메뉴 건너뛰기




Volumn 8, Issue 5, 2011, Pages 481-490

Repositioning leptin as a therapy for Alzheimer's disease

Author keywords

Alzheimer's disease; cognition; leptin; neurodevelopment; neurons

Indexed keywords

AMYLIN DERIVATIVE; AMYLOID BETA PROTEIN; ANTIOBESITY AGENT; ANTIVIRUS AGENT; LEPTIN; LEPTIN RECEPTOR; PEGYLATED RECOMBINANT NATIVE HUMAN LEPTIN; PLACEBO; PRAMLINTIDE; RECOMBINANT LEPTIN; RECOMBINANT METHIONYL HUMAN LEPTIN; UNCLASSIFIED DRUG;

EID: 80053998975     PISSN: 14750708     EISSN: 1744831X     Source Type: Journal    
DOI: 10.2217/thy.11.57     Document Type: Review
Times cited : (30)

References (93)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505), 425-432 (1994). (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 2
    • 53549113349 scopus 로고    scopus 로고
    • Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: Regulation by gender and adiposity
    • Chan JL, Wong SL, Mantzoros CS. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin. Pharmacokinet. 47(11), 753-764 (2008).
    • (2008) Clin. Pharmacokinet. , vol.47 , Issue.11 , pp. 753-764
    • Chan, J.L.1    Wong, S.L.2    Mantzoros, C.S.3
  • 4
    • 77649272503 scopus 로고    scopus 로고
    • Distribution of leptin-sensitive cells in the postnatal and adult mouse brain
    • Caron E, Sachot C, Prevot V et al. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J. Comp. Neurol. 518, 459-476 (2010).
    • (2010) J. Comp. Neurol. , vol.518 , pp. 459-476
    • Caron, E.1    Sachot, C.2    Prevot, V.3
  • 5
    • 26444530145 scopus 로고    scopus 로고
    • Leptin leptin receptors and the control of body weight
    • Friedman JM. Leptin, leptin receptors and the control of body weight. Nutr. Rev. 56(2), 38-46 (1998).
    • (1998) Nutr. Rev. , vol.56 , Issue.2 , pp. 38-46
    • Friedman, J.M.1
  • 6
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • DOI 10.1038/27376
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395(6704), 763-770 (1998). (Pubitemid 28485436)
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 10
    • 77956173468 scopus 로고    scopus 로고
    • Neurodevelopmental actions of leptin
    • Bouret SG. Neurodevelopmental actions of leptin. Brain Res. 1350, 2-9 (2010).
    • (2010) Brain Res. , vol.1350 , pp. 2-9
    • Bouret, S.G.1
  • 11
    • 0018409557 scopus 로고
    • Altered neuroanatomical organization in the central nervous system of the genetically obese (ob/ob) mouse
    • DOI 10.1016/0006-8993(79)90557-2
    • Bereiter D, Jeanrenaud B. Altered neuroanatomical organization in the central nervous system of the genetically obese (ob/ob) mouse. Brain Res. 165, 249-260 (1979). (Pubitemid 9153505)
    • (1979) Brain Research , vol.165 , Issue.2 , pp. 249-260
    • Bereiter, D.A.1    Jeanrenaud, B.2
  • 12
    • 17744375347 scopus 로고    scopus 로고
    • Regulation of neuronal and glial proteins by leptin: Implications for brain development
    • DOI 10.1210/en.140.6.2755
    • Ahima RS, Bjorbaek C, Osei S et al. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140, 2755-2762 (1999). (Pubitemid 32245155)
    • (1999) Endocrinology , vol.140 , Issue.6 , pp. 2755-2762
    • Ahima, R.S.1    Bjorbaek, C.2    Osei, S.3    Flier, J.S.4
  • 15
    • 10044238914 scopus 로고    scopus 로고
    • Obesity-related leptin regulates Alzheimer's Ab
    • Fewlass DC, Noboa K, Pi-Sunyer FX et al. Obesity-related leptin regulates Alzheimer's Ab. FASEB J. 18(15), 1870-1878 (2004).
    • (2004) FASEB J. , vol.18 , Issue.15 , pp. 1870-1878
    • Fewlass, D.C.1    Noboa, K.2    Pi-Sunyer, F.X.3
  • 16
    • 53149140231 scopus 로고    scopus 로고
    • Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
    • Greco SJ, Sarkar S, Johnston JM et al. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem. Biophys. Res. Comm. 376(3), 536-541 (2008).
    • (2008) Biochem. Biophys. Res. Comm. , vol.376 , Issue.3 , pp. 536-541
    • Greco, S.J.1    Sarkar, S.2    Johnston, J.M.3
  • 17
    • 77950358315 scopus 로고    scopus 로고
    • Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
    • Greco SJ, Bryan KJ, Sarkar S et al. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J. Alzheimers Dis. 19(4), 1155-1167 (2010).
    • (2010) J. Alzheimers Dis. , vol.19 , Issue.4 , pp. 1155-1167
    • Greco, S.J.1    Bryan, K.J.2    Sarkar, S.3
  • 18
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • DOI 10.1016/j.cell.2008.01.033, PII S0092867408001347
    • Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645-660 (2008). (Pubitemid 351253687)
    • (2008) Cell , vol.132 , Issue.4 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3
  • 20
    • 78649466467 scopus 로고    scopus 로고
    • CNS leptin and insulin action in the control of energy homeostasis
    • Belgardt BF, Bruning JC. CNS leptin and insulin action in the control of energy homeostasis. Ann. NY Acad. Sci. 1212, 97-113 (2010).
    • (2010) Ann. NY Acad. Sci. , vol.1212 , pp. 97-113
    • Belgardt, B.F.1    Bruning, J.C.2
  • 22
    • 48949117593 scopus 로고    scopus 로고
    • The blood-brain barrier as a cause of obesity
    • DOI 10.2174/138161208784705496
    • Banks WA. The blood-brain barrier as a cause of obesity. Curr. Pharm. Des. 14(16), 1606-1614 (2008). (Pubitemid 352002988)
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.16 , pp. 1606-1614
    • Banks, W.A.1
  • 23
    • 0032718072 scopus 로고    scopus 로고
    • CSF leptin levels after exogenous administration of recombinant methionyl human leptin [2]
    • DOI 10.1001/jama.282.16.1517
    • Fujioka K, Patane J, Lubina J et al. CSF leptin levels after exogeneous administration of recombinant methionyl human leptin. JAMA 282(16), 1517-1518 (1999). (Pubitemid 29504043)
    • (1999) Journal of the American Medical Association , vol.282 , Issue.16 , pp. 1517-1518
    • Fujioka, K.1    Patane, J.2    Lubina, J.3    Lau, D.4
  • 25
    • 76149128662 scopus 로고    scopus 로고
    • Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin deficient patients
    • Galgani JE, Greenway FL, Caglayan S et al. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin deficient patients J. Clin. Endocrinol. Metab. 95(2), 851-855 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.2 , pp. 851-855
    • Galgani, J.E.1    Greenway, F.L.2    Caglayan, S.3
  • 26
    • 33748184369 scopus 로고    scopus 로고
    • Fat and Energy partitioning: Longitudinal observations in leptin-treated adults homozygous for a Lep mutation
    • Heymsfield SB, Fong TM, Gantz I et al. Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a lep mutation. Obesity 14(2), 258-265 (2006). (Pubitemid 46214756)
    • (2006) Obesity , vol.14 , Issue.2 , pp. 258-265
    • Heymsfield, S.B.1    Fong, T.M.2    Gantz, I.3    Erondu, N.4
  • 28
    • 35649025295 scopus 로고    scopus 로고
    • Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight
    • DOI 10.1016/j.appet.2007.03.228, PII S0195666307002747
    • Licinio J, Milane M, Thakur S et al. Effects of leptin on intake of specific micro-and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight. Appetite 49(3), 594-599 (2007). (Pubitemid 350030335)
    • (2007) Appetite , vol.49 , Issue.3 , pp. 594-599
    • Licinio, J.1    Milane, M.2    Thakur, S.3    Whelan, F.4    Yildiz, B.O.5    Delibasi, T.6    De Miranda, P.B.7    Ozata, M.8    Bolu, E.9    DePaoli, A.10    Wong, M.L.11
  • 29
    • 57349192938 scopus 로고    scopus 로고
    • Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
    • Paz-Filho G, Esposito K, Hurwitz B et al. Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. Am. J. Physiol. Endocrinol. Metab. 295(6), E1401-E1408 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , Issue.6
    • Paz-Filho, G.1    Esposito, K.2    Hurwitz, B.3
  • 30
    • 58149240447 scopus 로고    scopus 로고
    • Leptin replacement improves cognitive development
    • Paz-Filho GJ, Babikian T, Asarnow R et al. Leptin replacement improves cognitive development. PLoS One 3(8), e3098 (2008).
    • (2008) PLoS One , vol.3 , Issue.8
    • Paz-Filho, G.J.1    Babikian, T.2    Asarnow, R.3
  • 31
    • 79955043136 scopus 로고    scopus 로고
    • Ten years of leptin replacement therapy
    • Paz-Filho G, Wong ML, Licinio J. Ten years of leptin replacement therapy. Obes. Rev. 12(501), e315-e323 (2011).
    • (2011) Obes. Rev. , vol.12 , Issue.501
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 35
    • 0037392395 scopus 로고    scopus 로고
    • Pegylated human recombinant leptin PEG-OB causes additional weight loss in severely energy-restricted overweight men
    • Hukshorn CJ, Westerterp-Plantenga MS, Saris WH. Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men. Am. J. Clin. Nutr. 77(4), 771-776 (2003).
    • (2003) Am. J. Clin. Nutr. , vol.77 , Issue.4 , pp. 771-776
    • Hukshorn, C.J.1    Westerterp-Plantenga, M.S.2    Saris, W.H.3
  • 36
    • 0038544687 scopus 로고    scopus 로고
    • The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men
    • DOI 10.1530/eje.0.1480649
    • Hukshorn CJ, Menheere PP, Westerterp-Plantenga MS et al. The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men. Eur. J. Endocrinol. 148(6), 649-655 (2003). (Pubitemid 36758295)
    • (2003) European Journal of Endocrinology , vol.148 , Issue.6 , pp. 649-655
    • Hukshorn, C.J.1    Menheere, P.P.C.A.2    Westerterp-Plantenga, M.S.3    Saris, W.H.M.4
  • 37
    • 74249091684 scopus 로고    scopus 로고
    • It takes two to tango: Combined amylin/leptin agonism as a potential approach to obesity drug development
    • Chan JL, Roth JD, Weyer C. It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development. J. Investig. Med. 57(7), 777-783 (2009).
    • (2009) J. Investig. Med. , vol.57 , Issue.7 , pp. 777-783
    • Chan, J.L.1    Roth, J.D.2    Weyer, C.3
  • 38
    • 79951716553 scopus 로고    scopus 로고
    • Leptin and amylin act in an additive manner to activate overlapping signaling pathway in peripheral tissues: In vitro and ex vivo studies in humans
    • Moon HS, Chamberland JP, Diakopoulos KN et al. Leptin and amylin act in an additive manner to activate overlapping signaling pathway in peripheral tissues: in vitro and ex vivo studies in humans. Diabet. Care 34, 132-138 (2011).
    • (2011) Diabet. Care , vol.34 , pp. 132-138
    • Moon, H.S.1    Chamberland, J.P.2    Diakopoulos, K.N.3
  • 39
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlinitide/ metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA et al. Enhanced weight loss with pramlinitide/ metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 17(9), 1736-1743 (2009).
    • (2009) Obesity , vol.17 , Issue.9 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 43
    • 77953954942 scopus 로고    scopus 로고
    • Rational for leptin-replacement therapy for severe lipodystrophy
    • Oral EA, Chan JL. Rational for leptin-replacement therapy for severe lipodystrophy. Endocr. Pract. 6(2), 324-333 (2010).
    • (2010) Endocr. Pract. , vol.6 , Issue.2 , pp. 324-333
    • Oral, E.A.1    Chan, J.L.2
  • 44
    • 12944321844 scopus 로고    scopus 로고
    • The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients
    • DOI 10.1016/j.metabol.2004.08.021, PII S0026049504003397
    • Musso C, Cochran E, Javor E et al. The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients. Metabolism 54(2), 255-263 (2005). (Pubitemid 40174856)
    • (2005) Metabolism: Clinical and Experimental , vol.54 , Issue.2 , pp. 255-263
    • Musso, C.1    Cochran, E.2    Javor, E.3    Young, J.4    DePaoli, A.M.5    Gorden, P.6
  • 45
    • 61449175863 scopus 로고    scopus 로고
    • R-metHuleptin improves highly active antiretroviral therapy-induces lipoatrophy and the metabolic syndrome but not through altering circulating IGF and IGF-binding protein levels: Observational and interventional studies in humans
    • Brennan AM, Lee JH, Tsiodras S et al. r-metHuleptin improves highly active antiretroviral therapy-induces lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur. J. Endocrinol. 160(2), 173-176 (2009).
    • (2009) Eur. J. Endocrinol. , vol.160 , Issue.2 , pp. 173-176
    • Brennan, A.M.1    Lee, J.H.2    Tsiodras, S.3
  • 46
    • 33745781499 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    • DOI 10.1210/jc.2005-1545
    • Lee JH, Chan JL, Sourlas E et al. recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J. Clin. Endocrinol. Metab. 91(7), 2605-2611 (2006). (Pubitemid 44024625)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2605-2611
    • Lee, J.H.1    Chan, J.L.2    Sourlas, E.3    Raptopoulos, V.4    Mantzoros, C.S.5
  • 47
    • 65249130126 scopus 로고    scopus 로고
    • The effects of recombinant human leptin on visceral fat dyslipidemia and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    • Mulligan K, Khatami H, Schwarz JM et al. The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. J. Clin. Endocrinol. Metab. 94(4), 1137-1144 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.4 , pp. 1137-1144
    • Mulligan, K.1    Khatami, H.2    Schwarz, J.M.3
  • 48
    • 65249122675 scopus 로고    scopus 로고
    • Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome
    • Mantzoros CS. Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome. J. Clin. Endocrinol. Metab. 94(4), 1089-1091 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.4 , pp. 1089-1091
    • Mantzoros, C.S.1
  • 50
    • 33846191186 scopus 로고    scopus 로고
    • Relationships between plasma leptin concentrations and human brain structure: A voxel-based morphometric study
    • DOI 10.1016/j.neulet.2006.11.019, PII S0304394006011992
    • Pannacciulli N, Le DS, Chen K et al. Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study. Neurosci. Lett. 412(3), 248-253 (2007). (Pubitemid 46109158)
    • (2007) Neuroscience Letters , vol.412 , Issue.3 , pp. 248-253
    • Pannacciulli, N.1    Le, D.S.N.T.2    Chen, K.3    Reiman, E.M.4    Krakoff, J.5
  • 51
    • 78149470437 scopus 로고    scopus 로고
    • When neurogenesis encounters aging and disease
    • Lazarov O, Mattson MP, Peterson DA et al. When neurogenesis encounters aging and disease. Trends Neurosci. 33(12), 569-579 (2010).
    • (2010) Trends Neurosci. , vol.33 , Issue.12 , pp. 569-579
    • Lazarov, O.1    Mattson, M.P.2    Peterson, D.A.3
  • 52
    • 49649118850 scopus 로고    scopus 로고
    • Leptin increases adult hippocampal neurogenesis in vivo and in vitro
    • Garza JC, Guo M, Zhang W et al. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J. Biol. Chem. 283, 18238-18247 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 18238-18247
    • Garza, J.C.1    Guo, M.2    Zhang, W.3
  • 53
    • 33646789779 scopus 로고    scopus 로고
    • Effects of leptin on memory processing
    • DOI 10.1016/j.peptides.2005.10.006, PII S0196978105004754
    • Farr SA, Banks WA, Morley JE. Effects of leptin on memory processing. Peptides 27, 1420-1425 (2006). (Pubitemid 43767004)
    • (2006) Peptides , vol.27 , Issue.6 , pp. 1420-1425
    • Farr, S.A.1    Banks, W.A.2    Morley, J.E.3
  • 54
    • 38349143059 scopus 로고    scopus 로고
    • Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    • Guo Z, Jiang H, Xu X et al. Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J. Biol. Chem. 283(3), 1754-1763 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.3 , pp. 1754-1763
    • Guo, Z.1    Jiang, H.2    Xu, X.3
  • 55
    • 79955431010 scopus 로고    scopus 로고
    • Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels
    • Garcia-Caceres C, Fuente-Martin E, Burgos-Ramos E et al. Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels. Endocrinology 152, 1809-1818 (2011).
    • (2011) Endocrinology , vol.152 , pp. 1809-1818
    • Garcia-Caceres, C.1    Fuente-Martin, E.2    Burgos-Ramos, E.3
  • 56
    • 33745667031 scopus 로고    scopus 로고
    • Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex
    • Udagawa J, Nimura M, Otani H. Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Neuro. Endocrinol. Lett. 27(1-2), 177-182 (2006). (Pubitemid 43970790)
    • (2006) Neuroendocrinology Letters , vol.27 , Issue.1-2 , pp. 177-182
    • Udagawa, J.1    Nimura, M.2    Otani, H.3
  • 57
    • 78649308474 scopus 로고    scopus 로고
    • The procognitive effects of leptin in the brain and their clinical implications
    • Paz-Filho G, Wong ML, Licinio J. The procognitive effects of leptin in the brain and their clinical implications. Int. J. Clin. Pract. 64(13), 1808-1812 (2010).
    • (2010) Int. J. Clin. Pract. , vol.64 , Issue.13 , pp. 1808-1812
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 58
    • 35648986699 scopus 로고    scopus 로고
    • Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected men
    • Huang JS, Letendre S, Marquie-Beck J et al. Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected men. J. Neuroimmu. Pharmacol. 2(4), 352-358 (2007).
    • (2007) J. Neuroimmu. Pharmacol. , vol.2 , Issue.4 , pp. 352-358
    • Huang, J.S.1    Letendre, S.2    Marquie-Beck, J.3
  • 60
    • 0141782327 scopus 로고    scopus 로고
    • The role of leptin in the etiopathogenesis of anorexia nervosa and bulimia
    • Calandra C, Musso F, Musso R. The role of leptin in the etiopathogenesis of anorexia nervosa and bulimia. Eat. Weight Disord. 8(2), 130-137 (2003).
    • (2003) Eat. Weight Disord. , vol.8 , Issue.2 , pp. 130-137
    • Calandra, C.1    Musso, F.2    Musso, R.3
  • 62
    • 2942622201 scopus 로고    scopus 로고
    • Low CSF leptin in female suicide attempters with major depression
    • DOI 10.1016/j.jad.2003.07.002, PII S0165032703002015
    • Westling S, Ahrén B, Träskman-Bendz L et al. Low CSF leptin in female suicide attempters with major depression. J. Affect. Disord. 81(1), 41-48 (2004). (Pubitemid 38759325)
    • (2004) Journal of Affective Disorders , vol.81 , Issue.1 , pp. 41-48
    • Westling, S.1    Ahren, B.2    Traskman-Bendz, L.3    Westrin, A.4
  • 63
    • 77953728023 scopus 로고    scopus 로고
    • Variations of plasma leptin and adiponectin levels in autistic patients
    • Blardi P, de Lalla A, Ceccatelli L et al. Variations of plasma leptin and adiponectin levels in autistic patients. Neurosci. Lett. 479(1), 54-57 (2010).
    • (2010) Neurosci. Lett. , vol.479 , Issue.1 , pp. 54-57
    • Blardi, P.1    De Lalla, A.2    Ceccatelli, L.3
  • 64
    • 67651159111 scopus 로고    scopus 로고
    • Weight loss, body fat mass and leptin in Parkinson's disease
    • Lorefalt B, Toss G, Granerus AK. Weight loss, body fat mass and leptin in Parkinson's disease. Movement Disord. 24, 885-890 (2009).
    • (2009) Movement Disord. , vol.24 , pp. 885-890
    • Lorefalt, B.1    Toss, G.2    Granerus, A.K.3
  • 65
    • 77749258420 scopus 로고    scopus 로고
    • Leptin and ghrelin concentrations and weight loss in Parkinsons disease
    • Fiszer U, Michalowska M, Baranowska B et al. Leptin and ghrelin concentrations and weight loss in Parkinson's disease. Acta Neurol. Scand. 121, 230-236 (2010).
    • (2010) Acta Neurol. Scand. , vol.121 , pp. 230-236
    • Fiszer, U.1    Michalowska, M.2    Baranowska, B.3
  • 66
    • 67349228783 scopus 로고    scopus 로고
    • Relationship between plasma leptin level and brain structure in elderly: A voxel-based morphometric study
    • Narita K, Kosaka H, Okazawa H et al. Relationship between plasma leptin level and brain structure in elderly: a voxel-based morphometric study. Biol. Psychiat. 65(11), 992-994 (2009).
    • (2009) Biol. Psychiat. , vol.65 , Issue.11 , pp. 992-994
    • Narita, K.1    Kosaka, H.2    Okazawa, H.3
  • 68
  • 69
    • 67650621405 scopus 로고    scopus 로고
    • Serum leptin level and cognition in the elderly: Findings from the Health ABC study
    • Holden KF, Lindquist K, Tylavsky FA et al. Serum leptin level and cognition in the elderly: findings from the Health ABC study. Neurobiol. Aging 30(9), 1483-1489 (2009).
    • (2009) Neurobiol. Aging , vol.30 , Issue.9 , pp. 1483-1489
    • Holden, K.F.1    Lindquist, K.2    Tylavsky, F.A.3
  • 70
    • 72549091935 scopus 로고    scopus 로고
    • Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
    • Lieb W, Beiser AS, Vasan RS et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 302(23), 2565-2572 (2009).
    • (2009) JAMA , vol.302 , Issue.23 , pp. 2565-2572
    • Lieb, W.1    Beiser, A.S.2    Vasan, R.S.3
  • 71
    • 77956183954 scopus 로고    scopus 로고
    • Alzheimer's disease: Brain expression of a metabolic disorder
    • Merlo S, Spampinato S, Canonico PL et al. Alzheimer's disease: brain expression of a metabolic disorder? Trends Endocrinol. Metab. 21(9), 537-544 (2010).
    • (2010) Trends Endocrinol. Metab. , vol.21 , Issue.9 , pp. 537-544
    • Merlo, S.1    Spampinato, S.2    Canonico, P.L.3
  • 72
    • 67649726068 scopus 로고    scopus 로고
    • Leptin: A novel therapeutic strategy for Alzheimer's disease
    • Tezapsidis N, Johnston JM, Smith MA et al. Leptin: a novel therapeutic strategy for Alzheimer's disease. J. Alzheimers Dis. 16(4), 731-740 (2009).
    • (2009) J. Alzheimers Dis. , vol.16 , Issue.4 , pp. 731-740
    • Tezapsidis, N.1    Johnston, J.M.2    Smith, M.A.3
  • 74
    • 2542502430 scopus 로고    scopus 로고
    • ApoE genotype accounts for the vast majority of AD risk and AD pathology
    • DOI 10.1016/j.neurobiolaging.2003.12.023, PII S0197458004001009
    • Raber J, Huang Y, Ashford JW. ApoE genotype accounts for the vast majority of AD risk and AD neuropathology. Neurobiol. Aging 25(5), 641-650 (2004). (Pubitemid 38686487)
    • (2004) Neurobiology of Aging , vol.25 , Issue.5 , pp. 641-650
    • Raber, J.1    Huang, Y.2    Ashford, J.W.3
  • 76
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6, 345-351 (2003).
    • (2003) Nat. Neurosci. , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 77
    • 42249094013 scopus 로고    scopus 로고
    • Adiposity hyperinsulinemia diabetes and Alzheimers disease: An epidemiological perspective
    • Luchsinger JA. Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. Eur. J. Pharmacol. 585(1), 119-129 (2008).
    • (2008) Eur. J. Pharmacol. , vol.585 , Issue.1 , pp. 119-129
    • Luchsinger, J.A.1
  • 78
    • 0032764016 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of dementia: The rotterdam study
    • Ott A, Stolk RP, van Harskamp F. Diabetes mellitus and the risk of dementia: the Rotterdam study. Neurology 53, 1937-1942 (1999).
    • (1999) Neurology , vol.53 , pp. 1937-1942
    • Ott, A.1    Stolk, R.P.2    Van Harskamp, F.3
  • 80
    • 59649109970 scopus 로고    scopus 로고
    • Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
    • Greco SJ, Sarkar S, Johnston JM et al. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem. Biophys. Res. Comm. 380(1), 98-104 (2009).
    • (2009) Biochem. Biophys. Res. Comm. , vol.380 , Issue.1 , pp. 98-104
    • Greco, S.J.1    Sarkar, S.2    Johnston, J.M.3
  • 82
    • 33846950833 scopus 로고    scopus 로고
    • Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy
    • Ebihara K, Kusakabe T, Hirata M et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J. Clin. Endocrinol. Metab. 92(2), 532-541 (2007).
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , Issue.2 , pp. 532-541
    • Ebihara, K.1    Kusakabe, T.2    Hirata, M.3
  • 83
    • 0035431169 scopus 로고    scopus 로고
    • The effects of leptin administration in non-obese human subjects
    • Mackintosh RM, Hirsch J. The effects of leptin administration in non-obese human subjects. Obes. Res. 9(8), 462-469 (2001). (Pubitemid 33600290)
    • (2001) Obesity Research , vol.9 , Issue.8 , pp. 462-469
    • Mackintosh, R.M.1    Hirsch, J.2
  • 84
    • 4143139576 scopus 로고    scopus 로고
    • APOE genotype effects on Alzheimer's disease onset and epidemiology
    • DOI 10.1385/JMN:23:3:157
    • Ashford JW. APOE genotype effects on Alzheimer's disease onset and epidemiology. J. Mol. Neurosci. 23, 157-165 (2004). (Pubitemid 41389382)
    • (2004) Journal of Molecular Neuroscience , vol.23 , Issue.3 , pp. 157-165
    • Ashford, J.W.1
  • 85
    • 77957138140 scopus 로고    scopus 로고
    • TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    • Roses AD, Lutz MW, Amrine-Madsen H et al. TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J. 10(5), 375-384 (2010).
    • (2010) Pharmacogenomics J. , vol.10 , Issue.5 , pp. 375-384
    • Roses, A.D.1    Lutz, M.W.2    Amrine-Madsen, H.3
  • 87
    • 41149088116 scopus 로고    scopus 로고
    • Leptin and the risk of Barrett's oesophagus
    • Kendall BJ, Macdonald GA, Hayward NK et al. Leptin and the risk of Barrett's oesophagus. Gut 57(4), 448-454 (2008).
    • (2008) Gut , vol.57 , Issue.4 , pp. 448-454
    • Kendall, B.J.1    Macdonald, G.A.2    Hayward, N.K.3
  • 88
    • 72549114690 scopus 로고    scopus 로고
    • Involvement of adiponectin and leptin in breast cancer: Clinical and in vitro studies
    • Jardé T, Caldefie-Chézet F, Goncalves-Mendes N et al. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocr. Relat. Cancer 16(4), 1197-1210 (2009).
    • (2009) Endocr. Relat. Cancer , vol.16 , Issue.4 , pp. 1197-1210
    • Jardé, T.1    Caldefie-Chézet, F.2    Goncalves-Mendes, N.3
  • 89
    • 78751566697 scopus 로고    scopus 로고
    • Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimers disease
    • Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol. 10, 187-198 (2011).
    • (2011) Lancet Neurol. , vol.10 , pp. 187-198
    • Kapogiannis, D.1    Mattson, M.P.2
  • 90
    • 0035988501 scopus 로고    scopus 로고
    • Leptin in functional hypothalamic amenorrhoea
    • Andrico S, Gambera A, Specchia C et al. Leptin in functional hypothalamic amenorrhoea. Hum. Reprod. 17(8), 2043-2048 (2002).
    • (2002) Hum. Reprod. , vol.17 , Issue.8 , pp. 2043-2048
    • Andrico, S.1    Gambera, A.2    Specchia, C.3
  • 93
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • DOI 10.1172/JC135055
    • Rosenbaum M, Sy M, Pavlovich K et al. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J. Clin. Invest. 118(7), 2583-2591 (2008). (Pubitemid 351949785)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.7 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.