Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance

Diabetes

Volumn 55, Issue 9, 2006, Pages 2654-2659

  Damcott, Coleen M ^a   Pollin, Toni I ^a   Reinhart, Laurie J ^a   Ott, Sandra H ^a   Shen, Haiqing ^a   Silver, Kristi D ^a   Mitchell, Braxton D ^a   Shuldiner, Alan R ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

AFDS, Amish Family Diabetes Study; AIRg, acute insulin response to glucose; DI, disposition index; IGT, impaired glucose tolerance; IVGTT, intravenous glucose tolerance test; LD, linkage disequilibrium; NGT, normal glucose tolerance

Indexed keywords

T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7 LIKE 2; INSULIN; T CELL FACTOR 4;

ADULT; AGED; AMISH; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME 10Q; CONTROLLED STUDY; GENE CONTROL; GENE REPLICATION; GENE STRUCTURE; GENOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CAUCASIAN; ETHNIC GROUP; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SECRETION; UNITED STATES;

ADULT; AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HUMANS; INSULIN; INSULIN RESISTANCE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PENNSYLVANIA; POLYMORPHISM, SINGLE NUCLEOTIDE; TCF TRANSCRIPTION FACTORS;

EID: 33750584981     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0338     Document Type: Article

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