메뉴 건너뛰기




Volumn 82, Issue 3, 2009, Pages 458-467

TGF-β1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium

Author keywords

Adenosine; Endothelium; Human; Membrane; Nitric oxide; TGF 1; Transport

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; CARRIER PROTEINS AND BINDING PROTEINS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; KT 5823; MESSENGER RNA; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTEIN SLC29A1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; SLC29A1 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

EID: 66249130069     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp045     Document Type: Article
Times cited : (20)

References (43)
  • 1
    • 0028793485 scopus 로고
    • Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans
    • Smits P, Williams SB, Lipson DE, Banitt P, Rogen GA, Creager MA. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.Circulation 1995;92:2135-2141.
    • (1995) Circulation , vol.92 , pp. 2135-2141
    • Smits, P.1    Williams, S.B.2    Lipson, D.E.3    Banitt, P.4    Rogen, G.A.5    Creager, M.A.6
  • 2
    • 0031944610 scopus 로고    scopus 로고
    • Role of nitric oxide in adenosine-induced vasodilation in humans
    • Costa F, Biaggioni I. Role of nitric oxide in adenosine-induced vasodilation in humans. Hypertension 1998;31:1061-1064.
    • (1998) Hypertension , vol.31 , pp. 1061-1064
    • Costa, F.1    Biaggioni, I.2
  • 3
    • 43049095683 scopus 로고    scopus 로고
    • Human in vivo research on the vascular effects of adenosine
    • Riksen NP, Rongen GA, Yellon D, Smits P. Human in vivo research on the vascular effects of adenosine. EurJ Pharmacol 2008;585:220-227.
    • (2008) EurJ Pharmacol , vol.585 , pp. 220-227
    • Riksen, N.P.1    Rongen, G.A.2    Yellon, D.3    Smits, P.4
  • 4
    • 6444227946 scopus 로고    scopus 로고
    • Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical endothelium
    • Vásquez G, Sanhueza F, Vásquez R, González M, San Martín R, Casanello P et al. Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical endothelium. J Physiol 2004;560:111-122.
    • (2004) J Physiol , vol.560 , pp. 111-122
    • Vásquez, G.1    Sanhueza, F.2    Vásquez, R.3    González, M.4    San Martín, R.5    Casanello, P.6
  • 5
    • 34247117001 scopus 로고    scopus 로고
    • Equilibrative nucleoside (ENTs) and cationic amino acid (CATs) transporters: Implications in foetal endothelial dysfunction in human pregnancy diseases
    • Casanello P, Escudero C, Sobrevia L Equilibrative nucleoside (ENTs) and cationic amino acid (CATs) transporters: implications in foetal endothelial dysfunction in human pregnancy diseases. Curr Vasc Pharmacol 2007;5: 69-84.
    • (2007) Curr Vasc Pharmacol , vol.5 , pp. 69-84
    • Casanello, P.1    Escudero, C.2    Sobrevia, L.3
  • 6
    • 0025115311 scopus 로고
    • Lack of innervation of human umbilical cord. An immunohistochemical study
    • Fox SB, Khong TY. Lack of innervation of human umbilical cord. An immunohistochemical study. Placenta 1990;11:59-62.
    • (1990) Placenta , vol.11 , pp. 59-62
    • Fox, S.B.1    Khong, T.Y.2
  • 8
    • 30144444635 scopus 로고    scopus 로고
    • Vessel tone and remodeling
    • Burnstock G. Vessel tone and remodeling. Nat Med 2006;12:16-17.
    • (2006) Nat Med , vol.12 , pp. 16-17
    • Burnstock, G.1
  • 9
    • 44149093091 scopus 로고    scopus 로고
    • A hypothesis for preeclampsia: Adenosine and inducible nitric oxide synthase in human placental microvascular endothelium
    • Escudero C, Sobrevia L A hypothesis for preeclampsia: adenosine and inducible nitric oxide synthase in human placental microvascular endothelium. Placenta 2008;29:469-483.
    • (2008) Placenta , vol.29 , pp. 469-483
    • Escudero, C.1    Sobrevia, L.2
  • 10
    • 33745605803 scopus 로고    scopus 로고
    • Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes
    • Farías M, San Martín R, Puebla C, Pearson JD, Casado JF, Pastor-Anglada M et al. Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol 2006;208:451-460.
    • (2006) J Cell Physiol , vol.208 , pp. 451-460
    • Farías, M.1    San Martín, R.2    Puebla, C.3    Pearson, J.D.4    Casado, J.F.5    Pastor-Anglada, M.6
  • 11
    • 42949099888 scopus 로고    scopus 로고
    • High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1in human umbilical vein endothelium
    • Puebla C, Farías M, González M, Vecchiola A, Aguayo C, Krause B et al. High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1in human umbilical vein endothelium. J Cell Physiol 2008;215:645-656.
    • (2008) J Cell Physiol , vol.215 , pp. 645-656
    • Puebla, C.1    Farías, M.2    González, M.3    Vecchiola, A.4    Aguayo, C.5    Krause, B.6
  • 12
    • 0007844316 scopus 로고    scopus 로고
    • Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs
    • Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.Nat Med 1997;3: 89-93.
    • (1997) Nat Med , vol.3 , pp. 89-93
    • Griffiths, M.1    Beaumont, N.2    Yao, S.Y.3    Sundaram, M.4    Boumah, C.E.5    Davies, A.6
  • 13
    • 0038612958 scopus 로고    scopus 로고
    • High glucose and endothelial cell growth: Novel effects independent of autocrine TGF-beta 1 and hyperosmolarity
    • McGinn S, Poronnik P, King M, Gallery ED, Pollock SA. High glucose and endothelial cell growth: novel effects independent of autocrine TGF-beta 1 and hyperosmolarity.Am J Physiol Cell Physiol 2003;284: C1374-C1386.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • McGinn, S.1    Poronnik, P.2    King, M.3    Gallery, E.D.4    Pollock, S.A.5
  • 14
    • 34547928359 scopus 로고    scopus 로고
    • D-Glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
    • Vásquez R, Farías M, Vega JL, San Martín R, Vecchiola A, Casanello P et al. D-Glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium. J Cell Physiol 2007;212:626-632.
    • (2007) J Cell Physiol , vol.212 , pp. 626-632
    • Vásquez, R.1    Farías, M.2    Vega, J.L.3    San Martín, R.4    Vecchiola, A.5    Casanello, P.6
  • 15
    • 0036842491 scopus 로고    scopus 로고
    • Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression
    • Saura M, Zaragoza C, Cao W, Bao C, Rodriguez-Puyol M, Rodriguez-Puyol D et al. Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression. Circ Res 2002;91:806-813.
    • (2002) Circ Res , vol.91 , pp. 806-813
    • Saura, M.1    Zaragoza, C.2    Cao, W.3    Bao, C.4    Rodriguez-Puyol, M.5    Rodriguez-Puyol, D.6
  • 16
    • 33750874051 scopus 로고    scopus 로고
    • TGF-beta transcriptional activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells
    • Valdés R, Fernandes-Veledo S, Aymerich I, Casado FJ, Pastor-Anglada M. TGF-beta transcriptional activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells. Cell Mol Life Sci 2006;63:2527-2537.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2527-2537
    • Valdés, R.1    Fernandes-Veledo, S.2    Aymerich, I.3    Casado, F.J.4    Pastor-Anglada, M.5
  • 17
    • 30844459673 scopus 로고    scopus 로고
    • Changes in maternal plasma levels of VEGF, bFGF, TGF-beta1, ET-1 and sKL during uncomplicated pregnancy, hypertensive pregnancy, and gestational diabetes
    • Lygnos MC, Pappa KI, Papadaki HA, Relakis C, Koumantakis E, Anagnou NP et al. Changes in maternal plasma levels of VEGF, bFGF, TGF-beta1, ET-1 and sKL during uncomplicated pregnancy, hypertensive pregnancy, and gestational diabetes. In Vivo 2006;20:157-163.
    • (2006) In Vivo , vol.20 , pp. 157-163
    • Lygnos, M.C.1    Pappa, K.I.2    Papadaki, H.A.3    Relakis, C.4    Koumantakis, E.5    Anagnou, N.P.6
  • 18
    • 33947127546 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus
    • Yener S, Demir T, Akinci B, Bayraktar F, Kebapcilar L, Ozcan MA et al. Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus. Diabetes Res Clin Pract 2007;76:193-198.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 193-198
    • Yener, S.1    Demir, T.2    Akinci, B.3    Bayraktar, F.4    Kebapcilar, L.5    Ozcan, M.A.6
  • 19
    • 3843083006 scopus 로고    scopus 로고
    • Transforming growth factor beta at clinical onset of Type 1 diabetes mellitus. A pilot study
    • Flores L, Naf S, Hernaez R, Conget I, Gomis R, Esmatjes E. Transforming growth factor beta at clinical onset of Type 1 diabetes mellitus. A pilot study. Diabet Med 2004;21:818-822.
    • (2004) Diabet Med , vol.21 , pp. 818-822
    • Flores, L.1    Naf, S.2    Hernaez, R.3    Conget, I.4    Gomis, R.5    Esmatjes, E.6
  • 20
    • 0034485840 scopus 로고    scopus 로고
    • Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients
    • Azar ST, Salti I, Zantout MS, Major S. Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients. J Clin Endocrinol Metab 2000;85:4680-4682.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4680-4682
    • Azar, S.T.1    Salti, I.2    Zantout, M.S.3    Major, S.4
  • 21
    • 0032704074 scopus 로고    scopus 로고
    • Endothelial dysfunction in Type 2 diabetic subjects with and without microalbuminuria
    • Meeking DR, Cummings MH, Thorne S, Donald A, Clarkson P, Crook JR et al. Endothelial dysfunction in Type 2 diabetic subjects with and without microalbuminuria. Diabet Med 1999;16:841-847.
    • (1999) Diabet Med , vol.16 , pp. 841-847
    • Meeking, D.R.1    Cummings, M.H.2    Thorne, S.3    Donald, A.4    Clarkson, P.5    Crook, J.R.6
  • 22
    • 34948849376 scopus 로고    scopus 로고
    • Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: A randomized controlled trial
    • Ahimastos AA, Aggarwal A, D'Orsa KM, Formosa MF, White AJ, Savarirayan R et al. Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial.JAMA 2007;298:1539-1547.
    • (2007) JAMA , vol.298 , pp. 1539-1547
    • Ahimastos, A.A.1    Aggarwal, A.2    D'Orsa, K.M.3    Formosa, M.F.4    White, A.J.5    Savarirayan, R.6
  • 23
    • 40349098206 scopus 로고    scopus 로고
    • Physiology of nucleoside transporters: Back to the future
    • Rose JB, Coe IR. Physiology of nucleoside transporters: back to the future. Physiology 2008;23:41-48.
    • (2008) Physiology , vol.23 , pp. 41-48
    • Rose, J.B.1    Coe, I.R.2
  • 24
    • 22144464451 scopus 로고    scopus 로고
    • Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
    • Casanello P, Torres A, Sanhueza F, González M, Farías M, Gallardo V et al. Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium.Circ Res 2005;97:16-24.
    • (2005) Circ Res , vol.97 , pp. 16-24
    • Casanello, P.1    Torres, A.2    Sanhueza, F.3    González, M.4    Farías, M.5    Gallardo, V.6
  • 25
    • 0037216768 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
    • Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003;284:R1-R12.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Fleming, I.1    Busse, R.2
  • 27
    • 0027278121 scopus 로고
    • Vasoactive intestinal peptide release and L-citrulline production from isolated ganglia of the myenteric plexus: Evidence for regulation of vasoactive intestinal peptide release by nitric oxide
    • Grider JR, Jin JG. Vasoactive intestinal peptide release and L-citrulline production from isolated ganglia of the myenteric plexus: evidence for regulation of vasoactive intestinal peptide release by nitric oxide. Neuroscience 1993;54:521-526.
    • (1993) Neuroscience , vol.54 , pp. 521-526
    • Grider, J.R.1    Jin, J.G.2
  • 28
    • 0037341668 scopus 로고    scopus 로고
    • Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium
    • Rojas S, Rojas R, Lamperti L, Casanello P, Sobrevia L. Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium. Exp Physiol 2003;88:209-219.
    • (2003) Exp Physiol , vol.88 , pp. 209-219
    • Rojas, S.1    Rojas, R.2    Lamperti, L.3    Casanello, P.4    Sobrevia, L.5
  • 29
    • 0031916983 scopus 로고    scopus 로고
    • Transporters for cationic amino acids in animal cells: Discovery, structure, and function
    • Devés R, Boyd CA. Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev 1998;78:487-545.
    • (1998) Physiol Rev , vol.78 , pp. 487-545
    • Devés, R.1    Boyd, C.A.2
  • 30
    • 50249099855 scopus 로고    scopus 로고
    • 2B adenosine receptors in placenta microvascular endothelial cells from preeclampsia
    • 2B adenosine receptors in placenta microvascular endothelial cells from preeclampsia. Placenta 2008;29:816-825.
    • (2008) Placenta , vol.29 , pp. 816-825
    • Escudero, C.1    Casanello, P.2    Sobrevia, L.3
  • 31
    • 8644236778 scopus 로고    scopus 로고
    • Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
    • Farré X, Guillen-Gómez E, Sánchez L, Hardisson D, Plaza Y, Lloberas J et al. Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Int J Cancer 2004;112:959-966.
    • (2004) Int J Cancer , vol.112 , pp. 959-966
    • Farré, X.1    Guillen-Gómez, E.2    Sánchez, L.3    Hardisson, D.4    Plaza, Y.5    Lloberas, J.6
  • 32
    • 44649136620 scopus 로고    scopus 로고
    • Protein domain library generation by overlap extension (PDLGO): A tool for enzyme engineering
    • Gratz A, Jose J. Protein domain library generation by overlap extension (PDLGO): a tool for enzyme engineering. Anal Biochem 2008;378: 171-176.
    • (2008) Anal Biochem , vol.378 , pp. 171-176
    • Gratz, A.1    Jose, J.2
  • 33
    • 66249139360 scopus 로고    scopus 로고
    • Puebla C. Transcriptional regulation of SLC29A1 promoter gene of equilibrative nucleoside transporter type 1 (hENT1) by D-glucose in human fetal endothelium. Santiago de Chile: Pontificia Universidad Católica de Chile; 2008 (Thesis).
    • Puebla C. Transcriptional regulation of SLC29A1 promoter gene of equilibrative nucleoside transporter type 1 (hENT1) by D-glucose in human fetal endothelium. Santiago de Chile: Pontificia Universidad Católica de Chile; 2008 (Thesis).
  • 34
  • 36
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine receptors as therapeutic targets
    • Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 2006;5:247-264.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 37
    • 0036793564 scopus 로고    scopus 로고
    • Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: A novel calcium-insensitive mechanism
    • Wyatt AW, Steinert JR, Wheeler-Jones CP, Morgan AJ, Sugden D, Pearson JD et al. Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J 2002;16:1584-1594.
    • (2002) FASEB J , vol.16 , pp. 1584-1594
    • Wyatt, A.W.1    Steinert, J.R.2    Wheeler-Jones, C.P.3    Morgan, A.J.4    Sugden, D.5    Pearson, J.D.6
  • 38
    • 3042655528 scopus 로고    scopus 로고
    • Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance
    • Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z et al. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 2004;64:4294- 4301.
    • (2004) Cancer Res , vol.64 , pp. 4294-4301
    • Huang, Y.1    Anderle, P.2    Bussey, K.J.3    Barbacioru, C.4    Shankavaram, U.5    Dai, Z.6
  • 39
    • 11844263366 scopus 로고    scopus 로고
    • Transforming growth factor-beta, cell signaling and cardiovascular disorders
    • Agrotis A, Kalinina N, Bobik A. Transforming growth factor-beta, cell signaling and cardiovascular disorders. Curr Vasc Pharmacol 2005;3:55-61.
    • (2005) Curr Vasc Pharmacol , vol.3 , pp. 55-61
    • Agrotis, A.1    Kalinina, N.2    Bobik, A.3
  • 40
    • 64249153706 scopus 로고    scopus 로고
    • TGF-beta regulates expression of KLF6 and its splice variants, and promotes cooperative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction
    • doi:10.1042/BJ20081434
    • Botella LM, Rodriguez-Sanz F, Komi Y, Fernandez-L A, Varela E, Garrido-Martin EM et al. TGF-beta regulates expression of KLF6 and its splice variants, and promotes cooperative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction. Biochem J 2008; doi:10.1042/BJ20081434.
    • Biochem J , vol.2008
    • Botella, L.M.1    Rodriguez-Sanz, F.2    Komi, Y.3    Fernandez-L, A.4    Varela, E.5    Garrido-Martin, E.M.6
  • 42
    • 50049098006 scopus 로고    scopus 로고
    • TGF-beta coordinately activates TAK1 /MEK/AKT/NFκB and SMAD pathways to promote osteoclast survival
    • Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, Oursler MJ. TGF-beta coordinately activates TAK1 /MEK/AKT/NFκB and SMAD pathways to promote osteoclast survival. Exp Cell Res 2008;31:2725-2738.
    • (2008) Exp Cell Res , vol.31 , pp. 2725-2738
    • Gingery, A.1    Bradley, E.W.2    Pederson, L.3    Ruan, M.4    Horwood, N.J.5    Oursler, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.