Characterization of the glutathione binding site of aldose reductase

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 537-548

  Ramana, Kota V ^a   Dixit, Bharat L ^a   Srivastava, Sanjay ^b   Bhatnagar, Aruni ^b   Balendiran, Ganesaratnam K ^c   Watowich, Stanley J ^a   Petrash, J Mark ^d   Srivastava, Satish K ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Louisville School of Medicine   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aldehydes; Aldose reductase; Glutathione; Regulation

Indexed keywords

ACROLEIN; ALDEHYDE REDUCTASE; GLUTATHIONE; GLYCINE; HEXOBARBITAL; LEUCINE; LYSINE; SERINE; TRYPTOPHAN; VALINE;

AMINO ACID SUBSTITUTION; BINDING SITE; CATALYSIS; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; GENE DELETION; MOLECULAR MODEL; MOLECULAR RECOGNITION; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ALDEHYDES; ANIMALS; CATALYTIC DOMAIN; GLUTATHIONE; HUMANS; HYPERGLYCEMIA; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0035969888     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00297-0     Document Type: Conference Paper

References (34)

1. Aldose reductase: Congenial and injurious profiles of an enigmatic enzyme
2. Aldose reductase in glucose toxicity: A potential target for the prevention of diabetic complications
3. The pharmacology of aldose reductase inhibitors
4. Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens
5. Management of diabetic neuropathy
6. Aldose reductase inhibitors: Recent developments
7. Structural and kinetic determinants of aldehyde reduction by aldose reductase
8. Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart
9. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase
10. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications
11. Aldose and aldehyde reductase exhibit isocorticosteroid reductase activity
12. The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain
13. Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
14. Substrate specificity of human aldose reductase: Identification of 4-hydroxynonenal as an endogenous substrate
15. A synthesis of 4-hydroxy-2-trans-nonenal and 4-(3H) 4-hydroxy-2-trans-nonenal
16. Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers
17. High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors
18. An anion binding site in human aldose reductase: Mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate
19. Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat
20. Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303
21. Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase
22. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation
23. Acrolein. IV. Evidence for the formation of the cytotoxic aldehyde acrolein from enzymatically oxidized spermine or spermidine
24. Crystal structure of human glyoxalase I - Evidence for gene duplication and 3D domain swapping
25. A putative glutathione-binding site in T4 glutaredoxin investigated by site-directed mutagenesis
26. A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution
27. Location of a potential transport binding site in a sigma class glutathione transferase by X-ray crystallography
28. Nephrotoxicity of the 1:1 acrolein-glutathione adduct in the rat
29. Fate and effects of acrolein
30. Conversion of 3-nitro-1-propanol (miserotoxin aglycone) to cytotoxic acrolein by alcohol dehydrogenase
31. trans-4-hydroxy-2-hexenal: A reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine
32. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
33. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
34. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease