S′2 substrate specificity and the role of His110 and his111 in the exopeptidase activity of human cathepsin B

Biochemical Journal

Volumn 361, Issue 3, 2002, Pages 613-619

  Krupa, Joanne C ^a   Hasnain, Sadiq ^a   Nägler, Dorit K ^a   Ménard, Robert ^a   Mort, John S ^a  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

Cysteine protease; Dipeptidase; Enzyme kinetics; Occluding loop; Quenched fluorescence substrates

Indexed keywords

ENZYMES; FLUORESCENCE; MUTAGENESIS; QUENCHING;

PEPTIDES;

BIOCHEMICAL ENGINEERING;

AROMATIC COMPOUND; ASPARTIC ACID; CATHEPSIN B; CYSTEINE PROTEINASE; DIPEPTIDYL CARBOXYPEPTIDASE; EXOPEPTIDASE; GLUTAMIC ACID; HISTIDINE; AMIDASE; CARBOXYTOLBUTAMIDE; DRUG DERIVATIVE; ION; RECOMBINANT PROTEIN; TOLBUTAMIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ELECTRICITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; FLUORESCENCE; HUMAN; LYSOSOME; MOLECULAR INTERACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMIDOHYDROLASES; ASPARTIC ACID; BINDING SITES; CATHEPSIN B; EXOPEPTIDASES; GLUTAMIC ACID; HISTIDINE; HUMANS; IONS; KINETICS; LYSOSOMES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TOLBUTAMIDE;

EID: 0036462513     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3610613     Document Type: Article

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