Serum leptin levels are higher in females affected by frontotemporal lobar degeneration than Alzheimer's disease

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 6, 2008, Pages 712-715

  Alberici, A ^a   Bocchio, L ^b   Geroldi, C ^b   Zanardini, R ^b   Bonomini, C ^b   Bugari, G ^c   Iacobello, C ^c   Caimi, L ^c   Gennarelli, M ^b   Zanetti, O ^b   Valerio, A ^a,d   Nisoli, E ^d   Borroni, B ^a   Padovani, A ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^c Spedali Civili   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; LEPTIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; BRAIN DEGENERATION; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FOOD INTAKE; FRONTOTEMPORAL LOBAR DEGENERATION; HORMONE BLOOD LEVEL; HUMAN; HYPERPHAGIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; BLOOD; DAILY LIFE ACTIVITY; DEMENTIA; MENTAL HEALTH; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; REFERENCE VALUE;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DEMENTIA; FEMALE; HUMANS; HYPERPHAGIA; LEPTIN; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; REFERENCE VALUES; SEX FACTORS;

EID: 44449094608     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.137026     Document Type: Article

References (16)

1. Snowden JS, Neary D, Mann DM. Frontotemporal dementia. Br J Psychiatry 2002;180:140-3.
2. Kertesz A, Davidson W, Fox H. Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia. Can J Neurol Sci 1997;24:29-36.
3. Alberici A, Geroldi C, Cotelli M, et al. The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease. Neurol Sci 2007;28:80-6.
4. Ikeda M, Brown J, Holland AJ, et al. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease. J Neurol Nerosurg Psychiatry 2002;73:371-2.
5. Kishi T, Elmguist JK. Body weight is regulated by brain: a link between feeding and emotion. Mol Psychiatry 2005;10:132-46.
6. Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci 2005;6:691-702.
7. Whitwell JL, Sampson EL, Loy CT, et al. VBN signature of abnormal eating behaviours in frontotemporal lobar degeneration. Neuroimage 2007;35:207-13.
8. Li XL, Aou S, Oomura Y, et al. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neurosciences 2002;113:607-15.
9. Fewlass DC, Noboa K, Pi-Sunyer X, et al. Obesity-related leptin regulates Alzheimer's Aβ. FASEB J 2004;18:1870-8.
10. Valerio A, Ghisi V, Dossena M, et al. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3β. J Biol Chem 2006;281:12950-8.
11. Farooqi DI, Bullmore E, Keogh J, et al. Leptin regulates striatal regions and human eating behavior. Science 2007;317:1355.
12. Power DA, Noel J, Collins R, et al. Circulating leptin levels and weight loss in Alzheimer's disease patients. Dement Geriatr Cogn Disord 2001;12:167-70.
13. Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546-54.
14. McKhann GM, Albert MS, Grossman M, et al. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol 2001;11:1803-09.
15. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
16. Borroni B, Grassi M, Agosti C, et al. Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates. BMC Neurol 2007;7:9.