Activation of L-arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells

Journal of Physiology

Volumn 490, Issue 3, 1996, Pages 775-781

  Sobrevia, L ^a   Nadal, A ^a   Yudilevich, D L ^a,b   Mann, G E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM; CITRULLINE; CYCLIC GMP; CYSTINE; DEOXYGLUCOSE; GLUCOSE; INSULIN; LEUCINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; SERINE;

AMINO ACID TRANSPORT; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; NORMAL HUMAN; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 0029670597     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021185     Document Type: Article

References (22)

1. BARON, A. D. (1994). Hemodynamic actions of insulin. American Journal of Physiology 267, E187-202.
2. 2+. Biochemical Journal 262, 431-437.
3. COHEN, R. A. (1993). Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87, V67-76.
4. GERRITSEN, M. E., BURKE, T. M. & ALLEN, L. A. (1988). Glucose starvation is required for insulin stimulation of glucose uptake and metabolism in cultured microvascular endothelial cells. Microvascular Research 35, 153-166.
5. GRAIER, W. F., WÄSCHER, T. C., LACKNER, L., TOPLAK, H., KREJS, G. J. & KUKOVETZ, W. R. (1993). Exposure to elevated D-glucose concentrations modulates vascular endothelial cell vasodilatory responses. Diabetes 42, 1497-1505.
6. INOGUCHI, T., XIA, P., KUNISAKI, M., HIGASHI, S., FEENER, E. P. & KING, G. L. (1994). Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissue. American Journal of Physiology 267, E369-379.
7. KAHN, N. N., BAUMAN, W. A., HATCHER, V. B. & SINHA, A. K. (1993). Inhibition of platelet aggregation and the stimulation of prostacyclin synthesis by insulin in humans. American Journal of Physiology 265, H2160-2167.
8. KAISER, N., SASSON, S., FEENER, E. P., BOUKOBZA-VARDI, N., EIGASHI, S., MOLLER, D. E., DAVIDHEISER, S , PRZYBYLSKI, R. J. & KING, G. L. (1993). Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes 42, 80-89.
9. KAO, J. P. Y., HAROOTUNIAN, A. T. & TSIEN, R. Y. (1989). Photochemically generated cytosolic calcium pulses and their detection by fluo-3. Journal of Biological Chemistry 264, 8179-8184.
10. KIM, J. W., CLOSS, E. I., ALBRITTON, L. M. & CUNNINGLAM, J. M. (1991). Transport of cationic amino acids by the mouse ecotropic retrovirus receptor. Nature 352, 725-728.
11. LORENZI, M., CAGLIERO, E. & TOLEDO, S. (1985). Glucose toxicity for human endothelial cells in culture: delayed replication, disturbed cell cycle and accelerated death. Diabetes 34, 621-627.
12. MONCADA, S., PALMER, R. M. J. & HIGGS, A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacological Reviews 43, 109-142.
13. MUÑOZ, M., SWEIRY, J. H. & MANN, G. E. (1995). Insulin stimulates cationic amino acid transport activity in the isolated perfused rat pancreas. Experimental Physiology 80, 745-753.
14. OLIVER, F. J., DE LA RUBIA, G., FEENER, E. P., LEE, M.-E., LOEKEN, M. R., SHIBA, T., QUERTERMOUS, T. & KING, G. L. (1991). Stimulation of endothelin-1 gene expression by insulin in endothelial cells. Journal of Biological Chemistry 266, 23251-23256.
15. PORTA, M., LA SELVA, M., MOLINATTI, P. & MOLINATTI, G. M. (1987). Endothelial cell fimetion in diabetic microangiopathy. Diabetes 30, 601-609.
16. POSTON, L. & TAYLOR, P. D. (1995). Endothelium-dependent vascular fimetions in insul independent diabetes mellitus. Clinical Science 88, 245-255.
17. SMITH, J. A. & LANG, D. (1990). Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99, 565-571.
18. + and nitric oxide synthase in human endothelial cells: association with a membrane hyperpolarization. Journal of Physiology 489, 183-192.
19. TESFAMARIAM, B. (1994). Free radicals in diabetic endothelial cell dysfunction. Free Radical Biology and Medicine 16, 383-391.
20. TOOKE, J. E. (1989). Microcirculation and diabetes. British Medical Bulletin 45, 206-223.
21. WU, G., MAJUMDAR, S., ZHANG, J., LEE, H. & MEININGER, C. J. (1994a). Insulin stimulates glycolysis and pentose cycle activity in bovine microvascular endothelial cells. Comparative Biochemistry and Physiology 108, 179-185.
22. WU, J. Y., ROBINSON, D., KUNG, H.-J. & HATZOGLOU, M. (1994b). Hormonal regulation of the gene for the type C ecotropic retrovirus receptor in rat liver cells. Journal of Virology 68, 1615-1623.