Aldose reductase expression is induced by hyperglycemia in diabetic nephropathy

Kidney International

Volumn 60, Issue 1, 2001, Pages 211-218

  Hodgkinson, Andrea D ^a   Søndergaard, Karen L ^a   Yang, Bingmei ^a   Cross, Debbie F ^a   Millward, Beverley A ^a   Demaine, Andrew G ^a  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

ALR2 gene; Blood sugar; Gene expression; Sorbitol dehydrogenase; Type 1 diabetes

Indexed keywords

ALDEHYDE REDUCTASE; GLUCOSE; IDITOL DEHYDROGENASE; MESSENGER RNA; PHYTOHEMAGGLUTININ; POLYOL; RIBONUCLEASE; RNA;

ADULT; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; ISCHEMIA; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE INJURY;

EID: 0034963234     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.00788.x     Document Type: Article

References (27)

1. Diabetic nephropathy in type 1 diabetes: An epidemiological study
2. The changing natural history of nephropathy in type 1 diabetes
3. Epidemiological approach to the etiology of type 1 diabetes mellitus and its complications
4. Familial clustering of diabetic kidney disease: Evidence for genetic susceptibility to diabetic nephropathy
5. Is diabetic nephropathy an inherited condition?
6. Familial factors determine the development of diabetic nephropathy in patients with IDDM
7. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial
8. T-cell receptor constant β-chain polymorphisms and susceptibility to type 1 diabetes
9. Chromosome 7q35 and susceptibility to diabetic microvascular complications
10. A polymorphism at the 5′ end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type 1 diabetes
11. Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy
12. Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in type 1 diabetes mellitus
13. Sorbitol, phosphoinositides, and sodium-potassium-ATPas in the pathogenesis of diabetic complications
14. Glucose inhibits myoinositol uptake and reduces myo-inositol content in cultured rat glomerular mesangial cells
15. Altered aldose reductase gene regulation in cultured human retinal pigment epithelial cells
16. Hyperglycaemia, pseudohypoxia and diabetic complications
17. Association of erythrocyte aldose reductase activity with diabetic complications in type 1 diabetes mellitus
18. Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes
19. Aldose reductase gene expression is increased in diabetic nephropathy
20. An AC (n) dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early onset diabetic retinopathy in NIDDM patients
21. A novel polymorphism in the aldose reductase gene promoter is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes
22. Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM and elevated luciferase gene transcription in vitro
23. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
24. Glucose transporter (GLUT 1) allele (Xbal-) associated with nephropathy in non-insulin dependent diabetes mellitus
25. Polymorphisms of the glucose transporter (GLUT 1) and aldose reductase gene and susceptibility to diabetic nephropathy in patients with type 1 diabetes mellitus
26. Down regulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells
27. Rat renal expression of mRNA coding for aldose reductase and sorbitol dehydrogenase and its osmotic regulation in inner medullary collecting duct cells