Effect of 10 days of bedrest on metabolic and vascular insulin action: A study in individuals at risk for type 2 diabetes

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 830-837

  Sonne, Mette P ^a   Alibegovic, Amra C ^b   Højbjerre, Lise ^a   Vaag, Allan ^b   Stallknecht, Bente ^a   Dela, Flemming ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

Author keywords

Exercise; Metabolism

Indexed keywords

ANTIDIABETIC AGENT; INSULIN;

ADULT; ARTICLE; BED REST; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; DRUG EFFECT; EXERCISE; FAMILY HEALTH; FOREARM; GENETICS; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINISM; INSULIN RESISTANCE; LOW BIRTH WEIGHT; MALE; METABOLISM; NEWBORN; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

ADULT; BED REST; BLOOD FLOW VELOCITY; DIABETES MELLITUS, TYPE 2; EXERCISE; FAMILY HEALTH; FOREARM; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; REGIONAL BLOOD FLOW;

EID: 77950575039     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00545.2009     Document Type: Article

References (33)

1. Andersen JL, Schjerling P, Andersen LL, Dela F. Resistance training and insulin action in humans: effects of de-training. J Physiol, 551: 1049-1058, 2003. (Pubitemid 37221095)
2. Battram DS, Graham TE, Dela F. Caffeine's impairment of insulinmediated glucose disposal cannot be solely attributed to adrenaline in humans. J Physiol 583: 1069-1077, 2007.
3. Bauman A, Craig CL. The place of physical activity in the WHO Global Strategy on Diet and Physical Activity. Int J Behav Nutr Phys Act 2: 10, 2005. (Pubitemid 41522361)
4. Bokemark L, Froden A, Attvall S, Wikstrand J, Fagerberg B. The euglycemic hyperinsulinemic clamp examination: variability and reproducibility. Scand J Clin Lab Invest 60: 27-36, 2000. (Pubitemid 30167642)
5. Booth FW, Laye MJ, Lees SJ, Rector RS, Thyfault JP. Reduced physical activity and risk of chronic disease: the biology behind the consequences. Eur J Appl Physiol 102: 381-390, 2008.
6. Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 55: 1436-1442, 2006. (Pubitemid 44195384)
7. Crouter SE, Churilla JR, Bassett DR Jr. Accuracy of the Actiheart for the assessment of energy expenditure in adults. Eur J Clin Nutr 62: 704-711, 2008. (Pubitemid 351803579)
8. Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, Frohlich JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 26: 2977-2982, 2003. (Pubitemid 37339486)
9. Currie J, Ramsbottom R, Ludlow H, Nevili A, Gilder M. Cardiorespiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women. Neurosci Lett 451: 152-155, 2009.
10. Dolkas CB, Greenleaf JE. Insulin and glucose responses during bed rest with isotonic and isometric exercise. J Appl Physiol 43: 1033-1038, 1977. (Pubitemid 8258277)
11. Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8: 657-662, 2007.
12. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502, 1972.
13. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vase Biol 27: 2650-2656, 2007. (Pubitemid 350158918)
14. Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 56: 2655-2667, 2007.
15. Karlsson HK, Atusen M, Zierath JR, Wallberg-Henriksson H, Koistinen HA. Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes 55: 1283-1288, 2006. (Pubitemid 44195366)
16. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, Fischer CP, Lindegaard B, Petersen AM, Taudorf S, Secher NH, Pilegaard H, Bruunsgaard H, Pedersen BK. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50: 431-438, 2007.
17. Laakso M, Edelman SV, Olefsky JM, Brechtel G, Wallace P, Baron AD. Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity. Diabetes 39: 965-974, 1990. (Pubitemid 20233731)
18. Lipman RL, Schnure JJ, Bradley EM, Lecocq FR. Impairment of peripheral glucose utilization in normal subjects by prolonged bed rest. J Lab Clin Med 76: 221-230, 1970.
19. Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell UB, Leon DA. Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 312: 406-410, 1996. (Pubitemid 26055355)
20. Mikines KJ, Richter EA, Dela F, Galbo H. Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body. J Appl Physiol. 70: 1245-1254, 1991.
21. Mikines KJ, Sonne B, Tronier B, Galbo H. Effects of acute exercise and detraining on insulin action in trained men. J Appl Physiol 66: 704-711, 1989. (Pubitemid 19072920)
22. Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-I serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 1.15: 3587-3593, 2005. (Pubitemid 43121847)
23. Olsen DB, Sacchetti M, Dela F, Ploug T, Saltin B. Glucose clearance is higher in arm than leg muscle in type 2 diabetes. J Physiol 565: 555-562, 2005. (Pubitemid 40872482)
24. Paradisi G, Steinberg HO, Hempfling A, Cronin J, Hook G, Shepard MK, Baron AD. Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation 103: 1410-1415, 2001. (Pubitemid 32220633)
25. Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 104: 12587-12594, 2007. (Pubitemid 47255198)
26. Rogers MA, King DS, Hagberg JM, Ehsani AA, Holloszy JO. Effect of 10 days of physical inactivity on glucose tolerance in master athletes. J Appl Physiol 68: 1833-1837, 1990.
27. Soop M, Nygren J, Brismar K, Thorell A, Ljungqvist O. The hyperinsulinaemic-euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects. Clin Sci (Land) 98: 367-374, 2000. (Pubitemid 30197849)
28. Stuart CA, Shangraw RE, Prince MJ, Peters EJ, Wolfe RR. Bed-restinduced insulin resistance occurs primarily in muscle. Metabolism 37: 802-806, 1988.
29. Tabata I., Suzuki Y, Fukunaga T, Yokozeki T, Akima H, Funato K. Resistance training affects G.LUT-4 content in skeletal muscle of humans after 19 days of head-down bed rest. J Appl Physiol 86: 909-914, 1999.
30. Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 132: 605-611, 2000. (Pubitemid 30217552)
31. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men [Erratum. Ann Intern Med 131(5): 394, 1999].
32. Ann Intern Med 130: 89-96, 1999.
33. Yki-Järvinen H, Young AA, Lamkin CL, Foley JE. Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79: 1713-1719, 1987. (Pubitemid 17117278)