Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 624-628

  Jaishankar, Priyadarshini ^a   Hansell, Elizabeth ^a,b   Zhao, Dong Mei ^a   Doyle, Patricia S ^a,b   McKerrow, James H ^a,b   Renslo, Adam R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiparasitics; Antitrypanosomals; Cysteine protease inhibitors; Cysteine proteases; Trypanosomes; Vinyl sulfones

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE INHIBITOR; K 777; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; TRYPANOSOMA;

ANIMALS; CYSTEINE PROTEINASE INHIBITORS; ETHYLENES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA;

EID: 38149118059     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.070     Document Type: Article

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