The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain Injury

Journal of Neurotrauma

Volumn 18, Issue 11, 2001, Pages 1229-1240

  Kupina, Nancy C ^a   Nath, Rathna ^a   Bernath, Eric E ^a   Inoue, Jun ^b   Mitsuyoshi, Azuma ^b   Yuen, Po Wai ^a   Wang, Kevin K W ^a   Hall, Edward D ^a  

^a PFIZER INC   (United States)

^b SENJU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Calpain activation; Calpain mediated spectrin proteolysis; Neuroprotection; Traumatic brain injury

Indexed keywords

BIOLOGICAL MARKER; CALPASTATIN; FODRIN; ISOFLURANE; SJA 6017; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN CORTEX; BRAIN FUNCTION; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; HIPPOCAMPUS; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN INJURIES; CALPAIN; CEREBRAL CORTEX; CYTOSKELETON; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; MICE; SPECTRIN; TIME FACTORS;

EID: 0035153398     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771501317095269     Document Type: Article

References (61)

1. Neurofilament proteolysis after focal ischemia: When do cells die after experimental stroke?
2. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways
3. Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury
4. The calpain hypothesis of neurodegeneration: Evidence for a common cytotoxic pathway
5. Calpain inhibitor AK295 protects neurons from focal ischemia. Effects of postocclusion intra-arterial administration
6. Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury
7. Effects of multidose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism
8. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury
9. Ultrastructural studies of difuse axonal injury in humans
10. Effect of L-alpha-phosphatidylinositol on a vascular smooth muscle calcium-dependent protease. Reduction of the calcium requirement for autolysis
11. 45Ca autoradiographic study
12. Integrated evaluation of central nervous system lesions: Stains for neurons, astrocytes, and microglia reveal that spatial and temporal features of MK-801-induced neuronal necrosis in the rat cerebral cortex
13. SJA 6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
14. β-amyloid precursor protein (β-APP) as a marker for axonal injury after head injury
15. The use of antibodies against neurofilament subunits for the detection of diffuse axonal injury in humans
16. Antioxidant pharmacotherapy
17. The mouse head injury model: Utility in the discovery of acute cerebroprotective agents
18. Proteolytic processing of human brain alpha spectrin (fodrin), identification of a hypersensitive site
19. Degradation of transcription factors c-jun and c-fos, by calpain
20. Calcium-activated proteolysis in rat neocortex induced by transient focal ischemia
21. μ-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury
22. Mechanisms of calpain proteolysis following traumatic brain injury: Implications for pathology and therapy. A review and update
23. Oxygen radicals in central nervous system damage
24. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia
25. Increased intracellular calpain detection in experimental focal cerebral ischemia
26. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
27. Calpain activation and cytoskeletal protein breakdown in the corpus callosum of head-injured patients
28. Calcium and the pathogenesis of traumatic CNS injury: Cellular and molecular mechanisms
29. 7211
30. Nonerthroid α-spectrin breakdown by calpain and interleukin 1β-converting enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
31. Evidence for activation of caspase-3-like protease in excitotoxin- and hypoxia/hypoglycemia-injured neurons
32. Immunohistochemical study of calpain-mediated breakdown products to (-spectrin following controlled cortical impact injury in the rat
33. 2+levels following cortical compression contusion trauma in rats
34. Calcium activated neutral proteinases as regulators of cellular function. Implications for alzheimers disease pathogenesis
35. Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma
36. Neurofilament 68 and neurofilament 200 protein levels decrease after traumatic brain injury
37. Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: An immunofluorescence study
38. A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
39. Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells
40. Initiating mechanisms involved in the pathobiology of traumatically induced injury and interventions targeted at blunting their progression
41. Calpain activity and translational expression increased in spinal cord injury
42. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
43. Spectrin proteolysis in the hippocampus: A biochemical marker for neuronal injury and neuroprotection
44. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
45. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat
46. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
47. The neuronal cytoskeleton is at risk after mild and moderate brain injury
48. Behavioral efficacy of post traumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis
49. Accumulation of calcium in the brain following head trauma
50. Mini-review: Pathophysiological role of calpain in experimental demyelination
51. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis
52. New era of calpain research: Discovery of tissue-specific calpains
53. Application of silber degeneration stains for neurotoxicity testing
54. Calcium activated neutral protease structure-function relationship and functional implications
55. 2+-dependent processes as mediators of neurotoxicity
56. Calpain and caspase: Can you tell the difference?
57. Calpain inhibition: An overview of its therapeutic potential
58. Calapin substrates, assay methods, regulation and its inhibitory agents
59. An alpha-mercaptoacrylic acid derivative is a selective nonpetptide cell-permeable calpain inhibitor and is neuroprotective
60. Therapeutic potential of calpain inhibitors in neurodegenerative disorders
61. Calpain inhibitors: Novel neuroprotectants and potential anticataract agents