Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

Immunity

Volumn 4, Issue 6, 1996, Pages 565-571

  Sykulev, Yuri ^a   Joo, Michael ^a   Vturina, Irina ^a   Tsomides, Theodore J ^a   Eisen, Herman N ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISOTOPE LABELING; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0030176270     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80483-5     Document Type: Article

References (37)

1. Alexander, J., Payne, J.A., Murray, R., Frelinger, J.A. and Cresswell, P. (1989). Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics 29, 380-388.
2. Ashton-Rickardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R.M., and Tonegawa, S. (1994). Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-663.
3. Bednarek, M.A., Sauma, S.Y., Gammon, M.C., Porter, G., Tamhankar, S., Williamson, A.R.,and Zweerink, H.J. (1991). The minimum peptide epitope from the influenza virus matrix protein: extra and intracellular loading of HLA-A2. J. Immunol. 147, 4047-4053.
4. Bouvier, M., and Wiley, D.C. (1994). Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules. Science 265, 398-402.
5. Brodsky, F.M., Parham, P., Barnstable, C.J., Crumpton, M.J., and Bodmer, W.F. (1979). Monoclonal antibodies for analysis of the HLA system. Immunol. Rev. 47, 3-61.
6. + CTL. Mol. Immunol. 31, 1285-1293.
7. Christinck, E.R., Luscher, M.A., Barber, B.H., and Williams, D.B. (1991). Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature 352, 67-70.
8. Corr, M., Slanetz, A.E., Boyd, L.F., Jelonek, M.T., Khilko, S., Al-Ramadi, B.K., Kim, Y.S., Maher, S.E., Bothwell, A.L.M., and Margulies, D.H. (1994). T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science 265, 946-949.
9. Demotz, S., Grey, H.M., and Sette, A. (1990). The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 249, 1028-1030.
10. Dutz, J.P., Walden, P.R., and Eisen, H.N. (1992). Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes. Int. Immunol. 4, 571-580.
11. Fields, B.A., Ober, B., Malchiodi, E.L. Lebedeva, M.I., Braden, B.C., Ysern, X., Kim, J.-K., Shao, X., Ward, E.S., and Mariuzza, R.A. (1995). Crystal structure of the Vα domain of a T cell antigen receptor. Science 270, 1821-1824.
12. Harding, C.V., and Unanue, E.R. (1990). Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346, 574-576.
13. Heemels, M.-T., and Ploegh, H.L. (1995). Generation, translocation, and presentation of MHC class-I restricted peptides. Annu. Rev. Biochem. 64, 463-491.
14. Kageyama, S., Tsomides, T.J., Sykulev, Y., and Eisen, H.N. (1995). Variations in the number of pepMHC class I complexes required to activate cytotoxic T cell responses. J. Immunol. 154, 567-576.
15. Kranz, D.M., Sherman, D.H., Sitkovsky, M.V., Pasternack, M.S., and Eisen, H.N. (1984). Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc. Natl. Acad. Sci. USA 81, 573-577.
16. d class I MHC molecule. Nature 344, 439-441.
17. k complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91, 12862-12866.
18. Morrison, J., Elvin, J., Latron, F., Gotch, F., Moots, R., Strominger, J.L., and McMichael, A. (1992). Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes. Eur. J. Immunol. 22, 903-907.
19. Oettgen, H.C., Terhorst, C., Cantley, L.C., and Rosoff, P.M. (1985). Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell 40, 583-590.
20. + T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251, 1228-1231.
21. d antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J. Immunol. 125, 2473-2477.
22. Reddehase, M.J., Rothbard, J.B., and Koszinowski, U.H. (1989). A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes. Nature 337, 651-653.
23. Rojo, J.M., and Janeway, C.A., Jr. (1988). The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized. J. Immunol. 140, 1081-1088.
24. Schumacher, T.N.M., and Tsomides, T.J. (1995). In vitro radiolabeling of peptides and proteins. In Current Protocols in Protein Science, J.E. Coligan, B.M. Dunn, H.L. Ploegh, D.W. Speicher, and P.T. Wingfield, eds. (New York: John Wiley and Sons), pp. 3.3.1-3.3.19.
25. Stanfield, R.L., Takimoto-Kamimura, M., Rini, J.M., Profy, A.T., and Wilson, I.A. (1993). Major antigen-induced domain rearrangements in an antibody. Structure 1, 83-93.
26. Sykulev, Y., Brunmark, A., Jackson, M., Cohen, R.J., Peterson, P.A., and Eisen, H.N. (1994a). Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1, 15-22.
27. Sykulev, Y., Brunmark, A., Tsomides., T.J., Kageyama, S., Jackson, M., Peterson, P.A., and Eisen, H.N. (1994b). High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91, 11487-11491.
28. + cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 92, 11990-11992.
29. Symer, D.E., Dintzis, R.Z., Diamond, D.J., and Dintzis, H.M. (1992). Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays. J. Exp. Med. 176, 1421-1430.
30. Tamura, T., and Nariuchi, H. (1992). T cell activation through TCR/-CD3 complex: IL-2 production of T cell clones stimulated with anti-CD3 without cross-linkage. J. Immunol. 148, 2370-2377.
31. Tsomides, T.J., and Eisen, H.N. (1993). Stoichiometric labeling of peptides by iodination on tyrosyl or histidyl residues. Anal. Biochem 210, 129-135.
32. Tsomides, T.J., Aldovini, A., Johnson, R.P., Walker, B.D., Young, R.A., and Eisen, H.N. (1994). Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180, 1283-1293.
33. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69, 989-998.
34. + T-cell clone. Proc. Natl. Acad. Sci. USA 90, 11272-11276.
35. Valitutti, S., Müller, S., Cella, M., Padovan, E., and Lanzavecchia, A. (1995). Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151.
36. Williams, A.F., and Beyers, A.D. (1992). At grips with interactions. Nature 356, 746-747.
37. Zychlinsky, A., Zheng, L.M., Liu, C.-C., and Young, J.D.-E. (1991). Cytolytic lymphocytes induce both apoptosis and necrosis in target cells. J. Immunol. 146, 393-400.