Aldose reductase: A novel therapeutic target for inflammatory pathologies

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 1, 2010, Pages 17-20

  Ramana, Kota V ^a   Srivastava, Satish K ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aldehydes; Aldose reductase; Inflammation; NF B; Oxidative stress

Indexed keywords

ALDEHYDE; ALDEHYDE REDUCTASE; ALDEHYDE REDUCTASE INHIBITOR; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ENZYME INHIBITOR; GLUCOSE; GLUTATHIONE; LIPID; POLYOL; SORBITOL; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; ATHEROSCLEROSIS; BREAST CANCER; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; CATALYSIS; CATARACT; CATARACTOGENESIS; CLINICAL TRIAL; COLON CANCER; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DOWN REGULATION; DRUG APPROVAL; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; DRUG USE; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE OVEREXPRESSION; GLUCOSE METABOLISM; HEART DISEASE; HUMAN; HYPERGLYCEMIA; INFLAMMATORY DISEASE; LIPID PEROXIDATION; LIVER CANCER; MICROANGIOPATHY; NONHUMAN; OVARY CANCER; RESTENOSIS; SEPSIS; SHORT SURVEY; UTERINE CERVIX CANCER; UVEITIS;

ALDEHYDE REDUCTASE; ANIMALS; HUMANS; INFLAMMATION;

EID: 70749089191     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.09.009     Document Type: Short Survey

References (21)

1. Alexiou P., Pegklidou K., Chatzopoulou M., Nicolaou I., and Demopoulos V.J. Aldose reductase enzyme and its implication to major health problems of the 21(st) century. Curr Med Chem 16 (2009) 734-752
2. Barski O.A., Tipparaju S.M., and Bhatnagar A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab Rev 40 (2008) 553-624
3. Fournier B., Bendeif E.E., Guillot B., Podjarny A., Lecomte C., and Jelsch C. Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase. J Am Chem Soc 131 (2009) 10929-10941
4. Hers H.G. The mechanism of the transformation of glucose in fructose in the seminal vesicles. Biochim Biophys Acta 22 (1956) 202-203
5. Kinoshita J.H., Kador P., and Catiles M. Aldose reductase in diabetic cataracts. JAMA 246 (1981) 257-261
6. Oates P.J. Aldose reductase, still a compelling target for diabetic neuropathy. Curr Drug Targets 9 (2008) 14-36
7. Petrash J.M., Harter T.M., Devine C.S., Olins P.O., Bhatnagar A., Liu S., and Srivastava S.K. Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303. J Biol Chem 267 (1992) 24833-24840
8. Ramana K.V., Dixit B.L., Srivastava S., Balendiran G.K., Srivastava S.K., and Bhatnagar A. Selective recognition of glutathiolated aldehydes by aldose reductase. Biochemistry 39 (2000) 12172-12180
9. Ramana K.V., Chandra D., Srivastava S., Bhatnagar A., Aggarwal B.B., and Srivastava S.K. Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem 277 (2002) 32063-32070
10. Ramana K.V., Friedrich B., Bhatnagar A., and Srivastava S.K. Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells. FASEB J 17 (2003) 315-317
11. Ramana K.V., Bhatnagar A., Srivastava S., Yadav U.C., Awasthi S., Awasthi Y.C., and Srivastava S.K. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. J Biol Chem 281 (2006) 17652-17660
12. Ramana K.V., Fadl A.A., Tammali R., Reddy A.B., Chopra A.K., and Srivastava S.K. Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem 281 (2006) 33019-33029
13. Ramana K.V., Willis M.S., White M.D., Horton J.W., DiMaio J.M., Srivastava D., Bhatnagar A., and Srivastava S.K. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 114 (2006) 1838-1846
14. Singh R., White M.A., Ramana K.V., Petrash J.M., Watowich S.J., Bhatnagar A., and Srivastava S.K. Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins 64 (2006) 101-110
15. Srivastava S., Watowich S.J., Petrash J.M., Srivastava S.K., and Bhatnagar A. Structural and kinetic determinants of aldehyde reduction by aldose reductase. Biochemistry 38 (1999) 42-54
16. Srivastava S.K., Ramana K.V., and Bhatnagar A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev 26 (2005) 380-392
17. Tammali R., Ramana K.V., Singhal S.S., Awasthi S., and Srivastava S.K. Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res 66 (2006) 9705-9713
18. Tammali R., Reddy A.B., Ramana K.V., Petrash J.M., and Srivastava S.K. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis 30 (2009) 799-807
19. van Heyningen R. Formation of polyols by the lens of the rat with 'sugar' cataract. Nature 468 (1959) 194-195
20. Yadav U.C., Srivastava S.K., and Ramana K.V. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci 48 (2007) 4634-4642
21. Yadav U.C., Ramana K.V., Aguilera-Aguirre L., Boldogh I., Boulares H.A., and Srivastava S.K. Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One 4 (2009) e6535