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Volumn 19, Issue 9, 2011, Pages 435-440

HIV-Nef and AIDS pathogenesis: Are we barking up the wrong tree?

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; ESCRT PROTEIN; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEF PROTEIN;

EID: 80052161955     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2011.06.002     Document Type: Review
Times cited : (22)

References (60)
  • 1
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • Kestler H.W., et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991, 65:651-662.
    • (1991) Cell , vol.65 , pp. 651-662
    • Kestler, H.W.1
  • 2
    • 0028804160 scopus 로고
    • Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
    • Deacon N.J., et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995, 270:988-991.
    • (1995) Science , vol.270 , pp. 988-991
    • Deacon, N.J.1
  • 3
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • Silvestri G., et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003, 18:441-452.
    • (2003) Immunity , vol.18 , pp. 441-452
    • Silvestri, G.1
  • 4
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • Hanna Z., et al. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998, 95:163-175.
    • (1998) Cell , vol.95 , pp. 163-175
    • Hanna, Z.1
  • 5
    • 0037302331 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
    • Stoddart C.A., et al. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J. Virol. 2003, 77:2124-2133.
    • (2003) J. Virol. , vol.77 , pp. 2124-2133
    • Stoddart, C.A.1
  • 6
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • Iafrate A.J., et al. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J. Virol. 2000, 74:9836-9844.
    • (2000) J. Virol. , vol.74 , pp. 9836-9844
    • Iafrate, A.J.1
  • 7
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • Garcia J.V., Miller A.D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 1991, 350:508-511.
    • (1991) Nature , vol.350 , pp. 508-511
    • Garcia, J.V.1    Miller, A.D.2
  • 8
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    • Schwartz O., et al. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 1996, 2:338-342.
    • (1996) Nat. Med. , vol.2 , pp. 338-342
    • Schwartz, O.1
  • 9
    • 0032999976 scopus 로고    scopus 로고
    • The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors
    • Piguet V., et al. The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol. Rev. 1999, 168:51-63.
    • (1999) Immunol. Rev. , vol.168 , pp. 51-63
    • Piguet, V.1
  • 10
    • 38349127341 scopus 로고    scopus 로고
    • Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit
    • Noviello C.M., et al. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J. Virol. 2008, 82:1249-1258.
    • (2008) J. Virol. , vol.82 , pp. 1249-1258
    • Noviello, C.M.1
  • 11
    • 0028200761 scopus 로고
    • Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
    • Rhee S.S., Marsh J.W. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. J. Virol. 1994, 68:5156-5163.
    • (1994) J. Virol. , vol.68 , pp. 5156-5163
    • Rhee, S.S.1    Marsh, J.W.2
  • 12
    • 50849129910 scopus 로고    scopus 로고
    • HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    • Schaefer M.R., et al. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS. Pathog. 2008, 4:e1000131.
    • (2008) PLoS. Pathog. , vol.4
    • Schaefer, M.R.1
  • 13
    • 67449092266 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway
    • daSilva L.L., et al. Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway. J. Virol. 2009, 83:6578-6590.
    • (2009) J. Virol. , vol.83 , pp. 6578-6590
    • daSilva, L.L.1
  • 14
    • 20044362379 scopus 로고    scopus 로고
    • Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
    • Madrid R., et al. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J. Biol. Chem. 2005, 280:5032-5044.
    • (2005) J. Biol. Chem. , vol.280 , pp. 5032-5044
    • Madrid, R.1
  • 15
    • 0344875506 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase
    • Stumptner-Cuvelette P., et al. Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol. Biol. Cell 2003, 14:4857-4870.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 4857-4870
    • Stumptner-Cuvelette, P.1
  • 16
    • 0030587831 scopus 로고    scopus 로고
    • Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef
    • Gratton S., et al. Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef. J. Immunol. 1996, 157:3305-3311.
    • (1996) J. Immunol. , vol.157 , pp. 3305-3311
    • Gratton, S.1
  • 17
    • 67650410034 scopus 로고    scopus 로고
    • Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase
    • Laguette N., et al. Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase. J. Virol. 2009, 83:7117-7128.
    • (2009) J. Virol. , vol.83 , pp. 7117-7128
    • Laguette, N.1
  • 18
    • 33646552033 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    • Thoulouze M.I., et al. Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 2006, 24:547-561.
    • (2006) Immunity , vol.24 , pp. 547-561
    • Thoulouze, M.I.1
  • 19
    • 69949128211 scopus 로고    scopus 로고
    • Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells
    • Muratori C., et al. Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe 2009, 6:218-230.
    • (2009) Cell Host Microbe , vol.6 , pp. 218-230
    • Muratori, C.1
  • 20
    • 23844471509 scopus 로고    scopus 로고
    • Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta
    • Stove V., et al. Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. J. Virol. 2005, 79:11422-11433.
    • (2005) J. Virol. , vol.79 , pp. 11422-11433
    • Stove, V.1
  • 21
    • 33746582688 scopus 로고    scopus 로고
    • The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling
    • Michel N., et al. The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol. Biol. Cell 2006, 17:3578-3590.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3578-3590
    • Michel, N.1
  • 22
    • 0027179109 scopus 로고
    • Endocytic regulation of the T lymphocyte co-receptor proteins CD4 and CD8
    • Marsh M., et al. Endocytic regulation of the T lymphocyte co-receptor proteins CD4 and CD8. Biochem. Soc. Trans. 1993, 21:703-706.
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 703-706
    • Marsh, M.1
  • 23
    • 0030887932 scopus 로고    scopus 로고
    • The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
    • Baur A.S., et al. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 1997, 6:283-291.
    • (1997) Immunity , vol.6 , pp. 283-291
    • Baur, A.S.1
  • 24
    • 0042174019 scopus 로고    scopus 로고
    • Protein sorting into multivesicular endosomes
    • Raiborg C., et al. Protein sorting into multivesicular endosomes. Curr. Opin. Cell Biol. 2003, 15:446-455.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 446-455
    • Raiborg, C.1
  • 25
    • 50949130687 scopus 로고    scopus 로고
    • Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
    • Jin Y.J., et al. Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation. J. Immunol. 2008, 180:7878-7886.
    • (2008) J. Immunol. , vol.180 , pp. 7878-7886
    • Jin, Y.J.1
  • 26
    • 28844495621 scopus 로고    scopus 로고
    • Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling
    • Simmons A., et al. Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling. Immunity 2005, 23:621-634.
    • (2005) Immunity , vol.23 , pp. 621-634
    • Simmons, A.1
  • 27
    • 18844453211 scopus 로고    scopus 로고
    • Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes
    • Yang P., Henderson A.J. Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. Virology 2005, 336:219-228.
    • (2005) Virology , vol.336 , pp. 219-228
    • Yang, P.1    Henderson, A.J.2
  • 28
    • 0242333900 scopus 로고    scopus 로고
    • Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells
    • Fomina A.F., et al. Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells. Exp. Cell Res. 2003, 291:150-166.
    • (2003) Exp. Cell Res. , vol.291 , pp. 150-166
    • Fomina, A.F.1
  • 29
    • 77951918362 scopus 로고    scopus 로고
    • Identification of the switch in early-to-late endosome transition
    • Poteryaev D., et al. Identification of the switch in early-to-late endosome transition. Cell 2010, 141:497-508.
    • (2010) Cell , vol.141 , pp. 497-508
    • Poteryaev, D.1
  • 30
    • 36048947746 scopus 로고    scopus 로고
    • Regulated secretion from CD4+ T cells
    • Jolly C., Sattentau Q.J. Regulated secretion from CD4+ T cells. Trends Immunol. 2007, 28:474-481.
    • (2007) Trends Immunol. , vol.28 , pp. 474-481
    • Jolly, C.1    Sattentau, Q.J.2
  • 31
    • 33746907799 scopus 로고    scopus 로고
    • Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1
    • Costa L.J., et al. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1. Retrovirology 2006, 3:33.
    • (2006) Retrovirology , vol.3 , pp. 33
    • Costa, L.J.1
  • 32
    • 0037074008 scopus 로고    scopus 로고
    • HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway
    • Blagoveshchenskaya A.D., et al. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell 2002, 111:853-866.
    • (2002) Cell , vol.111 , pp. 853-866
    • Blagoveshchenskaya, A.D.1
  • 33
    • 0038342442 scopus 로고    scopus 로고
    • HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    • Swingler S., et al. HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 2003, 424:213-219.
    • (2003) Nature , vol.424 , pp. 213-219
    • Swingler, S.1
  • 34
    • 0032845027 scopus 로고    scopus 로고
    • HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
    • 997-103
    • Swingler S., et al. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat. Med. 1999, 5. 997-103.
    • (1999) Nat. Med. , vol.5
    • Swingler, S.1
  • 35
    • 79951687153 scopus 로고    scopus 로고
    • HIV type 1 Nef is released from infected cells in CD45+ microvesicles and is present in the plasma of HIV-infected individuals
    • Raymond A.D., et al. HIV type 1 Nef is released from infected cells in CD45+ microvesicles and is present in the plasma of HIV-infected individuals. AIDS Res. Hum. Retroviruses 2010, 27:167-178.
    • (2010) AIDS Res. Hum. Retroviruses , vol.27 , pp. 167-178
    • Raymond, A.D.1
  • 36
    • 71849085384 scopus 로고    scopus 로고
    • HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells
    • Lenassi M., et al. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic 2010, 11:110-122.
    • (2010) Traffic , vol.11 , pp. 110-122
    • Lenassi, M.1
  • 37
    • 0346601814 scopus 로고    scopus 로고
    • The physiological relevance of CD4 receptor down-modulation during HIV infection
    • Lama J. The physiological relevance of CD4 receptor down-modulation during HIV infection. Curr. HIV Res. 2003, 1:167-184.
    • (2003) Curr. HIV Res. , vol.1 , pp. 167-184
    • Lama, J.1
  • 38
    • 0034795885 scopus 로고    scopus 로고
    • CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4+ T-cell depletion in human lymphoid tissue ex vivo
    • Glushakova S., et al. CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4+ T-cell depletion in human lymphoid tissue ex vivo. J. Virol. 2001, 75:10113-10117.
    • (2001) J. Virol. , vol.75 , pp. 10113-10117
    • Glushakova, S.1
  • 39
    • 78651244198 scopus 로고    scopus 로고
    • CD4 down-regulation by the HIV-1 nef protein is dispensable for optimal output and functionality of viral particles in primary T cells
    • Neri F., et al. CD4 down-regulation by the HIV-1 nef protein is dispensable for optimal output and functionality of viral particles in primary T cells. J. Gen. Virol. 2010, 92:141-150.
    • (2010) J. Gen. Virol. , vol.92 , pp. 141-150
    • Neri, F.1
  • 40
    • 33644862821 scopus 로고    scopus 로고
    • Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein
    • Sandrin V., Cosset F.L. Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein. J. Biol. Chem. 2006, 281:528-542.
    • (2006) J. Biol. Chem. , vol.281 , pp. 528-542
    • Sandrin, V.1    Cosset, F.L.2
  • 41
    • 2542492063 scopus 로고    scopus 로고
    • HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. A model for the Nef-dependent increase of HIV-1 infectivity
    • Schiavoni I., et al. HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. A model for the Nef-dependent increase of HIV-1 infectivity. J. Biol. Chem. 2004, 279:22996-23006.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22996-23006
    • Schiavoni, I.1
  • 42
    • 0029046227 scopus 로고
    • Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef
    • Goldsmith M.A., et al. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 1995, 69:4112-4121.
    • (1995) J. Virol. , vol.69 , pp. 4112-4121
    • Goldsmith, M.A.1
  • 43
    • 0029045360 scopus 로고
    • Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
    • Schwartz O., et al. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J. Virol. 1995, 69:4053-4059.
    • (1995) J. Virol. , vol.69 , pp. 4053-4059
    • Schwartz, O.1
  • 44
    • 33745070227 scopus 로고    scopus 로고
    • Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
    • Schindler M., et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006, 125:1055-1067.
    • (2006) Cell , vol.125 , pp. 1055-1067
    • Schindler, M.1
  • 46
    • 72849136276 scopus 로고    scopus 로고
    • Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression
    • Feldmann J., et al. Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression. J. Virol. 2009, 83:12968-12972.
    • (2009) J. Virol. , vol.83 , pp. 12968-12972
    • Feldmann, J.1
  • 47
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins K.L., et al. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 1998, 391:397-401.
    • (1998) Nature , vol.391 , pp. 397-401
    • Collins, K.L.1
  • 48
    • 33846009745 scopus 로고    scopus 로고
    • CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable
    • Agopian K., et al. CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology 2007, 358:119-135.
    • (2007) Virology , vol.358 , pp. 119-135
    • Agopian, K.1
  • 49
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
    • Sykulev Y., et al. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 1996, 4:565-571.
    • (1996) Immunity , vol.4 , pp. 565-571
    • Sykulev, Y.1
  • 50
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • Zitvogel L., et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 1998, 4:594-600.
    • (1998) Nat. Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1
  • 51
    • 33745424807 scopus 로고    scopus 로고
    • Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model
    • Peche H., et al. Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model. Am. J. Transplant. 2006, 6:1541-1550.
    • (2006) Am. J. Transplant. , vol.6 , pp. 1541-1550
    • Peche, H.1
  • 52
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M., et al. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS. ONE 2010, 5:e11469.
    • (2010) PLoS. ONE , vol.5
    • Szajnik, M.1
  • 53
    • 34848861342 scopus 로고    scopus 로고
    • MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner
    • Kim S.H., et al. MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J. Immunol. 2007, 179:2235-2241.
    • (2007) J. Immunol. , vol.179 , pp. 2235-2241
    • Kim, S.H.1
  • 54
    • 0032974475 scopus 로고    scopus 로고
    • Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells
    • Bossi G., Griffiths G.M. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells. Nat. Med. 1999, 5:90-96.
    • (1999) Nat. Med. , vol.5 , pp. 90-96
    • Bossi, G.1    Griffiths, G.M.2
  • 55
    • 0030744349 scopus 로고    scopus 로고
    • Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells
    • Xu X.N., et al. Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J. Exp. Med. 1997, 186:7-16.
    • (1997) J. Exp. Med. , vol.186 , pp. 7-16
    • Xu, X.N.1
  • 56
    • 17444407451 scopus 로고    scopus 로고
    • The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    • Andersson J., et al. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J. Immunol. 2005, 174:3143-3147.
    • (2005) J. Immunol. , vol.174 , pp. 3143-3147
    • Andersson, J.1
  • 57
    • 78650907444 scopus 로고    scopus 로고
    • HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?
    • Lamers S.L., et al. HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?. Curr. HIV Res. 2010, 8:638-640.
    • (2010) Curr. HIV Res. , vol.8 , pp. 638-640
    • Lamers, S.L.1
  • 58
    • 33645288761 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells
    • Qiao X., et al. Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat. Immunol. 2006, 7:302-310.
    • (2006) Nat. Immunol. , vol.7 , pp. 302-310
    • Qiao, X.1
  • 59
    • 78650156338 scopus 로고    scopus 로고
    • Trophoblast-derived exosomes mediate monocyte recruitment and differentiation
    • Atay S., et al. Trophoblast-derived exosomes mediate monocyte recruitment and differentiation. Am. J. Reprod. Immunol. 2011, 65:65-77.
    • (2011) Am. J. Reprod. Immunol. , vol.65 , pp. 65-77
    • Atay, S.1
  • 60
    • 78149360255 scopus 로고    scopus 로고
    • Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis
    • Qazi K.R., et al. Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. Thorax 2010, 65:1016-1024.
    • (2010) Thorax , vol.65 , pp. 1016-1024
    • Qazi, K.R.1


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