High glucose, nitric oxide, and adenosine: A vicious circle in chronic hyperglycaemia?

Cardiovascular Research

Volumn 86, Issue 1, 2010, Pages 9-11

  Pandolfi, Assunta ^a   Di Pietro, Natalia ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE; HETERODIMER; NITRIC OXIDE;

DIABETIC PATIENT; EDITORIAL; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HYPERGLYCEMIA; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SLC29A1 GENE; TRANSCRIPTION REGULATION; UMBILICAL VEIN; UPREGULATION;

ADENOSINE; ANIMALS; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; HUMANS; HYPERGLYCEMIA; NITRIC OXIDE; RISK FACTORS;

EID: 77949355546     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq055     Document Type: Editorial

References (15)

1. Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1999;48:937-942.
2. Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S et al. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation 2000;101:1780-1784.
3. Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res 1999;43:521-531.
4. Kojda G, Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 1999;43:562-571.
5. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998;97:1695-1701.
6. Brodsky SV, Morrishow AM, Dharia N, Gross SS, Goligorsky MS. Glucose scavenging of nitric oxide. Am J Physiol Renal Physiol 2001;280:480-486.
7. Oyadomari S, Gotoh T, Aoyagi K, Araki E, Shichiri M, Mori M. Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats. Nitric Oxide 2001;5:252-260.
8. Cosentino F, Hishikawa K, Katusic ZS, Luscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 1997;96:25-28.
9. Pandolfi A, Di Fulvio P, Di Silvestre S, Di Tomo P, Giardinelli A, La Sorda R et al. Increased vascular wall endothelial Nitric Oxide Synthase (eNOS) levels in umbilical cords from gestational diabetic women. Diabetologia 2005;48 (Abstract).
10. Vasquez G, Sanhueza F, Vasquez R, Gonzalez M, San Martin R, Casanello P et al. Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 2004;560:111-122.
11. Farias M, San Martin R, Puebla C, Pearson JD, Casado JF, Pastor-Anglada M et al. Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol 2006;208: 451-460.
12. Farías M, Puebla C, Westermeier F, Jo MJ, Pastor-Anglada M, Casanello P et al. Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBPα in human umbilical vein endothelial cells from gestational diabetes. Cardiovasc Res 2010;86:45-54.
13. Puebla C, Farias M, Gonzalez M, Vecchiola A, Aguayo C, Krause B et al. High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium. J Cell Physiol 2008;215:645-656.
14. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61.
15. San Martin R, Sobrevia L. Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta 2006;27: 1-10.