An aldose reductase intragenic polymorphism associated with diabetic retinopathy

Diabetes Research and Clinical Practice

Volumn 46, Issue 2, 1999, Pages 155-160

  Kao, Yan Lin ^a,b   Donaghue, Kim ^a,c   Chan, Albert ^a   Knight, John ^b   Silink, Martin ^a,c  

^a Ray Williams Inst Paediatr E   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Aldose reductase; Gene; Insulin dependent diabetes mellitus; Polymorphism; Retinopathy

Indexed keywords

ALDEHYDE REDUCTASE;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DNA POLYMORPHISM; DNA SEQUENCE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; SCHOOL CHILD; SEQUENCE ANALYSIS;

ADOLESCENT; ALDEHYDE REDUCTASE; ALLELES; CHILD; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; DINUCLEOTIDE REPEATS; FEMALE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0032711922     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(99)00087-X     Document Type: Article

References (18)

1. Bagnasco S.M., Uchida S., Balaban R.S. Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl. Proc. Natl. Acad. Sci. USA. 84:1987;1718-1720.
2. Bagnasco S.M., Murphy H.R., Bedford J.J. Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux. Am. J. Physiol. 254:1988;C788-C792.
3. Hohman T.C., Nishimura C., Robinson Jr W.G. Aldose reductase and polyol in cultured pericytes of human retinal capillaries. Exp. Eye Res. 48:1989;55-60.
4. Hamada Y., Kitoh R., Paskin P. Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients. Diabetes. 40:1991;1233-1240.
5. Lee A.Y.W., Chung S.K., Chung S.S.M. Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc. Natl. Acad. Sci. USA. 92:1995;2780-2784.
6. Kinoshita J.H., Fukushi S., Kador P., Merola L.O. Aldose reductase in diabetic complications of the eye. Metabolism. 28:1979;462.
7. Dvornik D., Simard-Duquensne N., Krami M. et al. Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. Science. 195:1973;205-206.
8. Robinson Jr W.G., Kador P.F., Kinoshita J.H. Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science. 221:1983;1177.
9. n dinucleotide repeat polymorphic marker at 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in Type 1 diabetes. Diabetes. 44:1995;727-732.
10. Heesom A.E., Hibberd M.L., Millward A., Demaine A.G. Polymorphism in the 5′ end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in Type 1 diabetes. Diabetes. 46:1997;287-291.
11. Patel A., Ratanachaiyavong S., Millward B.A., Demaine A.G. Polymorphism of the aldose reductase locus (ALR2) and susceptibility to diabetic microvascular complications. Enzymol. Mol. Biol. Carbonyl Metab. 4:1993;325-332.
12. Kicic E., Warren-Perry M., Cull V.S., Wise P.H., Chung S., Palmer T.N. Restriction fragment length polymorphisms of human aldose reductase gene: a preliminary report. Diabetes Res. Clin. Pract. 20:1993;165-168.
13. Patel A., Hibberd M.L., Millward B.A., Demaine A.G. Chromosome 7q35 and susceptibility to diabetic microvascular complications. J. Diabetes Complicat. 10:1996;62-67.
14. Graham A., Brown L., Hedge P.J., Gammack A.J., Markham A.F. Structure of the human aldose reductase gene. J. Biol. Chem. 266(11):1991;6872-6877.
15. Vallabh O.S., Marina S., Jovanka N., Yijuan S. Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy. J. Clin. Endocrinol. Metab. 83:1998;2886-2891.
16. Brown L., Hedge P.J., Markham A.F., Graham A. A human aldehyde dehydrogenase (aldose reductase) pseudogene: nucleotide sequence analysis and assignment to chromosome 3. Genomics. 14(2):1992;465-468.
17. Bateman J.B., Kojis T., Heinzmann C. Mapping of aldose reductase gene sequences to human chromosomes 1, 3, 7, 9, 11 and 13. Genomics. 17(3):1993;560-565.
18. Hibberd M.L., Millward B.A., Wong F.S. T-cell receptor constant beta-chain polymorphisms and susceptibility to Type 1 diabetes. Diabetic. Med. 9:1992;929-933.