The clinical application of genetic testing in type 2 diabetes: A patient and physician survey

Diabetologia

Volumn 52, Issue 11, 2009, Pages 2299-2305

  Grant, R W ^a,b   Hivert, M ^a   Pandiscio, J C ^a   Florez, J C ^a,b,c   Nathan, D M ^a,b   Meigs, J B ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Diabetes prediction; Genetic risk; Genetic testing; Medication adherence; Patient motivation; Type 2 diabetes

Indexed keywords

GLIPIZIDE; METFORMIN;

ADULT; AGED; ARTICLE; FEMALE; GENETIC RISK; GENETIC SCREENING; HEALTH SURVEY; HUMAN; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MEDICAL SPECIALIST; MOTIVATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT ATTITUDE; PATIENT COMPLIANCE; PHARMACOGENETICS; PHYSICIAN; PHYSICIAN ATTITUDE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RISK ASSESSMENT; UNITED STATES;

DATA COLLECTION; DATABASES, FACTUAL; DIABETES MELLITUS, TYPE 2; GENETIC TESTING; GENOME, HUMAN; HUMANS; MEDICINE; MOTIVATION; PATIENTS; PERCEPTION; PHARMACOGENETICS; PHYSICIANS, FAMILY; PREDICTIVE VALUE OF TESTS; PRIVACY; PROFESSIONAL PRACTICE; RISK ASSESSMENT;

EID: 70349880712     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1512-7     Document Type: Article

References (24)

1. TM Frayling 2007 Genome-wide association studies provide new insights into type 2 diabetes aetiology Nat Rev Genet 8 657 662 17703236 10.1038/nrg2178 1:CAS:528:DC%2BD2sXptFyrur0%3D (Pubitemid 47281993)
2. JC Florez 2008 The genetics of type 2 diabetes: a realistic appraisal in 2008 J Clin Endocrinol Metab 93 4633 4642 18782870 10.1210/jc.2008-1345 1:CAS:528:DC%2BD1cXhsVyqtb3O
3. ER Pearson LA Donnelly C Kimber, et al. 2007 Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study Diabetes 56 2178 2182 17519421 10.2337/db07-0440 1:CAS:528:DC%2BD2sXos12qsbk%3D (Pubitemid 47195841)
4. Y Feng G Mao X Ren, et al. 2008 Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients Diabetes Care 31 1939 1944 18599530 10.2337/dc07-2248 1:CAS:528:DC%2BD1cXht1KksLfP
5. MG Pezzolesi GD Poznik JC Mychaleckyj, et al. 2009 Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes Diabetes 58 1403 1410 19252134 10.2337/db08-1514 1:CAS:528: DC%2BD1MXntFanu78%3D
6. JC Florez KA Jablonski N Bayley Diabetes Prevention Program Research Group, et al. 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 241 250 16855264 10.1056/NEJMoa062418 1:CAS:528:DC%2BD28XntVWktrw%3D (Pubitemid 44079339)
7. O Ludovico F Pellegrini R Di Paola, et al. 2007 Heterogeneous effect of peroxisome proliferator-activated receptor g2 Ala12 variant on type 2 diabetes risk Obesity 15 1076 1081 17495182 10.1038/oby.2007.617 1:CAS:528: DC%2BD2sXmsFyltLs%3D
8. AF Moore KA Jablonski CC Mason Diabetes Prevention Program Research Group, et al. 2009 The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the Diabetes Prevention Program J Clin Endocrinol Metab 94 449 455 19017751 10.1210/jc.2008-1583 1:CAS:528: DC%2BD1MXhvFCqsLs%3D
9. RW Grant AF Moore JC Florez 2009 The genetic architecture of type 2 diabetes: recent progress and clinical implications Diabetes Care 32 1107 1114 19460916 10.2337/dc08-2171 1:CAS:528:DC%2BD1MXnvVOqsL0%3D
10. L Bonetta 2008 Getting up close and personal with your genome Cell 133 753 756 18510915 10.1016/j.cell.2008.05.008 1:CAS:528:DC%2BD1cXntFalsbY%3D (Pubitemid 351707692)
11. W Burke BM Psaty 2007 Personalized medicine in the era of genomics JAMA 298 1682 1684 17925520 10.1001/jama.298.14.1682 1:CAS:528:DC%2BD2sXhtFGhtrvL (Pubitemid 47606657)
12. JB Meigs P Shrader LM Sullivan, et al. 2008 Genotype score in addition to common risk factors for prediction of type 2 diabetes N Engl J Med 359 2208 2219 19020323 10.1056/NEJMoa0804742 1:CAS:528:DC%2BD1cXhtl2gurnE
13. V Lyssenko A Jonsson P Almgren, et al. 2008 Clinical risk factors, DNA variants, and the development of type 2 diabetes N Engl J Med 359 2220 2232 19020324 10.1056/NEJMoa0801869 1:CAS:528:DC%2BD1cXhtl2gurnF
14. C Cook F Heath RL Thompson 2000 A meta-analysis of response rates in web- or internet-based surveys Educ Psychol Meas 60 821 836 10.1177/ 00131640021970934
15. M Morren M Rijken A Baanders L Bensing 2007 Perceived genetic knowledge, attitudes towards genetic testing, and the relationship between these among patients with a chronic disease Patient Educ Couns 65 197 204 16939709 10.1016/j.pec.2006.07.005 (Pubitemid 46073559)
16. H Calsbeek M Morren J Bensing M Rijken 2007 Knowledge and attitudes towards genetic testing: a two year follow-up study in patients with asthma, diabetes mellitus and cardiovascular disease J Genet Couns 16 493 504 17318450 10.1007/s10897-006-9085-9 (Pubitemid 47305505)
17. Massachusetts General Hospital Center for Human Genetic Research (2006) SugarMGH. Available from http://www2.massgeneral.org/chgr/SUGARMGH.htm, accessed 1 June 2009
18. DM Berwick 2003 Disseminating innovations in health care JAMA 289 1969 1975 12697800 10.1001/jama.289.15.1969 (Pubitemid 37430229)
19. WH Herman TJ Hoerger M Brandle Diabetes Prevention Program Research Group, et al. 2005 The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance Ann Intern Med 142 323 332 15738451
20. M Pijl DRM Timmermans L Claassen, et al. 2009 Impact of communicating familial risk of diabetes on illness perceptions and self-reported behavioral outcomes: a randomized controlled trial Diabetes Care 32 597 599 19131458 10.2337/dc08-1049
21. TM Marteau C Lerman 2001 Genetic risk and behavioural change BMJ 322 1056 1059 11325776 10.1136/bmj.322.7293.1056 1:STN:280:DC%2BD3MzgvFelsw%3D%3D
22. DM Nathan JB Buse MB Davidson, et al. 2009 Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes Diabetologia 52 17 30 18941734 10.1007/s00125-008-1157-y 1:STN:280:DC%2BD1cjotVGitQ%3D%3D
23. TJ Hoerger JE Segel EW Gregg JB Saaddine 2008 Is glycemic control improving in U.S. adults? Diabetes Care 31 81 86 17934153 10.2337/dc07-1572
24. MM Engelgau LS Geiss JB Saaddine, et al. 2004 The evolving diabetes burden in the United States Ann Intern Med 140 945 950 15172919