Amyloid β serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration

Journal of Neurochemistry

Volumn 111, Issue 6, 2009, Pages 1425-1433

  Arevalo, Maria Ángeles ^a   Roldan, Pedro M ^b   Chacón, Pedro J ^b   Rodríguez Tebar, Alfredo ^b  

^a INSTITUTO CAJAL   (Spain)

^b CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

Author keywords

Amyloid ; Dendrite morphology; Enhancer of split; GABAergic synapses; Nerve growth factor; NF B

Indexed keywords

AMYLOID BETA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN RECEPTOR P75; SYNAPTOTAGMIN I;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITE; EMBRYO; ENHANCER OF SPLIT 1 GENE; GABAERGIC SYSTEM; GENE; GENE EXPRESSION; HIPPOCAMPUS; MORPHOLOGY; MOUSE; NERVE SPROUTING; NEUROGENIN 2 GENE; NONHUMAN; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN; ANIMALS; DENDRITES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; I-KAPPA B PROTEINS; IMMUNOPRECIPITATION; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTOR; NEURONS; NF-KAPPA B; SIGNAL TRANSDUCTION; TRANSFECTION; VESICULAR INHIBITORY AMINO ACID TRANSPORT PROTEINS;

EID: 70450211408     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06412.x     Document Type: Article

References (38)

1. Bae S., Bessho Y., Hojo M. Kageyama R. (2000) The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 127, 2933 2943. (Pubitemid 30487611)
2. Blochl A. Blochl R. (2007) A cell-biological model of p75NTR signaling. J. Neurochem. 102, 289 305.
3. Bui N. T., Livolsi A., Peyron J. F. Prehn J. H. (2001) Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J. Cell Biol. 152, 753 764.
4. Cleary J. P., Walsh D. M., Hofmeister J. J., Shankar G. M., Kuskowski M. A., Selkoe D. J. Ashe K. H. (2005) Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 8, 79 84.
5. Coulson E. J. (2006) Does the p75 neurotrophin receptor mediate a beta-induced toxicity in Alzheimer's disease? J. Neurochem. 98, 654 660.
6. DeRosa R., Garcia A. A., Braschi C., Capsoni S., Maffei L., Berardi N. Cattaneo A. (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc. Natl Acad. Sci. USA 102, 3811 3816.
7. Franklin J. L., Berechid B. E., Cutting F. B., Presente A., Chambers C. B., Foltz D. R., Ferreira A. Nye J. S. (1999) Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1 24. Curr. Biol. 9, 1448 1457.
8. Goslin K. Banker G. (1989) Experimental observations on the development of polarity by hippocampal neurons in culture. J. Cell Biol. 108, 1507 1516. (Pubitemid 19097054)
9. Hashimoto Y., Kaneko Y., Tsukamoto E. et al. (2004) Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. J. Neurochem. 90, 549 558.
10. Jin X., Hu H., Mathers P. H. Agmon A. (2003) Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures. J. Neurosci. 23, 5662 5673.
11. Kaltschmidt B., Uherek M., Wellmann H., Volk B. Kaltschmidt C. (1999) Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis. Proc. Natl Acad. Sci. USA 96, 9409 9414.
12. Kamenetz F., Tomita T., Hsieh H., Seabrook G., Borchelt D., Iwatsubo T., Sisodia S. Malinow R. (2003) APP processing and synaptic function. Neuron 37, 925 937.
13. Lipton S. A. Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613 622.
14. Liu G 2004) Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites 10530. Nat. Neurosci. 7, 373 379.
15. Louzada P. R., Lima A. C., Mendonca-Silva D. L., Noel F., De Mello F. G. Ferreira S. T. (2004) Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders. FASEB J. 18, 511 518.
16. Memet S. (2006) NF-kappaB functions in the nervous system: from development to disease. Biochem. Pharmacol. 72, 1180 1195.
17. Mukhopadhyay A., Manna S. K. Aggarwal B. B. (2000) Pervanadate-induced nuclear factor-kappa B activation requires tyrosine phosphorylation and degradation of ikappa balpha. Comparison with tumor necrosis factor-alpha. J. Biol. Chem. 275, 8549 8555.
18. Peng S., Wuu J., Mufson E. J. Fahnestock M. (2004) Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. J. Neuropathol. Exp. Neurol. 63, 641 649.
19. Perini G., la-Bianca V., Politi V., Della V. G., Dal-Pra I., Rossi F. Armato U. (2002) Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J. Exp. Med. 195, 907 918.
20. Rabizadeh S., Oh J., Zhong L. T., Yang J., Bitler C. M., Butcher L. L. Bredesen D. E. (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261, 345 348.
21. Rabizadeh S., Bitler C. M., Butcher L. L. Bredesen D. E. (1994) Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity. Proc. Natl Acad. Sci. USA 91, 10703 10706.
22. Redmond L., Oh S. R., Hicks C., Weinmaster G. Ghosh A. (2000) Nuclear Notch1 signaling and the regulation of dendritic development 4. Nat. Neurosci. 3, 30 40.
23. Religa D., Laudon H., Styczynska M., Winblad B., Naslund J. Haroutunian V. (2003) Amyloid beta pathology in Alzheimer's disease and schizophrenia. Am. J. Psychiatry 160, 867 872.
24. Salama-Cohen P., Arevalo M. A., Meier J., Grantyn R. Rodriguez-Tebar A. (2005) NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Mol. Biol. Cell 16, 339 347.
25. Salama-Cohen P., Arevalo M. A., Grantyn R. Rodriguez-Tebar A. (2006) Notch and NGF/p75NTR control dendrite morphology and the balance of excitatory/inhibitory synaptic input to hippocampal neurones through Neurogenin 3. J. Neurochem. 97, 1269 1278.
26. Selkoe D. J. (2004) Alzheimer disease: mechanistic understanding predicts novel therapies. Ann. Intern. Med. 140, 627 638.
27. Sestan N., rtavanis-Tsakonas S. Rakic P. (1999) Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286, 741 746.
28. Singh B., Henneberger C., Betances D., Arevalo M. A., Rodriguez-Tebar A., Meier J. C. Grantyn R. (2006) Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. J. Neurosci. 26, 7189 7200.
29. Susen K. Blochl A. (2005) Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75. J. Mol. Med. 83, 720 735.
30. Tuszynski M. H., Thal L., Pay M. et al. (2005) A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat. Med. 11, 551 555.
31. Valerio A., Boroni F., Benarese M., Sarnico I., Ghisi V., Bresciani L. G., Ferrario M., Borsani G., Spano P. Pizzi M. (2006) NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production. Eur. J. Neurosci. 23, 1711 1720.
32. Volosin M., Song W., Almeida R. D., Kaplan D. R., Hempstead B. L. Friedman W. J. (2006) Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. J. Neurosci. 26, 7756 7766.
33. Walsh D. M., Klyubin I., Fadeeva J. V., Cullen W. K., Anwyl R., Wolfe M. S., Rowan M. J. Selkoe D. J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535 539.
34. Walsh D. M., Townsend M., Podlisny M. B., Shankar G. M., Fadeeva J. V., Agnaf O. E., Hartley D. M. Selkoe D. J. (2005) Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J. Neurosci. 25, 2455 2462.
35. Wellmann H., Kaltschmidt B. Kaltschmidt C. (2001) Retrograde transport of transcription factor NF-kappa B in living neurons. J. Biol. Chem. 276, 11821 11829.
36. Yaar M., Zhai S., Pilch P. F., Doyle S. M., Eisenhauer P. B., Fine R. E. Gilchrest B. A. (1997) Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J. Clin. Invest. 100, 2333 2340.
37. Yaar M., Zhai S., Fine R. E., Eisenhauer P. B., Arble B. L., Stewart K. B. Gilchrest B. A. (2002) Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J. Biol. Chem. 277, 7720 7725.
38. Yankner B. A., Duffy L. K. Kirschner D. A. (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250, 279 282.