Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 35770-35781

  Jílková, Adéla ^a,b   Řezáčová, Pavlína ^a,c   Lepšík, Martin ^a   Horn, Martin ^a   Váchová, Jana ^a   Fanfrlík, Jindřich ^a   Brynda, Jiří ^a,c   McKerrow, James H ^d   Caffrey, Conor R ^d   Mareš, Michael ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PROTEIN; CATHEPSIN B; DRUG TARGETS; HUMAN BLOODS; KEY BINDING; NATURAL SUBSTRATES; PARASITE-; PEPTIDOMIMETICS; QUANTUM CHEMICAL CALCULATIONS; RATIONAL DESIGN; SCHISTOSOMA MANSONI; STRUCTURAL BASIS; SUBSITES; SYNTHETIC PEPTIDE; VINYL SULFONES;

BINDING ENERGY; BLOOD; PROTEINS; QUANTUM CHEMISTRY;

ENZYME INHIBITION;

ANTHELMINTIC AGENT; AR 198048; AR 198049; CARBOXYPEPTIDASE; CATHEPSIN B; HEMOGLOBIN; K 11002; K 11006; K 11017; K 11747; K 11777; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; WRR 145; WRR 185; WRR 200; WRR 282; WRR 283; WRR 284; WRR 285; WRR 286; WRR 347; WRR 359; WRR 453; WRR 483; WRR 499;

ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; IC 50; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; QUANTUM CHEMISTRY; SCHISTOSOMA MANSONI; STRUCTURE ANALYSIS;

ANIMALS; CATHEPSIN D; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; HELMINTH PROTEINS; HEMOGLOBINS; HUMANS; HYDROLYSIS; PEPTIDES; PEPTIDOMIMETICS; PROTEASE INHIBITORS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; STRUCTURE-ACTIVITY RELATIONSHIP;

SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMATIDAE;

EID: 80053911016     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.271304     Document Type: Article

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