Easy microwave assisted deprotection of N-Boc derivatives

Synlett

Volumn , Issue 2, 1998, Pages 147-148

  Siro, Jorge G ^a   Martín, Justina ^a   García Navío, José L ^a   Remuiñan, Modesto J ^a   Vaquero, Juan J ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001943967     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-1604     Document Type: Article

References (20)

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4. 4 / dioxane: Houghten, R.A.; Beckman, A.; Ostresh, J.M. Int. J. Pept. Protein Res. 1986, 27, 653.
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13. a) Ezquerra, J.; Rubio, A.; Martín, J.; García-Navío, J.L. Tetrahedron: Asymmetry 1997, 8, 669.
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15. For reviews on microwaves in organic synthesis, see: (a) Giguere, R.J. Organic Synthesis. Theory and Applications 1989, 1, 103.
16. (b) Mingos, M.P.; Baghrust, D.R. Chem. Soc. Rev. 1991, 20, 1.
17. (c) Bram, G.; Loupy, A.; Vilemin, D. in Solid Supports and Catalysis in Organic Synthesis, Smith, K. Ed., Ellis Horwood, New York, pp 302, 1992.
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19. A commercial microwave oven with 900 watts of power output was used. The power generated by the oven was measured before every experiment by the method described by Watkins, K.W. J. Chem. Ed. 1983, 60, 1043.
20. 2 (50 mL) and silica gel (230-400 mesh) (10 g) was added. The solvent was taken off on vacuo and the powdered solid obtained was irradiated in the microwave oven, in an open erlenmeyer flask for the time described (Table) at 450 watts. The resulting solid was thoroughly washed with acetone or methanol, and then isolated to afford pure products.