6,7 DIHYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; BRONCHODILATING AGENT; CAPSAZEPINE; CATECHOL; QUINOLINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BRONCHODILATOR AGENTS; CAPSAICIN; CATECHOLS; CHLORINE COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; RESPIRATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749107989     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.061     Document Type: Article

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