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Volumn 51, Issue 10, 2010, Pages 5105-5113

Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; ENDOTOXIN; GELATINASE A; GUGGULSTERONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROSTAGLANDIN E2; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CYTOKINE; LIPOPOLYSACCHARIDE; NOS2 PROTEIN, RAT; PREGNA 4,17 DIENE 3,16 DIONE; PREGNA-4,17-DIENE-3,16-DIONE; PREGNANE DERIVATIVE;

EID: 77958131749     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4873     Document Type: Article
Times cited : (37)

References (41)
  • 1
    • 67949088381 scopus 로고    scopus 로고
    • Epidemiology and course of disease in childhood uveitis
    • Smith JA, Mackensen F, Sen HN, et al. Epidemiology and course of disease in childhood uveitis. Ophthalmology. 2009;116:1544-1551.
    • (2009) Ophthalmology , vol.116 , pp. 1544-1551
    • Smith, J.A.1    Mackensen, F.2    Sen, H.N.3
  • 2
    • 33750321159 scopus 로고    scopus 로고
    • Uveitis: Advances in understanding of pathogenesis
    • Read RW. Uveitis: advances in understanding of pathogenesis. Curr Rheumatol Rep. 2006;8:260-266.
    • (2006) Curr Rheumatol Rep , vol.8 , pp. 260-266
    • Read, R.W.1
  • 3
    • 0025147232 scopus 로고
    • The natural history of uveitis
    • Nussenblatt RB. The natural history of uveitis. Int Ophthalmol. 1990;14:303-308.
    • (1990) Int Ophthalmol , vol.14 , pp. 303-308
    • Nussenblatt, R.B.1
  • 4
    • 57449099894 scopus 로고    scopus 로고
    • Distinct cytokine patterns in the aqueous humor of children, adolescents and adults with uveitis
    • Sijssens KM, Rijkers GT, Rothova A, Stilma JS, de Boer JH. Distinct cytokine patterns in the aqueous humor of children, adolescents and adults with uveitis. Ocul Immunol Inflamm. 2008;16:211-216.
    • (2008) Ocul Immunol Inflamm , vol.16 , pp. 211-216
    • Sijssens, K.M.1    Rijkers, G.T.2    Rothova, A.3    Stilma, J.S.4    de Boer, J.H.5
  • 5
    • 50449087570 scopus 로고    scopus 로고
    • Regulation of autoimmune inflammation by pro-inflammatory cytokines
    • Kim EY, Moudgil KD. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol Lett. 2008;30:120:1-5.
    • (2008) Immunol Lett , vol.30 , Issue.120 , pp. 1-5
    • Kim, E.Y.1    Moudgil, K.D.2
  • 6
    • 33750487482 scopus 로고    scopus 로고
    • Inflammatory mediators of uveitis: Cytokines and chemokines
    • Curnow SJ, Murray PI. Inflammatory mediators of uveitis: cytokines and chemokines. Curr Opin Ophthalmol. 2006;17:532-537.
    • (2006) Curr Opin Ophthalmol , vol.17 , pp. 532-537
    • Curnow, S.J.1    Murray, P.I.2
  • 7
    • 35748969896 scopus 로고    scopus 로고
    • Aldose reductase inhibition prevents endotoxin-induced uveitis in rats
    • Yadav UC, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2007;48:4634-4642.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 4634-4642
    • Yadav, U.C.1    Srivastava, S.K.2    Ramana, K.V.3
  • 8
    • 65549085743 scopus 로고    scopus 로고
    • Prevention of endotoxininduced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1
    • Yadav UC, Subramanyam S, Ramana KV. Prevention of endotoxininduced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci. 2009;50:2276-2282.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2276-2282
    • Yadav, U.C.1    Subramanyam, S.2    Ramana, K.V.3
  • 9
    • 57549118957 scopus 로고    scopus 로고
    • Focus on molecules: Nuclear factorkappaB
    • Srivastava SK, Ramana KV. Focus on molecules: nuclear factorkappaB. Exp Eye Res. 2009;88:2-3.
    • (2009) Exp Eye Res , vol.88 , pp. 2-3
    • Srivastava, S.K.1    Ramana, K.V.2
  • 13
    • 0037205046 scopus 로고    scopus 로고
    • A natural product that lowers cholesterol as an antagonist ligand for FXR
    • Urizar NL, Liverman AB, Dodds DT, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002; 296:1703-1706.
    • (2002) Science , vol.296 , pp. 1703-1706
    • Urizar, N.L.1    Liverman, A.B.2    Dodds, D.T.3
  • 14
    • 85047685018 scopus 로고    scopus 로고
    • The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor
    • Wu J, Xia C, Meier J, Li S, Hu X, Lala DS. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol. 2002;16:1590-1597.
    • (2002) Mol Endocrinol , vol.16 , pp. 1590-1597
    • Wu, J.1    Xia, C.2    Meier, J.3    Li, S.4    Hu, X.5    Lala, D.S.6
  • 15
    • 0003295132 scopus 로고    scopus 로고
    • Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump
    • Cui J, Huang L, Zhao A, et al. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem. 2003;278:10214-10220.
    • (2003) J Biol Chem , vol.278 , pp. 10214-10220
    • Cui, J.1    Huang, L.2    Zhao, A.3
  • 16
    • 8744234076 scopus 로고    scopus 로고
    • Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of antiapoptotic gene products, and enhances apoptosis
    • Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of antiapoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148-47158.
    • (2004) J Biol Chem , vol.279 , pp. 47148-47158
    • Shishodia, S.1    Aggarwal, B.B.2
  • 17
    • 0038457330 scopus 로고    scopus 로고
    • Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents
    • Meselhy MR. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry. 2003;62:213-218.
    • (2003) Phytochemistry , vol.62 , pp. 213-218
    • Meselhy, M.R.1
  • 18
    • 67649946223 scopus 로고    scopus 로고
    • Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    • Kubota S, Kurihara T, Mochimaru H, et al. Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation. Invest Ophthalmol Vis Sci. 2009;50:3512-3519.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 3512-3519
    • Kubota, S.1    Kurihara, T.2    Mochimaru, H.3
  • 19
    • 33745671359 scopus 로고    scopus 로고
    • Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats
    • Jin XH, Ohgami K, Shiratori K, et al. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2006;47:2562-2568.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 2562-2568
    • Jin, X.H.1    Ohgami, K.2    Shiratori, K.3
  • 20
    • 0033062493 scopus 로고    scopus 로고
    • Efficacy of curcumin in the management of chronic anterior uveitis
    • Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res. 1999;13: 318-322.
    • (1999) Phytother Res , vol.13 , pp. 318-322
    • Lal, B.1    Kapoor, A.K.2    Asthana, O.P.3
  • 21
    • 31044445848 scopus 로고    scopus 로고
    • Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway
    • Suzuki Y, Ohgami K, Shiratori K, et al. Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway. Exp Eye Res. 2006;82:275-281.
    • (2006) Exp Eye Res , vol.82 , pp. 275-281
    • Suzuki, Y.1    Ohgami, K.2    Shiratori, K.3
  • 22
    • 67349286984 scopus 로고    scopus 로고
    • Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts
    • An MJ, Cheon JH, Kim SW, Kim ES, Kim TI, Kim WH. Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. Cancer Lett. 2009; 279:93-100.
    • (2009) Cancer Lett , vol.279 , pp. 93-100
    • An, M.J.1    Cheon, J.H.2    Kim, S.W.3    Kim, E.S.4    Kim, T.I.5    Kim, W.H.6
  • 23
    • 0042130513 scopus 로고    scopus 로고
    • GUGULIPID: A natural cholesterol-lowering agent
    • Urizar NL, Moore DD. GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr. 2003;23:303-313.
    • (2003) Annu Rev Nutr , vol.23 , pp. 303-313
    • Urizar, N.L.1    Moore, D.D.2
  • 24
    • 49249128130 scopus 로고    scopus 로고
    • Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through activation of a protein tyrosine phosphatase SHP-1
    • Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Aggarwal BB. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through activation of a protein tyrosine phosphatase SHP-1. Cancer Res. 2008;68: 4406-4415.
    • (2008) Cancer Res , vol.68 , pp. 4406-4415
    • Ahn, K.S.1    Sethi, G.2    Sung, B.3    Goel, A.4    Ralhan, R.5    Aggarwal, B.B.6
  • 25
    • 38349143690 scopus 로고    scopus 로고
    • z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo
    • Xiao D, Singh SV. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008;7:171-180.
    • (2008) Mol Cancer Ther , vol.7 , pp. 171-180
    • Xiao, D.1    Singh, S.V.2
  • 26
    • 30144438848 scopus 로고    scopus 로고
    • Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down-regulation of TNF-alpha, IL-1beta and IL-2
    • Manjula N, Gayathri B, Vinaykumar KS, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A. Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down-regulation of TNF-alpha, IL-1beta and IL-2. Int Immunopharmacol. 2006;6:122-132.
    • (2006) Int Immunopharmacol , vol.6 , pp. 122-132
    • Manjula, N.1    Gayathri, B.2    Vinaykumar, K.S.3    Shankernarayanan, N.P.4    Vishwakarma, R.A.5    Balakrishnan, A.6
  • 27
    • 45049087913 scopus 로고    scopus 로고
    • Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity
    • Lv N, Song MY, Kim EK, Park JW, Kwon KB, Park BH. Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity. Mol Cell Endocrinol. 2008;289:49-59.
    • (2008) Mol Cell Endocrinol , vol.289 , pp. 49-59
    • Lv, N.1    Song, M.Y.2    Kim, E.K.3    Park, J.W.4    Kwon, K.B.5    Park, B.H.6
  • 28
    • 23344438688 scopus 로고    scopus 로고
    • Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behçet's disease: A pilot study
    • Duygulu F, Evereklioglu C, Calis M, Borlu M, Cekmen M, Ascioglu O. Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behçet's disease: a pilot study. Clin Rheumatol. 2005;24:324-330.
    • (2005) Clin Rheumatol , vol.24 , pp. 324-330
    • Duygulu, F.1    Evereklioglu, C.2    Calis, M.3    Borlu, M.4    Cekmen, M.5    Ascioglu, O.6
  • 29
    • 0028046452 scopus 로고
    • The role of nitric oxide synthase in endotoxin-induced uveitis: Effects of NG-nitro L-arginine
    • Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest Ophthalmol Vis Sci. 1994;35:3673-3680.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 3673-3680
    • Mandai, M.1    Yoshimura, N.2    Yoshida, M.3    Iwaki, M.4    Honda, Y.5
  • 31
    • 0035741959 scopus 로고    scopus 로고
    • Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis
    • Santos Lacomba M, Marcos Martin C, Gallardo Galera JM, et al. Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. 2001;33:251-255.
    • (2001) Ophthalmic Res , vol.33 , pp. 251-255
    • Santos Lacomba, M.1    Marcos Martin, C.2    Gallardo Galera, J.M.3
  • 32
    • 0026671219 scopus 로고
    • Cytokines in human intraocular inflammation
    • Franks WA, Limb GA, Stanford MR, et al. Cytokines in human intraocular inflammation. Curr Eye Res. 1992;11:187-191.
    • (1992) Curr Eye Res , vol.11 , pp. 187-191
    • Franks, W.A.1    Limb, G.A.2    Stanford, M.R.3
  • 33
    • 23644447065 scopus 로고    scopus 로고
    • Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behçet's disease: An open-label trial
    • Tugal-Tutkun I, Mudun A, Urgancioglu M, et al. Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behçet's disease: an open-label trial. Arthritis Rheum. 2005;52: 2478-2484.
    • (2005) Arthritis Rheum , vol.52 , pp. 2478-2484
    • Tugal-Tutkun, I.1    Mudun, A.2    Urgancioglu, M.3
  • 35
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NFkappa B activation
    • Surh YJ, Chun KS, Cha HH, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NFkappa B activation. Mutat Res. 2001;480-481:243-268.
    • (2001) Mutat Res , vol.480-481 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3
  • 36
    • 0038823737 scopus 로고    scopus 로고
    • Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors
    • Alexander G, Carlsen H, Blomhoff R. Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors. Invest Ophthalmol Vis Sci. 2003;44:2683-2688.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2683-2688
    • Alexander, G.1    Carlsen, H.2    Blomhoff, R.3
  • 37
    • 0035451621 scopus 로고    scopus 로고
    • 2-mediated oxidative stress activates NF-kappa B in lens epithelial cells
    • 2-mediated oxidative stress activates NF-kappa B in lens epithelial cells. Free Radic Biol Med. 2001;31:651-658.
    • (2001) Free Radic Biol Med , vol.31 , pp. 651-658
    • Dudek, E.J.1    Shang, F.2    Taylor, A.3
  • 38
    • 31544446372 scopus 로고    scopus 로고
    • Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation
    • Ichikawa H, Aggarwal BB. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006;12:662-668.
    • (2006) Clin Cancer Res , vol.12 , pp. 662-668
    • Ichikawa, H.1    Aggarwal, B.B.2
  • 39
    • 33751577977 scopus 로고    scopus 로고
    • Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis
    • Cheon JH, Kim JS, Kim JM, Kim N, Jung HC, Song IS. Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis. 2006;12:1152-1161.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1152-1161
    • Cheon, J.H.1    Kim, J.S.2    Kim, J.M.3    Kim, N.4    Jung, H.C.5    Song, I.S.6
  • 40
    • 43949085015 scopus 로고    scopus 로고
    • Guggulsterone blocks IL-1betamediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes
    • Lee YR, Lee JH, Noh EM, et al. Guggulsterone blocks IL-1betamediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci. 2008;82: 1203-1209.
    • (2008) Life Sci , vol.82 , pp. 1203-1209
    • Lee, Y.R.1    Lee, J.H.2    Noh, E.M.3
  • 41
    • 53349108487 scopus 로고    scopus 로고
    • Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice
    • Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H. Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice. Carcinogenesis. 2008;29:2011-2018.
    • (2008) Carcinogenesis , vol.29 , pp. 2011-2018
    • Sarfaraz, S.1    Siddiqui, I.A.2    Syed, D.N.3    Afaq, F.4    Mukhtar, H.5


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