메뉴 건너뛰기




Volumn 82, Issue 10, 2011, Pages 1500-1509

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

Author keywords

Alzheimer's disease; Amyloid beta; Cell cycle; Degeneration; p75NTR; Tau

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; BETA SECRETASE INHIBITOR; BRAIN DERIVED NEUROTROPHIC FACTOR; BUTYRIC ACID DERIVATIVE; BUTYRIC ACID PHENYL ESTER; CYSTEINYLALANYLTHREONYLASPARTYLISOLEUCYLLYSYLGLYCYLALANYLGLUTAMYLCYSTEINE; DNA VACCINE; ETANERCEPT; GAMMA SECRETASE INHIBITOR; INSULIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR P75; NEUROTROPHIN RECEPTOR P75 INHIBITOR; NOOTROPIC AGENT; PRO NERVE GROWTH FACTOR; PROTEIN INHIBITOR; PROTEIN PRECURSOR; PROTEIN TYROSINE KINASE A; RECOMBINANT NEUROTROPHIN RECEPTOR P75; RECOMBINANT PROTEIN; RECOMBINANT VACCINE; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

EID: 80054678078     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.040     Document Type: Conference Paper
Times cited : (56)

References (119)
  • 1
    • 0037012101 scopus 로고    scopus 로고
    • Neurotrophins: To cleave or not to cleave
    • DOI 10.1016/S0896-6273(01)00573-6
    • M.V. Chao, and M. Bothwell Neurotrophins: to cleave or not to cleave Neuron 33 2002 9 12 (Pubitemid 34088174)
    • (2002) Neuron , vol.33 , Issue.1 , pp. 9-12
    • Chao, M.V.1    Bothwell, M.2
  • 2
    • 2442463255 scopus 로고    scopus 로고
    • p75NTR is positively promiscuous: Novel partners and new insights
    • DOI 10.1016/j.neuron.2004.04.001, PII S0896627304002570
    • P.A. Barker p75NTR is positively promiscuous: novel partners and new insights Neuron 42 2004 529 533 (Pubitemid 38639874)
    • (2004) Neuron , vol.42 , Issue.4 , pp. 529-533
    • Barker, P.A.1
  • 3
    • 0030468789 scopus 로고    scopus 로고
    • Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
    • H.J. Gruss Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily Int J Clin Lab Res 26 1996 143 159
    • (1996) Int J Clin Lab Res , vol.26 , pp. 143-159
    • Gruss, H.J.1
  • 4
    • 77953647392 scopus 로고    scopus 로고
    • A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR)
    • J.M. Frade, and N. Lopez-Sanchez A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR) Cell Cycle 9 2010 1934 1941
    • (2010) Cell Cycle , vol.9 , pp. 1934-1941
    • Frade, J.M.1    Lopez-Sanchez, N.2
  • 5
    • 0029830141 scopus 로고    scopus 로고
    • Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization
    • DOI 10.1074/jbc.271.35.21151
    • S.M. Santee, and L.B. Owen-Schaub Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization J Biol Chem 271 1996 21151 21159 (Pubitemid 26292967)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.35 , pp. 21151-21159
    • Santee, S.M.1    Owen-Schaub, L.B.2
  • 6
    • 0030851905 scopus 로고    scopus 로고
    • NMR structure of the death domain of the p75 neurotrophin receptor
    • DOI 10.1093/emboj/16.16.4999
    • E. Liepinsh, L.L. Ilag, G. Otting, and C.F. Ibanez NMR structure of the death domain of the p75 neurotrophin receptor EMBO J 16 1997 4999 5005 (Pubitemid 27348408)
    • (1997) EMBO Journal , vol.16 , Issue.16 , pp. 4999-5005
    • Liepinsh, E.1    Ilag, L.L.2    Otting, G.3    Ibanez, C.F.4
  • 7
    • 0034054499 scopus 로고    scopus 로고
    • P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease
    • DOI 10.1006/exnr.1999.7252
    • A. Salehi, M. Ocampo, J. Verhaagen, and D.F. Swaab p75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease Exp Neurol 161 2000 245 258 (Pubitemid 30136547)
    • (2000) Experimental Neurology , vol.161 , Issue.1 , pp. 245-258
    • Salehi, A.1    Ocampo, M.2    Verhaagen, J.3    Swaab, D.F.4
  • 8
    • 0036445858 scopus 로고    scopus 로고
    • NTR expression in hippocampal neurons containing hyperphosphorylated τ in Alzheimer patients
    • DOI 10.1006/exnr.2002.8018
    • X.Y. Hu, H.Y. Zhang, S. Qin, H. Xu, D.F. Swaab, and J.N. Zhou Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients Exp Neurol 178 2002 104 111 (Pubitemid 35425613)
    • (2002) Experimental Neurology , vol.178 , Issue.1 , pp. 104-111
    • Hu, X.-Y.1    Zhang, H.-Y.2    Qin, S.3    Xu, H.4    Swaab, D.F.5    Zhou, J.-N.6
  • 9
    • 0026571233 scopus 로고
    • Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease
    • E.J. Mufson, and J.H. Kordower Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease Proc Natl Acad Sci U S A 89 1992 569 573
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 569-573
    • Mufson, E.J.1    Kordower, J.H.2
  • 10
    • 0031021296 scopus 로고    scopus 로고
    • Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein ε4 allele
    • T. Arendt, C. Schindler, M.K. Bruckner, K. Eschrich, V. Bigl, and D. Zedlick Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele J Neurosci 17 1997 516 529 (Pubitemid 27024565)
    • (1997) Journal of Neuroscience , vol.17 , Issue.2 , pp. 516-529
    • Arendt, T.1    Schindler, C.2    Bruckner, M.K.3    Eschrich, K.4    Bigl, V.5    Zedlick, D.6    Marcova, L.7
  • 11
    • 38249022776 scopus 로고
    • Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
    • J.H. Kordower, D.M. Gash, M. Bothwell, L. Hersh, and E.J. Mufson Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients Neurobiol Aging 10 1989 67 74 (Pubitemid 19164503)
    • (1989) Neurobiology of Aging , vol.10 , Issue.1 , pp. 67-74
    • Kordower, J.H.1    Gash, D.M.2    Bothwell, M.3    Hersh, L.4    Mufson, E.J.5
  • 12
    • 0024504222 scopus 로고
    • Nerve growth factor receptor mRNA distribution in human brain: Normal levels in basal forebrain in Alzheimer's disease
    • DOI 10.1016/0169-328X(89)90011-9
    • M. Goedert, A. Fine, D. Dawbarn, G.K. Wilcock, and M.V. Chao Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease Brain Res Mol Brain Res 5 1989 1 7 (Pubitemid 19011048)
    • (1989) Molecular Brain Research , vol.5 , Issue.1 , pp. 1-7
    • Goedert, M.1    Fine, A.2    Dawbarn, D.3    Wilcock, G.K.4    Chao, M.V.5
  • 13
    • 0025968661 scopus 로고
    • Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain
    • J.J. Treanor, D. Dawbarn, S.J. Allen, S.H. MacGowan, and G.K. Wilcock Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain Neurosci Lett 121 1991 73 76
    • (1991) Neurosci Lett , vol.121 , pp. 73-76
    • Treanor, J.J.1    Dawbarn, D.2    Allen, S.J.3    MacGowan, S.H.4    Wilcock, G.K.5
  • 14
    • 33645301867 scopus 로고    scopus 로고
    • Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
    • S.D. Ginsberg, S. Che, J. Wuu, S.E. Counts, and E.J. Mufson Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease J Neurochem 97 2006 475 487
    • (2006) J Neurochem , vol.97 , pp. 475-487
    • Ginsberg, S.D.1    Che, S.2    Wuu, J.3    Counts, S.E.4    Mufson, E.J.5
  • 15
    • 77149138009 scopus 로고    scopus 로고
    • Amyloid-beta peptides stimulate the expression of the p75NTR neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice
    • B. Chakravarthy, C. Gaudet, M. Menard, T. Atkinson, L. Brown, and F.M. Laferla Amyloid-beta peptides stimulate the expression of the p75NTR neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice J Alzheimers Dis 19 2010 915 925
    • (2010) J Alzheimers Dis , vol.19 , pp. 915-925
    • Chakravarthy, B.1    Gaudet, C.2    Menard, M.3    Atkinson, T.4    Brown, L.5    Laferla, F.M.6
  • 16
    • 79951538920 scopus 로고    scopus 로고
    • P75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain
    • Y.J. Wang, X. Wang, J.J. Lu, Q.X. Li, C.Y. Gao, and X.H. Liu p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain J Neurosci 31 2011 2292 2304
    • (2011) J Neurosci , vol.31 , pp. 2292-2304
    • Wang, Y.J.1    Wang, X.2    Lu, J.J.3    Li, Q.X.4    Gao, C.Y.5    Liu, X.H.6
  • 17
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease and frontotemporal dementia
    • DOI 10.1038/nrn2420, PII NRN2420
    • J. Gotz, and L.M. Ittner Animal models of Alzheimer's disease and frontotemporal dementia Nat Rev Neurosci 9 2008 532 544 (Pubitemid 351873467)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.7 , pp. 532-544
    • Gotz, J.1    Ittner, L.M.2
  • 18
    • 37549010213 scopus 로고    scopus 로고
    • The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism
    • S. Petratos, Q.X. Li, A.J. George, X. Hou, M.L. Kerr, and S.E. Unabia The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism Brain 131 2008 90 108
    • (2008) Brain , vol.131 , pp. 90-108
    • Petratos, S.1    Li, Q.X.2    George, A.J.3    Hou, X.4    Kerr, M.L.5    Unabia, S.E.6
  • 20
    • 77953810696 scopus 로고    scopus 로고
    • Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice
    • E. Masliah, F. Xie, S. Dayan, E. Rockenstein, M. Mante, and A. Adame Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice Neuroscience 169 2010 488 494
    • (2010) Neuroscience , vol.169 , pp. 488-494
    • Masliah, E.1    Xie, F.2    Dayan, S.3    Rockenstein, E.4    Mante, M.5    Adame, A.6
  • 21
    • 78751514071 scopus 로고    scopus 로고
    • Targeting the Nogo receptor complex in diseases of the central nervous system
    • C.L. McDonald, C. Bandtlow, and M. Reindl Targeting the Nogo receptor complex in diseases of the central nervous system Curr Med Chem 18 2011 234 244
    • (2011) Curr Med Chem , vol.18 , pp. 234-244
    • McDonald, C.L.1    Bandtlow, C.2    Reindl, M.3
  • 22
    • 69449094771 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo
    • J.K. Knowles, J. Rajadas, T.V. Nguyen, T. Yang, M.C. LeMieux, and Griend L Vander The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo J Neurosci 29 2009 10627 10637
    • (2009) J Neurosci , vol.29 , pp. 10627-10637
    • Knowles, J.K.1    Rajadas, J.2    Nguyen, T.V.3    Yang, T.4    Lemieux, M.C.5    Vander, G.L.6
  • 23
    • 66049128051 scopus 로고    scopus 로고
    • P75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model
    • T.G. Bengoechea, Z. Chen, D. O'Leary, E. Masliah, and K.F. Lee p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model Proc Natl Acad Sci U S A 106 2009 7870 7875
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7870-7875
    • Bengoechea, T.G.1    Chen, Z.2    O'Leary, D.3    Masliah, E.4    Lee, K.F.5
  • 24
    • 0034848604 scopus 로고    scopus 로고
    • The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease
    • DOI 10.1006/mcne.2001.1016
    • M. Fahnestock, B. Michalski, B. Xu, and M.D. Coughlin The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease Mol Cell Neurosci 18 2001 210 220 (Pubitemid 32846529)
    • (2001) Molecular and Cellular Neuroscience , vol.18 , Issue.2 , pp. 210-220
    • Fahnestock, M.1    Michalski, B.2    Xu, B.3    Coughlin, M.D.4
  • 27
    • 55749104402 scopus 로고    scopus 로고
    • Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures
    • M. Volosin, C. Trotter, A. Cragnolini, R.S. Kenchappa, M. Light, and B.L. Hempstead Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures J Neurosci 28 2008 9870 9879
    • (2008) J Neurosci , vol.28 , pp. 9870-9879
    • Volosin, M.1    Trotter, C.2    Cragnolini, A.3    Kenchappa, R.S.4    Light, M.5    Hempstead, B.L.6
  • 28
    • 0034279150 scopus 로고    scopus 로고
    • Neurotrophins induce death of hippocampal neurons via the p75 receptor
    • W.J. Friedman Neurotrophins induce death of hippocampal neurons via the p75 receptor J Neurosci 20 2000 6340 6346
    • (2000) J Neurosci , vol.20 , pp. 6340-6346
    • Friedman, W.J.1
  • 29
    • 33745700716 scopus 로고    scopus 로고
    • Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis
    • P. Podlesniy, A. Kichev, C. Pedraza, J. Saurat, M. Encinas, and B. Perez Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis Am J Pathol 169 2006 119 131
    • (2006) Am J Pathol , vol.169 , pp. 119-131
    • Podlesniy, P.1    Kichev, A.2    Pedraza, C.3    Saurat, J.4    Encinas, M.5    Perez, B.6
  • 30
    • 77949903194 scopus 로고    scopus 로고
    • Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism
    • Y.J. Wang, D. Valadares, Y. Sun, X. Wang, J.H. Zhong, and X.H. Liu Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism Neurotox Res 17 2010 257 267
    • (2010) Neurotox Res , vol.17 , pp. 257-267
    • Wang, Y.J.1    Valadares, D.2    Sun, Y.3    Wang, X.4    Zhong, J.H.5    Liu, X.H.6
  • 32
  • 33
    • 0032534629 scopus 로고    scopus 로고
    • β-Amyloid binds to p75(NTR) and activates NFκB in human neuroblastoma cells
    • P. Kuner, R. Schubenel, and C. Hertel Beta-amyloid binds to p75NTR and activates NFkappaB in human neuroblastoma cells J Neurosci Res 54 1998 798 804 (Pubitemid 28544380)
    • (1998) Journal of Neuroscience Research , vol.54 , Issue.6 , pp. 798-804
    • Kuner, P.1    Schubenel, R.2    Hertel, C.3
  • 36
    • 27344441077 scopus 로고    scopus 로고
    • The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of β-amyloid
    • DOI 10.1016/j.yexcr.2005.09.004, PII S0014482705004179
    • C. Costantini, V. Della-Bianca, E. Formaggio, C. Chiamulera, A. Montresor, and F. Rossi The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of beta-amyloid Exp Cell Res 311 2005 126 134 (Pubitemid 41527181)
    • (2005) Experimental Cell Research , vol.311 , Issue.1 , pp. 126-134
    • Costantini, C.1    Della-Bianca, V.2    Formaggio, E.3    Chiamulera, C.4    Montresor, A.5    Rossi, F.6
  • 37
    • 24044480687 scopus 로고    scopus 로고
    • Low concentrations of aggregated β-amyloid induce neurite formation via the neurotrophin receptor p75
    • DOI 10.1007/s00109-005-0671-3
    • K. Susen, and A. Blochl Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75 J Mol Med 83 2005 720 735 (Pubitemid 41225114)
    • (2005) Journal of Molecular Medicine , vol.83 , Issue.9 , pp. 720-735
    • Susen, K.1    Blochl, A.2
  • 38
    • 22244466071 scopus 로고    scopus 로고
    • Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in β-amyloid peptide-dependent cell death
    • DOI 10.1385/JMN:25:2:141
    • C. Costantini, F. Rossi, E. Formaggio, R. Bernardoni, D. Cecconi, and V. Della-Bianca Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death J Mol Neurosci 25 2005 141 156 (Pubitemid 41389355)
    • (2005) Journal of Molecular Neuroscience , vol.25 , Issue.2 , pp. 141-156
    • Costantini, C.1    Rossi, F.2    Formaggio, E.3    Bernardoni, R.4    Cecconi, D.5    Della-Bianca, V.6
  • 40
    • 11844260044 scopus 로고    scopus 로고
    • Structure and function of amyloid in Alzheimer's disease
    • DOI 10.1016/j.pneurobio.2004.10.004, PII S0301008204001972
    • C. Morgan, M. Colombres, M.T. Nunez, and N.C. Inestrosa Structure and function of amyloid in Alzheimer's disease Prog Neurobiol 74 2004 323 349 (Pubitemid 40092735)
    • (2004) Progress in Neurobiology , vol.74 , Issue.6 , pp. 323-349
    • Morgan, C.1    Colombres, M.2    Nunez, M.T.3    Inestrosa, N.C.4
  • 41
    • 0027994773 scopus 로고
    • Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease
    • T. Nakamura, M. Shoji, Y. Harigaya, M. Watanabe, K. Hosoda, and T.T. Cheung Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease Ann Neurol 36 1994 903 911
    • (1994) Ann Neurol , vol.36 , pp. 903-911
    • Nakamura, T.1    Shoji, M.2    Harigaya, Y.3    Watanabe, M.4    Hosoda, K.5    Cheung, T.T.6
  • 43
    • 70450211408 scopus 로고    scopus 로고
    • Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration
    • M.A. Arevalo, P.M. Roldan, P.J. Chacon, and A. Rodriguez-Tebar Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration J Neurochem 111 2009 1425 1433
    • (2009) J Neurochem , vol.111 , pp. 1425-1433
    • Arevalo, M.A.1    Roldan, P.M.2    Chacon, P.J.3    Rodriguez-Tebar, A.4
  • 44
    • 0035933783 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway
    • P.P. Roux, A.L. Bhakar, T.E. Kennedy, and P.A. Barker The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway J Biol Chem 276 2001 23097 23104
    • (2001) J Biol Chem , vol.276 , pp. 23097-23104
    • Roux, P.P.1    Bhakar, A.L.2    Kennedy, T.E.3    Barker, P.A.4
  • 45
    • 0035879182 scopus 로고    scopus 로고
    • A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons
    • M.F. DeFreitas, P.S. McQuillen, and C.J. Shatz A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons J Neurosci 21 2001 5121 5129 (Pubitemid 32622937)
    • (2001) Journal of Neuroscience , vol.21 , Issue.14 , pp. 5121-5129
    • DeFreitas, M.F.1    McQuillen, P.S.2    Shatz, C.J.3
  • 46
    • 0035882380 scopus 로고    scopus 로고
    • A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2
    • G. Khursigara, J. Bertin, H. Yano, H. Moffett, P.S. DiStefano, and M.V. Chao A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2 J Neurosci 21 2001 5854 5863 (Pubitemid 32737718)
    • (2001) Journal of Neuroscience , vol.21 , Issue.16 , pp. 5854-5863
    • Khursigara, G.1    Bertin, J.2    Yano, H.3    Moffett, H.4    DiStefano, P.S.5    Chao, M.V.6
  • 47
    • 67650482603 scopus 로고    scopus 로고
    • Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation
    • C. Matrone, R. Marolda, S. Ciafre, M.T. Ciotti, D. Mercanti, and P. Calissano Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation Proc Natl Acad Sci U S A 106 2009 11358 11363
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 11358-11363
    • Matrone, C.1    Marolda, R.2    Ciafre, S.3    Ciotti, M.T.4    Mercanti, D.5    Calissano, P.6
  • 48
    • 33745894132 scopus 로고    scopus 로고
    • Does the p75 neurotrophin receptor mediate Aβ-induced toxicity in Alzheimer's disease?
    • DOI 10.1111/j.1471-4159.2006.03905.x
    • E.J. Coulson Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease? J Neurochem 98 2006 654 660 (Pubitemid 44051267)
    • (2006) Journal of Neurochemistry , vol.98 , Issue.3 , pp. 654-660
    • Coulson, E.J.1
  • 49
    • 77955447833 scopus 로고    scopus 로고
    • Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration
    • S. Capsoni, C. Tiveron, D. Vignone, G. Amato, and A. Cattaneo Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration Proc Natl Acad Sci U S A 107 2010 12299 12304
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12299-12304
    • Capsoni, S.1    Tiveron, C.2    Vignone, D.3    Amato, G.4    Cattaneo, A.5
  • 51
    • 33846389267 scopus 로고    scopus 로고
    • Pro-NGF secreted by astrocytes promotes motor neuron cell death
    • DOI 10.1016/j.mcn.2006.11.005, PII S1044743106002570
    • M. Domeniconi, B.L. Hempstead, and M.V. Chao Pro-NGF secreted by astrocytes promotes motor neuron cell death Mol Cell Neurosci 34 2007 271 279 (Pubitemid 46137000)
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.2 , pp. 271-279
    • Domeniconi, M.1    Hempstead, B.L.2    Chao, M.V.3
  • 52
    • 54349117308 scopus 로고    scopus 로고
    • Human ProNGF: Biological effects and binding profiles at TrkA, P75NTR and sortilin
    • O. Clewes, M.S. Fahey, S.J. Tyler, J.J. Watson, H. Seok, and C. Catania Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin J Neurochem 107 2008 1124 1135
    • (2008) J Neurochem , vol.107 , pp. 1124-1135
    • Clewes, O.1    Fahey, M.S.2    Tyler, S.J.3    Watson, J.J.4    Seok, H.5    Catania, C.6
  • 53
    • 77956309945 scopus 로고    scopus 로고
    • Nerve growth factor attenuates oxidant-induced beta-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
    • I.G. Onyango, J.Y. Ahn, J.B. Tuttle, J.P. Bennett Jr., and R.H. Swerdlow Nerve growth factor attenuates oxidant-induced beta-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids J Neurochem 114 2010 1605 1618
    • (2010) J Neurochem , vol.114 , pp. 1605-1618
    • Onyango, I.G.1    Ahn, J.Y.2    Tuttle, J.B.3    Bennett, Jr.J.P.4    Swerdlow, R.H.5
  • 54
    • 26844507790 scopus 로고    scopus 로고
    • NTR molecular switch activates amyloid β-peptide generation during aging
    • DOI 10.1042/BJ20050700
    • C. Costantini, R. Weindruch, G. Della Valle, and L. Puglielli A TrkA to p75 NTR molecular switch activates amyloid beta-peptide generation during aging Biochem J 391 2005 59 67 (Pubitemid 41445476)
    • (2005) Biochemical Journal , vol.391 , Issue.1 , pp. 59-67
    • Costantini, C.1    Weindruch, R.2    Della Valle, G.3    Puglielli, L.4
  • 55
    • 33646591261 scopus 로고    scopus 로고
    • An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation
    • C. Costantini, H. Scrable, and L. Puglielli An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation EMBO J 25 2006 1997 2006
    • (2006) EMBO J , vol.25 , pp. 1997-2006
    • Costantini, C.1    Scrable, H.2    Puglielli, L.3
  • 56
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • T. Kawarabayashi, L.H. Younkin, T.C. Saido, M. Shoji, K.H. Ashe, and S.G. Younkin Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease J Neurosci 21 2001 372 381 (Pubitemid 32107428)
    • (2001) Journal of Neuroscience , vol.21 , Issue.2 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 57
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol Rev 81 2001 741 766 (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 61
    • 33749534896 scopus 로고    scopus 로고
    • NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons
    • DOI 10.1002/jnr.20996
    • E.T. Saez, M. Pehar, M.R. Vargas, L. Barbeito, and R.B. Maccioni Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons J Neurosci Res 84 2006 1098 1106 (Pubitemid 44523652)
    • (2006) Journal of Neuroscience Research , vol.84 , Issue.5 , pp. 1098-1106
    • Saez, E.T.1    Pehar, M.2    Vargas, M.R.3    Barbeito, L.4    Maccioni, R.B.5
  • 62
    • 56149091270 scopus 로고    scopus 로고
    • Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment
    • T. Yang, J.K. Knowles, Q. Lu, H. Zhang, O. Arancio, and L.A. Moore Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment PLoS ONE 3 2008 e3604
    • (2008) PLoS ONE , vol.3 , pp. 3604
    • Yang, T.1    Knowles, J.K.2    Lu, Q.3    Zhang, H.4    Arancio, O.5    Moore, L.A.6
  • 63
    • 33646876851 scopus 로고    scopus 로고
    • The cell cycle as a therapeutic target for Alzheimer's disease
    • DOI 10.1016/j.pharmthera.2005.09.005, PII S0163725805002081
    • R.L. Neve, and D.L. McPhie The cell cycle as a therapeutic target for Alzheimer's disease Pharmacol Ther 111 2006 99 113 (Pubitemid 43786202)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.1 , pp. 99-113
    • Neve, R.L.1    McPhie, D.L.2
  • 64
    • 0034708641 scopus 로고    scopus 로고
    • The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons
    • DOI 10.1074/jbc.275.12.8929
    • Y. Chen, D.L. McPhie, J. Hirschberg, and R.L. Neve The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons J Biol Chem 275 2000 8929 8935 (Pubitemid 30180250)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8929-8935
    • Chen, Y.1    McPhie, D.L.2    Hirschberg, J.3    Neve, R.L.4
  • 66
    • 34447641466 scopus 로고    scopus 로고
    • Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development
    • DOI 10.1038/sj.cdd.4402173, PII 4402173
    • K. Nakamura, K. Namekata, C. Harada, and T. Harada Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development Cell Death Differ 14 2007 1552 1554 (Pubitemid 47086740)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.8 , pp. 1552-1554
    • Nakamura, K.1    Namekata, K.2    Harada, C.3    Harada, T.4
  • 67
    • 76249123177 scopus 로고    scopus 로고
    • Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor
    • S.M. Morillo, P. Escoll, A. de la Hera, and J.M. Frade Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor Proc Natl Acad Sci U S A 107 2010 109 114
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 109-114
    • Morillo, S.M.1    Escoll, P.2    De La Hera, A.3    Frade, J.M.4
  • 68
    • 1842456983 scopus 로고    scopus 로고
    • The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E
    • DOI 10.1083/jcb.200301106
    • A. Chittka, J.C. Arevalo, M. Rodriguez-Guzman, P. Perez, M.V. Chao, and M. Sendtner The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E J Cell Biol 164 2004 985 996 (Pubitemid 38429125)
    • (2004) Journal of Cell Biology , vol.164 , Issue.7 , pp. 985-996
    • Chittka, A.1    Arevalo, J.C.2    Rodriguez-Guzman, M.3    Perez, P.4    Chao, M.V.5    Sendtner, M.6
  • 69
    • 59649093447 scopus 로고    scopus 로고
    • Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth
    • R. Pincheira, M. Baerwald, J.D. Dunbar, and D.B. Donner Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth EMBO J 28 2009 261 273
    • (2009) EMBO J , vol.28 , pp. 261-273
    • Pincheira, R.1    Baerwald, M.2    Dunbar, J.D.3    Donner, D.B.4
  • 72
    • 0033695190 scopus 로고    scopus 로고
    • NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
    • A.H. Salehi, P.P. Roux, C.J. Kubu, C. Zeindler, A. Bhakar, and L.L. Tannis NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis Neuron 27 2000 279 288
    • (2000) Neuron , vol.27 , pp. 279-288
    • Salehi, A.H.1    Roux, P.P.2    Kubu, C.J.3    Zeindler, C.4    Bhakar, A.5    Tannis, L.L.6
  • 73
    • 27644555712 scopus 로고    scopus 로고
    • Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells
    • G. Olivieri, U. Otten, F. Meier, G. Baysang, B. Dimitriades-Schmutz, and F. Muller-Spahn Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells Neurol Clin Neurophysiol 2002 2002 2 10
    • (2002) Neurol Clin Neurophysiol , vol.2002 , pp. 2-10
    • Olivieri, G.1    Otten, U.2    Meier, F.3    Baysang, G.4    Dimitriades-Schmutz, B.5    Muller-Spahn, F.6
  • 74
    • 0034254808 scopus 로고    scopus 로고
    • p75 Neurotrophin receptor signaling: Mechanisms for neurotrophic modulation of cell stress?
    • DOI 10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.CO;2-M
    • R.T. Dobrowsky Carter BD. p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress? J Neurosci Res 61 2000 237 243 (Pubitemid 30620054)
    • (2000) Journal of Neuroscience Research , vol.61 , Issue.3 , pp. 237-243
    • Dobrowsky, R.T.1    Carter, B.D.2
  • 77
    • 75149127212 scopus 로고    scopus 로고
    • Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice
    • G.L. Barrett, C.A. Reid, C. Tsafoulis, W. Zhu, D.A. Williams, and A.G. Paolini Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice Hippocampus 20 2010 145 152
    • (2010) Hippocampus , vol.20 , pp. 145-152
    • Barrett, G.L.1    Reid, C.A.2    Tsafoulis, C.3    Zhu, W.4    Williams, D.A.5    Paolini, A.G.6
  • 78
    • 0034085908 scopus 로고    scopus 로고
    • Neurotrophin receptor structure and interactions
    • DOI 10.1016/S0031-6865(99)00036-9, PII S0031686599000369
    • H. Yano, and M.V. Chao Neurotrophin receptor structure and interactions Pharm Acta Helv 74 2000 253 260 (Pubitemid 30182578)
    • (2000) Pharmaceutica Acta Helvetiae , vol.74 , Issue.2-3 , pp. 253-260
    • Yano, H.1    Chao, M.V.2
  • 80
    • 0036395237 scopus 로고    scopus 로고
    • β-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies
    • DOI 10.1006/mcne.2002.1163
    • S. Capsoni, S. Giannotta, and A. Cattaneo Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies Mol Cell Neurosci 21 2002 15 28 (Pubitemid 35178496)
    • (2002) Molecular and Cellular Neuroscience , vol.21 , Issue.1 , pp. 15-28
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 81
    • 60349115456 scopus 로고    scopus 로고
    • Delivery of NGF to the brain: Intranasal versus ocular administration in anti-NGF transgenic mice
    • S. Capsoni, S. Covaceuszach, G. Ugolini, F. Spirito, D. Vignone, and B. Stefanini Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice J Alzheimers Dis 16 2009 371 388
    • (2009) J Alzheimers Dis , vol.16 , pp. 371-388
    • Capsoni, S.1    Covaceuszach, S.2    Ugolini, G.3    Spirito, F.4    Vignone, D.5    Stefanini, B.6
  • 82
    • 0030451939 scopus 로고    scopus 로고
    • Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
    • M. Narisawa-Saito, K. Wakabayashi, S. Tsuji, H. Takahashi, and H. Nawa Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease Neuroreport 7 1996 2925 2928 (Pubitemid 26426361)
    • (1996) NeuroReport , vol.7 , Issue.18 , pp. 2925-2928
    • Narisawa-Saito, M.1    Wakabayashi, K.2    Tsuji, S.3    Takahashi, H.4    Nawa, H.5
  • 83
    • 71849109591 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression
    • M. Rohe, M. Synowitz, R. Glass, S.M. Paul, A. Nykjaer, and T.E. Willnow Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression J Neurosci 29 2009 15472 15478
    • (2009) J Neurosci , vol.29 , pp. 15472-15478
    • Rohe, M.1    Synowitz, M.2    Glass, R.3    Paul, S.M.4    Nykjaer, A.5    Willnow, T.E.6
  • 84
    • 42949114366 scopus 로고    scopus 로고
    • Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
    • DOI 10.1016/j.neurobiolaging.2007.01.010, PII S0197458007000127
    • L. Puglielli Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? Neurobiol Aging 29 2008 795 811 (Pubitemid 351618344)
    • (2008) Neurobiology of Aging , vol.29 , Issue.6 , pp. 795-811
    • Puglielli, L.1
  • 85
    • 79959252284 scopus 로고    scopus 로고
    • Matrix Metalloproteinase-9 Participates in NGF-Induced alpha-Secretase Cleavage of Amyloid-beta Protein Precursor in PC12 Cells
    • A. Fragkouli, A.K. Tzinia, I. Charalampopoulos, A. Gravanis, and E.C. Tsilibary Matrix Metalloproteinase-9 Participates in NGF-Induced alpha-Secretase Cleavage of Amyloid-beta Protein Precursor in PC12 Cells J Alzheimers Dis 24 2011 705 719
    • (2011) J Alzheimers Dis , vol.24 , pp. 705-719
    • Fragkouli, A.1    Tzinia, A.K.2    Charalampopoulos, I.3    Gravanis, A.4    Tsilibary, E.C.5
  • 86
    • 77950838482 scopus 로고    scopus 로고
    • CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease
    • R.J. Mandel CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease Curr Opin Mol Ther 12 2010 240 247
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 240-247
    • Mandel, R.J.1
  • 88
    • 54249099997 scopus 로고    scopus 로고
    • Towards non invasive nerve growth factor therapies for Alzheimer's disease
    • A. Cattaneo, S. Capsoni, and F. Paoletti Towards non invasive nerve growth factor therapies for Alzheimer's disease J Alzheimers Dis 15 2008 255 283
    • (2008) J Alzheimers Dis , vol.15 , pp. 255-283
    • Cattaneo, A.1    Capsoni, S.2    Paoletti, F.3
  • 89
    • 0030272315 scopus 로고    scopus 로고
    • Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons
    • X.F. Zhou, and R.A. Rush Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons Neuroscience 74 1996 945 953
    • (1996) Neuroscience , vol.74 , pp. 945-953
    • Zhou, X.F.1    Rush, R.A.2
  • 90
    • 45849151754 scopus 로고    scopus 로고
    • Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury
    • X.Y. Song, F. Li, F.H. Zhang, J.H. Zhong, and X.F. Zhou Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury PLoS ONE 3 2008 e1707
    • (2008) PLoS ONE , vol.3 , pp. 1707
    • Song, X.Y.1    Li, F.2    Zhang, F.H.3    Zhong, J.H.4    Zhou, X.F.5
  • 93
    • 33645799452 scopus 로고    scopus 로고
    • Leisure activity and risk of cognitive impairment: The Chongqing aging study
    • DOI 10.1212/01.wnl.0000192165.99963.2a, PII 0000611420060328000025
    • Y.J. Wang, H.D. Zhou, J. Li, M. Zhang, J. Deng, and M. Tang Leisure activity and risk of cognitive impairment: the Chongqing aging study Neurology 66 2006 911 913 (Pubitemid 43739769)
    • (2006) Neurology , vol.66 , Issue.6 , pp. 911-913
    • Wang, J.Y.J.1    Zhou, D.H.D.2    Li, J.3    Zhang, M.4    Deng, J.5    Tang, M.6    Gao, C.7    Li, J.8    Lian, Y.9    Chen, M.10
  • 94
    • 56349171225 scopus 로고    scopus 로고
    • High-dose dietary supplementation of vitamin A induces brain-derived neurotrophic factor and nerve growth factor production in mice with simultaneous deficiency of vitamin A and zinc
    • S. Kheirvari, K. Uezu, S. Yamamoto, and Y. Nakaya High-dose dietary supplementation of vitamin A induces brain-derived neurotrophic factor and nerve growth factor production in mice with simultaneous deficiency of vitamin A and zinc Nutr Neurosci 11 2008 228 234
    • (2008) Nutr Neurosci , vol.11 , pp. 228-234
    • Kheirvari, S.1    Uezu, K.2    Yamamoto, S.3    Nakaya, Y.4
  • 95
    • 77149138009 scopus 로고    scopus 로고
    • Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice
    • B. Chakravarthy, C. Gaudet, M. Menard, T. Atkinson, L. Brown, and F.M. Laferla Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice J Alzheimers Dis 19 2010 915 925
    • (2010) J Alzheimers Dis , vol.19 , pp. 915-925
    • Chakravarthy, B.1    Gaudet, C.2    Menard, M.3    Atkinson, T.4    Brown, L.5    Laferla, F.M.6
  • 96
    • 33747051514 scopus 로고    scopus 로고
    • Interaction of survival and death signaling in basal forebrain neurons: Roles of neurotrophins and proneurotrophins
    • DOI 10.1523/JNEUROSCI.1560-06.2006
    • M. Volosin, W. Song, R.D. Almeida, D.R. Kaplan, B.L. Hempstead, and W.J. Friedman Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins J Neurosci 26 2006 7756 7766 (Pubitemid 44315195)
    • (2006) Journal of Neuroscience , vol.26 , Issue.29 , pp. 7756-7766
    • Volosin, M.1    Song, W.2    Almeida, R.D.3    Kaplan, D.R.4    Hempstead, B.L.5    Friedman, W.J.6
  • 97
    • 54049150440 scopus 로고    scopus 로고
    • The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons
    • A.W. Harrington, Q.M. Li, C. Tep, J.B. Park, Z. He, and S.O. Yoon The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons J Biol Chem 283 2008 24690 24697
    • (2008) J Biol Chem , vol.283 , pp. 24690-24697
    • Harrington, A.W.1    Li, Q.M.2    Tep, C.3    Park, J.B.4    He, Z.5    Yoon, S.O.6
  • 98
    • 50849086093 scopus 로고    scopus 로고
    • P75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping
    • Y.S. Lim, T. McLaughlin, T.C. Sung, A. Santiago, K.F. Lee, and D.D. O'Leary p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping Neuron 59 2008 746 758
    • (2008) Neuron , vol.59 , pp. 746-758
    • Lim, Y.S.1    McLaughlin, T.2    Sung, T.C.3    Santiago, A.4    Lee, K.F.5    O'Leary, D.D.6
  • 99
    • 70449697890 scopus 로고    scopus 로고
    • Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease
    • A. Diarra, T. Geetha, P. Potter, and J.R. Babu Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease Biochem Biophys Res Commun 390 2009 352 356
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 352-356
    • Diarra, A.1    Geetha, T.2    Potter, P.3    Babu, J.R.4
  • 101
    • 57449115897 scopus 로고    scopus 로고
    • P75NTR antagonistic cyclic peptide decreases the size of beta amyloid-induced brain inflammation
    • M. Yaar, B.L. Arble, K.B. Stewart, N.H. Qureshi, N.W. Kowall, and B.A. Gilchrest p75NTR antagonistic cyclic peptide decreases the size of beta amyloid-induced brain inflammation Cell Mol Neurobiol 28 2008 1027 1031
    • (2008) Cell Mol Neurobiol , vol.28 , pp. 1027-1031
    • Yaar, M.1    Arble, B.L.2    Stewart, K.B.3    Qureshi, N.H.4    Kowall, N.W.5    Gilchrest, B.A.6
  • 103
    • 37049009970 scopus 로고    scopus 로고
    • Nogo receptor interacts with brain APP and Aβ to reduce pathologic changes in Alzheimer's transgenic mice
    • DOI 10.2174/156720507783018235
    • J.H. Park, and S.M. Strittmatter Nogo receptor interacts with brain APP and Abeta to reduce pathologic changes in Alzheimer's transgenic mice Curr Alzheimer Res 4 2007 568 570 (Pubitemid 350248393)
    • (2007) Current Alzheimer Research , vol.4 , Issue.5 , pp. 568-570
    • Park, J.H.1    Strittmatter, S.M.2
  • 104
    • 33845729398 scopus 로고    scopus 로고
    • Subcutaneous Nogo receptor removes brain amyloid-β and improves spatial memory in Alzheimer's transgenic mice
    • DOI 10.1523/JNEUROSCI.4504-06.2006
    • J.H. Park, G.A. Widi, D.A. Gimbel, N.Y. Harel, D.H. Lee, and S.M. Strittmatter Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice J Neurosci 26 2006 13279 13286 (Pubitemid 46011638)
    • (2006) Journal of Neuroscience , vol.26 , Issue.51 , pp. 13279-13286
    • Park, J.H.1    Widi, G.A.2    Gimbel, D.A.3    Harel, N.Y.4    Lee, D.H.S.5    Strittmatter, S.M.6
  • 105
    • 0037038435 scopus 로고    scopus 로고
    • P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    • DOI 10.1038/nature01176
    • K.C. Wang, J.A. Kim, R. Sivasankaran, R. Segal, and Z. He P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp Nature 420 2002 74 78 (Pubitemid 35291442)
    • (2002) Nature , vol.420 , Issue.6911 , pp. 74-78
    • Wang, K.C.1    Kim, J.A.2    Sivasankaran, R.3    Segal, R.4    He, Z.5
  • 106
    • 20844458088 scopus 로고    scopus 로고
    • Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: A potential strategy for axonal regeneration
    • DOI 10.1111/j.1471-4159.2004.02803.x
    • G. Xu, D.Y. Nie, J.T. Chen, C.Y. Wang, F.G. Yu, and L. Sun Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: a potential strategy for axonal regeneration J Neurochem 91 2004 1018 1023 (Pubitemid 39507378)
    • (2004) Journal of Neurochemistry , vol.91 , Issue.4 , pp. 1018-1023
    • Xu, G.1    Nie, D.-Y.2    Chen, J.-T.3    Wang, C.-Y.4    Yu, F.-G.5    Sun, L.6    Luo, X.-G.7    Ahmed, S.8    David, S.9    Xiao, Z.-C.10
  • 107
    • 34548408732 scopus 로고    scopus 로고
    • DNA vaccine and the CNS axonal regeneration
    • DOI 10.2174/138161207781368567
    • D.Y. Nie, G. Xu, S. Ahmed, and Z.C. Xiao DNA vaccine and the CNS axonal regeneration Curr Pharm Des 13 2007 2500 2506 (Pubitemid 47423676)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.24 , pp. 2500-2506
    • Nie, D.-Y.1    Xu, G.2    Ahmed, S.3    Xiao, Z.-C.4
  • 109
    • 77953744202 scopus 로고    scopus 로고
    • P75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17
    • R.S. Kenchappa, C. Tep, Z. Korade, S. Urra, F.C. Bronfman, and S.O. Yoon p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17 J Biol Chem 285 2010 20358 20368
    • (2010) J Biol Chem , vol.285 , pp. 20358-20368
    • Kenchappa, R.S.1    Tep, C.2    Korade, Z.3    Urra, S.4    Bronfman, F.C.5    Yoon, S.O.6
  • 110
    • 33845567392 scopus 로고    scopus 로고
    • TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
    • Z. Ahmed, G. Mazibrada, R.J. Seabright, R.G. Dent, M. Berry, and A. Logan TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin FASEB J 20 2006 1939 1941
    • (2006) FASEB J , vol.20 , pp. 1939-1941
    • Ahmed, Z.1    Mazibrada, G.2    Seabright, R.J.3    Dent, R.G.4    Berry, M.5    Logan, A.6
  • 111
    • 0034741796 scopus 로고    scopus 로고
    • Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques
    • D.M. Skovronsky, S. Fath, V.M. Lee, and M.E. Milla Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques J Neurobiol 49 2001 40 46
    • (2001) J Neurobiol , vol.49 , pp. 40-46
    • Skovronsky, D.M.1    Fath, S.2    Lee, V.M.3    Milla, M.E.4
  • 112
    • 58149343356 scopus 로고    scopus 로고
    • Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo
    • M.L. Kim, B. Zhang, I.P. Mills, M.E. Milla, K.R. Brunden, and V.M. Lee Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo J Neurosci 28 2008 12052 12061
    • (2008) J Neurosci , vol.28 , pp. 12052-12061
    • Kim, M.L.1    Zhang, B.2    Mills, I.P.3    Milla, M.E.4    Brunden, K.R.5    Lee, V.M.6
  • 114
    • 79959669857 scopus 로고    scopus 로고
    • Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology
    • K. Morimoto, J. Horio, H. Satoh, L. Sue, T. Beach, and S. Arita Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology J Alzheimers Dis 25 2011 59 76
    • (2011) J Alzheimers Dis , vol.25 , pp. 59-76
    • Morimoto, K.1    Horio, J.2    Satoh, H.3    Sue, L.4    Beach, T.5    Arita, S.6
  • 115
    • 79955979595 scopus 로고    scopus 로고
    • Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice
    • J.C. Wiley, C. Pettan-Brewer, and W.C. Ladiges Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice Aging Cell 10 2011 418 428
    • (2011) Aging Cell , vol.10 , pp. 418-428
    • Wiley, J.C.1    Pettan-Brewer, C.2    Ladiges, W.C.3
  • 116
    • 77949558495 scopus 로고    scopus 로고
    • ADAM-17: The enzyme that does it all
    • M. Gooz ADAM-17: the enzyme that does it all Crit Rev Biochem Mol Biol 45 2010 146 169
    • (2010) Crit Rev Biochem Mol Biol , vol.45 , pp. 146-169
    • Gooz, M.1
  • 117
    • 78649494332 scopus 로고    scopus 로고
    • Anti-TNF-alpha agents in the treatment of immune-mediated inflammatory diseases: Mechanisms of action and pitfalls
    • L.C. Silva, L.C. Ortigosa, and G. Benard Anti-TNF-alpha agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls Immunotherapy 2 2010 817 833
    • (2010) Immunotherapy , vol.2 , pp. 817-833
    • Silva, L.C.1    Ortigosa, L.C.2    Benard, G.3
  • 118
    • 58549116371 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease
    • Y.J. Wang, A. Pollard, J.H. Zhong, X.Y. Dong, X.B. Wu, and H.D. Zhou Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease Neurobiol Aging 30 2009 364 376
    • (2009) Neurobiol Aging , vol.30 , pp. 364-376
    • Wang, Y.J.1    Pollard, A.2    Zhong, J.H.3    Dong, X.Y.4    Wu, X.B.5    Zhou, H.D.6
  • 119
    • 77957233161 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene prevents brain Abeta deposition and cognitive impairment in a mouse model of Alzheimer's disease
    • Y.J. Wang, C.Y. Gao, M. Yang, X.H. Liu, Y. Sun, and A. Pollard Intramuscular delivery of a single chain antibody gene prevents brain Abeta deposition and cognitive impairment in a mouse model of Alzheimer's disease Brain Behav Immun 24 2010 1281 1293
    • (2010) Brain Behav Immun , vol.24 , pp. 1281-1293
    • Wang, Y.J.1    Gao, C.Y.2    Yang, M.3    Liu, X.H.4    Sun, Y.5    Pollard, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.