Structure of a glutathione conjugate bound to the active site of aldose reductase

Proteins: Structure, Function and Genetics

Volumn 64, Issue 1, 2006, Pages 101-110

  Singh, Ranvir ^a   White, Mark A ^a   Ramana, Kota V ^a   Petrash, J Mark ^b   Watowich, Stanley J ^a   Bhatnagar, Aruni ^c   Srivastava, Satish K ^a,d  

^a University of Texas Medical Branch School of Medicine   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c University of Louisville School of Medicine   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Active site; Aldo keto reductase; Competitive inhibitor; Crystal structure; Diabetic complications; Glutathiolation

Indexed keywords

ALDEHYDE; ALDEHYDE REDUCTASE; GLUTATHIONE; GLYCINE; HISTIDINE; HOLOENZYME; KETONE; LEUCINE; LIPOPROTEIN; PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SERINE; TYROSINE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME ACTIVE SITE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; HYPERGLYCEMIA; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE; HUMANS; MODELS, MOLECULAR; NADP; PROTEIN CONFORMATION;

EID: 33744811939     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.20988     Document Type: Article

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