메뉴 건너뛰기




Volumn 9, Issue 6, 2011, Pages 750-762

Functional link between adenosine and insulin: A hypothesis for fetoplacental vascular endothelial dysfunction in gestational diabetes

Author keywords

Adenosine; Endothelium; Fetus; Gestational diabetes; Insulin receptor; Placenta

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 6 ETHYL 2 PHENYL 4 PROPYL 3 PYRIDINECARBOXYLIC ACID 5 THIOCARBOXYLIC ACID 5 ETHYL 3 PROPYL ESTER; 6 N (2 HYDROXYCYCLOPENTYL)ADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; CAFFEINE; CVT3619; INSULIN; INSULIN RECEPTOR; MEMBRANE RECEPTOR; METFORMIN; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; UNCLASSIFIED DRUG;

EID: 80054067527     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016111797484062     Document Type: Article
Times cited : (20)

References (124)
  • 1
    • 34447118714 scopus 로고    scopus 로고
    • The human placenta in gestational diabetes mellitus. The insulin and cytokine network
    • Desoye G, Hauguel-de Mouzon S. The human placenta in gestational diabetes mellitus. The insulin and cytokine network. Diabetes Care 2007; 30: S120-S126.
    • (2007) Diabetes Care , vol.30
    • Desoye, G.1    Hauguel-De, M.S.2
  • 2
    • 67949114340 scopus 로고    scopus 로고
    • Watchful waiting: A management protocol for maternal glycaemia in the peripartum period
    • Barrett HL, Morris J, McElduff A. Watchful waiting: a management protocol for maternal glycaemia in the peripartum period. Aust NZ J Obstet Gynaecol 2009; 49: 162-167.
    • (2009) Aust NZ J Obstet Gynaecol , vol.49 , pp. 162-167
    • Barrett, H.L.1    Morris, J.2    McElduff, A.3
  • 3
    • 77956339500 scopus 로고    scopus 로고
    • Position Statement
    • American Diabetes Association Gestational Diabetes Mellitus
    • American Diabetes Association Gestational Diabetes Mellitus. Position Statement. Diab Care 2004; 27: S88-S90.
    • (2004) Diab Care , vol.27
  • 4
    • 78651276631 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus. American Diabetes Association
    • Position statement
    • Position statement. Diagnosis and classification of diabetes mellitus. American Diabetes Association. Diab Care 2011; 34: S62-S69.
    • (2011) Diab Care , vol.34
  • 5
    • 79958164780 scopus 로고    scopus 로고
    • Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?
    • Catalano PM, Hauguel-De Mouzon S. Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? Am J Obstet Gynecol 2011; 204: 479-487.
    • (2011) Am J Obstet Gynecol , vol.204 , pp. 479-487
    • Catalano, P.M.1    Hauguel-De, M.S.2
  • 7
    • 76749110706 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species and functional adaptation of the placenta
    • Myatt L. Reactive oxygen and nitrogen species and functional adaptation of the placenta. Placenta 2010; 31: S66-S69.
    • (2010) Placenta , vol.31
    • Myatt, L.1
  • 8
    • 79959405707 scopus 로고    scopus 로고
    • Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium
    • Westermeier F, Salomón C, González M, et al. Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium. Diabetes 2011; 60:1677-1687.
    • (2011) Diabetes , vol.60 , pp. 1677-1687
    • Westermeier, F.1    Salomón, C.2    González, M.3
  • 9
    • 30144444635 scopus 로고    scopus 로고
    • Vessel tone and remodeling
    • Burnstock G. Vessel tone and remodeling. Nat Med 2006; 12: 16-17.
    • (2006) Nat Med , vol.12 , pp. 16-17
    • Burnstock, G.1
  • 10
    • 70349658872 scopus 로고    scopus 로고
    • Adenosine: An old drug newly discovered
    • Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology 2009; 111: 904-915.
    • (2009) Anesthesiology , vol.111 , pp. 904-915
    • Eltzschig, H.K.1
  • 11
    • 70349687091 scopus 로고    scopus 로고
    • Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia
    • Westermeier F, Puebla C, Vega JL, et al. Equilibrative nucleoside transporters in fetal endothelial dysfunction in diabetes mellitus and hyperglycaemia. Curr Vasc Pharmacol 2009; 7: 435-449.
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 435-449
    • Westermeier, F.1    Puebla, C.2    Vega, J.L.3
  • 12
    • 79952007627 scopus 로고    scopus 로고
    • Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes
    • Sobrevia L, Abarzúa F, Nien JK, et al. Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes. Placenta 2011; 25: S159-S164.
    • (2011) Placenta , vol.25
    • Sobrevia, L.1    Abarzúa, F.2    Nien, J.K.3
  • 13
    • 33746431414 scopus 로고    scopus 로고
    • Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand
    • Westgate JA, Lindsay RS, Beattie J, et al. Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand. Diabetes Care 2006; 29: 1345-1350.
    • (2006) Diabetes Care , vol.29 , pp. 1345-1350
    • Westgate, J.A.1    Lindsay, R.S.2    Beattie, J.3
  • 14
    • 33846904257 scopus 로고    scopus 로고
    • Inverse changes in fetal insulin-like growth factor (IGF)-1 and IGF binding protein-1 in association with higher birth weight in maternal diabetes
    • Lindsay RS, Westgate JA, Beattie J, et al. Inverse changes in fetal insulin-like growth factor (IGF)-1 and IGF binding protein-1 in association with higher birth weight in maternal diabetes. Clin Endocrinol 2007; 66: 322-328.
    • (2007) Clin Endocrinol , vol.66 , pp. 322-328
    • Lindsay, R.S.1    Westgate, J.A.2    Beattie, J.3
  • 15
    • 64549160282 scopus 로고    scopus 로고
    • Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus
    • Colomiere M, Permezel M, Riley C, Desoye G, Lappas M. Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. Eur J Endocrinol 2009; 160: 567-578.
    • (2009) Eur J Endocrinol , vol.160 , pp. 567-578
    • Colomiere, M.1    Permezel, M.2    Riley, C.3    Desoye, G.4    Lappas, M.5
  • 16
    • 0032503048 scopus 로고    scopus 로고
    • Simultaneous measurement of adenosine and hypoxanthine in human umbilical cord plasma using reversed-phase high-performance liquid chromatography with photodiode-array detection and on-line validation of peak purity
    • Maguire MH, Szabó I, Valkó IE, Finley BE, Bennett TL. Simultaneous measurement of adenosine and hypoxanthine in human umbilical cord plasma using reversed-phase high-performance liquid chromatography with photodiode-array detection and on-line validation of peak purity. J Chromatogr B Biomed Sci Appl 1998; 707: 33-41.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.707 , pp. 33-41
    • Maguire, M.H.1    Szabó, I.2    Valkó, I.E.3    Finley, B.E.4    Bennett, T.L.5
  • 17
    • 33750496901 scopus 로고    scopus 로고
    • Insulin restores glucose-inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
    • Muñoz G, San Martín R, Farías M, Cea L, Casanello P, Sobrevia L. Insulin restores glucose-inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. J Cell Physiol 2006; 209: 826-835.
    • (2006) J Cell Physiol , vol.209 , pp. 826-835
    • Muñoz, G.1    Martín, S.R.2    Farías, M.3    Cea, L.4    Casanello, P.5    Sobrevia, L.6
  • 18
    • 21344460058 scopus 로고    scopus 로고
    • The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus
    • Srinivasan M, Herrero P, McGill JB, et al. The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus. J Am Coll Cardiol 2005; 46: 42-48.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 42-48
    • Srinivasan, M.1    Herrero, P.2    McGill, J.B.3
  • 19
    • 77954670603 scopus 로고    scopus 로고
    • Antimetabolic syndrome effects of adenosine ingestion in stroke-prone spontaneously hypertensive rats fed a high-fat diet
    • Ardiansyah, Shirakawa H, Sugita Y, Koseki T, Komai M. Antimetabolic syndrome effects of adenosine ingestion in stroke-prone spontaneously hypertensive rats fed a high-fat diet. Br J Nutr 2010; 104: 48-55.
    • (2010) Br J Nutr , vol.104 , pp. 48-55
    • Ardiansyah, S.H.1    Sugita, Y.2    Koseki, T.3    Komai, M.4
  • 20
    • 0036904503 scopus 로고    scopus 로고
    • Umbilical vein blood volume flow rate and umbilical artery pulsatility as 'venous-arterial index' in the prediction of neonatal compromise
    • Tchirikov M, Rybakowski C, Hüneke B, Schoder V, Schröder HJ. Umbilical vein blood volume flow rate and umbilical artery pulsatility as 'venous-arterial index' in the prediction of neonatal compromise. Ultrasound Obstet Gynecol 2002; 20: 580-585.
    • (2002) Ultrasound Obstet Gynecol , vol.20 , pp. 580-585
    • Tchirikov, M.1    Rybakowski, C.2    Hüneke, B.3    Schoder, V.4    Schröder, H.J.5
  • 21
    • 19944365506 scopus 로고    scopus 로고
    • Restricted innervation of uterus and placenta during pregnancy: Evidence for a role of the repelling signal Semaphorin 3A
    • Marzioni D, Tamagnone L, Capparuccia L, et al. Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. Dev Dyn 2004; 231: 839-848.
    • (2004) Dev Dyn , vol.231 , pp. 839-848
    • Marzioni, D.1    Tamagnone, L.2    Capparuccia, L.3
  • 22
    • 0025253578 scopus 로고
    • Action of adenosine and characterization of adenosine receptors in human placental vasculature
    • Reviriego J, Alonso MJ, Ibañez C, Marín J. Action of adenosine and characterization of adenosine receptors in human placental vasculature. Gen Pharmacol 1990; 21: 227-233.
    • (1990) Gen Pharmacol , vol.21 , pp. 227-233
    • Reviriego, J.1    Alonso, M.J.2    Ibañez, C.3    Marín, J.4
  • 23
    • 6444227946 scopus 로고    scopus 로고
    • Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium
    • Vásquez G, Sanhueza F, Vásquez R, et al. Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 2004; 560: 111-122.
    • (2004) J Physiol , vol.560 , pp. 111-122
    • Vásquez, G.1    Sanhueza, F.2    Vásquez, R.3
  • 24
    • 27944492352 scopus 로고    scopus 로고
    • Gestational diabetes and the adenosine/ L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium
    • San Martín R, Sobrevia L. Gestational diabetes and the adenosine/ L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta 2006; 27: 1-10.
    • (2006) Placenta , vol.27 , pp. 1-10
    • Martín, S.R.1    Sobrevia, L.2
  • 25
    • 79952033865 scopus 로고    scopus 로고
    • Nomenclature and classification of adenosine receptors: An update
    • International Union of Basic and Clinical Pharmacology LXXXI
    • Fredholm BB, Ijzerman AP, Jacobson KA, Linden J, Müller CE. International Union of Basic and Clinical Pharmacology LXXXI. Nomenclature and classification of adenosine receptors: an update. Pharmacol Rev 2011; 63: 1-34.
    • (2011) Pharmacol Rev , vol.63 , pp. 1-34
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Linden, J.4    Müller, C.E.5
  • 26
    • 0036793564 scopus 로고    scopus 로고
    • Early activation of the p42/p44 MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: A novel calcium insensitive mechanism
    • Wyatt AW, Steinert JR, Wheeler-Jones CPD, et al. Early activation of the p42/p44 MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium insensitive mechanism. FASEB J 2002; 16: 1584-1594.
    • (2002) FASEB J , vol.16 , pp. 1584-1594
    • Wyatt, A.W.1    Steinert, J.R.2    Wheeler-Jones, C.P.D.3
  • 27
    • 50249099855 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia
    • Escudero C, Casanello P, Sobrevia L. Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. Placenta 2008; 29: 816-825.
    • (2008) Placenta , vol.29 , pp. 816-825
    • Escudero, C.1    Casanello, P.2    Sobrevia, L.3
  • 28
    • 33645990346 scopus 로고    scopus 로고
    • The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium
    • Ray CJ, Marshall JM. The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. J Physiol 2006; 570: 85-96.
    • (2006) J Physiol , vol.570 , pp. 85-96
    • Ray, C.J.1    Marshall, J.M.2
  • 29
    • 77949355546 scopus 로고    scopus 로고
    • High glucose, nitric oxide, and adenosine: A vicious circle in chronic hyperglycemia?
    • Pandolfi A, Di Pietro N. High glucose, nitric oxide, and adenosine: a vicious circle in chronic hyperglycemia? Cardiovasc Res 2010; 86: 9-11.
    • (2010) Cardiovasc Res , vol.86 , pp. 9-11
    • Pandolfi, A.1    Di Pietro, N.2
  • 31
    • 0029670597 scopus 로고    scopus 로고
    • Activation of Larginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells
    • Sobrevia L, Nadal A, Yudilevich DL, Mann GE. Activation of Larginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. J Physiol 1996; 1; 490: 775-781.
    • (1996) J Physiol , vol.1 , Issue.490 , pp. 775-781
    • Sobrevia, L.1    Nadal, A.2    Yudilevich, D.L.3    Mann, G.E.4
  • 32
    • 33745605803 scopus 로고    scopus 로고
    • Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes
    • Farías M, San Martín R, Puebla C, et al. Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol 2006; 208: 451-460.
    • (2006) J Cell Physiol , vol.208 , pp. 451-460
    • Farías, M.1    Martín, S.R.2    Puebla, C.3
  • 33
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Current role in type 2 diabetes mellitus
    • Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005; 65: 385-411.
    • (2005) Drugs , vol.65 , pp. 385-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 34
    • 77950950434 scopus 로고    scopus 로고
    • Pharmacokinetics of metformin during pregnancy
    • Eyal S, Easterling TR, Carr D, et al. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos 2010; 38: 833-840.
    • (2010) Drug Metab Dispos , vol.38 , pp. 833-840
    • Eyal, S.1    Easterling, T.R.2    Carr, D.3
  • 35
    • 0025652548 scopus 로고
    • Uteroplacental Doppler ultrasound in routine antenatal care
    • Brown MA, North L, Hargood J. Uteroplacental Doppler ultrasound in routine antenatal care. Aust N Z J Obstet Gynaecol 1990; 30: 303-307.
    • (1990) Aust N Z J Obstet Gynaecol , vol.30 , pp. 303-307
    • Brown, M.A.1    North, L.2    Hargood, J.3
  • 36
    • 28844464831 scopus 로고    scopus 로고
    • Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes
    • Biri A, Onan A, Devrim E, Babacan F, Kavutcu M, Durak I. Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes. Placenta 2006; 27: 327-332.
    • (2006) Placenta , vol.27 , pp. 327-332
    • Biri, A.1    Onan, A.2    Devrim, E.3    Babacan, F.4    Kavutcu, M.5    Durak, I.6
  • 39
    • 66249130069 scopus 로고    scopus 로고
    • TGF-ß1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
    • Vega JL, Puebla C, Vásquez R, et al. TGF-ß1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium. Cardiovasc Res 2009; 82: 458-467.
    • (2009) Cardiovasc Res , vol.82 , pp. 458-467
    • Vega, J.L.1    Puebla, C.2    Vásquez, R.3
  • 40
    • 0037278538 scopus 로고    scopus 로고
    • Maternal and fetal nitric oxide production in normal and abnormal pregnancy
    • von Mandach U, Lauth D, Huch R. Maternal and fetal nitric oxide production in normal and abnormal pregnancy. J Matern Fetal Neonatal Med 2003; 13: 22-27.
    • (2003) J Matern Fetal Neonatal Med , vol.13 , pp. 22-27
    • von Mandach, U.1    Lauth, D.2    Huch, R.3
  • 42
    • 79959466725 scopus 로고    scopus 로고
    • Insulin-stimulated Larginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation
    • doi:10.1002/jcp.22635
    • González M, Gallardo V, Rodríguez N, et al. Insulin-stimulated Larginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation. J Cell Physiol 2011; doi:10.1002/jcp.22635.
    • (2011) J Cell Physiol
    • González, M.1    Gallardo, V.2    Rodríguez, N.3
  • 44
    • 20444448958 scopus 로고    scopus 로고
    • Gestational diabetes mellitus - time to treat
    • Greene MF, Solomon CG. Gestational diabetes mellitus - time to treat. N Engl J Med 2005; 352: 2544-2546.
    • (2005) N Engl J Med , vol.352 , pp. 2544-2546
    • Greene, M.F.1    Solomon, C.G.2
  • 45
    • 0035985081 scopus 로고    scopus 로고
    • Vascular function, insulin resistance and fatty acids
    • Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia 2002; 45: 623-634.
    • (2002) Diabetologia , vol.45 , pp. 623-634
    • Steinberg, H.O.1    Baron, A.D.2
  • 46
    • 0037305965 scopus 로고    scopus 로고
    • Insulin and myocardial blood flow
    • Sundell J, Knuuti J. Insulin and myocardial blood flow. Cardiovasc Res 2003; 57: 312-319.
    • (2003) Cardiovasc Res , vol.57 , pp. 312-319
    • Sundell, J.1    Knuuti, J.2
  • 47
    • 77950575039 scopus 로고    scopus 로고
    • The effect of ten days of bed rest on metabolic and vascular insulin action. A study in individuals at risk for type 2 diabetes
    • Sonne MP, Alibegovic AC, Hojbjerre L, Vaag A, Stallknecht B, Dela F. The effect of ten days of bed rest on metabolic and vascular insulin action. A study in individuals at risk for type 2 diabetes. J Appl Physiol 2010; 108: 830-837.
    • (2010) J Appl Physiol , vol.108 , pp. 830-837
    • Sonne, M.P.1    Alibegovic, A.C.2    Hojbjerre, L.3    Vaag, A.4    Stallknecht, B.5    Dela, F.6
  • 48
    • 77955347040 scopus 로고    scopus 로고
    • Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling
    • Timmerman KL, Lee JL, Dreyer HC, et al. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab 2010; 95: 3848-3857.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3848-3857
    • Timmerman, K.L.1    Lee, J.L.2    Dreyer, H.C.3
  • 49
    • 80054061379 scopus 로고    scopus 로고
    • Differential reactivity to insulin in human umbilical and chorionic vessels from normal and gestational diabetic pregnancies
    • (Abstract)
    • Jo M, Krause B, Casanello P, Sobrevia L. Differential reactivity to insulin in human umbilical and chorionic vessels from normal and gestational diabetic pregnancies. J Dev Orig Health Dis 2009; 1: S307 (Abstract).
    • (2009) J Dev Orig Health Dis , vol.1
    • Jo, M.1    Krause, B.2    Casanello, P.3    Sobrevia, L.4
  • 50
    • 34247140171 scopus 로고    scopus 로고
    • Regulation of insulin receptor function
    • Youngren J. Regulation of insulin receptor function. Cell Mol Life Sci 2007; 64: 873-891.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 873-891
    • Youngren, J.1
  • 51
    • 0020445542 scopus 로고
    • Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte
    • Joost HG, Steinfelder HJ. Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte. Mol Pharmacol 1982; 22: 614-618.
    • (1982) Mol Pharmacol , vol.22 , pp. 614-618
    • Joost, H.G.1    Steinfelder, H.J.2
  • 52
    • 0028269845 scopus 로고
    • Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle
    • Vergauwen L, Hespel P, Richter EA. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest 1994; 93: 974-981.
    • (1994) J Clin Invest , vol.93 , pp. 974-981
    • Vergauwen, L.1    Hespel, P.2    Richter, E.A.3
  • 53
    • 33751168727 scopus 로고    scopus 로고
    • Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells
    • Johansson GS, Arnqvist HJ. Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells. Am J Physiol 2006; 291: E1124-E1130.
    • (2006) Am J Physiol , vol.291
    • Johansson, G.S.1    Arnqvist, H.J.2
  • 54
    • 34547773217 scopus 로고    scopus 로고
    • Adenosine receptor activation ameliorates type 1 diabetes
    • Németh ZH, Bleich D, Csóka B, et al. Adenosine receptor activation ameliorates type 1 diabetes. FASEB J 2007; 21: 2379-2388.
    • (2007) FASEB J , vol.21 , pp. 2379-2388
    • Németh, Z.H.1    Bleich, D.2    Csóka, B.3
  • 56
    • 79551591770 scopus 로고    scopus 로고
    • Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans
    • Figler RA, Wang G, Srinivasan S, et al. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes 2011; 60: 669-679.
    • (2011) Diabetes , vol.60 , pp. 669-679
    • Figler, R.A.1    Wang, G.2    Srinivasan, S.3
  • 57
    • 0025022723 scopus 로고
    • ADPase activity in human maternal and cord blood: Possible evidence for a placentaspecific vascular protective mechanism
    • Barradas MA, Mikhailidis DP, Dandona P. ADPase activity in human maternal and cord blood: possible evidence for a placentaspecific vascular protective mechanism. Int J Gynaecol Obstet 1990; 31:15-20.
    • (1990) Int J Gynaecol Obstet , vol.31 , pp. 15-20
    • Barradas, M.A.1    Mikhailidis, D.P.2    Dandona, P.3
  • 59
    • 79951629970 scopus 로고    scopus 로고
    • Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia
    • Chen X, Scholl TO, Leskiw M, Savaille J, Stein TP. Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia. Diabetes Care 2010; 33: 2049-2054.
    • (2010) Diabetes Care , vol.33 , pp. 2049-2054
    • Chen, X.1    Scholl, T.O.2    Leskiw, M.3    Savaille, J.4    Stein, T.P.5
  • 60
    • 0023113113 scopus 로고
    • The effect of nonesterified fatty acids on vascular ADP-degrading enzyme activity
    • Barradas MA, Mikhailidis DP, Dandona P. The effect of nonesterified fatty acids on vascular ADP-degrading enzyme activity. Diabetes Res Clin Pract 1987; 3: 9-19.
    • (1987) Diabetes Res Clin Pract , vol.3 , pp. 9-19
    • Barradas, M.A.1    Mikhailidis, D.P.2    Dandona, P.3
  • 62
    • 0141569161 scopus 로고    scopus 로고
    • The Gs-coupled adenosine A2B receptor recruits divergent pathways to regulate ERK1/2 and p38
    • Schulte G, Fredholm BB. The Gs-coupled adenosine A2B receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res 2003; 290: 168-176.
    • (2003) Exp Cell Res , vol.290 , pp. 168-176
    • Schulte, G.1    Fredholm, B.B.2
  • 63
    • 18044370690 scopus 로고    scopus 로고
    • A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade
    • Donoso MV, López R, Miranda R, Briones R, Huidobro-Toro JP. A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. Am J Physiol 2005; 288: H2439-H2449.
    • (2005) Am J Physiol , vol.288
    • Donoso, M.V.1    López, R.2    Miranda, R.3    Briones, R.4    Huidobro-Toro, J.P.5
  • 64
    • 0036142817 scopus 로고    scopus 로고
    • Adenosine receptors: G protein - mediated signaling and the role of accessory proteins
    • Klinger M, Freissmuth M, Nanoff C. Adenosine receptors: G protein- mediated signaling and the role of accessory proteins. Cell Signal 2002; 2: 99-108.
    • (2002) Cell Signal , vol.2 , pp. 99-108
    • Klinger, M.1    Freissmuth, M.2    Nanoff, C.3
  • 66
    • 84855348866 scopus 로고    scopus 로고
    • Physiological and pharmacological roles of vascular nucleoside transporters
    • doi: 10.1097/FJC.0b013e31820eb788
    • Li RW, Yang C, Sit AS, Lin SY, Ho EY, Leung GP. Physiological and pharmacological roles of vascular nucleoside transporters. J Cardiovasc Pharmacol 2011; doi: 10.1097/FJC.0b013e31820eb788.
    • (2011) J Cardiovasc Pharmacol
    • Li, R.W.1    Yang, C.2    Sit, A.S.3    Lin, S.Y.4    Ho, E.Y.5    Leung, G.P.6
  • 67
    • 77949419461 scopus 로고    scopus 로고
    • Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBPa in human umbilical vein endothelial cells from gestational diabetes
    • Farías M, Puebla C, Westermeier F, et al. Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBPa in human umbilical vein endothelial cells from gestational diabetes. Cardiovasc Res 2010; 86: 45-54.
    • (2010) Cardiovasc Res , vol.86 , pp. 45-54
    • Farías, M.1    Puebla, C.2    Westermeier, F.3
  • 68
    • 79952005409 scopus 로고    scopus 로고
    • Differential modulation of insulin receptor isoforms expression and NOS activity by insulin in human placenta microvascular endothelial cells from gestational diabetes
    • A.80 (Abstract)
    • Salomón C, Westermeier F, Casanello P, Sobrevia L. Differential modulation of insulin receptor isoforms expression and NOS activity by insulin in human placenta microvascular endothelial cells from gestational diabetes. Placenta 2010; 31: A.80 (Abstract).
    • (2010) Placenta , pp. 31
    • Salomón, C.1    Westermeier, F.2    Casanello, P.3    Sobrevia, L.4
  • 69
    • 70349668934 scopus 로고    scopus 로고
    • A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia
    • Sobrevia L, González M. A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia. Curr Vasc Pharmacol 2009; 7: 467-474.
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 467-474
    • Sobrevia, L.1    González, M.2
  • 70
    • 0029789432 scopus 로고    scopus 로고
    • Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
    • Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest 1996; 98: 894-898.
    • (1996) J Clin Invest , vol.98 , pp. 894-898
    • Zeng, G.1    Quon, M.J.2
  • 72
    • 0024548162 scopus 로고
    • Structure of the human insulin receptor gene and characterization of its promoter
    • Seino S, Seino M, Nishi S, Bell G. Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 1989; 86: 114-118.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 114-118
    • Seino, S.1    Seino, M.2    Nishi, S.3    Bell, G.4
  • 73
    • 0032504250 scopus 로고    scopus 로고
    • Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor
    • Kristensen C, Wiberg FC, Schäffer L, Andersen AS. Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor. J Biol Chem 1998; 273: 17780-17786.
    • (1998) J Biol Chem , vol.273 , pp. 17780-17786
    • Kristensen, C.1    Wiberg, F.C.2    Schäffer, L.3    Andersen, A.S.4
  • 74
    • 77954826307 scopus 로고    scopus 로고
    • Kinetic evidence for the sequential association of insulin binding sites 1 and 2 to the insulin receptor and the influence of receptor isoform
    • Thorsøe KS, Schlein M, Steensgaard DB, Brandt J, Schluckebier G, Naver H. Kinetic evidence for the sequential association of insulin binding sites 1 and 2 to the insulin receptor and the influence of receptor isoform. Biochemistry 2010; 49: 6234-6246.
    • (2010) Biochemistry , vol.49 , pp. 6234-6246
    • Thorsøe, K.S.1    Schlein, M.2    Steensgaard, D.B.3    Brandt, J.4    Schluckebier, G.5    Naver, H.6
  • 75
    • 0347383733 scopus 로고    scopus 로고
    • Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells
    • Bergandi L, Silvagno F, Russo I, et al. Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 12: 2215-2221.
    • (2003) Arterioscler Thromb Vasc Biol , vol.12 , pp. 2215-2221
    • Bergandi, L.1    Silvagno, F.2    Russo, I.3
  • 76
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006; 113: 1888-1904.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 78
    • 0021985413 scopus 로고
    • Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
    • Ullrich A, Bell JR, Chen EY, et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 1985; 313: 756-761.
    • (1985) Nature , vol.313 , pp. 756-761
    • Ullrich, A.1    Bell, J.R.2    Chen, E.Y.3
  • 79
    • 0021924895 scopus 로고
    • The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signaling
    • Ebina Y, Ellis L, Jarnagin K, et al. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling. Cell 1985; 40: 747-758.
    • (1985) Cell , vol.40 , pp. 747-758
    • Ebina, Y.1    Ellis, L.2    Jarnagin, K.3
  • 80
    • 0032932822 scopus 로고    scopus 로고
    • Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    • Frasca F, Pandini G, Scalia P, et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 1999; 19: 3278-3288.
    • (1999) Mol Cell Biol , vol.19 , pp. 3278-3288
    • Frasca, F.1    Pandini, G.2    Scalia, P.3
  • 81
    • 0034767113 scopus 로고    scopus 로고
    • Molecular mechanism of insulin resistance in type 2 diabetes mellitus: Role of the insulin receptor variant forms
    • Sesti G, Federici M, Lauro D, Sbraccia P, Lauro R. Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms. Diabetes Metab Res Rev 2001; 17: 363-373.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 363-373
    • Sesti, G.1    Federici, M.2    Lauro, D.3    Sbraccia, P.4    Lauro, R.5
  • 82
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 2009; 30: 586-623.
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 83
    • 0037508585 scopus 로고    scopus 로고
    • Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate- 1
    • Sciacca L, Prisco M, Wu A, Belfiore A, Vigneri R, Baserga R. Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate- 1. Endocrinology 2003; 144: 2650-2658.
    • (2003) Endocrinology , vol.144 , pp. 2650-2658
    • Sciacca, L.1    Prisco, M.2    Wu, A.3    Belfiore, A.4    Vigneri, R.5    Baserga, R.6
  • 84
    • 77955515434 scopus 로고    scopus 로고
    • Insulin analogues differently activate insulin receptor isoforms and post-receptor signaling
    • Sciacca L, Cassarino MF, Genua M, et al. Insulin analogues differently activate insulin receptor isoforms and post-receptor signaling. Diabetologia 2010; 53: 1743-1753.
    • (2010) Diabetologia , vol.53 , pp. 1743-1753
    • Sciacca, L.1    Cassarino, M.F.2    Genua, M.3
  • 85
    • 77955488730 scopus 로고    scopus 로고
    • Muscleblind - like 1 (mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic Enhancer
    • Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster N. Muscleblind- like 1 (mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic Enhancer. J Biol Chem 2010; 285: 25426-25437.
    • (2010) J Biol Chem , vol.285 , pp. 25426-25437
    • Sen, S.1    Talukdar, I.2    Liu, Y.3    Tam, J.4    Reddy, S.5    Webster, N.6
  • 86
    • 79952781105 scopus 로고    scopus 로고
    • Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B
    • Giudice J, Leskow FC, Arndt-Jovin DJ, Jovin TM, Jares-Erijman EA. Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B. J Cell Sci 2011; 124: 801-811.
    • (2011) J Cell Sci , vol.124 , pp. 801-811
    • Giudice, J.1    Leskow, F.C.2    Arndt-Jovin, D.J.3    Jovin, T.M.4    Jares-Erijman, E.A.5
  • 87
    • 0024995838 scopus 로고
    • A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance
    • Moller DE, Yokota A, White MF, Pazianos AG, Flier JS. A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance. J Biol Chem 1989; 265: 14979-149785.
    • (1989) J Biol Chem , vol.265 , pp. 14979-149785
    • Moller, D.E.1    Yokota, A.2    White, M.F.3    Pazianos, A.G.4    Flier, J.S.5
  • 88
    • 0025362295 scopus 로고
    • Functionally distinct insulin receptors generated by tissue-specific alternative splicing
    • Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 1990; 9: 2409-2413.
    • (1990) EMBO J , vol.9 , pp. 2409-2413
    • Mosthaf, L.1    Grako, K.2    Dull, T.J.3    Coussens, L.4    Ullrich, A.5    McClain, D.A.6
  • 89
    • 0026652518 scopus 로고
    • Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues
    • Benecke H, Flier JS, Moller DE. Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest 1992; 89: 2066-2070.
    • (1992) J Clin Invest , vol.89 , pp. 2066-2070
    • Benecke, H.1    Flier, J.S.2    Moller, D.E.3
  • 90
    • 0037131385 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    • Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 2002; 277: 39684-39695.
    • (2002) J Biol Chem , vol.277 , pp. 39684-39695
    • Pandini, G.1    Frasca, F.2    Mineo, R.3    Sciacca, L.4    Vigneri, R.5    Belfiore, A.6
  • 91
    • 0025801714 scopus 로고
    • Altered expression of insulin receptor types A and B in the skeletal muscle of noninsulin - dependent diabetes mellitus patients
    • Mosthaf L, Vogt B, Häring HU, Ullrich A. Altered expression of insulin receptor types A and B in the skeletal muscle of noninsulin- dependent diabetes mellitus patients. Proc Natl Acad Sci USA 1991; 88: 4728-4730.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4728-4730
    • Mosthaf, L.1    Vogt, B.2    Häring, H.U.3    Ullrich, A.4
  • 92
    • 0027322636 scopus 로고
    • Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (noninsulin - dependent) diabetic subjects
    • Kellerer M, Sesti G, Seffer E, et al. Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (noninsulin- dependent) diabetic subjects. Diabetologia 1993; 36: 628-632.
    • (1993) Diabetologia , vol.36 , pp. 628-632
    • Kellerer, M.1    Sesti, G.2    Seffer, E.3
  • 93
    • 0028319209 scopus 로고
    • Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein
    • Sesti G, Tullio AN, D'Alfonso R, et al. Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein. Acta Diabetol 1994; 31: 59-65.
    • (1994) Acta Diabetol , vol.31 , pp. 59-65
    • Sesti, G.1    Tullio, A.N.2    D'Alfonso, R.3
  • 94
    • 0034873099 scopus 로고    scopus 로고
    • Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy
    • Savkur R, Philips V, Cooper H. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet 2001; 29: 40-47.
    • (2001) Nat Genet , vol.29 , pp. 40-47
    • Savkur, R.1    Philips, V.2    Cooper, H.3
  • 95
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 7: 412-419.
    • (1985) Diabetologia , vol.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 96
    • 0031594757 scopus 로고    scopus 로고
    • [3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies
    • Fredholm BB, Lindström K, Dionisotti S, Ongini E. [3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies. J Neurochem 1998; 70:1210-1216.
    • (1998) J Neurochem , vol.70 , pp. 1210-1216
    • Fredholm, B.B.1    Lindström, K.2    Dionisotti, S.3    Ongini, E.4
  • 98
    • 0031931065 scopus 로고    scopus 로고
    • Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells
    • Klotz KN, Hessling J, Hegler J, et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 1998; 357: 1-9.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.357 , pp. 1-9
    • Klotz, K.N.1    Hessling, J.2    Hegler, J.3
  • 99
    • 0032836645 scopus 로고    scopus 로고
    • Characterization of human A(2B) adenosine receptors: Radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells
    • Linden J, Thai T, Figler H, Jin X, Robeva AS. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 1999; 56: 705-713.
    • (1999) Mol Pharmacol , vol.56 , pp. 705-713
    • Linden, J.1    Thai, T.2    Figler, H.3    Jin, X.4    Robeva, A.S.5
  • 100
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine receptors as therapeutic targets
    • Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 2006; 5: 247-264.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 101
    • 0034704901 scopus 로고    scopus 로고
    • Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors
    • Kim YC, Ji X, Melman N, Linden J, Jacobson KA. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem 2000; 43: 1165-1172.
    • (2000) J Med Chem , vol.43 , pp. 1165-1172
    • Kim, Y.C.1    Ji, X.2    Melman, N.3    Linden, J.4    Jacobson, K.A.5
  • 102
    • 0027459193 scopus 로고
    • Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors
    • Daly JW, Padgett WL, Secunda SI, Thompson RD, Olsson RA. Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Pharmacology 1993; 46: 91-100.
    • (1993) Pharmacology , vol.46 , pp. 91-100
    • Daly, J.W.1    Padgett, W.L.2    Secunda, S.I.3    Thompson, R.D.4    Olsson, R.A.5
  • 105
    • 0032866557 scopus 로고    scopus 로고
    • Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
    • Jacobson KA, Hoffmann C, Kim YC, et al. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Prog Brain Res 1999; 120: 119-132.
    • (1999) Prog Brain Res , vol.120 , pp. 119-132
    • Jacobson, K.A.1    Hoffmann, C.2    Kim, Y.C.3
  • 107
    • 70349306892 scopus 로고    scopus 로고
    • A1 adenosine receptor antagonists, agonists, and allosteric enhancers
    • Kiesman WF, Elzein E, Zablocki J. A1 adenosine receptor antagonists, agonists, and allosteric enhancers Handb Exp Pharmacol 2009; 193: 25-58.
    • (2009) Handb Exp Pharmacol , vol.193 , pp. 25-58
    • Kiesman, W.F.1    Elzein, E.2    Zablocki, J.3
  • 108
    • 43249092553 scopus 로고    scopus 로고
    • Metformin vs. insulin for the treatment of gestational diabetes
    • MiG. Trial Investigators
    • Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG. Trial Investigators. Metformin vs. insulin for the treatment of gestational diabetes. N Engl J Med 2008; 358: 2003-2015.
    • (2008) N Engl J Med , vol.358 , pp. 2003-2015
    • Rowan, J.A.1    Hague, W.M.2    Gao, W.3    Battin, M.R.4    Moore, M.P.5
  • 109
    • 0029851827 scopus 로고    scopus 로고
    • Nutrition in pregnancy and the concentrations of proinsulin, 32-33 split proinsulin, insulin, and C-peptide in cord plasma
    • Godfrey KM, Robinson S, Hales CN, Barker DJ, Osmond C, Taylor KP. Nutrition in pregnancy and the concentrations of proinsulin, 32-33 split proinsulin, insulin, and C-peptide in cord plasma. Diabet Med 1996; 13: 868-873.
    • (1996) Diabet Med , vol.13 , pp. 868-873
    • Godfrey, K.M.1    Robinson, S.2    Hales, C.N.3    Barker, D.J.4    Osmond, C.5    Taylor, K.P.6
  • 110
    • 0035092746 scopus 로고    scopus 로고
    • Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus
    • Homko C, Sivan E, Chen X, Reece EA, Boden G. Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus. J Clin Endocrinol Metab 2001; 86: 568-573.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 568-573
    • Homko, C.1    Sivan, E.2    Chen, X.3    Reece, E.A.4    Boden, G.5
  • 111
    • 0041324849 scopus 로고    scopus 로고
    • Insulin resistance and beta-cell dysfunction in normoglycaemic European women with a history of gestational diabetes
    • Kousta E, Lawrence NJ, Godsland IF, et al. Insulin resistance and beta-cell dysfunction in normoglycaemic European women with a history of gestational diabetes. Clin Endocrinol 2003; 59: 289-297.
    • (2003) Clin Endocrinol , vol.59 , pp. 289-297
    • Kousta, E.1    Lawrence, N.J.2    Godsland, I.F.3
  • 112
    • 0020445542 scopus 로고
    • Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte
    • Joost HG, Steinfelder HJ. Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte. Mol Pharmacol 1982; 22: 614-618.
    • (1982) Mol Pharmacol , vol.22 , pp. 614-618
    • Joost, H.G.1    Steinfelder, H.J.2
  • 113
    • 0020556363 scopus 로고
    • Effect of adenosine deaminase and an adenosine analogue on insulin sensitivity in soleus muscle of the rat
    • Espinal J, Challiss RA, Newsholme EA. Effect of adenosine deaminase and an adenosine analogue on insulin sensitivity in soleus muscle of the rat. FEBS Lett 1983; 158: 103-106.
    • (1983) FEBS Lett , vol.158 , pp. 103-106
    • Espinal, J.1    Challiss, R.A.2    Newsholme, E.A.3
  • 114
    • 18744429939 scopus 로고
    • Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist
    • Green A. Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist. J Biol Chem 1987; 262: 15702-15707.
    • (1987) J Biol Chem , vol.262 , pp. 15702-15707
    • Green, A.1
  • 115
    • 0030011431 scopus 로고    scopus 로고
    • In vitro effect of adenosine agonist GR79236 on the insulin sensitivity of glucose utilisation in rat soleus and human rectus abdominus muscle
    • Webster JM, Heseltine L, Taylor R. In vitro effect of adenosine agonist GR79236 on the insulin sensitivity of glucose utilisation in rat soleus and human rectus abdominus muscle. Biochim Biophys Acta 1996; 1316: 109-113.
    • (1996) Biochim Biophys Acta , vol.1316 , pp. 109-113
    • Webster, J.M.1    Heseltine, L.2    Taylor, R.3
  • 116
    • 0030957207 scopus 로고    scopus 로고
    • Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity
    • Ciaraldi TP, Morales AJ, Hickman MG, Odom-Ford R, Olefsky JM, Yen SS. Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity. J Clin Endocrinol Metab 1997; 82: 1421-1425.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1421-1425
    • Ciaraldi, T.P.1    Morales, A.J.2    Hickman, M.G.3    Odom-Ford, R.4    Olefsky, J.M.5    Yen, S.S.6
  • 117
    • 0034457449 scopus 로고    scopus 로고
    • Insulin-induced increment of coronary flow reserve is not abolished by dexamethasone in healthy young men
    • Laine H, Nuutila P, Luotolahti M, et al. Insulin-induced increment of coronary flow reserve is not abolished by dexamethasone in healthy young men. J Clin Endocrinol Metab 2000; 85: 1868-1873.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1868-1873
    • Laine, H.1    Nuutila, P.2    Luotolahti, M.3
  • 118
    • 1342343980 scopus 로고    scopus 로고
    • Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes
    • Laine H, Sundell J, Nuutila P, et al. Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes. Heart 2004; 90: 270-276.
    • (2004) Heart , vol.90 , pp. 270-276
    • Laine, H.1    Sundell, J.2    Nuutila, P.3
  • 119
    • 0036224167 scopus 로고    scopus 로고
    • Dose-dependent vasodilating effects of insulin on adenosine-stimulated myocardial blood flow
    • Sundell J, Nuutila P, Laine H, et al. Dose-dependent vasodilating effects of insulin on adenosine-stimulated myocardial blood flow. Diabetes 2002; 51: 1125-1130.
    • (2002) Diabetes , vol.51 , pp. 1125-1130
    • Sundell, J.1    Nuutila, P.2    Laine, H.3
  • 120
    • 0031695494 scopus 로고    scopus 로고
    • Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions
    • Han DH, Hansen PA, Nolte LA, Holloszy JO. Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions. Diabetes 1998; 47: 1671-1675.
    • (1998) Diabetes , vol.47 , pp. 1671-1675
    • Han, D.H.1    Hansen, P.A.2    Nolte, L.A.3    Holloszy, J.O.4
  • 121
    • 0033558127 scopus 로고    scopus 로고
    • Role of adenosine in regulating glucose uptake during contractions and hypoxia in rat skeletal muscle
    • Derave W, Hespel P. Role of adenosine in regulating glucose uptake during contractions and hypoxia in rat skeletal muscle. J Physiol 1999; 515: 255-263.
    • (1999) J Physiol , vol.515 , pp. 255-263
    • Derave, W.1    Hespel, P.2
  • 122
    • 27944433726 scopus 로고    scopus 로고
    • Differential effect of insulin and elevated glucose level on adenosine handling in rat T lymphocytes
    • Pawelczyk T, Sakowicz-Burkiewicz M, Kocbuch K, Szutowicz A. Differential effect of insulin and elevated glucose level on adenosine handling in rat T lymphocytes. J Cell Biochem 2005; 96: 1296-1310.
    • (2005) J Cell Biochem , vol.96 , pp. 1296-1310
    • Pawelczyk, T.1    Sakowicz-Burkiewicz, M.2    Kocbuch, K.3    Szutowicz, A.4
  • 123
    • 58149357464 scopus 로고    scopus 로고
    • Comparison of the antilipolytic effects of an A1 adenosine receptor partial agonist in normal and diabetic rats
    • Dhalla AK, Santikul M, Chisholm JW, Belardinelli L, Reaven GM. Comparison of the antilipolytic effects of an A1 adenosine receptor partial agonist in normal and diabetic rats. Diabetes Obes Metab 2009; 11: 95-101.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 95-101
    • Dhalla, A.K.1    Santikul, M.2    Chisholm, J.W.3    Belardinelli, L.4    Reaven, G.M.5
  • 124
    • 77955123992 scopus 로고    scopus 로고
    • Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles
    • Kolnes AJ, Ingvaldsen A, Bolling A, et al. Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. Acta Physiol (Oxf) 2010; 200: 65-74.
    • (2010) Acta Physiol (Oxf) , vol.200 , pp. 65-74
    • Kolnes, A.J.1    Ingvaldsen, A.2    Bolling, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.