Apoptosis signalling by 4-hydroxynonenal: A role for JNK-c-Jun/AP-1 pathway

Redox Report

Volumn 12, Issue 1-2, 2007, Pages 30-34

  Kutuk, Ozgur ^a   Basaga, Huveyda ^a  

^a SABANCI UNIVERSITY   (Turkey)

Author keywords

3T3 fibroblasts; 4 hydroxynonenal; Apoptosis; c Jun AP 1; JNK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 HYDROXYNONENAL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CYTOCHROME C; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN C JUN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; RESVERATROL; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; CELL CYCLE REGULATION; CELL DEATH; CELL PROTECTION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONFERENCE PAPER; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; FIBROBLAST CULTURE; HUMAN; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

3T3 CELLS; ALDEHYDES; ANIMALS; APOPTOSIS; CASPASES; CELL CYCLE; MAP KINASE KINASE 4; MICE; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 33846822132     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100007X162329     Document Type: Conference Paper

References (34)

1. Grune T, Siems WG, Zollner H, Esterbauer H. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Cancer Res 1994; 54: 5231-5235.
2. Siems W, Zollner H, Grune T, Esterbauer H. Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product. J Lipid Res 1997; 38: 612-622.
3. Siems WG, Hapner SJ, van Kuijk FJ. 4-Hydroxynonenal inhibits Na(+)-K(+)-ATPase. Free Radic Biol Med 1996; 20: 215-223.
4. Parola M, Robino G, Marra F et al. HNE interacts directly with JNK isoforms in human hepatic stellate cells. J Clin Invest 1998; 102: 1942-1950.
5. Schwarzer E, Muller O, Arese P, Siems WG, Grune T. Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity. FEBS Lett 1996; 388: 119-122.
6. Grune T, Davies KJ. The proteasomal system and HNE-modified proteins. Mol Aspects Med 2003; 24: 195-204.
7. Kutuk O, Basaga H. Bcl-2 protein family: implications in vascular apoptosis and atherosclerosis. Apoptosis 2006; 11: 1661-1675.
8. Zhang W, He Q, Chan LL et al. Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free Radic Biol Med 2001; 30: 699-706.
9. Liu W, Kato M, Akhand AA et al. 4-Hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J Cell Sci 2000; 113: 635-641.
10. Leonarduzzi G, Arkan MC, Basaga H, Chiarpotto E, Sevanian A, Poli G. Lipid oxidation products in cell signaling. Free Radic Biol Med 2000; 28: 1370-1378.
11. Leonarduzzi G, Robbesyn F, Poli G. Signaling kinases modulated by 4-hydroxynonenal. Free Radic Biol Med 2004; 37: 1694-1702.
12. Newton AC. The ins and outs of protein kinase C. Methods Mol Biol 2003; 233: 3-7.
13. Dianzani MU. 4-Hydroxynonenal and cell signalling. Free Radic Res 1998; 28: 553-560.
14. Paola D, Domenicotti C, Nitti M et al. Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells. Biochem Biophys Res Commun 2000; 268: 642-646.
15. Nitti M, Domenicotti C, d'Abramo C et al. Activation of PKC-beta isoforms mediates HNE-induced MCP-1 release by macrophages. Biochem Biophys Res Commun 2002; 294: 547-552.
16. Chiarpotto E, Domenicotti C, Paola D et al. Regulation of rat hepatocyte protein kinase C beta isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: a signaling pathway to modulate vesicular transport of glycoproteins. Hepatology 1999; 29: 1565-1572.
17. Castello L, Marengo B, Nitti M et al. 4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: the role of PKC-delta. Biochim Biophys Acta 2005; 1737: 83-93.
18. Akiba S, Kumazawa S, Yamaguchi H et al. Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal. Biochim Biophys Acta 2006; 1763: 797-804.
19. Escargueil-Blanc I, Salvayre R, Vacaresse N et al. Mildly oxidized LDL induces activation of platelet-derived growth factor beta-receptor pathway. Circulation 2001; 104: 1814-1821.
20. Negre-Salvayre A, Vieira O, Escargueil-Blanc I, Salvayre R. Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. Mol Aspects Med 2003; 24: 251-261
21. Liu W, Akhand AA, Kato M et al. 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition. J Cell Sci 1999; 112: 2409-2417.
22. Kapiotis S, Hermann M, Held I, Seelos C, Ehringer H, Gmeiner BM. Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler Thromb Vasc Biol 1997; 17: 2868-2874.
23. Awasthi YC, Sharma R, Cheng JZ et al. Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med 2003; 24: 219-230.
24. Kutuk O, Poli G, Basaga H. Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. Toxicol Sci 2006; 90: 120-132.
25. Soh Y, Jeong KS, Lee IJ, Bae MA, Kim YC, Song BJ. Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC12 cells. Mol Pharmacol 2000; 58: 535-541.
26. Uchida K, Shiraishi M, Naito Y, Torii Y, Nakamura Y, Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem 1999; 274: 2234-2242.
27. Kakishita H, Hattori Y. Vascular smooth muscle cell activation and growth by 4-hydroxynonenal. Life Sci 2001; 69: 689-697.
28. Camandola S, Scavazza A, Leonarduzzi G et al. Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage. Biofactors 1997; 6: 173-179.
29. Ruef J, Moser M, Bode C, Kubler W, Runge MS. 4-Hydroxynonenal induces apoptosis, NF-kappaB-activation and formation of 8-isoprostane in vascular smooth muscle cells. Basic Res Cardiol 2001; 96: 143-150.
30. Ji C, Kozak KR, Marnett LJ. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem 2001; 276: 18223-18228.
31. Imajo M, Tsuchiya Y, Nishida E. Regulatory mechanisms and functions of MAP kinase signaling pathways. IUBMB Life 2006; 58: 312-317.
32. Cheng JZ, Singhal SS, Sharma A et al. Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling. Arch Biochem Biophys 2001; 392:197-207.
33. Bruckner SR, Perry G, Estus S. 4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis. J Neurochem 2003; 85: 999-1005.
34. Yang Y, Sharma A, Sharma R et al. Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. J Biol Chem 2003; 278: 41380-41388.