Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression

Journal of Virology

Volumn 83, Issue 24, 2009, Pages 12968-12972

  Feldmann, Jérôme ^a,b   Leligdowicz, Aleksandra ^a   Jaye, Assan ^a   Dong, Tao ^b   Whittle, Hilton ^a   Rowland Jones, Sarah L ^a,b  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; HLA DR ANTIGEN; NEF PROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNITY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; VIRUS ISOLATION; VIRUS LOAD; VIRUS STRAIN;

ADULT; AGED; AGED, 80 AND OVER; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RECEPTORS, ANTIGEN, T-CELL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 72849136276     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01252-09     Document Type: Article

References (27)

1. Bell, I., C. Ashman, J. Maughan, E. Hooker, F. Cook, and T. A. Reinhart. 1998. Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation. J. Gen. Virol. 79:2717-2727.
2. Berry, N., S. Jaffar, M. Schim van der Loeff, K. Ariyoshi, E. Harding, P. T. N'Gom, F. Dias, A. Wilkins, D. Ricard, P. Aaby, R. Tedder, and H. Whittle. 2002. Low level viremia and high CD4% predict normal survival in a cohort of HIV type-2-infected villagers. AIDS Res. Hum. Retrovir. 18:1167-1173.
3. Clamp, M., J. Cuff, S. M. Searle, and G. J. Barton. 2004. The Jalview Java alignment editor. Bioinformatics 20:426-427.
4. Clerici, M., S. Butto, M. Lukwiya, M. Saresella, S. Declich, D. Trabattoni, C. Pastori, S. Piconi, C. Fracasso, M. Fabiani, P. Ferrante, G. Rizzardini, L. Lopalco, et al. 2000. Immune activation in Africa is environmentally-driven and is associated with upregulation of CCR5. AIDS 14:2083-2092. (Pubitemid 30792480)
5. Damond, F., D. Descamps, I. Farfara, J. N. Telles, S. Puyeo, P. Campa, A. Lepretre, S. Matheron, F. Brun-Vezinet, and F. Simon. 2001. Quantification of proviral load of human immunodeficiency virus type 2 subtypes A and B using real-time PCR. J. Clin. Microbiol. 39:4264-4268.
6. + T cells. Nature 417:95-98.
7. Grossman, Z., M. Meier-Schellersheim, W. E. Paul, and L. J. Picker. 2006. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat. Med. 12:289-295.
8. Hanson, A., A. D. Sarr, A. Shea, N. Jones, S. Mboup, P. Kanki, and H. Cao. 2005. Distinct profile of T cell activation in HIV type 2 compared to HIV type 1 infection: differential mechanism for immunoprotection. AIDS Res. Hum. Retrovir. 21:791-798.
9. Hirsch, V. M. 2004. What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS? AIDS Rev. 6:40-53.
10. Hirsch, V. M., R. A. Olmsted, M. Murphey-Corb, R. H. Purcell, and P. R. Johnson. 1989. An African primate lentivirus (SIVsm) closely related to HIV-2. Nature 339:389-392.
11. + T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions. J. Virol. 79:6299-6311.
12. Huigen, M. C., W. Kamp, and H. S. Nottet. 2004. Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection. Eur. J. Clin. Investig. 34:57-66.
13. + T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis. 197:126-133.
14. Jobe, O., K. Ariyoshi, A. Marchant, S. Sabally, T. Corrah, N. Berry, S. Jaffar, and H. Whittle. 1999. Proviral load and immune function in blood and lymph node during HIV-1 and HIV-2 infection. Clin. Exp. Immunol. 116:474-478.
15. Kawai, T., and S. Akira. 2007. Antiviral signaling through pattern recognition receptors. J. Biochem. 141:137-145. (Pubitemid 46775751)
16. Larkin, M. A., G. Blackshields, N. P. Brown, R. Chenna, P. A. McGettigan, H. McWilliam, F. Valentin, I. M. Wallace, A. Wilm, R. Lopez, J. D. Thompson, T. J. Gibson, and D. G. Higgins. 2007. Clustal W and Clustal X version 2.0. Bioinformatics 23:2947-2948.
17. Leligdowicz, A., L. M. Yindom, C. Onyango, R. Sarge-Njie, A. Alabi, M. Cotten, T. Vincent, C. da Costa, P. Aaby, A. Jaye, T. Dong, A. McMichael, H. Whittle, and S. Rowland-Jones. 2007. Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. J. Clin. Investig. 117:3067-3074.
18. Ling, B., C. Apetrei, I. Pandrea, R. S. Veazey, A. A. Lackner, B. Gormus, and P. A. Marx. 2004. Classic AIDS in a sooty mangabey after an 18-year natural infection. J. Virol. 78:8902-8908. (Pubitemid 39025155)
19. Lukwiya, M., G. Rizzardini, D. Trabattoni, S. Piconi, M. Saresella, S. Declich, S. Fossati, and M. Clerici. 2001. Evaluation of immune activation in HIV-infected and uninfected African individuals by single-cell analysis of cytokine production. J. Acquir. Immune Defic. Syndr. 28:429-436.
20. Popper, S. J., A. D. Sarr, A. Gueye-Ndiaye, S. Mboup, M. E. Essex, and P. J. Kanki. 2000. Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo. J. Virol. 74:1554-1557. (Pubitemid 30044108)
21. Rowland-Jones, S. L., and H. C. Whittle. 2007. Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1? Nat. Immunol. 8:329-331.
22. Schindler, M., J. Munch, O. Kutsch, H. Li, M. L. Santiago, F. Bibollet- Ruche, M. C. Muller-Trutwin, F. J. Novembre, M. Peeters, V. Courgnaud, E. Bailes, P. Roques, D. L. Sodora, G. Silvestri, P. M. Sharp, B. H. Hahn, and F. Kirchhoff. 2006. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 125:1055-1067. (Pubitemid 43884762)
23. + T cells in natural SIV infection. PLoS Pathog. 4:e1000107.
24. Schmidt, H. A., and A. von Haeseler. 2007. Maximum-likelihood analysis using TREE-PUZZLE. Curr. Protoc. Bioinformatics 6:unit 6.6.
25. Silvestri, G., D. L. Sodora, R. A. Koup, M. Paiardini, S. P. O'Neil, H. M. McClure, S. I. Staprans, and M. B. Feinberg. 2003. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 18:441-452. (Pubitemid 36351522)
26. + T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. J. Immunol. 178:1680-1691.
27. Wilkins, A., D. Ricard, J. Todd, H. Whittle, F. Dias, and A. Paulo Da Silva. 1993. The epidemiology of HIV infection in a rural area of Guinea-Bissau. AIDS 7:1119-1122. (Pubitemid 23246458)