Inhibition of aldose reductase prevents growth factor-induced g 1-s phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells

Molecular Cancer Therapeutics

Volumn 9, Issue 4, 2010, Pages 813-824

  Ramana, Kota V ^a   Tammali, Ravinder ^a   Srivastava, Satish K ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; BASIC FIBROBLAST GROWTH FACTOR; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYCLINE; EPIDERMAL GROWTH FACTOR; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SORBINIL; TRANSCRIPTION FACTOR E2F1; ZOPOLRESTAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DNA BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALDEHYDE REDUCTASE; ANIMALS; BENZOTHIAZOLES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DNA, NEOPLASM; E2F1 TRANSCRIPTION FACTOR; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLIDINES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEOPLASM PROTEINS; PHOSPHORYLATION; PHTHALAZINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; S PHASE; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77950830294     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0795     Document Type: Article

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