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Volumn 17, Issue 5, 2001, Pages 363-373

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: Role of the insulin receptor variant forms

Author keywords

Genetics of type 2 diabetes; Hybrid receptor; IGF I receptor; Insulin receptor isoforms; Insulin resistance; Type 2 diabetes

Indexed keywords

AMINO ACID; HYBRID PROTEIN; INSULIN; INSULIN RECEPTOR; ISOPROTEIN; SIGNAL PEPTIDE; SOMATOMEDIN C RECEPTOR;

EID: 0034767113     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.225     Document Type: Article
Times cited : (84)

References (77)
  • 1
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • (1997) Diabetes. Rev , vol.5 , pp. 177-269
    • De Fronzo, R.A.1
  • 6
  • 26
    • 0025867117 scopus 로고
    • Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action
    • (1991) Mol Endocrinol , vol.5 , pp. 734-739
    • Mcclain, D.A.1
  • 36
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparision with insulin receptor suggests structural determinants that define functional specificity
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3
  • 37
    • 0024465470 scopus 로고
    • Immunological relationships between receptors for insulin and insulin-like growth factor-1
    • (1989) Biochem J , vol.263 , pp. 553-563
    • Soos, M.A.1    Siddle, K.2
  • 41
    • 0027502045 scopus 로고
    • Purified hybrid insulin/insulin-like growth factor-1 receptors bind insulin-like growth factor-I, but not insulin, with high affinity
    • (1993) Biochem J , vol.290 , pp. 419-426
    • Soos, M.A.1    Field, C.E.2    Siddle, K.3
  • 46
    • 0031965286 scopus 로고    scopus 로고
    • Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia
    • (1998) Diabetes , vol.47 , pp. 87-92
    • Federici, M.1    Lauro, D.2    D'Adamo, M.3
  • 59
    • 0030453978 scopus 로고    scopus 로고
    • Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of non-insulin-dependent diabetes mellitus subjects
    • (1996) J Clin Invest , vol.98 , pp. 2887-2893
    • Federici, M.1    Zucaro, L.2    Porzio, O.3
  • 61
    • 0029888364 scopus 로고    scopus 로고
    • Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin resistant women with gestational hypertension
    • (1996) Diabetologia , vol.39 , pp. 952-960
    • Valensise, H.1    Liu, Y.Y.2    Federici, M.3
  • 70
    • 0030923338 scopus 로고    scopus 로고
    • The va1985 met insulin-receptor variant in the Danish Caucasian population: Lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance
    • (1997) Am J Hum Genet , vol.60 , pp. 1532-1535
    • Hansen, L.1    Hansen, T.2    Clausen, J.O.3
  • 77
    • 0033694512 scopus 로고    scopus 로고
    • Ecombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3077-3084
    • Cusi, K.1    DeFronzo, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.