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Volumn 27, Issue 12, 2009, Pages 3093-3102

MiR-21 regulates adipogenic differentiation through the modulation of TGF-β signaling in mesenchymal stem cells derived from human adipose tissue

Author keywords

Adipogenic differentiation; Human adipose tissue derived mesenchymal stem cells; MicroRNA; MicroRNA 21; TGF

Indexed keywords

COMPLEMENTARY RNA; LUCIFERASE; MICRORNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 73349117464     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.235     Document Type: Article
Times cited : (338)

References (43)
  • 2
    • 0027751663 scopus 로고
    • The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 3
    • 0347357618 scopus 로고    scopus 로고
    • A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
    • Johnston RJ, Hobert O. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature 2003;426:845-849.
    • (2003) Nature , vol.426 , pp. 845-849
    • Johnston, R.J.1    Hobert, O.2
  • 4
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs-microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack F Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.2
  • 5
    • 40749111551 scopus 로고    scopus 로고
    • Skin microRNA promotes differentiation by repressing 'stemness'
    • Yi R, Poy MN, Stoffel M et al. Skin microRNA promotes differentiation by repressing 'stemness'. Nature 2008;452:225-229.
    • (2008) Nature , vol.452 , pp. 225-229
    • Yi, R.1    Poy, M.N.2    Stoffel, M.3
  • 6
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu N, Papagiannakopoulos T, Pan G et al. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009;137(4):606-608.
    • (2009) Cell , vol.137 , Issue.4 , pp. 606-608
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3
  • 7
    • 10344243662 scopus 로고    scopus 로고
    • MicroRNA-143 regulates adipocyte differentiation
    • Esau C, Kang X, Peralta E et al. MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 2004;279:52361-52365.
    • (2004) J Biol Chem , vol.279 , pp. 52361-52365
    • Esau, C.1    Kang, X.2    Peralta, E.3
  • 8
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-6033.
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 9
    • 58649087374 scopus 로고    scopus 로고
    • miR-21: A small multi-faceted RNA
    • Krichevsky AM, Gabriely G. miR-21: A small multi-faceted RNA. J Cell Mol Med 2009;13(1):39-53.
    • (2009) J Cell Mol Med , vol.13 , Issue.1 , pp. 39-53
    • Krichevsky, A.M.1    Gabriely, G.2
  • 10
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133(2):647-658.
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3
  • 11
    • 42549169404 scopus 로고    scopus 로고
    • miR-21 microRNA expression in human gastric carcinomas and its clinical association
    • Chan SH, Wu CW, Li AF et al. miR-21 microRNA expression in human gastric carcinomas and its clinical association. Anticancer Res 2008;28(2A):907-911.
    • (2008) Anticancer Res , vol.28 , Issue.2 A , pp. 907-911
    • Chan, S.H.1    Wu, C.W.2    Li, A.F.3
  • 12
    • 34548746977 scopus 로고    scopus 로고
    • MicroRNA signatures in human ovarian cancer
    • Iorio MV, Visone R, Di Leva G et al. MicroRNA signatures in human ovarian cancer. Cancer Res 2007;67(18):8699-8707.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8699-8707
    • Iorio, M.V.1    Visone, R.2    Di Leva, G.3
  • 13
    • 50849137458 scopus 로고    scopus 로고
    • MicroRNA expression profiles in serous ovarian carcinoma
    • Nam EJ, Yoon H, Kim SW et al. MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 2008;14(9):2690-2695.
    • (2008) Clin Cancer Res , vol.14 , Issue.9 , pp. 2690-2695
    • Nam, E.J.1    Yoon, H.2    Kim, S.W.3
  • 14
    • 34447134869 scopus 로고    scopus 로고
    • Patterns of known and novel small RNAs in human cervical cancer
    • Lui WO, Pourmand N, Patterson BK et al. Patterns of known and novel small RNAs in human cervical cancer. Cancer Res 2007;67(13):6031-6043.
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6031-6043
    • Lui, W.O.1    Pourmand, N.2    Patterson, B.K.3
  • 15
    • 34248187964 scopus 로고    scopus 로고
    • MicroRNA expression profiles in head and neck cancer cell lines
    • Tran N, McLean T, Zhang X et al. MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007;358(1):12-17.
    • (2007) Biochem Biophys Res Commun , vol.358 , Issue.1 , pp. 12-17
    • Tran, N.1    McLean, T.2    Zhang, X.3
  • 16
    • 68149170082 scopus 로고    scopus 로고
    • Analysis of deregulated miRNAs is helpful to distinguish poorly differentiated thyroid carcinoma from papillary thyroid carcinoma
    • Schwertheim S, Sheu SY, Worm K et al. Analysis of deregulated miRNAs is helpful to distinguish poorly differentiated thyroid carcinoma from papillary thyroid carcinoma. Horm Metab Res 2009;41(6):475-481.
    • (2009) Horm Metab Res , vol.41 , Issue.6 , pp. 475-481
    • Schwertheim, S.1    Sheu, S.Y.2    Worm, K.3
  • 17
    • 34447318648 scopus 로고    scopus 로고
    • MicroRNAs are aberrantly expressed in hypertrophic heart: Do they play a role in cardiac hypertrophy?
    • Cheng Y, Ji R, Yue J et al. MicroRNAs are aberrantly expressed in hypertrophic heart: Do they play a role in cardiac hypertrophy? Am J Pathol 2007;170(6):1831-1840.
    • (2007) Am J Pathol , vol.170 , Issue.6 , pp. 1831-1840
    • Cheng, Y.1    Ji, R.2    Yue, J.3
  • 18
    • 34249729491 scopus 로고    scopus 로고
    • Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
    • Tatsuguchi M, Seok HY, Callis TE et al. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 2007;42(6):1137-1141.
    • (2007) J Mol Cell Cardiol , vol.42 , Issue.6 , pp. 1137-1141
    • Tatsuguchi, M.1    Seok, H.Y.2    Callis, T.E.3
  • 19
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    • van Rooij E, Sutherland LB, Liu N et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006;103(48):18255-18260.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.48 , pp. 18255-18260
    • van Rooij, E.1    Sutherland, L.B.2    Liu, N.3
  • 20
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    • Ji R, Cheng Y, Yue J et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 2007;100(11):1579-1588.
    • (2007) Circ Res , vol.100 , Issue.11 , pp. 1579-1588
    • Ji, R.1    Cheng, Y.2    Yue, J.3
  • 21
    • 58149352800 scopus 로고    scopus 로고
    • An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation
    • Talotta F, Cimmino A, Matarazzo MR et al. An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene 2009;28(1):73-84.
    • (2009) Oncogene , vol.28 , Issue.1 , pp. 73-84
    • Talotta, F.1    Cimmino, A.2    Matarazzo, M.R.3
  • 22
  • 23
    • 54849412067 scopus 로고    scopus 로고
    • Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells
    • Chen A, Luo M, Yuan G et al. Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells. Biotechnol Lett 2008;30(12):2045-2052.
    • (2008) Biotechnol Lett , vol.30 , Issue.12 , pp. 2045-2052
    • Chen, A.1    Luo, M.2    Yuan, G.3
  • 24
    • 54249136806 scopus 로고    scopus 로고
    • MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    • Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008;68(19):8164-8172.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 8164-8172
    • Papagiannakopoulos, T.1    Shapiro, A.2    Kosik, K.S.3
  • 25
    • 0342542810 scopus 로고
    • Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts
    • Ignotz RA, Massagué J. Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc Natl Acad Sci U S A 1985;82(24):8530-8534.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , Issue.24 , pp. 8530-8534
    • Ignotz, R.A.1    Massagué, J.2
  • 26
    • 0022474418 scopus 로고
    • Transforming growth factor type beta is a specific inhibitor of 3T3 T mesenchymal stem cell differentiation
    • Sparks RL, Scott RE. Transforming growth factor type beta is a specific inhibitor of 3T3 T mesenchymal stem cell differentiation. Exp Cell Res 1986;165(2):345-352.
    • (1986) Exp Cell Res , vol.165 , Issue.2 , pp. 345-352
    • Sparks, R.L.1    Scott, R.E.2
  • 27
    • 0024566348 scopus 로고
    • Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta
    • Torti FM, Torti SV, Larrick JW et al. Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta. J Cell Biol 1989;108(3):1105-1113.
    • (1989) J Cell Biol , vol.108 , Issue.3 , pp. 1105-1113
    • Torti, F.M.1    Torti, S.V.2    Larrick, J.W.3
  • 28
    • 0028001051 scopus 로고
    • Transforming growth factor beta (TGF-beta) inhibits the differentiation of human adipocyte precursor cells in primary culture
    • Petruschke T, Röhrig K, Hauner H. Transforming growth factor beta (TGF-beta) inhibits the differentiation of human adipocyte precursor cells in primary culture. Int J Obes Relat Metab Disord 1994;18(8):532-536.
    • (1994) Int J Obes Relat Metab Disord , vol.18 , Issue.8 , pp. 532-536
    • Petruschke, T.1    Röhrig, K.2    Hauner, H.3
  • 29
    • 0031454239 scopus 로고    scopus 로고
    • Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice
    • Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest 1997;100(11):2697-2713.
    • (1997) J Clin Invest , vol.100 , Issue.11 , pp. 2697-2713
    • Clouthier, D.E.1    Comerford, S.A.2    Hammer, R.E.3
  • 30
    • 18744373595 scopus 로고    scopus 로고
    • Human adipose tissue is a source of multipotent stem cells
    • Zuk PA, Zhu M, Ashjian P et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295.
    • (2002) Mol Biol Cell , vol.13 , pp. 4279-4295
    • Zuk, P.A.1    Zhu, M.2    Ashjian, P.3
  • 31
    • 14544305075 scopus 로고    scopus 로고
    • The human adipose tissue is a source of multipotent stem cells
    • Rodriguez AM, Elabd C, Amri EZ et al. The human adipose tissue is a source of multipotent stem cells. Biochimie 2005;87:125-128.
    • (2005) Biochimie , vol.87 , pp. 125-128
    • Rodriguez, A.M.1    Elabd, C.2    Amri, E.Z.3
  • 32
    • 1342310860 scopus 로고    scopus 로고
    • Differentiation potential of adipose derived adult stem (ADAS) cells
    • Gimble JM, Guilak F. Differentiation potential of adipose derived adult stem (ADAS) cells. Curr Top Dev Biol 2003;58:137-160.
    • (2003) Curr Top Dev Biol , vol.58 , pp. 137-160
    • Gimble, J.M.1    Guilak, F.2
  • 33
    • 35848934162 scopus 로고    scopus 로고
    • Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia
    • Kim YJ, Kim HK, Cho HH et al. Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia. Cell Physiol Biochem 2007;20:867-876.
    • (2007) Cell Physiol Biochem , vol.20 , pp. 867-876
    • Kim, Y.J.1    Kim, H.K.2    Cho, H.H.3
  • 34
    • 65949105697 scopus 로고    scopus 로고
    • miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue
    • Kim YJ, Bae SW, Yu SS et al. miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res 2009;24(5):816-825.
    • (2009) J Bone Miner Res , vol.24 , Issue.5 , pp. 816-825
    • Kim, Y.J.1    Bae, S.W.2    Yu, S.S.3
  • 35
    • 16844373628 scopus 로고    scopus 로고
    • Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    • Forrester E, Chytil A, Bierie B et al. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 2005;65(6):2296-2302.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2296-2302
    • Forrester, E.1    Chytil, A.2    Bierie, B.3
  • 36
    • 67649610073 scopus 로고    scopus 로고
    • TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta
    • Rojas A, Padidam M, Cress D et al. TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta. Biochim Biophys Acta 2009;1793(7):1165-1173.
    • (2009) Biochim Biophys Acta , vol.1793 , Issue.7 , pp. 1165-1173
    • Rojas, A.1    Padidam, M.2    Cress, D.3
  • 38
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390(6659):465-471.
    • (1997) Nature , vol.390 , Issue.6659 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 39
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massagué J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 40
    • 65549154497 scopus 로고    scopus 로고
    • Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells
    • Yang J, Wahdan-Alaswad R, Danielpour D. Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells. Cancer Res 2009;69(6):2185-2190.
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2185-2190
    • Yang, J.1    Wahdan-Alaswad, R.2    Danielpour, D.3
  • 41
    • 33646794060 scopus 로고    scopus 로고
    • Essential role of Smad3 in angiotensin II-induced vascular fibrosis
    • Wang W, Huang XR, Canlas E et al. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 2006;98(8):1032-1039.
    • (2006) Circ Res , vol.98 , Issue.8 , pp. 1032-1039
    • Wang, W.1    Huang, X.R.2    Canlas, E.3
  • 42
    • 26244439497 scopus 로고    scopus 로고
    • The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3
    • Kim SG, Kim HA, Jong HS et al. The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3. Mol Biol Cell 2005;16(10):4672- 4683.
    • (2005) Mol Biol Cell , vol.16 , Issue.10 , pp. 4672-4683
    • Kim, S.G.1    Kim, H.A.2    Jong, H.S.3
  • 43
    • 0034194304 scopus 로고    scopus 로고
    • Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation
    • Choy L, Skillington J, Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 2000;149(3):667-682.
    • (2000) J Cell Biol , vol.149 , Issue.3 , pp. 667-682
    • Choy, L.1    Skillington, J.2    Derynck, R.3


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