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Volumn 58, Issue 9, 2011, Pages 723-739

Genetics of type 2 diabetes: The GWAS era and future perspectives

Author keywords

Clinical translation; Genetics; Genome wide association studies; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CALPAIN 10; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SULFONYLUREA DERIVATIVE;

EID: 80053927394     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ11-0113     Document Type: Review
Times cited : (146)

References (80)
  • 1
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a populationbased twin study
    • Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a populationbased twin study. (1999) Diabetologia 42: 139-145.
    • (1999) Diabetologia , vol.42 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 3
    • 0035960122 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical pathophysiology of maturityonset diabetes of the young
    • Fajans SS, Bell GI, Polonsky KS (2001) Molecular mechanisms and clinical pathophysiology of maturityonset diabetes of the young. N Engl J Med 345: 971-980.
    • (2001) N Engl J Med , vol.345 , pp. 971-980
    • Fajans, S.S.1    Bell, G.I.2    Polonsky, K.S.3
  • 9
    • 33750594321 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    • Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes 55: 2645-2648.
    • (2006) Diabetes , vol.55 , pp. 2645-2648
    • Zhang, C.1    Qi, L.2    Hunter, D.J.3    Meigs, J.B.4    Manson, J.E.5    van Dam, R.M.6    Hu, F.B.7
  • 11
    • 33750584981 scopus 로고    scopus 로고
    • Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
    • Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR (2006) Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55: 2654-2659.
    • (2006) Diabetes , vol.55 , pp. 2654-2659
    • Damcott, C.M.1    Pollin, T.I.2    Reinhart, L.J.3    Ott, S.H.4    Shen, H.5    Silver, K.D.6    Mitchell, B.D.7    Shuldiner, A.R.8
  • 14
    • 34147119644 scopus 로고    scopus 로고
    • Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
    • Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S (2007) Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia 50: 980-984.
    • (2007) Diabetologia , vol.50 , pp. 980-984
    • Hayashi, T.1    Iwamoto, Y.2    Kaku, K.3    Hirose, H.4    Maeda, S.5
  • 15
    • 33847618213 scopus 로고    scopus 로고
    • A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
    • Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T (2007) A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 50: 747-751.
    • (2007) Diabetologia , vol.50 , pp. 747-751
    • Horikoshi, M.1    Hara, K.2    Ito, C.3    Nagai, R.4    Froguel, P.5    Kadowaki, T.6
  • 17
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52: 568-572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6    Walker, M.7    Levy, J.C.8    Sampson, M.9    Halford, S.10    McCarthy, M.I.11    Hattersley, A.T.12    Frayling, T.M.13
  • 18
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium
    • International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437: 1299-1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 38
    • 57349191471 scopus 로고    scopus 로고
    • Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population
    • Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, Kim HJ, Ahn CW, Cha BS, Nam M, Nam CM, Lee HC (2008) Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J Hum Genet 53: 991-998.
    • (2008) J Hum Genet , vol.53 , pp. 991-998
    • Lee, Y.H.1    Kang, E.S.2    Kim, S.H.3    Han, S.J.4    Kim, C.H.5    Kim, H.J.6    Ahn, C.W.7    Cha, B.S.8    Nam, M.9    Nam, C.M.10    Lee, H.C.11
  • 39
    • 66649101376 scopus 로고    scopus 로고
    • Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: A study of 3,734 subjects comprising three ethnicities living in Singapore
    • Tan JT, Nurbaya S, Gardner D, Ye S, Tai ES, Ng DP (2009) Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes 58: 1445-1449.
    • (2009) Diabetes , vol.58 , pp. 1445-1449
    • Tan, J.T.1    Nurbaya, S.2    Gardner, D.3    Ye, S.4    Tai, E.S.5    Ng, D.P.6
  • 40
    • 67349205597 scopus 로고    scopus 로고
    • Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
    • Hu C, Wang C, Zhang R, Ma X, Wang J, Lu J, Qin W, Bao Y, Xiang K, Jia W (2009) Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52: 1322-1325.
    • (2009) Diabetologia , vol.52 , pp. 1322-1325
    • Hu, C.1    Wang, C.2    Zhang, R.3    Ma, X.4    Wang, J.5    Lu, J.6    Qin, W.7    Bao, Y.8    Xiang, K.9    Jia, W.10
  • 45
  • 53
    • 56349096931 scopus 로고    scopus 로고
    • Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    • UK Type 2 Diabetes Genetics Consortium
    • Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN (2008) Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57: 3129-3135.
    • (2008) Diabetes , vol.57 , pp. 3129-3135
    • Lango, H.1    Palmer, C.N.2    Morris, A.D.3    Zeggini, E.4    Hattersley, A.T.5    McCarthy, M.I.6    Frayling, T.M.7    Weedon, M.N.8
  • 55
    • 70349880712 scopus 로고    scopus 로고
    • The clinical application of genetic testing in type 2 diabetes: A patient and physician survey
    • Grant RW, Hivert M, Pandiscio JC, Florez JC, Nathan DM, Meigs JB (2009) The clinical application of genetic testing in type 2 diabetes: a patient and physician survey. Diabetologia 52: 2299-2305.
    • (2009) Diabetologia , vol.52 , pp. 2299-2305
    • Grant, R.W.1    Hivert, M.2    Pandiscio, J.C.3    Florez, J.C.4    Nathan, D.M.5    Meigs, J.B.6
  • 56
    • 4344665860 scopus 로고    scopus 로고
    • Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    • Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53: 2330-2337.
    • (2004) Diabetes , vol.53 , pp. 2330-2337
    • Chimienti, F.1    Devergnas, S.2    Favier, A.3    Seve, M.4
  • 57
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270: 12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 61
    • 79951481957 scopus 로고    scopus 로고
    • Initial impact of the sequencing of the human genome
    • Lander ES (2011) Initial impact of the sequencing of the human genome. Nature 470: 187-197.
    • (2011) Nature , vol.470 , pp. 187-197
    • Lander, E.S.1
  • 62
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • The 1000 Genomes Project Consortium
    • The 1000 Genomes Project Consortium (2010) A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073.
    • (2010) Nature , vol.467 , pp. 1061-1073
  • 64
    • 79951472909 scopus 로고    scopus 로고
    • Charting a course for genomic medicine from base pairs to bedside
    • National Human Genome Research Institute
    • Green ED, Guyer MS; National Human Genome Research Institute (2011) Charting a course for genomic medicine from base pairs to bedside. Nature 470: 204-213.
    • (2011) Nature , vol.470 , pp. 204-213
    • Green, E.D.1    Guyer, M.S.2
  • 67
    • 40949087723 scopus 로고    scopus 로고
    • Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    • Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S (2008) Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57: 791-795.
    • (2008) Diabetes , vol.57 , pp. 791-795
    • Omori, S.1    Tanaka, Y.2    Takahashi, A.3    Hirose, H.4    Kashiwagi, A.5    Kaku, K.6    Kawamori, R.7    Nakamura, Y.8    Maeda, S.9
  • 71
    • 35848945259 scopus 로고    scopus 로고
    • Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    • Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T (2007) Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50: 2461-2466.
    • (2007) Diabetologia , vol.50 , pp. 2461-2466
    • Horikoshi, M.1    Hara, K.2    Ito, C.3    Shojima, N.4    Nagai, R.5    Ueki, K.6    Froguel, P.7    Kadowaki, T.8
  • 79
    • 77957310400 scopus 로고    scopus 로고
    • The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
    • Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H (2010) The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. J Hum Genet 55: 600-604.
    • (2010) J Hum Genet , vol.55 , pp. 600-604
    • Onuma, H.1    Tabara, Y.2    Kawamoto, R.3    Shimizu, I.4    Kawamura, R.5    Takata, Y.6    Nishida, W.7    Ohashi, J.8    Miki, T.9    Kohara, K.10    Makino, H.11    Osawa, H.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.