Prediction of aggregation prone regions of therapeutic proteins

Journal of Physical Chemistry B

Volumn 114, Issue 19, 2010, Pages 6614-6624

  Chennamsetty, Naresh ^a,b   Voynov, Vladimir ^a,b   Kayser, Veysel ^a,b   Helk, Bernhard ^a,b   Trout, Bernhardt L ^a,b  

^a USA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPUTER SIMULATION; PHOSPHATASES; PHOTODEGRADATION; STABILITY;

ANTIBODY AGGREGATION; ANTIBODY FRAGMENT; ATOMISTIC SIMULATIONS; CUMULATIVE EFFECTS; DEVELOPABILITY; DYNAMIC EXPOSURE; ENHANCED STABILITY; GLUTAMIC ACID; HIGH-THROUGHPUT; HOMOLOGY MODELING; HYDROPHOBIC PATCH; IMPLICIT SOLVENT MODEL; PARAMETER RANGE; PROTEIN ACTIVITY; PROTEIN STABILITY; RHEUMATOID ARTHRITIS; SAP TECHNOLOGY; STATIC STRUCTURES; THERAPEUTIC PROTEIN;

ANTIBODIES;

EID: 77952467953     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp911706q     Document Type: Article

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