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Volumn 13, Issue 4-5, 2010, Pages 99-108

The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches

Author keywords

Breast cancer; Cancer stem cells (CSCs); Cyclopamine; Early relapse; Late recurrence; Perfosine; Repertaxin; Sulphoraphane; Tumor initiating cell directed therapies; Tumor initiating cells (TICs)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; CISPLATIN; CURCUMIN; CYCLOPAMINE; CYCLOPHOSPHAMIDE; DOCETAXEL; DOFEQUIDAR FUMARATE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; IS 3295; LAPATINIB; LETROZOLE; METFORMIN; METHOTREXATE; MITOXANTRONE; PACLITAXEL; PERIFOSINE; PIPERINE; PROTEIN INHIBITOR; RAPAMYCIN; SALINOMYCIN; SULFORAPHANE; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 77957961187     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2010.08.001     Document Type: Article
Times cited : (81)

References (98)
  • 1
    • 85160367055 scopus 로고    scopus 로고
    • Early Breast Cancer Trials Collaborative Group, Multi-agent chemotherapy for early breast cancer. Cochrane Database Syst. Rev.
    • Early Breast Cancer Trials Collaborative Group, 2002. Multi-agent chemotherapy for early breast cancer. Cochrane Database Syst. Rev. p. CD000487.
    • (2002)
  • 2
    • 12944288172 scopus 로고    scopus 로고
    • Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis
    • Abraham B.K., Fritz P., McClellan M., Hauptvogel P., Athelogou M., Brauch H. Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin. Cancer Res. 2005, 11:1154-1159.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1154-1159
    • Abraham, B.K.1    Fritz, P.2    McClellan, M.3    Hauptvogel, P.4    Athelogou, M.5    Brauch, H.6
  • 4
    • 26444490562 scopus 로고    scopus 로고
    • Expression of CD44s, CD44v3 and CD44v6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan
    • Auvinen P., Tammi R., Tammi M., Johansson R., Kosma V.M. Expression of CD44s, CD44v3 and CD44v6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan. Histopathology 2005, 47:420-428.
    • (2005) Histopathology , vol.47 , pp. 420-428
    • Auvinen, P.1    Tammi, R.2    Tammi, M.3    Johansson, R.4    Kosma, V.M.5
  • 5
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic M., Lin H., Young L., Hawes D., Giuliano A., McNamara G., Datar R.H., Cote R.J. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin. Cancer Res. 2006, 12:5615-5621.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3    Hawes, D.4    Giuliano, A.5    McNamara, G.6    Datar, R.H.7    Cote, R.J.8
  • 6
    • 77953765387 scopus 로고    scopus 로고
    • Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models
    • Bandyopadhyay A., Wang L., Agyin J., et al. Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PLoS One 2010, 5:e10365.
    • (2010) PLoS One , vol.5
    • Bandyopadhyay, A.1    Wang, L.2    Agyin, J.3
  • 7
    • 0037495268 scopus 로고    scopus 로고
    • Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas
    • Berner H.S., Suo Z., Risberg B., et al. Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas. Histopathology 2003, 42:546-554.
    • (2003) Histopathology , vol.42 , pp. 546-554
    • Berner, H.S.1    Suo, Z.2    Risberg, B.3
  • 8
    • 33645729203 scopus 로고    scopus 로고
    • Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer
    • Berry D.A., Cirrincione C., Henderson I.C., Citron M.L., Budman D.R., Goldstein L.J. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA 2006, 295:1658-1667.
    • (2006) JAMA , vol.295 , pp. 1658-1667
    • Berry, D.A.1    Cirrincione, C.2    Henderson, I.C.3    Citron, M.L.4    Budman, D.R.5    Goldstein, L.J.6
  • 9
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon L.Y., Spevak C.C., Wong G., Xia W., Gilad E. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J. Biol. Chem. 2009, 284:26533-26546.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 10
    • 70349826431 scopus 로고    scopus 로고
    • Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib
    • Broxterman H.J., Gotink K.J., Verheul H.M. Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist. Updat. 2009, 12:114-126.
    • (2009) Drug Resist. Updat. , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 11
    • 0038713666 scopus 로고    scopus 로고
    • Resistance to cytotoxic and anti-angiogenic anticancer agents: similarities and differences
    • Broxterman H.J., Lankelma J., Hoekman K. Resistance to cytotoxic and anti-angiogenic anticancer agents: similarities and differences. Drug Resist. Updat. 2003, 6:111-127.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 111-127
    • Broxterman, H.J.1    Lankelma, J.2    Hoekman, K.3
  • 13
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E., Ginestier C., Iovino F., Wicinski J., Cervera N., Finetti P., et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 2009, 69:1302-1313.
    • (2009) Cancer Res. , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3    Wicinski, J.4    Cervera, N.5    Finetti, P.6
  • 14
    • 0037687355 scopus 로고    scopus 로고
    • Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
    • Citron M.L., Berry D.A., Cirrincione C., Hudis C., Winer E.P., Gradishar W.J., et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J. Clin. Oncol. 2003, 21:1431-1439.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1431-1439
    • Citron, M.L.1    Berry, D.A.2    Cirrincione, C.3    Hudis, C.4    Winer, E.P.5    Gradishar, W.J.6
  • 15
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton C.J., Li X., Landis M., Dixon J.M., Neumeister V.M., Sjolund A., et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:13820-13825.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 16
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5:275-284.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 17
    • 34250652449 scopus 로고    scopus 로고
    • Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
    • Desmedt C., Piette F., Loi S., Wang Y., Lallemand F., Haibe-Kains B., et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin. Cancer Res. 2007, 13:3207-3214.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3207-3214
    • Desmedt, C.1    Piette, F.2    Loi, S.3    Wang, Y.4    Lallemand, F.5    Haibe-Kains, B.6
  • 18
    • 18244387224 scopus 로고    scopus 로고
    • CD44 expression is associated with increased survival in node-negative invasive breast carcinoma
    • Diaz L.K., Zhou X., Wright E.T., Cristofanilli M., Smith T., Yang Y., et al. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin. Cancer Res. 2005, 11:3309-3314.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3309-3314
    • Diaz, L.K.1    Zhou, X.2    Wright, E.T.3    Cristofanilli, M.4    Smith, T.5    Yang, Y.6
  • 19
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M., Cho R.W., Lobo N.A., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 21
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler C.E., Rich J.N. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J. Clin. Oncol. 2008, 26:2839-2845.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 22
    • 34247581697 scopus 로고    scopus 로고
    • Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways
    • Farnie G., Clarke R.B., Spence K., Pinnock N., Brennan K., Anderson N.G., Bundred N.J. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J. Natl. Cancer Inst. 2007, 99:616-627.
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 616-627
    • Farnie, G.1    Clarke, R.B.2    Spence, K.3    Pinnock, N.4    Brennan, K.5    Anderson, N.G.6    Bundred, N.J.7
  • 23
    • 66349097441 scopus 로고    scopus 로고
    • Development of mammary tumors by conditional expression of GLI1
    • Fiaschi M., Rozell B., Bergstrom A., Toftgard R. Development of mammary tumors by conditional expression of GLI1. Cancer Res. 2009, 69:4810-4817.
    • (2009) Cancer Res. , vol.69 , pp. 4810-4817
    • Fiaschi, M.1    Rozell, B.2    Bergstrom, A.3    Toftgard, R.4
  • 24
    • 34247391483 scopus 로고    scopus 로고
    • Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs
    • Fojo T. Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs. Drug Resist. Updat. 2007, 10:59-67.
    • (2007) Drug Resist. Updat. , vol.10 , pp. 59-67
    • Fojo, T.1
  • 25
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C., Hur M.H., Charafe-Jauffret E., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 26
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • Ginestier C., Liu S., Diebel M.E., Korkaya H., Luo M., Brown M., et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J. Clin. Invest. 2010, 120:485-497.
    • (2010) J. Clin. Invest. , vol.120 , pp. 485-497
    • Ginestier, C.1    Liu, S.2    Diebel, M.E.3    Korkaya, H.4    Luo, M.5    Brown, M.6
  • 28
    • 57349087670 scopus 로고    scopus 로고
    • Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice
    • Grange C., Lanzardo S., Cavallo F., Camussi G., Bussolati B. Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia 2008, 10:1433-1443.
    • (2008) Neoplasia , vol.10 , pp. 1433-1443
    • Grange, C.1    Lanzardo, S.2    Cavallo, F.3    Camussi, G.4    Bussolati, B.5
  • 29
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 30
    • 67649427323 scopus 로고    scopus 로고
    • Tumor initiating cancer stem cells from human breast cancer cell lines
    • Han J.S., Crowe D.L. Tumor initiating cancer stem cells from human breast cancer cell lines. Int. J. Oncol. 2009, 34:1449-1453.
    • (2009) Int. J. Oncol. , vol.34 , pp. 1449-1453
    • Han, J.S.1    Crowe, D.L.2
  • 32
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann P.C., Huber S.L., Herrler T., et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007, 1:313-323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 33
    • 76049096035 scopus 로고    scopus 로고
    • Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors
    • Hirose H., Ishii H., Mimori K., Ohta D., Ohkuma M., Tsujii H., et al. Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors. Oncol. Rep. 2010, 23:35-43.
    • (2010) Oncol. Rep. , vol.23 , pp. 35-43
    • Hirose, H.1    Ishii, H.2    Mimori, K.3    Ohta, D.4    Ohkuma, M.5    Tsujii, H.6
  • 34
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch H.A., Iliopoulos D., Tsichlis P.N., Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009, 69:7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 39
    • 71049189661 scopus 로고    scopus 로고
    • Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export
    • Katayama R., Koike S., Sato S., Sugimoto Y., Tsuruo T., Fujita N. Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci. 2009, 100:2060-2068.
    • (2009) Cancer Sci. , vol.100 , pp. 2060-2068
    • Katayama, R.1    Koike, S.2    Sato, S.3    Sugimoto, Y.4    Tsuruo, T.5    Fujita, N.6
  • 41
    • 77449144736 scopus 로고    scopus 로고
    • Therapeutic strategies to eliminate breast cancer stem cells
    • Klopp A., Woodward W. Therapeutic strategies to eliminate breast cancer stem cells. Curr. Breast Cancer Rep. 2009, 1:222-228.
    • (2009) Curr. Breast Cancer Rep. , vol.1 , pp. 222-228
    • Klopp, A.1    Woodward, W.2
  • 43
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya H., Paulson A., Iovino F., Wicha M.S. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008, 27:6120-6130.
    • (2008) Oncogene , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3    Wicha, M.S.4
  • 44
    • 77956034139 scopus 로고    scopus 로고
    • Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    • Lagadec C., Vlashi E., Della Donna L., Meng Y., Dekmezian C., Kim K., Pajonk F. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res. 2010, 12:R13.
    • (2010) Breast Cancer Res. , vol.12
    • Lagadec, C.1    Vlashi, E.2    Della Donna, L.3    Meng, Y.4    Dekmezian, C.5    Kim, K.6    Pajonk, F.7
  • 45
    • 77953172448 scopus 로고    scopus 로고
    • Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2
    • Lee J.H., Jung C., Javadian-Elyaderani P., Schweyer S., Schutte D., Shoukier M., et al. Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2. Cancer Res. 2010, 70:4569-4579.
    • (2010) Cancer Res. , vol.70 , pp. 4569-4579
    • Lee, J.H.1    Jung, C.2    Javadian-Elyaderani, P.3    Schweyer, S.4    Schutte, D.5    Shoukier, M.6
  • 46
    • 4444327331 scopus 로고    scopus 로고
    • Next stop, the twilight zone: hedgehog network regulation of mammary gland development
    • Lewis M.T., Veltmaat J.M. Next stop, the twilight zone: hedgehog network regulation of mammary gland development. J. Mammary Gland Biol. Neoplasia 2004, 9:165-181.
    • (2004) J. Mammary Gland Biol. Neoplasia , vol.9 , pp. 165-181
    • Lewis, M.T.1    Veltmaat, J.M.2
  • 47
    • 44249127696 scopus 로고    scopus 로고
    • Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells
    • Li H.Z., Yi T.B., Wu Z.Y. Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells. BMC Cancer 2008, 8:135.
    • (2008) BMC Cancer , vol.8 , pp. 135
    • Li, H.Z.1    Yi, T.B.2    Wu, Z.Y.3
  • 49
    • 9144269759 scopus 로고    scopus 로고
    • Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    • Li Y., Welm B., Podsypanina K., Huang S., Chamorro M., Zhang X., et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:15853-15858.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 15853-15858
    • Li, Y.1    Welm, B.2    Podsypanina, K.3    Huang, S.4    Chamorro, M.5    Zhang, X.6
  • 50
    • 77951730125 scopus 로고    scopus 로고
    • Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    • Li Y., Zhang T., Korkaya H., Liu S., Lee H.F., Newman B., Yu Y., et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin. Cancer Res. 2010, 16:2580-2590.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2580-2590
    • Li, Y.1    Zhang, T.2    Korkaya, H.3    Liu, S.4    Lee, H.F.5    Newman, B.6    Yu, Y.7
  • 51
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C., Mazouni C., Hess K.R., Andre F., Tordai A., Mejia J.A., et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J. Clin. Oncol. 2008, 26:1275-1281.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3    Andre, F.4    Tordai, A.5    Mejia, J.A.6
  • 52
    • 33845941448 scopus 로고    scopus 로고
    • The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
    • Lindvall C., Evans N.C., Zylstra C.R., Li Y., Alexander C.M., Williams B.O. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J. Biol. Chem. 2006, 281:35081-35087.
    • (2006) J. Biol. Chem. , vol.281 , pp. 35081-35087
    • Lindvall, C.1    Evans, N.C.2    Zylstra, C.R.3    Li, Y.4    Alexander, C.M.5    Williams, B.O.6
  • 53
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu B.Y., McDermott S.P., Khwaja S.S., Alexander C.M. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:4158-4163.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 54
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • Liu G., Yuan X., Zeng Z., Tunici P., Ng H., Abdulkadir I.R., et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol. Cancer 2006, 5:67.
    • (2006) Mol. Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3    Tunici, P.4    Ng, H.5    Abdulkadir, I.R.6
  • 55
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S., Dontu G., Mantle I.D., Patel S., Ahn N.S., Jackson K.W., Suri P., Wicha M.S. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006, 66:6063-6071.
    • (2006) Cancer Res. , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 56
    • 62549096930 scopus 로고    scopus 로고
    • Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab
    • Magnifico A., Albano L., Campaner S., Delia D., Castiglioni F., Gasparini P., et al. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin. Cancer Res. 2009, 15:2010-2021.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2010-2021
    • Magnifico, A.1    Albano, L.2    Campaner, S.3    Delia, D.4    Castiglioni, F.5    Gasparini, P.6
  • 57
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 59
    • 77950441537 scopus 로고    scopus 로고
    • Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
    • Mazzone M., Selfors L.M., Albeck J., Overholtzer M., Sale S., Carroll D.L., et al. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:5012-5017.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 5012-5017
    • Mazzone, M.1    Selfors, L.M.2    Albeck, J.3    Overholtzer, M.4    Sale, S.5    Carroll, D.L.6
  • 60
    • 67349164276 scopus 로고    scopus 로고
    • Breast cancer cells expressing stem cell markers CD44+ CD24low are eliminated by Numb-1 peptide-activated T cells
    • Mine T., Matsueda S., Li Y., Tokumitsu H., Gao H., Danes C., Wong K.K., et al. Breast cancer cells expressing stem cell markers CD44+ CD24low are eliminated by Numb-1 peptide-activated T cells. Cancer Immunol. Immunother. 2009, 58:1185-1194.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1185-1194
    • Mine, T.1    Matsueda, S.2    Li, Y.3    Tokumitsu, H.4    Gao, H.5    Danes, C.6    Wong, K.K.7
  • 61
    • 66449110672 scopus 로고    scopus 로고
    • Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE
    • Misra S., Hascall V.C., De Giovanni C., Markwald R.R., Ghatak S. Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE. J. Biol. Chem. 2009, 284:12432-12446.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12432-12446
    • Misra, S.1    Hascall, V.C.2    De Giovanni, C.3    Markwald, R.R.4    Ghatak, S.5
  • 62
    • 46849094497 scopus 로고    scopus 로고
    • Intergroup, Standard chemotherapy (CMF or AC) versus capecitabine in early-stage breast cancer (BC) patients aged 65 and older: results of CALGB/CTSU 49907
    • (Abstract)
    • Muss H.B., Berry D.L., Cirrincione C., Theodoulou M., Mauer A., Cohen H., et al. Intergroup, Standard chemotherapy (CMF or AC) versus capecitabine in early-stage breast cancer (BC) patients aged 65 and older: results of CALGB/CTSU 49907. J. Clin. Oncol. 2008, 26. (Abstract).
    • (2008) J. Clin. Oncol. , vol.26
    • Muss, H.B.1    Berry, D.L.2    Cirrincione, C.3    Theodoulou, M.4    Mauer, A.5    Cohen, H.6
  • 63
    • 45049086574 scopus 로고    scopus 로고
    • The clinicopathologic and prognostic significance of CD44+/CD24(-/low) and CD44-/CD24+ tumor cells in invasive breast carcinomas
    • Mylona E., Giannopoulou I., Fasomytakis E., Nomikos A., Magkou C., Bakarakos P., Nakopoulou L. The clinicopathologic and prognostic significance of CD44+/CD24(-/low) and CD44-/CD24+ tumor cells in invasive breast carcinomas. Hum. Pathol. 2008, 39:1096-1102.
    • (2008) Hum. Pathol. , vol.39 , pp. 1096-1102
    • Mylona, E.1    Giannopoulou, I.2    Fasomytakis, E.3    Nomikos, A.4    Magkou, C.5    Bakarakos, P.6    Nakopoulou, L.7
  • 64
    • 77649270350 scopus 로고    scopus 로고
    • Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling
    • Nakanishi T., Chumsri S., Khakpour N., Brodie A.H., Leyland-Jones B., Hamburger A.W., Ross D.D., Burger A.M. Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling. Br. J. Cancer 2010, 102:815-826.
    • (2010) Br. J. Cancer , vol.102 , pp. 815-826
    • Nakanishi, T.1    Chumsri, S.2    Khakpour, N.3    Brodie, A.H.4    Leyland-Jones, B.5    Hamburger, A.W.6    Ross, D.D.7    Burger, A.M.8
  • 65
    • 77952045656 scopus 로고    scopus 로고
    • In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis
    • Neumeister V., Agarwal S., Bordeaux J., Camp R.L., Rimm D.L. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. Am. J. Pathol. 2010, 176:2131-2138.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2131-2138
    • Neumeister, V.1    Agarwal, S.2    Bordeaux, J.3    Camp, R.L.4    Rimm, D.L.5
  • 66
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell P.C. The clonal evolution of tumor cell populations. Science 1976, 194:23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 67
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse R. Wnt signaling and stem cell control. Cell Res. 2008, 18:523-527.
    • (2008) Cell Res. , vol.18 , pp. 523-527
    • Nusse, R.1
  • 68
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S., Tosoni D., Confalonieri S., Mazzarol G., Vecchi M., Ronzoni S., et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010, 140:62-73.
    • (2010) Cell , vol.140 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3    Mazzarol, G.4    Vecchi, M.5    Ronzoni, S.6
  • 69
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • Phillips T.M., McBride W.H., Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J. Natl. Cancer Inst. 2006, 98:1777-1785.
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 70
    • 0009710448 scopus 로고    scopus 로고
    • High-dose chemotherapy: how resistant is breast cancer?
    • Pusztai L., Hortobagyi G.N. High-dose chemotherapy: how resistant is breast cancer?. Drug Resist. Updat. 1998, 1:62-72.
    • (1998) Drug Resist. Updat. , vol.1 , pp. 62-72
    • Pusztai, L.1    Hortobagyi, G.N.2
  • 71
    • 70350238323 scopus 로고    scopus 로고
    • Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells
    • Reim F., Dombrowski Y., Ritter C., Buttmann M., Hausler S., Ossadnik M., et al. Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells. Cancer Res. 2009, 69:8058-8066.
    • (2009) Cancer Res. , vol.69 , pp. 8058-8066
    • Reim, F.1    Dombrowski, Y.2    Ritter, C.3    Buttmann, M.4    Hausler, S.5    Ossadnik, M.6
  • 72
    • 70449519397 scopus 로고    scopus 로고
    • A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
    • Saito K., Inagaki S., Mituyama T., et al. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature 2009, 461:1296-1299.
    • (2009) Nature , vol.461 , pp. 1296-1299
    • Saito, K.1    Inagaki, S.2    Mituyama, T.3
  • 73
    • 77953022034 scopus 로고    scopus 로고
    • Implication of microRNAs in drug resistance for designing novel cancer therapy
    • Sarkar F.H., Li Y., Wang Z., Kong D., Ali S. Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist. Updat. 2010, 13:57-66.
    • (2010) Drug Resist. Updat. , vol.13 , pp. 57-66
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4    Ali, S.5
  • 78
    • 67650912118 scopus 로고    scopus 로고
    • The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells
    • Tanaka H., Nakamura M., Kameda C., Kubo M., Sato N., Kuroki S., Tanaka M., Katano M. The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells. Anticancer Res. 2009, 29:2147-2157.
    • (2009) Anticancer Res. , vol.29 , pp. 2147-2157
    • Tanaka, H.1    Nakamura, M.2    Kameda, C.3    Kubo, M.4    Sato, N.5    Kuroki, S.6    Tanaka, M.7    Katano, M.8
  • 79
    • 67449113764 scopus 로고    scopus 로고
    • Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers
    • Tanei T., Morimoto K., Shimazu K., Kim S.J., Tanji Y., Taguchi T., et al. Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers. Clin. Cancer Res. 2009, 15:4234-4241.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4234-4241
    • Tanei, T.1    Morimoto, K.2    Shimazu, K.3    Kim, S.J.4    Tanji, Y.5    Taguchi, T.6
  • 80
    • 0037444482 scopus 로고    scopus 로고
    • A beta-catenin survival signal is required for normal lobular development in the mammary gland
    • Tepera S.B., McCrea P.D., Rosen J.M. A beta-catenin survival signal is required for normal lobular development in the mammary gland. J. Cell Sci. 2003, 116:1137-1149.
    • (2003) J. Cell Sci. , vol.116 , pp. 1137-1149
    • Tepera, S.B.1    McCrea, P.D.2    Rosen, J.M.3
  • 82
    • 77950849807 scopus 로고    scopus 로고
    • Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance
    • To K., Fotovati A., Reipas K.M., Law J.H., Hu K., Wang J., et al. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Res. 2010, 70:2840-2851.
    • (2010) Cancer Res. , vol.70 , pp. 2840-2851
    • To, K.1    Fotovati, A.2    Reipas, K.M.3    Law, J.H.4    Hu, K.5    Wang, J.6
  • 83
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • Todaro M., Alea M.P., Di Stefano A.B., Cammareri P., Vermeulen L., Iovino F. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007, 1:389-402.
    • (2007) Cell Stem Cell , vol.1 , pp. 389-402
    • Todaro, M.1    Alea, M.P.2    Di Stefano, A.B.3    Cammareri, P.4    Vermeulen, L.5    Iovino, F.6
  • 84
    • 46149112989 scopus 로고    scopus 로고
    • Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance
    • Toole B.P., Slomiany M.G. Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist. Updat. 2008, 11:110-121.
    • (2008) Drug Resist. Updat. , vol.11 , pp. 110-121
    • Toole, B.P.1    Slomiany, M.G.2
  • 85
    • 68249099424 scopus 로고    scopus 로고
    • Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy, Expert Opin. Ther. Pat. 19, 1039-1056.
    • Tremblay, M.R., Nesler, M., Weatherhead, R., Castro, A.C., 2009. Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy, Expert Opin. Ther. Pat. 19, 1039-1056.
    • (2009)
    • Tremblay, M.R.1    Nesler, M.2    Weatherhead, R.3    Castro, A.C.4
  • 86
    • 0030915612 scopus 로고    scopus 로고
    • Cancer dormancy: opportunities for new therapeutic approaches
    • Uhr J.W., Scheuermann R.H., Street N.E., Vitetta E.S. Cancer dormancy: opportunities for new therapeutic approaches. Nat. Med. 1997, 3:505-509.
    • (1997) Nat. Med. , vol.3 , pp. 505-509
    • Uhr, J.W.1    Scheuermann, R.H.2    Street, N.E.3    Vitetta, E.S.4
  • 87
    • 67649921349 scopus 로고    scopus 로고
    • Intensive dose-dense compared with conventionally scheduled preoperative chemotherapy for high-risk primary breast cancer
    • Untch M., Möbus V., Kuhn W., Konecny G.E. Intensive dose-dense compared with conventionally scheduled preoperative chemotherapy for high-risk primary breast cancer. J. Clin. Oncol. 2009, 27:2938-2945.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2938-2945
    • Untch, M.1    Möbus, V.2    Kuhn, W.3    Konecny, G.E.4
  • 88
    • 79954460690 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • Vazquez-Martin A., Oliveras-Ferraros C., Barco S.D., Menendez J.A. The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells. Breast Cancer Res. Treat. 2010, 10.1007/s10549-010-0924-x.
    • (2010) Breast Cancer Res. Treat.
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Barco, S.D.3    Menendez, J.A.4
  • 89
    • 28944442051 scopus 로고    scopus 로고
    • Dose-dense adjuvant chemotherapy in early breast cancer patients: results from a randomized trial
    • Venturini M., Del Mastro M.L., Aitini E., Buzzi P. Dose-dense adjuvant chemotherapy in early breast cancer patients: results from a randomized trial. J. Natl. Cancer Inst. 2005, 97:1724-1733.
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 1724-1733
    • Venturini, M.1    Del Mastro, M.L.2    Aitini, E.3    Buzzi, P.4
  • 91
    • 75349108271 scopus 로고    scopus 로고
    • Notch promotes radioresistance of glioma stem cells
    • Wang J., Wakeman T.P., Lathia J.D., et al. Notch promotes radioresistance of glioma stem cells. Stem Cells 2009, 28:17-28.
    • (2009) Stem Cells , vol.28 , pp. 17-28
    • Wang, J.1    Wakeman, T.P.2    Lathia, J.D.3
  • 92
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: an old idea - a paradigm shift
    • Wicha M.S., Liu S., Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res. 2006, 66:1883-1890.
    • (2006) Cancer Res. , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 95
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self-renewal and tumorigenicity of breast cancer cells
    • Yu F., Yao H., Zhu P., Zhang X., Pan Q., Gong C., et al. Let-7 regulates self-renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3    Zhang, X.4    Pan, Q.5    Gong, C.6
  • 96
    • 77649257221 scopus 로고    scopus 로고
    • Selective targeting of radiation-resistant tumor-initiating cells
    • Zhang M., Atkinson R.J., Rosen J.M. Selective targeting of radiation-resistant tumor-initiating cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:3522-3527.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 3522-3527
    • Zhang, M.1    Atkinson, R.J.2    Rosen, J.M.3
  • 97
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou J., Wulfkuhle J., Zhang H., Gu P., Yang Y., Deng J., et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:16158-16563.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 16158-16563
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3    Gu, P.4    Yang, Y.5    Deng, J.6
  • 98
    • 77954671617 scopus 로고    scopus 로고
    • Loss of tumor-initiating cell activity in cyclophosphamide-treated breast xenografts
    • Zielske S.P., Spalding A.C., Lawrence T.S. Loss of tumor-initiating cell activity in cyclophosphamide-treated breast xenografts. Transl. Oncol. 2010, 3:149-152.
    • (2010) Transl. Oncol. , vol.3 , pp. 149-152
    • Zielske, S.P.1    Spalding, A.C.2    Lawrence, T.S.3


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