Novel anthraquinone derivatives: Synthesis via click chemistry approach and their induction of apoptosis in BGC gastric cancer cells via reactive oxygen species(ROS)-dependent mitochondrial pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6505-6508

  Wang, Shaoru ^a   Wang, Qilong ^b   Wang, Yan ^b   Liu, Lin ^a   Weng, Xiaocheng ^a   Li, Guorui ^a   Zhang, Xiaolian ^b   Zhou, Xiang ^a,b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Anthraquinone; Apoptosis; Induction; Mitochondrial; Oxygen species

Indexed keywords

ANTHRAQUINONE DERIVATIVE; CYTOCHROME C; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CYTOPLASM; DRUG DESIGN; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PERMEABILITY; REACTIVE OXYGEN SPECIES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 56249112956     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.047     Document Type: Article

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