Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes

Journal of Cellular Physiology

Volumn 208, Issue 2, 2006, Pages 451-460

  Farías, Marcelo ^a   San Martín, Rody ^a   Puebla, Carlos ^a   Pearson, Jeremy D ^b   Casado, Javier F ^c   Pastor Anglada, Marçal ^c   Casanello, Paola ^a   Sobrevia, Luis ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ADULT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FETUS; FETUS DEVELOPMENT; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NEWBORN; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION;

ADENOSINE; ADENOVIRIDAE; BIOLOGICAL TRANSPORT; CASE-CONTROL STUDIES; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DIABETES, GESTATIONAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FEMALE; GENES, REPORTER; HUMANS; LUCIFERASES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PREGNANCY; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; UMBILICAL VEINS;

ADENOVIRIDAE;

EID: 33745605803     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20680     Document Type: Article

References (32)

1. Aguayo C, Casado J, González M, Pearson JD, San Martín R, Casanello P, Pastor-Anglada M, Sobrevia L. 2005. Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia. Placenta 26:641-653.
2. Anastasiou E, Lekakis JP, Alevizaki M, Papamichael CM, Megas J, Souvatzoglou A, Stamatelopoulos SF. 1998. Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes. Diabetes Care 21:2111-2115.
3. Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD. 2004. The equilibrative nucleoside transporter family, SLC29. Pflügers Arch 447:735-743.
4. +/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res 91:127-134.
5. Casanello P, Torres A, Sanhueza F, González M, Farías M, Gallardo V, Pastor-Anglada M, San Martín R, Sobrevia L. 2005. Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium. Circ Res 97:16-24.
6. Chen HH, Wang DL. 2004. Nitric oxide inhibits matrix metalloproteinase-2 expression via the induction of activating transcription factor 3 in endothelial cells. Mol Pharmacol 65:1130-1140.
7. Devés R, Boyd CA. 1998. Transporters for cationic amino acids in animal cells: Discovery, structure, and function. Physiol Rev 78:487-545.
8. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498.
9. Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schonfeld C, Loffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. 2005. HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med 202:1493-1505.
10. Endres CJ, Unadkat JD. 2005. Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-mercaptopurine riboside, and dipyridamole. Mol Pharmacol 67:837-844.
11. Ethier MF, Chander V, Dobson JG, Jr. 1993. Adenosine stimulates proliferation of human endothelial cells in culture. Am J Physiol Heart Circ Physiol 265:H131-H138.
12. Farre X, Guillen-Gómez E, Sánchez L, Hardisson D, Plaza Y, Lloberas J, Casado FJ, Palacios J, Pastor-Anglada M. 2004. Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Int J Cancer 112:959-966.
13. Fleming I, Busse R. 2003. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 284:R1-R12.
14. Garfinkel S, Brown S, Wessendorf JH, Maciag T. 1994. Post-transcriptional regulation of interleukin 1 alpha in various strains of young and senescent human umbilical vein endothelial cells. Proc Natl Acad Sci USA 91:1559-1563.
15. Gluckman PD, Hanson MA. 2004. Living with the past: Evolution, development, and patterns of disease. Science 305:1733-1736.
16. Görlach A. 2005. Control of adenosine transport in hypoxia. Circ Res 97:1-3.
17. Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP. 2002. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem 277:16464-16469.
18. Harper JF. 1998. Peritz's F test: BASIC program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput Biol Med 14:437-445.
19. Michiels C. 2003. Endothelial cell functions. J Cell Physiol 196:430-443.
20. Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. 2005. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 57:217-252.
21. Myatt L. 2006. Placental adaptive responses and fetal programming. J Physiol 572:25-30.
22. Noji T, Karasawa A, Kusaka H. 2004. Adenosine uptake inhibitors. Eur J Pharmacol 495:1-16.
23. Park SW, Wei LN. 2003. Regulation of c-myc gene by nitric oxide via inactivating NF-κB complex in P19 mouse embryonal carcinoma cells. J Biol Chem 278:29776-29782.
24. Park SK, Lin HL, Murphy S. 1997. Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-κB binding to DNA. Biochem J 332:609-613.
25. Parodi J, Flores C, Aguayo C, Rudolph MI, Casanello P, Sobrevia L. 2002. Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P2Y2 purinoceptors in human umbilical vein endotheiial cells. Circ Res 90:570-577.
26. San Martín R, Sobrevia L. 2006. Gestational diabetes and the adenosine/L-Arginine/Nitric Oxide (ALANO) pathway in human umbilical vein endothelium. Placenta 27:1-10.
27. Sobrevia L, Jarvis SM, Yudilevich DL. 1994. Adenosine transport in cultured human umbilical vein endothelial cells is reduced in diabetes. Am J Physiol Cell Physiol 267:C39-C47.
28. Soler C, Felipe A, Casado FJ, Celada A, Pastor-Anglada M. 2000. Nitric oxide regulates nucleoside transport in activated B lymphocytes. J Leukoc Biol 67:345-349.
29. Strohm C, Barancik M, von Bruehl M, Strniskova M, Ullmann C, Zimmermann R, Schaper W. 2002. Transcription inhibitor actinomycin-D abolishes the cardioprotective effect of ischemic reconditioning. Cardiovasc Res 55:602-618.
30. Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. 1999. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 13:3191-3197.
31. Vásquez G, Sanhueza F, Vásquez R, González M, San Martín R, Casanello P, Sobrevia L. 2004. Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 560:111-122.
32. Yoneyama Y, Sawa R, Suzuki S, Ishino H, Miura A, Kuwabara Y, Kuwajima T, Ito N, Kiyokawa Y, Otsubo Y, Araki T. 2002. Regulation of plasma adenosine levels in normal pregnancy. Gynecol Obstet Invest 53:71-74.