An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 4, 1999, Pages 443-451

  Okonkwo, David O ^a   Povlishock, John T ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclosporin A; Permeability transition; Permeability transition pore; Trauma Neuroprotection Membrane failure

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CYCLOSPORIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN MITOCHONDRION; CONTROLLED STUDY; DRUG EFFECT; MALE; MEMBRANE PERMEABILITY; MITOCHONDRION SWELLING; NERVE FIBER TRANSECTION; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033509493     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199904000-00010     Document Type: Article

References (24)

1. Adams JH, Graham DI, Murray LS, Scott G (1982) Diffuse axonal injury due to nonmissile injury in humans: an analysis of 45 cases. Ann Neurol 12:557-563
2. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15(4):961-973
3. Balakirev M, Khramstov VV, Zimmer G (1997) Modulation of mitochondrial permeability transition by nitric oxide. Eur J Biochem 246:710-718
4. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, et al (1990) Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem 55(4): 1222-1230
5. Buchan A, Pulisinelli WA (1990) Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neuroscience 10(1):311-316
6. Chadhuri B, Stephan C (1995) Only in the presence of immunophilins can cyclosporin and FK506 disrupt in vivo binding of calcineurin A to its autoinhibitory domain yet strengthen interaction between calcineurin A and B subunits. Biochem Biophys Res Commun 215(2):781-790
7. Colicos MA, Dash PK (1996) Apoptotic morphology of dentate gyms granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res 739(1, 2): 120131
8. Colicos MA, Dixon CE, Dash PK (1996) Delayed, selective neuronal death following experimental cortical impact injury in rats: possible role in memory deficits. Brain Res 739(1, 2):111-119
9. Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH (1993) Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci USA 90(21):9808-9812
10. Dawson TM, Steiner JP, Lyons WE, Fotuhi M, Blue M, Snyder SH (1994) The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience 62:569-580
11. Duchen MR, McGuiness O, Brown LA, Crompton M (1993) On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc Res 27:1790-1794
12. Folbergrova J, Li PA, Uchino H, Smith ML, Siesjo BK (1997) Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects. Exp Brain Res 114(1):44-50
13. Gallant PE, Galbraith JA (1997) Axonal structure and function after axolemmal leakage in the squid giant axon. J Neurotrauma 14(11): 811-822
14. Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW (1993) β-Amyloid precursor protein (β-APP) as a marker of axonal injury after head injury. Neurosci Lett 160:139-144
15. George EB, Glass JD, Griffin JW (1995) Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci 15(10):6445-6452
16. Gold BG (1997) FK506 and the role of immunophilins in nerve regeneration. Mol Neurobiol 15(3):285-306
17. Gunter TE, Pfeiffer DR (1990) Mechanisms by which mitochondria transport calcium. Am J Physiol 258(5):C755-C786
18. Halestrap AP, Davidson AM (1990) Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem J 268(1): 153-160
19. Halestrap AP, Conner CP, Griffiths EJ, Kerr PM (1997) Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts form ischemia/reperfusion injury. Mol Cell Biochem 174(1, 2):167-172
20. Li PA, Uchino H, Elmer E, Siesjo BK (1997) Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia. Brain Res 753(1):133140
21. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66(4):807-815
22. LoPachin RM, Lehning EJ (1997) Mechanisms of calcium entry during axon injury and degeneration. Tox and Appl Pharm 143:233-244
23. LoPachin RM, Stys PK (1995) Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation. J Neurosci 15:6735-6746
24. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K (1994) A new model of diffuse brain injury in rats. Part I. Pathophysiology and biomechanics. J Neurosurg 80(2): 291-300