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Volumn 11, Issue 4, 2010, Pages 402-416

Aldose reductase inhibitors and diabetic kidney disease

Author keywords

AKR1B1 gene; Aldose reductase inhibitor; Diabetic kidney disease; Diabetic nephropathy; Hemodynamics; Oxidative stress; Polyol pathway; Renal fibrosis

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ARI 809; EPALRESTAT; FIDARESTAT; IMIRESTAT; INSULIN; PLACEBO; POLYOL; RANIRESTAT; SORBINIL; UNCLASSIFIED DRUG; ZOPOLRESTAT;

EID: 77950168857     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (37)

References (168)
  • 1
    • 44449173135 scopus 로고    scopus 로고
    • Diabetic nephropathy
    • Brenner BM (Ed), Saunders Elsevier, Philadelphia, PA, USA
    • Parving HH, Mauer M, Ritz E: Diabetic nephropathy. In: Brenner and Rector's The Kidney, 2. Brenner BM (Ed), Saunders Elsevier, Philadelphia, PA, USA (2008):1265-1298.
    • (2008) Brenner and Rector's the Kidney , vol.2 , pp. 1265-1298
    • Parving, H.H.1    Mauer, M.2    Ritz, E.3
  • 2
    • 79960614571 scopus 로고    scopus 로고
    • National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2007
    • Centers for Disease Control and Prevention: Atlanta, GA, USA
    • Centers for Disease Control and Prevention: National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2007. US Department of Health and Human Services, Atlanta, GA, USA (2008).
    • (2008) US Department of Health and Human Services
  • 4
    • 48149097372 scopus 로고    scopus 로고
    • The kidney in diabetes: Dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007
    • Fioretto P, Caramori ML, Mauer M: The kidney in diabetes: Dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007. Diabetologia (2008) 51(8):1347-1355.
    • (2008) Diabetologia , vol.51 , Issue.8 , pp. 1347-1355
    • Fioretto, P.1    Caramori, M.L.2    Mauer, M.3
  • 5
    • 67749084303 scopus 로고    scopus 로고
    • Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005)
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ: Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med (2009) 169(14):1307-1316.
    • (2009) Arch Intern Med , vol.169 , Issue.14 , pp. 1307-1316
    • Nathan, D.M.1    Zinman, B.2    Cleary, P.A.3    Backlund, J.Y.4    Genuth, S.5    Miller, R.6    Orchard, T.J.7
  • 9
    • 38849177363 scopus 로고    scopus 로고
    • Aldose reductase, still a compelling target for diabetic neuropathy
    • Oates PJ: Aldose reductase, still a compelling target for diabetic neuropathy. Curr Drug Targets (2008) 9(1):14-36.
    • (2008) Curr Drug Targets , vol.9 , Issue.1 , pp. 14-36
    • Oates, P.J.1
  • 10
    • 0001733320 scopus 로고    scopus 로고
    • The polyol pathway and diabetic retinopathy
    • Duh E (Ed), Humana Press, Totowa, NJ, USA
    • Lorenzi M, Oates PJ: The polyol pathway and diabetic retinopathy In: Diabetic retinopathy. Duh E (Ed), Humana Press, Totowa, NJ, USA (2008):159-186.
    • (2008) Diabetic Retinopathy , pp. 159-186
    • Lorenzi, M.1    Oates, P.J.2
  • 11
    • 0024655085 scopus 로고
    • Aldose reductase in the etiology of diabetic complications 2. Nephropathy
    • Stribling D, Armstrong FM, Harrison HE: Aldose reductase in the etiology of diabetic complications: 2. Nephropathy. J Diabetic Complications (1989) 3(2):70-76.
    • (1989) J Diabetic Complications , vol.3 , Issue.2 , pp. 70-76
    • Stribling, D.1    Armstrong, F.M.2    Harrison, H.E.3
  • 12
    • 0027326529 scopus 로고
    • Aldose reductase inhibitors: Recent developments
    • Sarges R, Oates PJ: Aldose reductase inhibitors: Recent developments. Prog Drug Res (1993) 40:99-161.
    • (1993) Prog Drug Res , vol.40 , pp. 99-161
    • Sarges, R.1    Oates, P.J.2
  • 13
    • 0028237145 scopus 로고
    • Diabetic nephropathy, renal hemodynamics, and aldose reductase inhibitors
    • Oates PJ: Diabetic nephropathy, renal hemodynamics, and aldose reductase inhibitors. Drug Dev Res (1994) 32(2):104-116.
    • (1994) Drug Dev Res , vol.32 , Issue.2 , pp. 104-116
    • Oates, P.J.1
  • 14
    • 0033857113 scopus 로고    scopus 로고
    • Aldose reductase and the role of the polyol pathway in diabetic nephropathy
    • Dunlop M: Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int (2000) 58(Suppl 77):S3-S12.
    • (2000) Kidney Int , vol.58 , Issue.SUPPL. 77
    • Dunlop, M.1
  • 15
    • 0022480141 scopus 로고
    • Early glomerular hyperfiltration in insulindependent diabetics and late nephropathy
    • Mogensen CE: Early glomerular hyperfiltration in insulindependent diabetics and late nephropathy. Scand J Clin Lab Invest (1986) 46(3):201-206.
    • (1986) Scand J Clin Lab Invest , vol.46 , Issue.3 , pp. 201-206
    • Mogensen, C.E.1
  • 16
    • 29644435379 scopus 로고    scopus 로고
    • The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study
    • Amin R, Turner C, van Aken S, Bahu TK, Watts A, Lindsell DR, Dalton RN, Dunger DB: The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study. Kidney Int (2005) 68(4):1740-1749.
    • (2005) Kidney Int , vol.68 , Issue.4 , pp. 1740-1749
    • Amin, R.1    Turner, C.2    Van Aken, S.3    Bahu, T.K.4    Watts, A.5    Lindsell, D.R.6    Dalton, R.N.7    Dunger, D.B.8
  • 17
    • 0015424572 scopus 로고
    • A model of glomerular ultrafiltration in the rat
    • Deen WM, Robertson CR, Brenner BM: A model of glomerular ultrafiltration in the rat. Am J Physiol (1972) 223(5):1178-1183.
    • (1972) Am J Physiol , vol.223 , Issue.5 , pp. 1178-1183
    • Deen, W.M.1    Robertson, C.R.2    Brenner, B.M.3
  • 18
    • 0019460233 scopus 로고
    • Glomerular hemodynamics in experimental diabetes mellitus
    • Hostetter TH, Troy JL, Brenner BM: Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int (1981) 19(3): 410-415.
    • (1981) Kidney Int , vol.19 , Issue.3 , pp. 410-415
    • Hostetter, T.H.1    Troy, J.L.2    Brenner, B.M.3
  • 19
    • 0025334809 scopus 로고
    • Prediction of clinical diabetic nephropathy in IDDM patients. Alternatives to microalbuminuria?
    • Mogensen CE: Prediction of clinical diabetic nephropathy in IDDM patients. Alternatives to microalbuminuria? Diabetes (1990) 39(7):761-767.
    • (1990) Diabetes , vol.39 , Issue.7 , pp. 761-767
    • Mogensen, C.E.1
  • 22
    • 67049162377 scopus 로고    scopus 로고
    • Early nephropathy in type 1 diabetes: The importance of early renal function decline
    • Perkins BA, Krolewski AS: Early nephropathy in type 1 diabetes: The importance of early renal function decline. Curr Opin Nephrol Hypertens (2009) 18(3):233-240.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , Issue.3 , pp. 233-240
    • Perkins, B.A.1    Krolewski, A.S.2
  • 25
    • 21344454447 scopus 로고    scopus 로고
    • The early natural history of nephropathy in type 1 diabetes: III Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients
    • International Diabetic Nephopathy Study Group
    • Steinke JM, Sinaiko AR, Kramer MS, Suissa S, Chavers BM, Mauer M, International Diabetic Nephopathy Study Group: The early natural history of nephropathy in type 1 diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients. Diabetes (2005) 54(7):2164-2171.
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2164-2171
    • Steinke, J.M.1    Sinaiko, A.R.2    Kramer, M.S.3    Suissa, S.4    Chavers, B.M.5    Mauer, M.6
  • 26
    • 68149137068 scopus 로고    scopus 로고
    • Nonalbuminuric renal impairment in type 2 diabetic patients and in the general population (National Evaluation of the Frequency of Renal Impairment Co-existing with NIDDM [NEFRON](11)
    • Thomas MC, Macisaac RJ, Jerums G, Weekes A, Moran J, Shaw JE, Atkins RC: Nonalbuminuric renal impairment in type 2 diabetic patients and in the general population (National Evaluation of the Frequency of Renal Impairment Co-existing with NIDDM [NEFRON] 11). Diabetes Care (2009) 32(8):1497-1502.
    • (2009) Diabetes Care , vol.32 , Issue.8 , pp. 1497-1502
    • Thomas, M.C.1    MacIsaac, R.J.2    Jerums, G.3    Weekes, A.4    Moran, J.5    Shaw, J.E.6    Atkins, R.C.7
  • 27
    • 33748309114 scopus 로고    scopus 로고
    • Risk factors for renal dysfunction in type 2 diabetes: UK Prospective Diabetes Study 74
    • UKPDS Study Group
    • Retnakaran R, Cull CA, Thorne KI, Adler AI, Holman RR, UKPDS Study Group: Risk factors for renal dysfunction in type 2 diabetes: UK Prospective Diabetes Study 74. Diabetes (2006) 55(6):1832-1839.
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1832-1839
    • Retnakaran, R.1    Cull, C.A.2    Thorne, K.I.3    Adler, A.I.4    Holman, R.R.5
  • 28
    • 0024422014 scopus 로고
    • Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients
    • Steffes MW, Osterby R, Chavers B, Mauer SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes (1989) 38(9):1077-1081.
    • (1989) Diabetes , vol.38 , Issue.9 , pp. 1077-1081
    • Steffes, M.W.1    Osterby, R.2    Chavers, B.3    Mauer, S.M.4
  • 30
    • 0032731318 scopus 로고    scopus 로고
    • The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
    • Gilbert RE, Cooper ME: The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Kidney Int (1999) 56(5):1627-1637.
    • (1999) Kidney Int , vol.56 , Issue.5 , pp. 1627-1637
    • Gilbert, R.E.1    Cooper, M.E.2
  • 31
    • 0035204171 scopus 로고    scopus 로고
    • Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy
    • Cooper ME: Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia (2001) 44(11):1957-1972.
    • (2001) Diabetologia , vol.44 , Issue.11 , pp. 1957-1972
    • Cooper, M.E.1
  • 33
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group
    • No authors listed
    • No authors listed: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 329(14):977-986.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 977-986
  • 34
    • 0034118392 scopus 로고    scopus 로고
    • Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists
    • Taal MW, Brenner BM: Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. Kidney Int (2000) 57(5):1803-1817.
    • (2000) Kidney Int , vol.57 , Issue.5 , pp. 1803-1817
    • Taal, M.W.1    Brenner, B.M.2
  • 35
    • 0029902698 scopus 로고    scopus 로고
    • The hyperfiltration theory: A paradigm shift in nephrology
    • Brenner BM, Lawler EV, Mackenzie HS: The hyperfiltration theory: A paradigm shift in nephrology. Kidney Int (1996) 49(6):1774-1777.
    • (1996) Kidney Int , vol.49 , Issue.6 , pp. 1774-1777
    • Brenner, B.M.1    Lawler, E.V.2    MacKenzie, H.S.3
  • 37
    • 34249102220 scopus 로고    scopus 로고
    • Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells
    • Zhuo JL, Li XC: Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells. J Renin Angiotensin Aldosterone Syst (2007) 8(1):23-33.
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , Issue.1 , pp. 23-33
    • Zhuo, J.L.1    Li, X.C.2
  • 38
    • 49449123811 scopus 로고
    • A symmetry rule for the circular dichroism of reducing sugars, and the proportion of carbonyl forms in aqueous solutions thereof
    • Hayward LD, Angyal SJ: A symmetry rule for the circular dichroism of reducing sugars, and the proportion of carbonyl forms in aqueous solutions thereof. Carbohydr Res (1977) 53(1):13-20.
    • (1977) Carbohydr Res , vol.53 , Issue.1 , pp. 13-20
    • Hayward, L.D.1    Angyal, S.J.2
  • 40
    • 33947671901 scopus 로고    scopus 로고
    • Advanced glycation endproducts: What is their relevance to diabetic complications?
    • Ahmed N, Thornalley PJ: Advanced glycation endproducts: What is their relevance to diabetic complications? Diabetes Obes Metab (2007) 9(3):233-245.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.3 , pp. 233-245
    • Ahmed, N.1    Thornalley, P.J.2
  • 41
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
    • Baynes JW, Thorpe SR: Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes (1999) 48(1):1-9.
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 1-9
    • Baynes, J.W.1    Thorpe, S.R.2
  • 42
    • 0023803371 scopus 로고
    • Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease
    • Brownlee M, Cerami A, Vlassara H: Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease. Diabetes Metab Rev (1988) 4(5):437-451.
    • (1988) Diabetes Metab Rev , vol.4 , Issue.5 , pp. 437-451
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 43
    • 34248383624 scopus 로고    scopus 로고
    • The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its complications
    • Yan SF, Barile GR, D'Agati V, Du Yan S, Ramasamy R, Schmidt AM: The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its complications. Curr Diab Rep (2007) 7(2):146-153.
    • (2007) Curr Diab Rep , vol.7 , Issue.2 , pp. 146-153
    • Yan, S.F.1    Barile, G.R.2    D'Agati, V.3    Du Yan, S.4    Ramasamy, R.5    Schmidt, A.M.6
  • 46
    • 0035434130 scopus 로고    scopus 로고
    • Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C
    • Ido Y, Chang KC, Lejeune WS, Bjercke RJ, Reiser KM, Williamson JR, Tilton RG: Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation (2001) 8(4):251-263.
    • (2001) Microcirculation , vol.8 , Issue.4 , pp. 251-263
    • Ido, Y.1    Chang, K.C.2    Lejeune, W.S.3    Bjercke, R.J.4    Reiser, K.M.5    Williamson, J.R.6    Tilton, R.G.7
  • 47
    • 32244439639 scopus 로고    scopus 로고
    • Cunningham C: Role for GLUT1 in diabetic glomerulosclerosis
    • Heilig CW, Brosius FC 3rd, Cunningham C: Role for GLUT1 in diabetic glomerulosclerosis. Expert Rev Mol Med (2006) 8(4):1-18.
    • (2006) Expert Rev Mol Med , vol.8 , Issue.4 , pp. 1-18
    • Heilig, C.W.1    Brosius III, F.C.2
  • 48
    • 0021265346 scopus 로고
    • Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil
    • Beyer-Mears A, Ku L, Cohen MP: Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil. Diabetes (1984) 33(6):604-607.
    • (1984) Diabetes , vol.33 , Issue.6 , pp. 604-607
    • Beyer-Mears, A.1    Ku, L.2    Cohen, M.P.3
  • 49
    • 0023583909 scopus 로고
    • Evidence for existence of polyol pathway in cultured rat mesangial cells
    • Kikkawa R, Umemura K, Haneda M, Arimura T, Ebata K, Shigeta Y: Evidence for existence of polyol pathway in cultured rat mesangial cells. Diabetes (1987) 36(2):240-243.
    • (1987) Diabetes , vol.36 , Issue.2 , pp. 240-243
    • Kikkawa, R.1    Umemura, K.2    Haneda, M.3    Arimura, T.4    Ebata, K.5    Shigeta, Y.6
  • 50
    • 34547487924 scopus 로고    scopus 로고
    • The role of protein kinase C activation in diabetic nephropathy
    • Noh H, King GL: The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl (2007) (106):S49-S53.
    • (2007) Kidney Int Suppl , vol.106
    • Noh, H.1    King, G.L.2
  • 51
    • 34548802931 scopus 로고    scopus 로고
    • Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: Effect of the anti-oxidant α-lipoic acid
    • Singh LP, Cheng DW, Kowluru R, Levi E, Jiang Y: Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: Effect of the anti-oxidant α-lipoic acid. Cell Biochem Funct (2007) 25(5):537-550.
    • (2007) Cell Biochem Funct , vol.25 , Issue.5 , pp. 537-550
    • Singh, L.P.1    Cheng, D.W.2    Kowluru, R.3    Levi, E.4    Jiang, Y.5
  • 52
    • 70349804297 scopus 로고    scopus 로고
    • Nox proteins in signal transduction
    • Brown DI, Griendling KK: Nox proteins in signal transduction. Free Radic Biol Med (2009) 47(9):1239-1253.
    • (2009) Free Radic Biol Med , vol.47 , Issue.9 , pp. 1239-1253
    • Brown, D.I.1    Griendling, K.K.2
  • 53
    • 34547788748 scopus 로고    scopus 로고
    • Suppressing renal NADPH oxidase to treat diabetic nephropathy
    • Tojo A, Asaba K, Onozato ML: Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin Ther Targets (2007) 11(8):1011-1018.
    • (2007) Expert Opin Ther Targets , vol.11 , Issue.8 , pp. 1011-1018
    • Tojo, A.1    Asaba, K.2    Onozato, M.L.3
  • 54
    • 34547414931 scopus 로고    scopus 로고
    • NADH oxidase activity of rat and human liver xanthine oxidoreductase: Potential role in superoxide production
    • Maia L, Duarte RO, Ponces-Freire A, Moura JJ, Mira L: NADH oxidase activity of rat and human liver xanthine oxidoreductase: Potential role in superoxide production. J Biol Inorg Chem (2007) 12(6):777-787.
    • (2007) J Biol Inorg Chem , vol.12 , Issue.6 , pp. 777-787
    • Maia, L.1    Duarte, R.O.2    Ponces-Freire, A.3    Moura, J.J.4    Mira, L.5
  • 55
    • 29244447160 scopus 로고    scopus 로고
    • Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    • Siu YP, Leung KT, Tong MK, Kwan TH: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis (2006) 47(1):51-59.
    • (2006) Am J Kidney Dis , vol.47 , Issue.1 , pp. 51-59
    • Siu, Y.P.1    Leung, K.T.2    Tong, M.K.3    Kwan, T.H.4
  • 58
    • 48249127629 scopus 로고    scopus 로고
    • From fibrosis to sclerosis: Mechanisms of glomerulosclerosis in diabetic nephropathy
    • Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC 3rd: From fibrosis to sclerosis: Mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes (2008) 57(6):1439-1445.
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1439-1445
    • Qian, Y.1    Feldman, E.2    Pennathur, S.3    Kretzler, M.4    Brosius III, F.C.5
  • 60
    • 36148929033 scopus 로고    scopus 로고
    • Reactive oxygen species, PKC-β1, and PKC-γ1 mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells
    • Xia L, Wang H, Munk S, Frecker H, Goldberg HJ, Fantus IG, Whiteside CI: Reactive oxygen species, PKC-β1, and PKC-γ1 mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells. Am J Physiol Endocrinol Metab (2007) 293(5):E1280-1288.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.5
    • Xia, L.1    Wang, H.2    Munk, S.3    Frecker, H.4    Goldberg, H.J.5    Fantus, I.G.6    Whiteside, C.I.7
  • 62
    • 0036605475 scopus 로고    scopus 로고
    • Diabetic vascular dysfunction: Links to glucoseinduced reductive stress and VEGF
    • Tilton RG: Diabetic vascular dysfunction: Links to glucoseinduced reductive stress and VEGF. Microsc Res Tech (2002) 57(5):390-407.
    • (2002) Microsc Res Tech , vol.57 , Issue.5 , pp. 390-407
    • Tilton, R.G.1
  • 65
    • 33646068113 scopus 로고    scopus 로고
    • Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucoseexposed human mesangial cells
    • Drel VR, Pacher P, Stevens MJ, Obrosova IG: Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucoseexposed human mesangial cells. Free Radic Biol Med (2006) 40(8):1454-1465.
    • (2006) Free Radic Biol Med , vol.40 , Issue.8 , pp. 1454-1465
    • Drel, V.R.1    Pacher, P.2    Stevens, M.J.3    Obrosova, I.G.4
  • 66
    • 48249085391 scopus 로고    scopus 로고
    • Oxidative stress as a major culprit in kidney disease in diabetes
    • Forbes JM, Coughlan MT, Cooper ME: Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes (2008) 57(6):1446-1454.
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1446-1454
    • Forbes, J.M.1    Coughlan, M.T.2    Cooper, M.E.3
  • 67
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 87(1):315-424.
    • (2007) Physiol Rev , vol.87 , Issue.1 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 68
    • 37149042831 scopus 로고    scopus 로고
    • Novel insights in the treatment of diabetic nephropathy
    • Schrijvers BF, De Vriese AS: Novel insights in the treatment of diabetic nephropathy. Acta Clin Belg (2007) 62(5):278-290.
    • (2007) Acta Clin Belg , vol.62 , Issue.5 , pp. 278-290
    • Schrijvers, B.F.1    De Vriese, A.S.2
  • 70
    • 67650242157 scopus 로고    scopus 로고
    • Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: An inception cohort study
    • Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH: Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: An inception cohort study. Diabetes (2009) 58(7):1668-1671.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1668-1671
    • Hovind, P.1    Rossing, P.2    Tarnow, L.3    Johnson, R.J.4    Parving, H.H.5
  • 71
    • 33947131284 scopus 로고    scopus 로고
    • Diabetic nephropathy: Where hemodynamics meets metabolism
    • Forbes JM, Fukami K, Cooper ME: Diabetic nephropathy: Where hemodynamics meets metabolism. Exp Clin Endocrinol Diabetes (2007) 115(2):69-84.
    • (2007) Exp Clin Endocrinol Diabetes , vol.115 , Issue.2 , pp. 69-84
    • Forbes, J.M.1    Fukami, K.2    Cooper, M.E.3
  • 72
    • 34547636295 scopus 로고    scopus 로고
    • Mechanical forces in diabetic kidney disease: A trigger for impaired glucose metabolism
    • Gnudi L, Thomas SM, Viberti G: Mechanical forces in diabetic kidney disease: A trigger for impaired glucose metabolism. J Am Soc Nephrol (2007) 18(8):2226-2232.
    • (2007) J Am Soc Nephrol , vol.18 , Issue.8 , pp. 2226-2232
    • Gnudi, L.1    Thomas, S.M.2    Viberti, G.3
  • 75
    • 45149095472 scopus 로고    scopus 로고
    • Lowering of proteinuria in response to antihypertensive therapy predicts improved renal function in late but not in early diabetic nephropathy: A pooled analysis
    • Jerums G, Panagiotopoulos S, Premaratne E, Power DA, MacIsaac RJ: Lowering of proteinuria in response to antihypertensive therapy predicts improved renal function in late but not in early diabetic nephropathy: A pooled analysis. Am J Nephrol (2008) 28(4):614-627.
    • (2008) Am J Nephrol , vol.28 , Issue.4 , pp. 614-627
    • Jerums, G.1    Panagiotopoulos, S.2    Premaratne, E.3    Power, D.A.4    MacIsaac, R.J.5
  • 76
    • 33749065865 scopus 로고    scopus 로고
    • Progression of renal disease: Renoprotective specificity of renin-angiotensin system blockade
    • Griffin KA, Bidani AK: Progression of renal disease: Renoprotective specificity of renin-angiotensin system blockade. Clin J Am Soc Nephrol (2006) 1(5):1054-1065.
    • (2006) Clin J Am Soc Nephrol , vol.1 , Issue.5 , pp. 1054-1065
    • Griffin, K.A.1    Bidani, A.K.2
  • 77
    • 28844504752 scopus 로고    scopus 로고
    • Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: Systematic review and meta-analysis
    • Casas JP, Chua W, Loukogeorgakis S, Vallance P, Smeeth L, Hingorani AD, MacAllister RJ: Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: Systematic review and meta-analysis. Lancet (2005) 366(9502):2026-2033.
    • (2005) Lancet , vol.366 , Issue.9502 , pp. 2026-2033
    • Casas, J.P.1    Chua, W.2    Loukogeorgakis, S.3    Vallance, P.4    Smeeth, L.5    Hingorani, A.D.6    MacAllister, R.J.7
  • 78
    • 34547692874 scopus 로고    scopus 로고
    • Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms
    • Penning TM, Drury JE: Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Arch Biochem Biophys (2007) 464(2):241-250.
    • (2007) Arch Biochem Biophys , vol.464 , Issue.2 , pp. 241-250
    • Penning, T.M.1    Drury, J.E.2
  • 79
    • 4344658774 scopus 로고    scopus 로고
    • Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    • Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M: Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes (2004) 53(9):2404-2411.
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2404-2411
    • Dagher, Z.1    Park, Y.S.2    Asnaghi, V.3    Hoehn, T.4    Gerhardinger, C.5    Lorenzi, M.6
  • 80
    • 0024546981 scopus 로고
    • Aldose reductase activities in microdissected rat renal tubule segments
    • Sands JM, Terada Y, Bernard LM, Knepper MA: Aldose reductase activities in microdissected rat renal tubule segments. Am J Physiol (1989) 256(4 Pt 2):F563-F569.
    • (1989) Am J Physiol , vol.256 , Issue.4 PART 2
    • Sands, J.M.1    Terada, Y.2    Bernard, L.M.3    Knepper, M.A.4
  • 81
    • 0018760411 scopus 로고
    • Quantitative histochemistry of the sorbitol pathway in glomeruli and small arteries of human diabetic kidney
    • Corder CN, Braughler JM, Culp PA: Quantitative histochemistry of the sorbitol pathway in glomeruli and small arteries of human diabetic kidney. Folia Histochem Cytochem (Krakow) (1979) 17(2):137-145.
    • (1979) Folia Histochem Cytochem (Krakow) , vol.17 , Issue.2 , pp. 137-145
    • Corder, C.N.1    Braughler, J.M.2    Culp, P.A.3
  • 82
    • 0034919876 scopus 로고    scopus 로고
    • Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients
    • Kasajima H, Yamagishi S-I, Sugai S, Yagihashi N, Yagihashi S: Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients. Virchows Arch (2001) 439(1):46-54.
    • (2001) Virchows Arch , vol.439 , Issue.1 , pp. 46-54
    • Kasajima, H.1    Yamagishi, S.-I.2    Sugai, S.3    Yagihashi, N.4    Yagihashi, S.5
  • 83
    • 43149110398 scopus 로고    scopus 로고
    • Intracellular organic osmolytes: Function and regulation
    • Burg MB, Ferraris JD: Intracellular organic osmolytes: Function and regulation. J Biol Chem (2008) 283(12):7309-7313.
    • (2008) J Biol Chem , vol.283 , Issue.12 , pp. 7309-7313
    • Burg, M.B.1    Ferraris, J.D.2
  • 85
    • 33747069158 scopus 로고    scopus 로고
    • Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2- terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage
    • Ho EC, Lam KS, Chen YS, Yip JC, Arvindakshan M, Yamagishi S, Yagihashi S, Oates PJ, Ellery CA, Chung SS, Chung SK: Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2- terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage. Diabetes (2006) 55(7):1946-1953.
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 1946-1953
    • Ho, E.C.1    Lam, K.S.2    Chen, Y.S.3    Yip, J.C.4    Arvindakshan, M.5    Yamagishi, S.6    Yagihashi, S.7    Oates, P.J.8    Ellery, C.A.9    Chung, S.S.10    Chung, S.K.11
  • 86
    • 33644663628 scopus 로고    scopus 로고
    • Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice
    • Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK: Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes (2005) 54(11):3119-3125.
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3119-3125
    • Cheung, A.K.1    Fung, M.K.2    Lo, A.C.3    Lam, T.T.4    So, K.F.5    Chung, S.S.6    Chung, S.K.7
  • 87
    • 0028838996 scopus 로고
    • Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA
    • Yamaoka T, Nishimura C, Yamashita K, Itakura M, Yamada T, Fujimoto J, Kokai Y: Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia (1995) 38(3):255-261.
    • (1995) Diabetologia , vol.38 , Issue.3 , pp. 255-261
    • Yamaoka, T.1    Nishimura, C.2    Yamashita, K.3    Itakura, M.4    Yamada, T.5    Fujimoto, J.6    Kokai, Y.7
  • 88
    • 0026475568 scopus 로고
    • Aldose reductase: Model for a new paradigm of enzymic perfection in detoxification catalysts
    • Grimshaw CE: Aldose reductase: Model for a new paradigm of enzymic perfection in detoxification catalysts. Biochemistry (1992) 31(42):10139-10145.
    • (1992) Biochemistry , vol.31 , Issue.42 , pp. 10139-10145
    • Grimshaw, C.E.1
  • 91
    • 28844505052 scopus 로고    scopus 로고
    • Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications
    • Obrosova IG: Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications. Antioxid Redox Signal (2005) 7(11-12):1543-1552.
    • (2005) Antioxid Redox Signal , vol.7 , Issue.11-12 , pp. 1543-1552
    • Obrosova, I.G.1
  • 92
    • 21544463410 scopus 로고    scopus 로고
    • Aldose reductase in diabetic microvascular complications
    • Chung SS, Chung SK: Aldose reductase in diabetic microvascular complications. Curr Drug Targets (2005) 6(4): 475-486.
    • (2005) Curr Drug Targets , vol.6 , Issue.4 , pp. 475-486
    • Chung, S.S.1    Chung, S.K.2
  • 94
    • 44849131679 scopus 로고    scopus 로고
    • Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis
    • Gleissner CA, Sanders JM, Nadler J, Ley K: Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 28(6):1137-1143.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.6 , pp. 1137-1143
    • Gleissner, C.A.1    Sanders, J.M.2    Nadler, J.3    Ley, K.4
  • 97
    • 77950158331 scopus 로고    scopus 로고
    • Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications
    • Reddy AB, Ramana KV: Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications. Recent Pat Cardiovasc Drug Discov (2010) 5(1): 25-32.
    • (2010) Recent Pat Cardiovasc Drug Discov , vol.5 , Issue.1 , pp. 25-32
    • Reddy, A.B.1    Ramana, K.V.2
  • 98
    • 77956958851 scopus 로고    scopus 로고
    • Aldose reductase is a potent regulator of TGF-β1 induced expression of fibronectin in human mesangial cells
    • doi:10.1007/s11033-009-9887-6
    • Huang P, Zhang Y, Jiang T, Zeng W, Zhang N: Aldose reductase is a potent regulator of TGF-β1 induced expression of fibronectin in human mesangial cells. Mol Biol Rep (2009):doi:10.1007/s11033-009-9887-6.
    • (2009) Mol Biol Rep
    • Huang, P.1    Zhang, Y.2    Jiang, T.3    Zeng, W.4    Zhang, N.5
  • 99
    • 65649103414 scopus 로고    scopus 로고
    • Aldose reductase enzyme and its implication to major health problems of the 21st century
    • Alexiou P, Pegklidou K, Chatzopoulou M, Nicolaou I, Demopoulos VJ: Aldose reductase enzyme and its implication to major health problems of the 21st century. Curr Med Chem (2009) 16(6): 734-752.
    • (2009) Curr Med Chem , vol.16 , Issue.6 , pp. 734-752
    • Alexiou, P.1    Pegklidou, K.2    Chatzopoulou, M.3    Nicolaou, I.4    Demopoulos, V.J.5
  • 100
    • 44949089602 scopus 로고    scopus 로고
    • Aldose reductase inhibitors for the treatment of diabetic polyneuropathy
    • Chalk C, Benstead TJ, Moore F: Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. Cochrane Database Syst Rev (2007) 17(4):CD004572.
    • (2007) Cochrane Database Syst Rev , vol.17 , Issue.4
    • Chalk, C.1    Benstead, T.J.2    Moore, F.3
  • 101
    • 0015929739 scopus 로고
    • The sorbitol pathway and the complications of diabetes
    • Gabbay KH: The sorbitol pathway and the complications of diabetes. N Engl J Med (1973) 288(16):831-836.
    • (1973) N Engl J Med , vol.288 , Issue.16 , pp. 831-836
    • Gabbay, K.H.1
  • 103
    • 0028946316 scopus 로고
    • Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens
    • Lee AY, Chung SK, Chung SS: Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci USA (1995) 92(7):2780-2784.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.7 , pp. 2780-2784
    • Lee, A.Y.1    Chung, S.K.2    Chung, S.S.3
  • 104
    • 0024796973 scopus 로고
    • Aldose reductase inhibition and glomerular abnormalities in diabetic rats
    • Daniels BS, Hostetter TH: Aldose reductase inhibition and glomerular abnormalities in diabetic rats. Diabetes (1989) 38(8):981-986.
    • (1989) Diabetes , vol.38 , Issue.8 , pp. 981-986
    • Daniels, B.S.1    Hostetter, T.H.2
  • 105
    • 0028934305 scopus 로고
    • The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat
    • Soulis-Liparota T, Cooper ME, Dunlop M, Jerums G: The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat. Diabetologia (1995) 38(4):387-394.
    • (1995) Diabetologia , vol.38 , Issue.4 , pp. 387-394
    • Soulis-Liparota, T.1    Cooper, M.E.2    Dunlop, M.3    Jerums, G.4
  • 106
    • 33644834586 scopus 로고    scopus 로고
    • Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes
    • Pacher P, Szabó C: Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. Curr Opin Pharmacol (2006) 6(2):136-141.
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.2 , pp. 136-141
    • Pacher, P.1    Szabó, C.2
  • 107
    • 0001098505 scopus 로고
    • A perspective of aldose reductase inhibitors
    • Maryanoff BE, Maryanoff CA (Eds), JAI Press, Greenwich, CT, USA
    • Eggler JF, Larson ER, Lipinski CA, Mylari BL, Urban FJ: A perspective of aldose reductase inhibitors. In: Advances in Medicinal Chemistry: Volume 2. Maryanoff BE, Maryanoff CA (Eds), JAI Press, Greenwich, CT, USA (1993):197-246.
    • (1993) Advances in Medicinal Chemistry , vol.2 , pp. 197-246
    • Eggler, J.F.1    Larson, E.R.2    Lipinski, C.A.3    Mylari, B.L.4    Urban, F.J.5
  • 108
    • 67650076664 scopus 로고    scopus 로고
    • Ranirestat for the management of diabetic sensorimotor polyneuropathy
    • Bril V, Hirose T, Tomioka S, Buchanan R, Ranirestat Study G: Ranirestat for the management of diabetic sensorimotor polyneuropathy. Diabetes Care (2009) 32(7):1256-1260.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1256-1260
    • Bril, V.1    Hirose, T.2    Tomioka, S.3    Buchanan, R.4    Ranirestat Study, G.5
  • 109
    • 0029103124 scopus 로고
    • Mechanism of human aldehyde reductase: Characterization of the active site pocket
    • Barski OA, Gabbay KH, Grimshaw CE, Bohren KM: Mechanism of human aldehyde reductase: Characterization of the active site pocket. Biochemistry (1995) 34(35):11264-11275.
    • (1995) Biochemistry , vol.34 , Issue.35 , pp. 11264-11275
    • Barski, O.A.1    Gabbay, K.H.2    Grimshaw, C.E.3    Bohren, K.M.4
  • 112
    • 61449183458 scopus 로고    scopus 로고
    • Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis
    • Magee GM, Bilous RW, Cardwell CR, Hunter SJ, Kee F, Fogarty DG: Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis. Diabetologia (2009) 52(4):691-697.
    • (2009) Diabetologia , vol.52 , Issue.4 , pp. 691-697
    • Magee, G.M.1    Bilous, R.W.2    Cardwell, C.R.3    Hunter, S.J.4    Kee, F.5    Fogarty, D.G.6
  • 114
    • 0024457571 scopus 로고
    • Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors
    • Tilton RG, Chang K, Pugliese G, Eades DM, Province MA, Sherman WR, Kilo C, Williamson JR: Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes (1989) 37(10):1258-1270.
    • (1989) Diabetes , vol.37 , Issue.10 , pp. 1258-1270
    • Tilton, R.G.1    Chang, K.2    Pugliese, G.3    Eades, D.M.4    Province, M.A.5    Sherman, W.R.6    Kilo, C.7    Williamson, J.R.8
  • 115
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • Haraldsson B, Nyström J, Deen WM: Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev (2008) 88(2):451-487.
    • (2008) Physiol Rev , vol.88 , Issue.2 , pp. 451-487
    • Haraldsson, B.1    Nyström, J.2    Deen, W.M.3
  • 116
    • 0022643952 scopus 로고
    • Diminished proteinuria in diabetes mellitus by sorbinil, an aldose reductase inhibitor
    • Beyer-Mears A, Cruz E, Edelist T, Varagiannis E: Diminished proteinuria in diabetes mellitus by sorbinil, an aldose reductase inhibitor. Pharmacology (1986) 32(1):52-60.
    • (1986) Pharmacology , vol.32 , Issue.1 , pp. 52-60
    • Beyer-Mears, A.1    Cruz, E.2    Edelist, T.3    Varagiannis, E.4
  • 117
    • 0023799939 scopus 로고
    • Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat
    • McCaleb ML, Sredy J, Millen J, Ackerman DM, Dvornik D: Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat. J Diabetic Complications (1988) 2(1):16-18.
    • (1988) J Diabetic Complications , vol.2 , Issue.1 , pp. 16-18
    • McCaleb, M.L.1    Sredy, J.2    Millen, J.3    Ackerman, D.M.4    Dvornik, D.5
  • 118
    • 0025730517 scopus 로고
    • Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats
    • Goldfarb S, Ziyadeh FN, Kern EF, Simmons DA: Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats. Diabetes (1991) 40(4):465-471.
    • (1991) Diabetes , vol.40 , Issue.4 , pp. 465-471
    • Goldfarb, S.1    Ziyadeh, F.N.2    Kern, E.F.3    Simmons, D.A.4
  • 119
    • 0025760023 scopus 로고
    • Reduction of glomerular hyperfiltration in normoalbuminuric IDDM patients by 6 mo of aldose reductase inhibition
    • Pedersen MM, Christiansen JS, Mogensen CE: Reduction of glomerular hyperfiltration in normoalbuminuric IDDM patients by 6 mo of aldose reductase inhibition. Diabetes (1991) 40(5):527-531.
    • (1991) Diabetes , vol.40 , Issue.5 , pp. 527-531
    • Pedersen, M.M.1    Christiansen, J.S.2    Mogensen, C.E.3
  • 121
    • 0029016824 scopus 로고
    • Reduction of glomerular hyperfiltration during short-term aldose reductase inhibition in normoalbuminuric, insulin-dependent diabetic patients
    • Pedersen MM, Mogensen CE, Christiansen JS: Reduction of glomerular hyperfiltration during short-term aldose reductase inhibition in normoalbuminuric, insulin-dependent diabetic patients. Endocrinol Metab (1995) 2:55-62.
    • (1995) Endocrinol Metab , vol.2 , pp. 55-62
    • Pedersen, M.M.1    Mogensen, C.E.2    Christiansen, J.S.3
  • 122
    • 5644220210 scopus 로고
    • Aldose reductase inhibition reduces urinary albumin excretion rate in incipient diabetic nephropathy
    • Blohmé G, Smith U: Aldose reductase inhibition reduces urinary albumin excretion rate in incipient diabetic nephropathy. Diabetologia (1989) 32:Abs 467A.
    • (1989) Diabetologia , vol.32
    • Blohmé, G.1    Smith, U.2
  • 123
    • 77950100053 scopus 로고    scopus 로고
    • Aldose reductase inhibitor zopolrestat reduces elevated urinary albumin excretion rate in type 1 diabetes mellitus subjects with incipient diabetic nephropathy
    • The Zopolrestat Diabetic Nephropathy Study Group
    • Oates PJ, Klioze SS, Schwartz PF, Boland AD, The Zopolrestat Diabetic Nephropathy Study Group: Aldose reductase inhibitor zopolrestat reduces elevated urinary albumin excretion rate in type 1 diabetes mellitus subjects with incipient diabetic nephropathy. J Am Soc Nephrol (2008) 19:Abs 642A.
    • (2008) J Am Soc Nephrol , vol.19
    • Oates, P.J.1    Klioze, S.S.2    Schwartz, P.F.3    Boland, A.D.4
  • 124
    • 0034869770 scopus 로고    scopus 로고
    • Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in type 2 diabetic patients
    • Iso K, Tada H, Kuboki K, Inokuchi T: Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in type 2 diabetic patients. J Diabetes Complications (2001) 15(5):241-244.
    • (2001) J Diabetes Complications , vol.15 , Issue.5 , pp. 241-244
    • Iso, K.1    Tada, H.2    Kuboki, K.3    Inokuchi, T.4
  • 126
    • 0026550163 scopus 로고
    • Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+
    • Tilton RG, Baier LD, Harlow JE, Smith SR, Ostrow E, Williamson JR: Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+. Kidney Int (1992) 41(4):778-788.
    • (1992) Kidney Int , vol.41 , Issue.4 , pp. 778-788
    • Tilton, R.G.1    Baier, L.D.2    Harlow, J.E.3    Smith, S.R.4    Ostrow, E.5    Williamson, J.R.6
  • 128
    • 0019250369 scopus 로고
    • Immunohistochemical localization of aldose reductase. II. Rat eye and kidney
    • Ludvigson MA, Sorenson RL: Immunohistochemical localization of aldose reductase. II. Rat eye and kidney. Diabetes (1980) 29(6):450-459.
    • (1980) Diabetes , vol.29 , Issue.6 , pp. 450-459
    • Ludvigson, M.A.1    Sorenson, R.L.2
  • 129
    • 38949151661 scopus 로고    scopus 로고
    • Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    • Ziyadeh FN, Wolf G: Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev (2008) 4(1):39-45.
    • (2008) Curr Diabetes Rev , vol.4 , Issue.1 , pp. 39-45
    • Ziyadeh, F.N.1    Wolf, G.2
  • 131
    • 77950160882 scopus 로고    scopus 로고
    • Vascular endothelial growth factor immunoreactivity is reduced in serum and plasma from diabetic rats treated with an aldose reductase inhibitor
    • Oates P, Ellery CA: Vascular endothelial growth factor immunoreactivity is reduced in serum and plasma from diabetic rats treated with an aldose reductase inhibitor. Diabetes (2000) 49(Suppl 1):Abs A377.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Oates, P.1    Ellery, C.A.2
  • 133
    • 0024821312 scopus 로고
    • Effects of sorbinil on glomerular structure and function in long-term-diabetic rats
    • Mauer SM, Steffes MW, Azar S, Brown DM: Effects of sorbinil on glomerular structure and function in long-term-diabetic rats. Diabetes (1989) 38(7):839-846.
    • (1989) Diabetes , vol.38 , Issue.7 , pp. 839-846
    • Mauer, S.M.1    Steffes, M.W.2    Azar, S.3    Brown, D.M.4
  • 135
    • 66149140626 scopus 로고    scopus 로고
    • Transcription factors in the pathogenesis of diabetic nephropathy
    • Sanchez AP, Sharma K: Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev Mol Med (2009) 11:e13.
    • (2009) Expert Rev Mol Med , vol.11
    • Sanchez, A.P.1    Sharma, K.2
  • 136
    • 33745295937 scopus 로고    scopus 로고
    • Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy
    • Yang B, Hodgkinson AD, Oates PJ, Kwon HM, Millward BA, Demaine AG: Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy. Diabetes (2006) 55(5):1450-1455.
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1450-1455
    • Yang, B.1    Hodgkinson, A.D.2    Oates, P.J.3    Kwon, H.M.4    Millward, B.A.5    Demaine, A.G.6
  • 137
    • 42749093061 scopus 로고    scopus 로고
    • High glucose induction of DNA-binding activity of the transcription factor NFκB in patients with diabetic nephropathy
    • Yang B, Hodgkinson A, Oates PJ, Millward BA, Demaine AG: High glucose induction of DNA-binding activity of the transcription factor NFκB in patients with diabetic nephropathy. Biochim Biophys Acta (2008) 1782(5):295-302.
    • (2008) Biochim Biophys Acta , vol.1782 , Issue.5 , pp. 295-302
    • Yang, B.1    Hodgkinson, A.2    Oates, P.J.3    Millward, B.A.4    Demaine, A.G.5
  • 138
    • 0029076281 scopus 로고
    • Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-β as a key mediator
    • Sharma K, Ziyadeh FN: Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-β as a key mediator. Diabetes (1995) 44(10):1139-1146.
    • (1995) Diabetes , vol.44 , Issue.10 , pp. 1139-1146
    • Sharma, K.1    Ziyadeh, F.N.2
  • 140
    • 0031778083 scopus 로고    scopus 로고
    • An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-β and protein kinase C activity in cultured human mesangial cells
    • Ishii H, Tada H, Isogai S: An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-β and protein kinase C activity in cultured human mesangial cells. Diabetologia (1998) 41(4):362-364.
    • (1998) Diabetologia , vol.41 , Issue.4 , pp. 362-364
    • Ishii, H.1    Tada, H.2    Isogai, S.3
  • 141
    • 8344266747 scopus 로고    scopus 로고
    • Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression
    • Dan Q, Wong RLC, Yin S, Chung SK, Chung SSM, Lam KSL: Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression. Nephron (2004) 98(3):e89-e99.
    • (2004) Nephron , vol.98 , Issue.3
    • Dan, Q.1    Wong, R.L.C.2    Yin, S.3    Chung, S.K.4    Chung, S.S.M.5    Lam, K.S.L.6
  • 142
    • 0033803537 scopus 로고    scopus 로고
    • Epalrestat, an aldose reductase ihibitor, reduces the levels of Nε-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients
    • Hamada Y, Nakamura J, Naruse K, Komori T, Kato K, Kasuya Y, Nagai R, Horiuchi S, Hotta N: Epalrestat, an aldose reductase ihibitor, reduces the levels of Nε-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients. Diabetes Care (2000) 23(10):1539-1544.
    • (2000) Diabetes Care , vol.23 , Issue.10 , pp. 1539-1544
    • Hamada, Y.1    Nakamura, J.2    Naruse, K.3    Komori, T.4    Kato, K.5    Kasuya, Y.6    Nagai, R.7    Horiuchi, S.8    Hotta, N.9
  • 143
    • 9144228074 scopus 로고    scopus 로고
    • Nε-(carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone
    • Jono T, Nagai R, Lin X, Ahmed N, Thornalley PJ, Takeya M, Horiuchi S: Nε-(carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone. J Biochem (2004) 136(3):351-358.
    • (2004) J Biochem , vol.136 , Issue.3 , pp. 351-358
    • Jono, T.1    Nagai, R.2    Lin, X.3    Ahmed, N.4    Thornalley, P.J.5    Takeya, M.6    Horiuchi, S.7
  • 144
    • 0035122180 scopus 로고    scopus 로고
    • 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone
    • Niwa T, Tsukushi S: 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int Suppl (2001) 78:S37-S41.
    • (2001) Kidney Int Suppl , vol.78
    • Niwa, T.1    Tsukushi, S.2
  • 145
    • 0032973663 scopus 로고    scopus 로고
    • Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy
    • Miyata T, Sugiyama S, Suzuki D, Inagi R, Kurokawa K: Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy. Kidney Int Suppl (1999) 71:S54-S56.
    • (1999) Kidney Int Suppl , vol.71
    • Miyata, T.1    Sugiyama, S.2    Suzuki, D.3    Inagi, R.4    Kurokawa, K.5
  • 147
    • 0041809017 scopus 로고    scopus 로고
    • Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications
    • Demaine AG: Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications. Curr Med Chem (2003) 10(15):1389-1398.
    • (2003) Curr Med Chem , vol.10 , Issue.15 , pp. 1389-1398
    • Demaine, A.G.1
  • 148
    • 45549098620 scopus 로고    scopus 로고
    • Association between (AC)n dinucleotide repeat polymorphism at the 5'- end of the aldose reductase gene and diabetic nephropathy: A meta-analysis
    • Xu M, Chen X, Yan L, Cheng H, Chen W: Association between (AC)n dinucleotide repeat polymorphism at the 5'- end of the aldose reductase gene and diabetic nephropathy: A meta-analysis. J Mol Endocrinol (2008) 40(5):243-251.
    • (2008) J Mol Endocrinol , vol.40 , Issue.5 , pp. 243-251
    • Xu, M.1    Chen, X.2    Yan, L.3    Cheng, H.4    Chen, W.5
  • 149
    • 0036266819 scopus 로고    scopus 로고
    • Genetic studies of late diabetic complications: The overlooked importance of diabetes duration before complication onset
    • Rogus JJ, Warram JH, Krolewski AS: Genetic studies of late diabetic complications: The overlooked importance of diabetes duration before complication onset. Diabetes (2002) 51(6):1655-1662.
    • (2002) Diabetes , vol.51 , Issue.6 , pp. 1655-1662
    • Rogus, J.J.1    Warram, J.H.2    Krolewski, A.S.3
  • 152
    • 0032693720 scopus 로고    scopus 로고
    • Aldose reductase inhibitors: Therapeutic implications for diabetic complications
    • Oates PJ, Mylari BL: Aldose reductase inhibitors: Therapeutic implications for diabetic complications. Expert Opin Investig Drugs (1999) 8(12):2095-2119.
    • (1999) Expert Opin Investig Drugs , vol.8 , Issue.12 , pp. 2095-2119
    • Oates, P.J.1    Mylari, B.L.2
  • 153
    • 7044249529 scopus 로고    scopus 로고
    • Association of glomerulopathy with the 5'-end polymorphism of the aldose reductase gene and renal insufficiency in type 2 diabetic patients
    • Zhao HL, Tong PC, Lai FM, Tomlinson B, Chan JC: Association of glomerulopathy with the 5'-end polymorphism of the aldose reductase gene and renal insufficiency in type 2 diabetic patients. Diabetes (2004) 53(11):2984-2991.
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2984-2991
    • Zhao, H.L.1    Tong, P.C.2    Lai, F.M.3    Tomlinson, B.4    Chan, J.C.5
  • 154
    • 59249086682 scopus 로고    scopus 로고
    • Aldose reductase genotypes and cardiorenal complications: An 8-year prospective analysis of 1,074 type 2 diabetic patients
    • So WY, Wang Y, Ng MC, Yang X, Ma RC, Lam V, Kong AP, Tong PC, Chan JC: Aldose reductase genotypes and cardiorenal complications: An 8-year prospective analysis of 1,074 type 2 diabetic patients. Diabetes Care (2008) 31(11):2148-2153.
    • (2008) Diabetes Care , vol.31 , Issue.11 , pp. 2148-2153
    • So, W.Y.1    Wang, Y.2    Ng, M.C.3    Yang, X.4    Ma, R.C.5    Lam, V.6    Kong, A.P.7    Tong, P.C.8    Chan, J.C.9
  • 155
    • 0037339778 scopus 로고    scopus 로고
    • The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy
    • Hodgkinson AD, Bartlett T, Oates PJ, Millward BA, Demaine AG: The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Diabetes (2003) 52(3):846-851.
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 846-851
    • Hodgkinson, A.D.1    Bartlett, T.2    Oates, P.J.3    Millward, B.A.4    Demaine, A.G.5
  • 156
    • 0033651497 scopus 로고    scopus 로고
    • Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy
    • Ceriello A, Morocutti A, Mercuri F, Quagliaro L, Moro M, Damante G, Viberti GC: Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy. Diabetes (2000) 49(12):2170-2177.
    • (2000) Diabetes , vol.49 , Issue.12 , pp. 2170-2177
    • Ceriello, A.1    Morocutti, A.2    Mercuri, F.3    Quagliaro, L.4    Moro, M.5    Damante, G.6    Viberti, G.C.7
  • 157
    • 0344837811 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocindiabetic rats
    • Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ: Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocindiabetic rats. Diabetes (2003) 52(3):864-871.
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 864-871
    • Obrosova, I.G.1    Minchenko, A.G.2    Vasupuram, R.3    White, L.4    Abatan, O.I.5    Kumagai, A.K.6    Frank, R.N.7    Stevens, M.J.8
  • 159
    • 0034038502 scopus 로고    scopus 로고
    • Effects of dl-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
    • Stevens MJ, Obrosova IG, Cao X, Van Huysen C, Greene DA: Effects of dl-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes (2000) 49(6):1006-1015.
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 1006-1015
    • Stevens, M.J.1    Obrosova, I.G.2    Cao, X.3    Van Huysen, C.4    Greene, D.A.5
  • 161
    • 0035091486 scopus 로고    scopus 로고
    • Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy
    • Hodgkinson AD, Millward BA, Demaine AG: Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy. Kidney Int (2001) 59(3):985-989.
    • (2001) Kidney Int , vol.59 , Issue.3 , pp. 985-989
    • Hodgkinson, A.D.1    Millward, B.A.2    Demaine, A.G.3
  • 162
    • 38449106779 scopus 로고    scopus 로고
    • Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study
    • Al-Kateb H, Boright AP, Mirea L, Xie X, Sutradhar R, Mowjoodi A, Bharaj B, Liu M, Bucksa JM, Arends VL, Steffes MW et al: Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study. Diabetes (2008) 57(1): 218-228.
    • (2008) Diabetes , vol.57 , Issue.1 , pp. 218-228
    • Al-Kateb, H.1    Boright, A.P.2    Mirea, L.3    Xie, X.4    Sutradhar, R.5    Mowjoodi, A.6    Bharaj, B.7    Liu, M.8    Bucksa, J.M.9    Arends, V.L.10    Steffes, M.W.11
  • 164
    • 70350536554 scopus 로고    scopus 로고
    • Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy
    • MG, Katavetin P, Kure M, Poznik GD, Skupien J, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS: Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes (2009) 58(11):2698-2702.
    • (2009) Diabetes , vol.58 , Issue.11 , pp. 2698-2702
    • Mg Katavetin, P.1    Kure, M.2    Poznik, G.D.3    Skupien, J.4    Mychaleckyj, J.C.5    Rich, S.S.6    Warram, J.H.7    Krolewski, A.S.8
  • 165
    • 70949106507 scopus 로고    scopus 로고
    • The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes
    • Möllsten A, Jorsal A, Lajer M, Vionnet N, Tarnow L: The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes. Diabetologia (2009) 52(12):2590-2593.
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2590-2593
    • Möllsten, A.1    Jorsal, A.2    Lajer, M.3    Vionnet, N.4    Tarnow, L.5
  • 167
    • 33845543860 scopus 로고    scopus 로고
    • Reduction of elevated urinary albumin excretion in diabetic rats by polyol pathway inhibitors correlates with changes in urinary sorbitol excretion
    • Oates P, Ellery C, Beebe D, Coutcher J, Qian Y-Z, Lowe V, O'Neill S: Reduction of elevated urinary albumin excretion in diabetic rats by polyol pathway inhibitors correlates with changes in urinary sorbitol excretion. Diabetes (2005) 54(Suppl 1):Abs 195.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 1 , pp. 195
    • Oates, P.1    Ellery, C.2    Beebe, D.3    Coutcher, J.4    Qian, Y.-Z.5    Lowe, V.6    O'Neill, S.7
  • 168
    • 0032499911 scopus 로고    scopus 로고
    • Reversal of lesions of diabetic nephropathy after pancreas transplantation
    • Fioretto P, Steffes MW, Sutherland DE, Goetz FC, Mauer M: Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med (1998) 339(2):69-75.
    • (1998) N Engl J Med , vol.339 , Issue.2 , pp. 69-75
    • Fioretto, P.1    Steffes, M.W.2    Sutherland, D.E.3    Goetz, F.C.4    Mauer, M.5


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