Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: Regulation by gender and adiposity

Clinical Pharmacokinetics

Volumn 47, Issue 11, 2008, Pages 753-764

  Chan, Jean L ^a   Wong, Shekman L ^b   Mantzoros, Christos S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b THERAVANCE INC   (United States)

Author keywords

Adipokines, pharmacokinetics; Fasting; Gender differences; Metreleptin, pharmacokinetics; Research and development; Weight loss

Indexed keywords

LEPTIN; RECOMBINANT LEPTIN; RECOMBINANT METHIONYL HUMAN LEPTIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CALORIC INTAKE; CALORIC RESTRICTION; CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; ERYTHEMA; FEMALE; FOOD INTAKE; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; HUMAN EXPERIMENT; INJECTION SITE REACTION; KIDNEY CLEARANCE; LOW CALORY DIET; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OBESITY; PARAMETER; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; WEIGHT REDUCTION;

ADIPOSITY; ADMINISTRATION, CUTANEOUS; ADULT; AREA UNDER CURVE; FASTING; FEMALE; HUMANS; LEPTIN; MALE; SEX FACTORS;

EID: 53549113349     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200847110-00006     Document Type: Article

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