The role of chemokines and their receptors in angiogenesis

Cellular and Molecular Life Sciences

Volumn 68, Issue 17, 2011, Pages 2811-2830

  Kiefer, Friedemann ^a   Siekmann, Arndt F ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

Author keywords

Angiogenesis; Cancer; Chemokines; Embryonic development; Immune response; Seven transmembrane receptors; Tumour

Indexed keywords

ANTINEOPLASTIC AGENT; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR12; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; CXCL13 CHEMOKINE; CXCL4 CHEMOKINE; CXCL4L1 CHEMOKINE; G PROTEIN COUPLED RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CXCR4; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; PLERIXAFOR; RANTES; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; BRAIN TUMOR; BREAST CARCINOMA; CANCER GROWTH; CELL MIGRATION; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DISEASE COURSE; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LYMPHANGIOGENESIS; METASTASIS; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR VASCULARIZATION; WOUND HEALING;

CHEMOKINES; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

VERTEBRATA;

EID: 80051790554     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0677-7     Document Type: Review

References (215)

1. W Risau 1997 Mechanisms of angiogenesis Nature 386 6626 671 674 9109485 1:STN:280:DyaK2s3mtlGksg%3D%3D (Pubitemid 27193480)
2. AK Olsson A Dimberg J Kreuger L Claesson-Welsh 2006 VEGF receptor signalling - in control of vascular function Nat Rev Mol Cell Biol 7 5 359 371 16633338 1:CAS:528:DC%2BD28XjslSktrc%3D
3. P Carmeliet V Ferreira G Breier S Pollefeyt L Kieckens M Gertsenstein M Fahrig A Vandenhoeck K Harpal C Eberhardt C Declercq J Pawling L Moons D Collen W Risau A Nagy 1996 Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele Nature 380 6573 435 439 8602241 1:CAS:528:DyaK28XitVKqtLg%3D (Pubitemid 26102719)
4. N Ferrara K Carver-Moore H Chen M Dowd L Lu KS O'Shea L Powell-Braxton KJ Hillan MW Moore 1996 Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Nature 380 6573 439 442 8602242 1:CAS:528:DyaK28XitVKqtLk%3D (Pubitemid 26102720)
5. A Nasevicius J Larson SC Ekker 2000 Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant Yeast 17 4 294 301 11119306 1:CAS:528:DC%2BD3MXms1Squw%3D%3D (Pubitemid 32051422)
6. T Gridley 2010 Notch signaling in the vasculature Curr Top Dev Biol 92 277 309 20816399 1:CAS:528:DC%2BC3cXht12jtLjN
7. F le Noble V Fleury A Pries P Corvol A Eichmann RS Reneman 2005 Control of arterial branching morphogenesis in embryogenesis: go with the flow Cardiovasc Res 65 3 619 628 15664388 1:CAS:528:DC%2BD2MXmsVKlsA%3D%3D (Pubitemid 40138982)
8. S Germain C Monnot L Muller A Eichmann 2010 Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding Curr Opin Hematol 17 3 245 251 20308893 1:CAS:528:DC%2BC3cXkvVymtrs%3D
9. P Carmeliet 2003 Angiogenesis in health and disease Nat Med 9 6 653 660 12778163 1:CAS:528:DC%2BD3sXktFOntbY%3D (Pubitemid 36749213)
10. J Jenab-Wolcott BJ Giantonio 2009 Bevacizumab: current indications and future development for management of solid tumors Expert Opin Biol Ther 9 4 507 517 19344286 1:CAS:528:DC%2BD1MXktFCjsr4%3D
11. A Ozkiris 2010 Anti-VEGF agents for age-related macular degeneration Expert Opin Ther Pat 20 1 103 118 20021287
12. A Fantin JM Vieira G Gestri L Denti Q Schwarz S Prykhozhij F Peri SW Wilson C Ruhrberg 2010 Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction Blood 116 5 829 840 20404134 1:CAS:528:DC%2BC3cXhtVCku73L
13. R Adamson 2009 Role of macrophages in normal wound healing: an overview J Wound Care 18 8 349 351 19862875 1:STN:280:DC%2BD1Mjit1Sjug%3D%3D
14. K Hall S Ran 2010 Regulation of tumor angiogenesis by the local environment Front Biosci 15 195 212 20036815 1:CAS:528:DC%2BC3cXovFamtro%3D
15. R Bohmer B Neuhaus S Buhren D Zhang M Stehling B Bock F Kiefer 2010 Regulation of developmental lymphangiogenesis by Syk(+) leukocytes Dev Cell 18 3 437 449 20230750
16. EJ Gordon S Rao JW Pollard SL Nutt RA Lang NL Harvey 2010 Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation Development 137 22 3899 3910 20978081 1:CAS:528:DC%2BC3cXhsF2js7fJ
17. A Zlotnik O Yoshie 2000 Chemokines: a new classification system and their role in immunity Immunity 12 2 121 127 10714678 1:CAS:528:DC%2BD3cXhslKqsL8%3D (Pubitemid 30398626)
18. G Lazennec A Richmond 2010 Chemokines and chemokine receptors: new insights into cancer-related inflammation Trends Mol Med 16 3 133 144 20163989 1:CAS:528:DC%2BC3cXjt1Wiu74%3D
19. M Thelen JV Stein 2008 How chemokines invite leukocytes to dance Nat Immunol 9 9 953 959 18711432 1:CAS:528:DC%2BD1cXhtVSisL7M
20. RM Strieter MD Burdick BN Gomperts JA Belperio MP Keane 2005 CXC chemokines in angiogenesis Cytokine Growth Factor Rev 16 6 593 609 16046180 1:CAS:528:DC%2BD2MXhtFKnu7fL (Pubitemid 41505519)
21. CL Addison TO Daniel MD Burdick H Liu JE Ehlert YY Xue L Buechi A Walz A Richmond RM Strieter 2000 The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity J Immunol 165 9 5269 5277 11046061 1:CAS:528:DC%2BD3cXnvVOnt7k%3D
22. M Wolf MB Delgado SA Jones B Dewald I Clark-Lewis M Baggiolini 1998 Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2 Eur J Immunol 28 1 164 170 9485196 1:CAS:528:DyaK1cXpvVyitw%3D%3D (Pubitemid 28048287)
23. R Salcedo JH Resau D Halverson EA Hudson M Dambach D Powell K Wasserman JJ Oppenheim 2000 Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells FASEB J 14 13 2055 2064 11023990 1:CAS:528: DC%2BD3MXhtF2rt7s%3D
24. IU Schraufstatter J Chung M Burger 2001 IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways Am J Physiol Lung Cell Mol Physiol 280 6 L1094 L1103 11350788 1:CAS:528:DC%2BD3MXksFKmtb0%3D
25. J Heidemann H Ogawa MB Dwinell P Rafiee C Maaser HR Gockel MF Otterson DM Ota N Lugering W Domschke DG Binion 2003 Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2 J Biol Chem 278 10 8508 8515 12496258 1:CAS:528:DC%2BD3sXhsF2htrs%3D (Pubitemid 36800603)
26. RM Devalaraja LB Nanney J Du Q Qian Y Yu MN Devalaraja A Richmond 2000 Delayed wound healing in CXCR2 knockout mice J Invest Dermatol 115 2 234 244 10951241 1:CAS:528:DC%2BD3cXlvFOltL8%3D (Pubitemid 30637193)
27. G Cacalano J Lee K Kikly AM Ryan S Pitts-Meek B Hultgren WI Wood MW Moore 1994 Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog Science 265 5172 682 684 8036519 1:CAS:528:DyaK2cXltVKgtr8%3D (Pubitemid 24268283)
28. R Salcedo K Wasserman HA Young MC Grimm OM Howard MR Anver HK Kleinman WJ Murphy JJ Oppenheim 1999 Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha Am J Pathol 154 4 1125 1135 10233851 1:CAS:528:DyaK1MXislKrs7k%3D (Pubitemid 29169747)
29. JM Burns BC Summers Y Wang A Melikian R Berahovich Z Miao ME Penfold MJ Sunshine DR Littman CJ Kuo K Wei BE McMaster K Wright MC Howard TJ Schall 2006 A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development J Exp Med 203 9 2201 2213 16940167 1:CAS:528:DC%2BD28XptlSgsL0%3D (Pubitemid 44352240)
30. Z Miao KE Luker BC Summers R Berahovich MS Bhojani A Rehemtulla CG Kleer JJ Essner A Nasevicius GD Luker MC Howard TJ Schall 2007 CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature Proc Natl Acad Sci U S A 104 40 15735 15740 17898181 1:CAS:528:DC%2BD2sXhtFGns7%2FJ (Pubitemid 350035369)
31. A Guyon JL Nahon 2007 Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity J Mol Endocrinol 38 3 365 376 17339399 1:CAS:528:DC%2BD2sXlsVWgurc%3D (Pubitemid 46723252)
32. S Rajagopal J Kim S Ahn S Craig CM Lam NP Gerard C Gerard RJ Lefkowitz 2010 Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7 Proc Natl Acad Sci U S A 107 2 628 632 20018651
33. A Levoye K Balabanian F Baleux F Bachelerie B Lagane 2009 CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling Blood 113 24 6085 6093 19380869 1:CAS:528:DC%2BD1MXnslSmurk%3D
34. F Sierro C Biben L Martinez-Munoz M Mellado RM Ransohoff M Li B Woehl H Leung J Groom M Batten RP Harvey AC Martinez CR Mackay F Mackay 2007 Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 Proc Natl Acad Sci U S A 104 37 14759 14764 17804806 1:CAS:528:DC%2BD2sXhtVOns7nO (Pubitemid 350003216)
35. B Boldajipour H Mahabaleshwar E Kardash M Reichman-Fried H Blaser S Minina D Wilson Q Xu E Raz 2008 Control of chemokine-guided cell migration by ligand sequestration Cell 132 3 463 473 18267076 1:CAS:528:DC%2BD1cXivVahurk%3D (Pubitemid 351191997)
36. C Dambly-Chaudiere N Cubedo A Ghysen 2007 Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1 BMC Dev Biol 7 23 17394634
37. TE Maione GS Gray J Petro AJ Hunt AL Donner SI Bauer HF Carson RJ Sharpe 1990 Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides Science 247 4938 77 79 1688470 1:CAS:528:DyaK3cXhslKgs7g%3D
38. S Taylor J Folkman 1982 Protamine is an inhibitor of angiogenesis Nature 297 5864 307 312 6176876 1:CAS:528:DyaL38XlsFKjsbk%3D (Pubitemid 12025053)
39. C Weber 2005 Platelets and chemokines in atherosclerosis: partners in crime Circ Res 96 6 612 616 15802619 1:CAS:528:DC%2BD2MXis1elsLw%3D (Pubitemid 40478327)
40. HD Flad E Brandt 2010 Platelet-derived chemokines: pathophysiology and therapeutic aspects Cell Mol Life Sci 67 14 2363 2386 20213276 1:CAS:528:DC%2BC3cXnslSmtLc%3D
41. S Struyf MD Burdick P Proost J Van Damme RM Strieter 2004 Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis Circ Res 95 9 855 857 15459074 1:CAS:528:DC%2BD2cXoslSlu7c%3D (Pubitemid 39434999)
42. SK Gupta JP Singh 1994 Inhibition of endothelial cell proliferation by platelet factor-4 involves a unique action on S phase progression J Cell Biol 127 4 1121 1127 7962072 1:CAS:528:DyaK2cXmslOms7w%3D (Pubitemid 24355998)
43. Y Sato M Abe R Takaki 1990 Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells Biochem Biophys Res Commun 172 2 595 600 2173572 1:CAS:528:DyaK3cXmt1GitL4%3D (Pubitemid 20384463)
44. S Gengrinovitch SM Greenberg T Cohen H Gitay-Goren P Rockwell TE Maione BZ Levi G Neufeld 1995 Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms J Biol Chem 270 25 15059 15065 7797488 1:CAS:528:DyaK2MXmsFKqsbs%3D
45. C Perollet ZC Han C Savona JP Caen A Bikfalvi 1998 Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization Blood 91 9 3289 3299 9558385 1:CAS:528:DyaK1cXislCnsrY%3D (Pubitemid 28193879)
46. V Jouan X Canron M Alemany JP Caen G Quentin J Plouet A Bikfalvi 1999 Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action Blood 94 3 984 993 10419890 1:CAS:528:DyaK1MXkvFCju7g%3D (Pubitemid 29361830)
47. N Ferrara 2010 Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action Mol Biol Cell 21 5 687 690 20185770 1:CAS:528:DC%2BC3cXjs1ertrw%3D
48. EC Keeley B Mehrad RM Strieter 2008 Chemokines as mediators of neovascularization Arterioscler Thromb Vasc Biol 28 11 1928 1936 18757292 1:CAS:528:DC%2BD1cXht1Ggtb3N
49. M Loetscher B Gerber P Loetscher SA Jones L Piali I Clark-Lewis M Baggiolini B Moser 1996 Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes J Exp Med 184 3 963 969 9064356 1:CAS:528:DyaK28XlsFamt7g%3D
50. B Moser P Loetscher 2001 Lymphocyte traffic control by chemokines Nat Immunol 2 2 123 128 11175804 1:CAS:528:DC%2BD3MXhtVOlsLw%3D (Pubitemid 33707929)
51. L Lasagni M Francalanci F Annunziato E Lazzeri S Giannini L Cosmi C Sagrinati B Mazzinghi C Orlando E Maggi F Marra S Romagnani M Serio P Romagnani 2003 An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4 J Exp Med 197 11 1537 1549 12782716 1:CAS:528:DC%2BD3sXksVOitL4%3D (Pubitemid 36682550)
52. P Romagnani F Annunziato L Lasagni E Lazzeri C Beltrame M Francalanci M Uguccioni G Galli L Cosmi L Maurenzig M Baggiolini E Maggi S Romagnani M Serio 2001 Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity J Clin Invest 107 1 53 63 11134180 1:CAS:528:DC%2BD3MXitVOnsw%3D%3D (Pubitemid 32047414)
53. J Yang A Richmond 2004 The angiostatic activity of interferon-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan Mol Ther 9 6 846 855 15194051 1:CAS:528:DC%2BD2cXkvVehu7Y%3D (Pubitemid 38878130)
54. GS Campanella RA Colvin AD Luster 2010 CXCL10 can inhibit endothelial cell proliferation independently of CXCR3 PLoS One 5 9 e12700 20856926
55. M Mellado JM Rodriguez-Frade S Manes A Martinez 2001 Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation Annu Rev Immunol 19 397 421 11244042 1:CAS:528:DC%2BD3MXivFKguro%3D (Pubitemid 32368041)
56. AC Hanyaloglu M von Zastrow 2008 Regulation of GPCRs by endocytic membrane trafficking and its potential implications Annu Rev Pharmacol Toxicol 48 537 568 18184106 1:CAS:528:DC%2BD1cXisFymsr0%3D (Pubitemid 351738163)
57. M Mariani R Lang E Binda P Panina-Bordignon D D'Ambrosio 2004 Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells Eur J Immunol 34 1 231 240 14971049 1:CAS:528:DC%2BD2cXnslymtg%3D%3D (Pubitemid 38111539)
58. A Mueller PG Strange 2004 Mechanisms of internalization and recycling of the chemokine receptor, CCR5 Eur J Biochem 271 2 243 252 14717692 1:CAS:528:DC%2BD2cXhtValsL4%3D (Pubitemid 38130452)
59. DA Zidar JD Violin EJ Whalen RJ Lefkowitz 2009 Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands Proc Natl Acad Sci U S A 106 24 9649 9654 19497875 1:CAS:528: DC%2BD1MXotFCqurc%3D
60. N Signoret A Pelchen-Matthews M Mack AE Proudfoot M Marsh 2000 Endocytosis and recycling of the HIV coreceptor CCR5 J Cell Biol 151 6 1281 1294 11121442 1:CAS:528:DC%2BD3cXovFantLk%3D
61. N Zimmermann JJ Conkright ME Rothenberg 1999 CC chemokine receptor-3 undergoes prolonged ligand-induced internalization J Biol Chem 274 18 12611 12618 10212240 1:CAS:528:DyaK1MXjtFGgu7c%3D
62. J Elsner M Mack H Bruhl Y Dulkys D Kimmig G Simmons PR Clapham D Schlondorff A Kapp TN Wells AE Proudfoot 2000 Differential activation of CC chemokine receptors by AOP-RANTES J Biol Chem 275 11 7787 7794 10713092 1:CAS:528:DC%2BD3cXitVylsb8%3D (Pubitemid 30159684)
63. A Sorkin M von Zastrow 2009 Endocytosis and signalling: intertwining molecular networks Nat Rev Mol Cell Biol 10 9 609 622 19696798 1:CAS:528:DC%2BD1MXhtVaksr3E
64. EM Borroni A Mantovani M Locati R Bonecchi 2010 Chemokine receptors intracellular trafficking Pharmacol Ther 127 1 1 8 20451553 1:CAS:528: DC%2BC3cXntVahtLs%3D
65. JB Rubin 2009 Chemokine signaling in cancer: one hump or two? Semin Cancer Biol 19 2 116 122 18992347 1:CAS:528:DC%2BD1MXisFWgtr4%3D
66. SG Ward 2006 T lymphocytes on the move: chemokines, PI 3-kinase and beyond Trends Immunol 27 2 80 87 16413226 1:CAS:528:DC%2BD28XhsFyrt70%3D (Pubitemid 43221974)
67. B Vanhaesebroeck K Ali A Bilancio B Geering LC Foukas 2005 Signalling by PI3 K isoforms: insights from gene-targeted mice Trends Biochem Sci 30 4 194 204 15817396 1:CAS:528:DC%2BD2MXjtVyqsrw%3D (Pubitemid 40463309)
68. E Hirsch VL Katanaev C Garlanda O Azzolino L Pirola L Silengo S Sozzani A Mantovani F Altruda MP Wymann 2000 Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation Science 287 5455 1049 1053 10669418 1:CAS:528:DC%2BD3cXhtFyqtbs%3D
69. DG Cronshaw C Owen Z Brown SG Ward 2004 Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis J Immunol 172 12 7761 7770 15187160 1:CAS:528:DC%2BD2cXks1agsL0%3D (Pubitemid 38747644)
70. AP Curnock Y Sotsios KL Wright SG Ward 2003 Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases J Immunol 170 8 4021 4030 12682230 1:CAS:528:DC%2BD3sXislekurk%3D (Pubitemid 36428163)
71. S Merlot RA Firtel 2003 Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways J Cell Sci 116 Pt 17 3471 3478 12893811 1:CAS:528:DC%2BD3sXntFyjt7Y%3D (Pubitemid 37063391)
72. S Barbero R Bonavia A Bajetto C Porcile P Pirani JL Ravetti GL Zona R Spaziante T Florio G Schettini 2003 Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt Cancer Res 63 8 1969 1974 12702590 1:CAS:528:DC%2BD3sXivFynsbg%3D (Pubitemid 36460865)
73. Y Suzuki M Rahman H Mitsuya 2001 Diverse transcriptional response of CD4(+) T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming effects of SDF-1 on CD4(+) T cells J Immunol 167 6 3064 3073 11544290 1:CAS:528:DC%2BD3MXmvFGitro%3D (Pubitemid 32852543)
74. KE McGrath AD Koniski KM Maltby JK McGann J Palis 1999 Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4 Dev Biol 213 2 442 456 10479460 1:CAS:528:DyaK1MXlslentL0%3D (Pubitemid 29444352)
75. SW Chong A Emelyanov Z Gong V Korzh 2001 Expression pattern of two zebrafish genes, cxcr4a and cxcr4b Mech Dev 109 2 347 354 11731248 1:CAS:528:DC%2BD3MXos1KgtLg%3D (Pubitemid 33112047)
76. AF Siekmann C Standley KE Fogarty SA Wolfe ND Lawson 2009 Chemokine signaling guides regional patterning of the first embryonic artery Genes Dev 23 19 2272 2277 19797767 1:CAS:528:DC%2BD1MXht12qtbfM
77. K Tachibana S Hirota H Iizasa H Yoshida K Kawabata Y Kataoka Y Kitamura K Matsushima N Yoshida S Nishikawa T Kishimoto T Nagasawa 1998 The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract Nature 393 6685 591 594 9634237 1:CAS:528:DyaK1cXjvV2rurg%3D (Pubitemid 28319250)
78. T Ara K Tokoyoda R Okamoto PA Koni T Nagasawa 2005 The role of CXCL12 in the organ-specific process of artery formation Blood 105 8 3155 3161 15626744 1:CAS:528:DC%2BD2MXjtlSmurk%3D
79. Y Takabatake T Sugiyama H Kohara T Matsusaka H Kurihara PA Koni Y Nagasawa T Hamano I Matsui N Kawada E Imai T Nagasawa H Rakugi Y Isaka 2009 The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature J Am Soc Nephrol 20 8 1714 1723 19443644 1:CAS:528:DC%2BD1MXhtVers73E
80. T Nagasawa S Hirota K Tachibana N Takakura S Nishikawa Y Kitamura N Yoshida H Kikutani T Kishimoto 1996 Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 Nature 382 6592 635 638 8757135 1:CAS:528:DyaK28XltVagsbo%3D (Pubitemid 26268957)
81. H Gerrits DS van Ingen Schenau NE Bakker AJ van Disseldorp A Strik LS Hermens TB Koenen MA Krajnc-Franken JA Gossen 2008 Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice Genesis 46 5 235 245 18442043 1:CAS:528:DC%2BD1cXotFGgtr8%3D (Pubitemid 351961759)
82. T Gridley 2007 Notch signaling in vascular development and physiology Development 134 15 2709 2718 17611219 1:CAS:528:DC%2BD2sXhtVWnu7%2FM (Pubitemid 47305050)
83. GA Strasser JS Kaminker M Tessier-Lavigne 2010 Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching Blood 115 24 5102 5110 20154215 1:CAS:528: DC%2BC3cXos1Kqsbc%3D
84. Y Kubota K Takubo T Shimizu H Ohno K Kishi M Shibuya H Saya T Suda 2009 M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis J Exp Med 206 5 1089 1102 19398755 1:CAS:528: DC%2BD1MXlvVGmurk%3D
85. AF Siekmann L Covassin ND Lawson 2008 Modulation of VEGF signalling output by the Notch pathway Bioessays 30 4 303 313 18348190 1:CAS:528: DC%2BD1cXltl2rs7w%3D (Pubitemid 351482328)
86. LK Phng H Gerhardt 2009 Angiogenesis: a team effort coordinated by notch Dev Cell 16 2 196 208 19217422 1:CAS:528:DC%2BD1MXis1aksr8%3D
87. CK Williams M Segarra L Sierra Mde RC Sainson G Tosato AL Harris 2008 Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells Cancer Res 68 6 1889 1895 18339870 1:CAS:528:DC%2BD1cXjtFOhsbk%3D (Pubitemid 351416575)
88. IM Packham C Gray PR Heath PG Hellewell PW Ingham DC Crossman M Milo TJ Chico 2009 Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos Physiol Genomics 38 3 319 327 19509081 1:CAS:528:DC%2BC3cXhtlaktrfL
89. R Melchionna D Porcelli A Mangoni D Carlini G Liuzzo G Spinetti A Antonini MC Capogrossi M Napolitano 2005 Laminar shear stress inhibits CXCR4 expression on endothelial cells: functional consequences for atherogenesis FASEB J 19 6 629 631 15705741 1:CAS:528:DC%2BD2MXjtFaks7Y%3D (Pubitemid 40471267)
90. T Tammela K Alitalo 2010 Lymphangiogenesis: molecular mechanisms and future promise Cell 140 4 460 476 20178740 1:CAS:528:DC%2BC3cXlt1KltrY%3D
91. G Oliver 2004 Lymphatic vasculature development Nat Rev Immunol 4 1 35 45 14704766 1:CAS:528:DC%2BD2cXkvVCisw%3D%3D (Pubitemid 38084130)
92. MJ Karkkainen P Haiko K Sainio J Partanen J Taipale TV Petrova M Jeltsch DG Jackson M Talikka H Rauvala C Betsholtz K Alitalo 2004 Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins Nat Immunol 5 1 74 80 14634646 1:CAS:528:DC%2BD3sXhtVWhtrzO (Pubitemid 38081471)
93. J Bussmann FL Bos A Urasaki K Kawakami HJ Duckers S Schulte-Merker 2010 Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk Development 137 16 2653 2657 20610484 1:CAS:528: DC%2BC3cXht1KjtLrO
94. CC Bertozzi AA Schmaier P Mericko PR Hess Z Zou M Chen CY Chen B Xu MM Lu D Zhou E Sebzda MT Santore DJ Merianos M Stadtfeld AW Flake T Graf R Skoda JS Maltzman GA Koretzky ML Kahn 2010 Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling Blood 116 4 661 670 20363774 1:CAS:528:DC%2BC3cXhtVClu7jN
95. L Carramolino J Fuentes C Garcia-Andres V Azcoitia D Riethmacher M Torres 2010 Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis Circ Res 106 7 1197 1201 20203303 1:CAS:528:DC%2BC3cXkslKqsLo%3D
96. J Fu H Gerhardt JM McDaniel B Xia X Liu L Ivanciu A Ny K Hermans R Silasi-Mansat S McGee E Nye T Ju MI Ramirez P Carmeliet RD Cummings F Lupu L Xia 2008 Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice J Clin Invest 118 11 3725 3737 18924607 1:CAS:528:DC%2BD1cXhtlGltLjI
97. K Suzuki-Inoue O Inoue G Ding S Nishimura K Hokamura K Eto H Kashiwagi Y Tomiyama Y Yatomi K Umemura Y Shin M Hirashima Y Ozaki 2010 Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets J Biol Chem 285 32 24494 24507 20525685 1:CAS:528:DC%2BC3cXpsFemsL4%3D
98. P Uhrin J Zaujec JM Breuss D Olcaydu P Chrenek H Stockinger E Fuertbauer M Moser P Haiko R Fassler K Alitalo BR Binder D Kerjaschki 2010 Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation Blood 115 19 3997 4005 20110424 1:CAS:528: DC%2BC3cXmvVCitrY%3D
99. F Abtahian A Guerriero E Sebzda MM Lu R Zhou A Mocsai EE Myers B Huang DG Jackson VA Ferrari V Tybulewicz CA Lowell JJ Lepore GA Koretzky ML Kahn 2003 Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk Science 299 5604 247 251 12522250 1:CAS:528: DC%2BD3sXhs1GktA%3D%3D (Pubitemid 36125210)
100. IR Turnbull M Colonna 2007 Activating and inhibitory functions of DAP12 Nat Rev Immunol 7 2 155 161 17220916 1:CAS:528:DC%2BD2sXpvVCjuw%3D%3D (Pubitemid 46174861)
101. RH Adams K Alitalo 2007 Molecular regulation of angiogenesis and lymphangiogenesis Nat Rev Mol Cell Biol 8 6 464 478 17522591 1:CAS:528:DC%2BD2sXlsFOhsb4%3D (Pubitemid 46823443)
102. RE Mebius T Miyamoto J Christensen J Domen T Cupedo IL Weissman K Akashi 2001 The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+ CD4+ CD3- cells, as well as macrophages J Immunol 166 11 6593 6601 11359812 1:CAS:528:DC%2BD3MXjvFartbw%3D (Pubitemid 32467199)
103. D Kim RE Mebius JD MacMicking S Jung T Cupedo Y Castellanos J Rho BR Wong R Josien N Kim PD Rennert Y Choi 2000 Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE J Exp Med 192 10 1467 1478 11085748 1:CAS:528:DC%2BD3cXotlaisrY%3D
104. Z Sun D Unutmaz YR Zou MJ Sunshine A Pierani S Brenner-Morton RE Mebius DR Littman 2000 Requirement for RORgamma in thymocyte survival and lymphoid organ development Science 288 5475 2369 2373 10875923 1:CAS:528: DC%2BD3cXkslWis74%3D (Pubitemid 30448162)
105. SA van de Pavert BJ Olivier G Goverse MF Vondenhoff M Greuter P Beke K Kusser UE Hopken M Lipp K Niederreither R Blomhoff K Sitnik WW Agace TD Randall WJ de Jonge RE Mebius 2009 Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation Nat Immunol 10 11 1193 1199 19783990
106. SA Luther KM Ansel JG Cyster 2003 Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development J Exp Med 197 9 1191 1198 12732660 1:CAS:528:DC%2BD3sXjs1ygsLo%3D (Pubitemid 36570074)
107. D Finke H Acha-Orbea A Mattis M Lipp J Kraehenbuhl 2002 CD4+ CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5 Immunity 17 3 363 373 12354388 1:CAS:528:DC%2BD38XnsFGrsLs%3D (Pubitemid 35279556)
108. DL Drayton S Liao RH Mounzer NH Ruddle 2006 Lymphoid organ development: from ontogeny to neogenesis Nat Immunol 7 4 344 353 16550197 1:CAS:528:DC%2BD28Xis1Gmuro%3D
109. PD Rennert D James F Mackay JL Browning PS Hochman 1998 Lymph node genesis is induced by signaling through the lymphotoxin beta receptor Immunity 9 1 71 79 9697837 1:CAS:528:DyaK1cXltVSis7c%3D (Pubitemid 28361296)
110. K Honda H Nakano H Yoshida S Nishikawa P Rennert K Ikuta M Tamechika K Yamaguchi T Fukumoto T Chiba SI Nishikawa 2001 Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis J Exp Med 193 5 621 630 11238592 1:CAS:528:DC%2BD3MXhslGls7o%3D (Pubitemid 32539558)
111. T Cupedo RE Mebius 2005 Cellular interactions in lymph node development J Immunol 174 1 21 25 15611222 1:CAS:528:DC%2BD2cXhtFaiur3O (Pubitemid 40007386)
112. E Dejardin NM Droin M Delhase E Haas Y Cao C Makris ZW Li M Karin CF Ware DR Green 2002 The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways Immunity 17 4 525 535 12387745 1:CAS:528:DC%2BD38XosVKrtL8%3D (Pubitemid 35223540)
113. VN Ngo H Korner MD Gunn KN Schmidt DS Riminton MD Cooper JL Browning JD Sedgwick JG Cyster 1999 Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen J Exp Med 189 2 403 412 9892622 1:CAS:528:DyaK1MXmvFeltQ%3D%3D (Pubitemid 29063261)
114. MY Kim FM McConnell FM Gaspal A White SH Glanville V Bekiaris LS Walker J Caamano E Jenkinson G Anderson PJ Lane 2007 Function of CD4+ CD3- cells in relation to B- and T-zone stroma in spleen Blood 109 4 1602 1610 17018858 1:CAS:528:DC%2BD2sXjt1Cgsbw%3D (Pubitemid 46239594)
115. L Ohl G Henning S Krautwald M Lipp S Hardtke G Bernhardt O Pabst R Forster 2003 Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs J Exp Med 197 9 1199 1204 12732661 1:CAS:528:DC%2BD3sXjs1ygsLs%3D (Pubitemid 36570075)
116. S Winter C Loddenkemper A Aebischer K Rabel K Hoffmann TF Meyer M Lipp UE Hopken 2010 The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation J Mol Med 88 11 1169 1180 20798913 1:CAS:528:DC%2BC3cXhtlSjsbjL
117. V Baeriswyl G Christofori 2009 The angiogenic switch in carcinogenesis Semin Cancer Biol 19 5 329 337 19482086 1:CAS:528:DC%2BD1MXhsV2msbnL
118. A Mantovani B Savino M Locati L Zammataro P Allavena R Bonecchi 2010 The chemokine system in cancer biology and therapy Cytokine Growth Factor Rev 21 1 27 39 20004131 1:CAS:528:DC%2BC3cXivFKgsrk%3D
119. A Mantovani 2009 Cancer: inflaming metastasis Nature 457 7225 36 37 19122629 1:CAS:528:DC%2BD1MXhtVGguw%3D%3D
120. G Luboshits S Shina O Kaplan S Engelberg D Nass B Lifshitz-Mercer S Chaitchik I Keydar A Ben-Baruch 1999 Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma Cancer Res 59 18 4681 4687 10493525 1:CAS:528:DyaK1MXmtVKkt7w%3D (Pubitemid 29428976)
121. M Ohta Y Kitadai S Tanaka M Yoshihara W Yasui N Mukaida K Haruma K Chayama 2002 Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas Int J Cancer 102 3 220 224 12397639 1:CAS:528:DC%2BD38Xotlait7k%3D (Pubitemid 35222287)
122. BK Popivanova FI Kostadinova K Furuichi MM Shamekh T Kondo T Wada K Egashira N Mukaida 2009 Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice Cancer Res 69 19 7884 7892 19773434 1:CAS:528:DC%2BD1MXht1Skt7bK
123. RJ Nibbs DS Gilchrist V King A Ferra S Forrow KD Hunter GJ Graham 2007 The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors J Clin Invest 117 7 1884 1892 17607362 1:CAS:528: DC%2BD2sXnvVansrg%3D (Pubitemid 47036322)
124. S Vetrano EM Borroni A Sarukhan B Savino R Bonecchi C Correale V Arena M Fantini M Roncalli A Malesci A Mantovani M Locati S Danese 2010 The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6 Gut 59 2 197 206 19846409
125. CB Collins EN McNamee JD Wermers MD Lebsack J Rivera-Nieves 2010 Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer Gut 59 2 151 152 20176637
126. JA Joyce JW Pollard 2009 Microenvironmental regulation of metastasis Nat Rev Cancer 9 4 239 252 19279573 1:CAS:528:DC%2BD1MXivFCjsLg%3D
127. A Mantovani A Sica 2010 Macrophages, innate immunity and cancer: balance, tolerance, and diversity Curr Opin Immunol 22 2 231 237 20144856 1:CAS:528:DC%2BC3cXks1Srtr8%3D
128. L Bingle NJ Brown CE Lewis 2002 The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies J Pathol 196 3 254 265 11857487 1:STN:280:DC%2BD387it1eksQ%3D%3D (Pubitemid 34189413)
129. A Mantovani A Sica S Sozzani P Allavena A Vecchi M Locati 2004 The chemokine system in diverse forms of macrophage activation and polarization Trends Immunol 25 12 677 686 15530839 1:CAS:528:DC%2BD2cXptl2ktbs%3D (Pubitemid 39457982)
130. BZ Qian JW Pollard 2010 Macrophage diversity enhances tumor progression and metastasis Cell 141 1 39 51 20371344 1:CAS:528:DC%2BC3cXlsVSgtLc%3D
131. T Hagemann J Wilson F Burke H Kulbe NF Li A Pluddemann K Charles S Gordon FR Balkwill 2006 Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype J Immunol 176 8 5023 5032 16585599 1:CAS:528:DC%2BD28XjtV2gt7k%3D
132. S Kim H Takahashi WW Lin P Descargues S Grivennikov Y Kim JL Luo M Karin 2009 Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis Nature 457 7225 102 106 19122641 1:CAS:528:DC%2BD1MXhtVGhsA%3D%3D
133. H Roca ZS Varsos S Sud MJ Craig C Ying KJ Pienta 2009 CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization J Biol Chem 284 49 34342 34354 19833726 1:CAS:528:DC%2BD1MXhsVylsr7O
134. SK Biswas L Gangi S Paul T Schioppa A Saccani M Sironi B Bottazzi A Doni B Vincenzo F Pasqualini L Vago M Nebuloni A Mantovani A Sica 2006 A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation) Blood 107 5 2112 2122 16269622 1:CAS:528:DC%2BD28XitFChtLc%3D (Pubitemid 43289397)
135. MA Venneri M De Palma M Ponzoni F Pucci C Scielzo E Zonari R Mazzieri C Doglioni L Naldini 2007 Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer Blood 109 12 5276 5285 17327411 1:CAS:528:DC%2BD2sXmslOrsL8%3D (Pubitemid 46890548)
136. A Sica P Larghi A Mancino L Rubino C Porta MG Totaro M Rimoldi SK Biswas P Allavena A Mantovani 2008 Macrophage polarization in tumour progression Semin Cancer Biol 18 5 349 355 18467122 1:CAS:528:DC%2BD1cXpsVGmsLo%3D
137. C Ruhrberg M De Palma 2010 A double agent in cancer: deciphering macrophage roles in human tumors Nat Med 16 8 861 862 20689550 1:CAS:528:DC%2BC3cXpslOitLk%3D
138. P Monti BE Leone F Marchesi G Balzano A Zerbi F Scaltrini C Pasquali G Calori F Pessi C Sperti V Di Carlo P Allavena L Piemonti 2003 The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity Cancer Res 63 21 7451 7461 14612545 1:CAS:528:DC%2BD3sXovVGltbw%3D (Pubitemid 37413488)
139. P Allavena C Garlanda MG Borrello A Sica A Mantovani 2008 Pathways connecting inflammation and cancer Curr Opin Genet Dev 18 1 3 10 18325755 1:CAS:528:DC%2BD1cXmsVartbw%3D (Pubitemid 351694444)
140. A Sica V Bronte 2007 Altered macrophage differentiation and immune dysfunction in tumor development J Clin Invest 117 5 1155 1166 17476345 1:CAS:528:DC%2BD2sXlt1Omtrs%3D (Pubitemid 46718400)
141. A Saccani T Schioppa C Porta SK Biswas M Nebuloni L Vago B Bottazzi MP Colombo A Mantovani A Sica 2006 p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance Cancer Res 66 23 11432 11440 17145890 1:CAS:528:DC%2BD28Xht1KnsL3L (Pubitemid 46009975)
142. C Porta M Rimoldi G Raes L Brys P Ghezzi D Di Liberto F Dieli S Ghisletti G Natoli P De Baetselier A Mantovani A Sica 2009 Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB Proc Natl Acad Sci U S A 106 35 14978 14983 19706447 1:CAS:528:DC%2BD1MXhtFGnurbP
143. T Hagemann T Lawrence I McNeish KA Charles H Kulbe RG Thompson SC Robinson FR Balkwill 2008 "Re-educating" tumor-associated macrophages by targeting NF-kappaB J Exp Med 205 6 1261 1268 18490490 1:CAS:528: DC%2BD1cXntFansbk%3D (Pubitemid 351831483)
144. L Song S Asgharzadeh J Salo K Engell HW Wu R Sposto T Ara AM Silverman YA DeClerck RC Seeger LS Metelitsa 2009 Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages J Clin Invest 119 6 1524 1536 19411762 1:CAS:528:DC%2BD1MXntVCjt7s%3D
145. Y Luo H Zhou J Krueger C Kaplan SH Lee C Dolman D Markowitz W Wu C Liu RA Reisfeld R Xiang 2006 Targeting tumor-associated macrophages as a novel strategy against breast cancer J Clin Invest 116 8 2132 2141 16862213 1:CAS:528:DC%2BD28XnvF2mtrk%3D (Pubitemid 44162322)
146. S Mandruzzato S Solito E Falisi S Francescato V Chiarion-Sileni S Mocellin A Zanon CR Rossi D Nitti V Bronte P Zanovello 2009 IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients J Immunol 182 10 6562 6568 19414811 1:CAS:528:DC%2BD1MXltlymt7Y%3D
147. PC Rodriguez MS Ernstoff C Hernandez M Atkins J Zabaleta R Sierra AC Ochoa 2009 Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes Cancer Res 69 4 1553 1560 19201693 1:CAS:528:DC%2BD1MXhslynsb4%3D
148. ZG Fridlender J Sun S Kim V Kapoor G Cheng L Ling GS Worthen SM Albelda 2009 Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN Cancer Cell 16 3 183 194 19732719 1:CAS:528:DC%2BD1MXhsVChs7vN
149. P Scapini JA Lapinet-Vera S Gasperini F Calzetti F Bazzoni MA Cassatella 2000 The neutrophil as a cellular source of chemokines Immunol Rev 177 195 203 11138776 1:CAS:528:DC%2BD3cXptVent74%3D
150. DI Gabrilovich S Nagaraj 2009 Myeloid-derived suppressor cells as regulators of the immune system Nat Rev Immunol 9 3 162 174 19197294 1:CAS:528:DC%2BD1MXhsFeqsbw%3D
151. I Kryczek M Banerjee P Cheng L Vatan W Szeliga S Wei E Huang E Finlayson D Simeone TH Welling A Chang G Coukos R Liu W Zou 2009 Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments Blood 114 6 1141 1149 19470694 1:CAS:528:DC%2BD1MXhtVSgsbbE
152. F Ghiringhelli L Apetoh A Tesniere L Aymeric Y Ma C Ortiz K Vermaelen T Panaretakis G Mignot E Ullrich JL Perfettini F Schlemmer E Tasdemir M Uhl P Genin A Civas B Ryffel J Kanellopoulos J Tschopp F Andre R Lidereau NM McLaughlin NM Haynes MJ Smyth G Kroemer L Zitvogel 2009 Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors Nat Med 15 10 1170 1178 19767732 1:CAS:528:DC%2BD1MXhtFGjt7rK
153. AJ Merogi AJ Marrogi R Ramesh WR Robinson CD Fermin SM Freeman 1997 Tumor-host interaction: analysis of cytokines, growth factors, and tumor-infiltrating lymphocytes in ovarian carcinomas Hum Pathol 28 3 321 331 9042797 1:STN:280:DyaK2s7psFChtg%3D%3D (Pubitemid 27106085)
154. J Yoneda H Kuniyasu MA Crispens JE Price CD Bucana IJ Fidler 1998 Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice J Natl Cancer Inst 90 6 447 454 9521169 1:CAS:528:DyaK1cXitlejtbg%3D (Pubitemid 28160636)
155. J Yatsunami N Tsuruta K Ogata K Wakamatsu K Takayama M Kawasaki Y Nakanishi N Hara S Hayashi 1997 Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung Cancer Lett 120 1 101 108 9570392 1:CAS:528:DyaK2sXmsl2gtrs%3D (Pubitemid 27483317)
156. DA Arenberg SL Kunkel PJ Polverini M Glass MD Burdick RM Strieter 1996 Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice J Clin Invest 97 12 2792 2802 8675690 1:CAS:528: DyaK28XjvVWks7o%3D (Pubitemid 26197092)
157. DR Smith PJ Polverini SL Kunkel MB Orringer RI Whyte MD Burdick CA Wilke RM Strieter 1994 Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma J Exp Med 179 5 1409 1415 7513008 1:CAS:528: DyaK2cXisVahtLg%3D (Pubitemid 24129558)
158. ES White KR Flaherty S Carskadon A Brant MD Iannettoni J Yee MB Orringer DA Arenberg 2003 Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis Clin Cancer Res 9 2 853 860 12576459 1:CAS:528:DC%2BD3sXhtVKktrw%3D (Pubitemid 36182624)
159. DG Bostwick KA Iczkowski 1998 Microvessel density in prostate cancer: prognostic and therapeutic utility Semin Urol Oncol 16 3 118 123 9741415 1:STN:280:DyaK1cvht1CntA%3D%3D (Pubitemid 28394936)
160. BB Moore DA Arenberg K Stoy T Morgan CL Addison SB Morris M Glass C Wilke YY Xue S Sitterding SL Kunkel MD Burdick RM Strieter 1999 Distinct CXC chemokines mediate tumorigenicity of prostate cancer cells Am J Pathol 154 5 1503 1512 10329603 1:CAS:528:DyaK1MXjtl2hsr8%3D (Pubitemid 29226445)
161. H Shen R Schuster KF Stringer SE Waltz AB Lentsch 2006 The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth FASEB J 20 1 59 64 16394268 1:CAS:528:DC%2BD28XislSmsg%3D%3D (Pubitemid 43100476)
162. J Mestas MD Burdick K Reckamp A Pantuck RA Figlin RM Strieter 2005 The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma J Immunol 175 8 5351 5357 16210641 1:CAS:528:DC%2BD2MXhtVylsbfE (Pubitemid 41456421)
163. EC Keeley B Mehrad RM Strieter 2011 Chemokines as mediators of tumor angiogenesis and neovascularization Exp Cell Res 317 5 685 690 21040721 1:CAS:528:DC%2BC3MXjsFaitro%3D
164. BG Galvez L Genis S Matias-Roman SA Oblander K Tryggvason SS Apte AG Arroyo 2005 Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis J Biol Chem 280 2 1292 1298 15516694 1:CAS:528:DC%2BD2MXitFCmtw%3D%3D
165. SM Stamatovic RF Keep M Mostarica-Stojkovic AV Andjelkovic 2006 CCL2 regulates angiogenesis via activation of Ets-1 transcription factor J Immunol 177 4 2651 2661 16888027 1:CAS:528:DC%2BD28Xns1Kgs7s%3D (Pubitemid 44201024)
166. M Strasly G Doronzo P Cappello D Valdembri M Arese S Mitola P Moore G Alessandri M Giovarelli F Bussolino 2004 CCL16 activates an angiogenic program in vascular endothelial cells Blood 103 1 40 49 12958070 1:CAS:528: DC%2BD2cXhsFCruw%3D%3D (Pubitemid 38029916)
167. H Saji M Koike T Yamori S Saji M Seiki K Matsushima M Toi 2001 Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma Cancer 92 5 1085 1091 11571719 1:STN:280:DC%2BD3Mritl2isg%3D%3D (Pubitemid 32861655)
168. T Ueno M Toi H Saji M Muta H Bando K Kuroi M Koike H Inadera K Matsushima 2000 Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer Clin Cancer Res 6 8 3282 3289 10955814 1:CAS:528:DC%2BD3cXmsVOmt7c%3D (Pubitemid 30637758)
169. LS Barcelos A Talvani AS Teixeira GD Cassali SP Andrade MM Teixeira 2004 Production and in vivo effects of chemokines CXCL1-3/KC and CCL2/JE in a model of inflammatory angiogenesis in mice Inflamm Res 53 10 576 584 15597153 1:CAS:528:DC%2BD2cXhtVKhtrnL (Pubitemid 40110123)
170. V Goede L Brogelli M Ziche HG Augustin 1999 Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 Int J Cancer 82 5 765 770 10417778 1:CAS:528:DyaK1MXltFOitb8%3D (Pubitemid 29356979)
171. R Salcedo ML Ponce HA Young K Wasserman JM Ward HK Kleinman JJ Oppenheim WJ Murphy 2000 Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression Blood 96 1 34 40 10891427 1:CAS:528:DC%2BD3cXksVKjs7Y%3D (Pubitemid 30456447)
172. C Chavey F Bibeau S Gourgou-Bourgade S Burlinchon F Boissiere D Laune S Roques G Lazennec 2007 Oestrogen receptor negative breast cancers exhibit high cytokine content Breast Cancer Res 9 1 R15 17261184
173. S Singh AP Singh B Sharma LB Owen RK Singh 2010 CXCL8 and its cognate receptors in melanoma progression and metastasis Future Oncol 6 1 111 116 20021212 1:CAS:528:DC%2BD1MXhsFyitL3K
174. BL Richards RJ Eisma JD Spiro RL Lindquist DL Kreutzer 1997 Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma Am J Surg 174 5 507 512 9374226 1:CAS:528:DyaK2sXnsFSqu70%3D (Pubitemid 27486015)
175. RK Singh M Gutman R Radinsky CD Bucana IJ Fidler 1994 Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice Cancer Res 54 12 3242 3247 8205546 1:CAS:528:DyaK2cXksFCqsrw%3D (Pubitemid 24208936)
176. S Ugurel G Rappl W Tilgen U Reinhold 2001 Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival J Clin Oncol 19 2 577 583 11208853 1:STN:280: DC%2BD3M7nvVGisA%3D%3D (Pubitemid 32112873)
177. M Arya HR Patel M Williamson 2003 Chemokines: key players in cancer Curr Med Res Opin 19 6 557 564 14594528 1:CAS:528:DC%2BD3sXotlentro%3D (Pubitemid 37122049)
178. TY Yang SC Chen MW Leach D Manfra B Homey M Wiekowski L Sullivan CH Jenh SK Narula SW Chensue SA Lira 2000 Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma J Exp Med 191 3 445 454 10662790 1:CAS:528:DC%2BD3cXhtV2itr4%3D
179. K Kawada M Sonoshita H Sakashita A Takabayashi Y Yamaoka T Manabe K Inaba N Minato M Oshima MM Taketo 2004 Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes Cancer Res 64 11 4010 4017 15173015 1:CAS:528:DC%2BD2cXksVKnsL8%3D (Pubitemid 38697317)
180. Y Feng CC Broder PE Kennedy EA Berger 1996 HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor Science 272 5263 872 877 8629022 1:CAS:528:DyaK28XivFajsLc%3D (Pubitemid 26154590)
181. Y Ueda NF Neel E Schutyser D Raman A Richmond 2006 Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells Cancer Res 66 11 5665 5675 16740704 1:CAS:528:DC%2BD28XltFyjt7Y%3D (Pubitemid 43927119)
182. Y Zhou PH Larsen C Hao VW Yong 2002 CXCR4 is a major chemokine receptor on glioma cells and mediates their survival J Biol Chem 277 51 49481 49487 12388552 1:CAS:528:DC%2BD38XpsFaks7c%3D (Pubitemid 36014384)
183. A Ben-Baruch 2008 Organ selectivity in metastasis: regulation by chemokines and their receptors Clin Exp Metastasis 25 4 345 356 17891505 1:CAS:528:DC%2BD1cXptVSqu7c%3D (Pubitemid 351748979)
184. RE Bachelder MA Wendt AM Mercurio 2002 Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4 Cancer Res 62 24 7203 7206 12499259 1:CAS:528:DC%2BD3sXhtVyruw%3D%3D (Pubitemid 36025239)
185. G Helbig KW Christopherson P Bhat-Nakshatri S Kumar H Kishimoto KD Miller HE Broxmeyer H Nakshatri 2003 NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4 J Biol Chem 278 24 21631 21638 12690099 1:CAS:528:DC%2BD3sXksVemsL8%3D (Pubitemid 36792563)
186. O Salvucci A Bouchard A Baccarelli J Deschenes G Sauter R Simon R Bianchi M Basik 2006 The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study Breast Cancer Res Treat 97 3 275 283 16344916 1:CAS:528:DC%2BD28XmtFSitrg%3D (Pubitemid 43945757)
187. A Muller B Homey H Soto N Ge D Catron ME Buchanan T McClanahan E Murphy W Yuan SN Wagner JL Barrera A Mohar E Verastegui A Zlotnik 2001 Involvement of chemokine receptors in breast cancer metastasis Nature 410 6824 50 56 11242036 1:CAS:528:DC%2BD3MXhvVSgu74%3D (Pubitemid 32225831)
188. T Lapidot 2001 Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions Ann N Y Acad Sci 938 83 95 11458529 1:CAS:528:DC%2BD3MXlsV2ktb0%3D (Pubitemid 32620021)
189. T Nagasawa 2000 A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis Int J Hematol 72 4 408 411 11197205 1:CAS:528:DC%2BD3MXntVSjsg%3D%3D
190. B Furusato A Mohamed M Uhlen JS Rhim 2010 CXCR4 and cancer Pathol Int 60 7 497 505 20594270 1:CAS:528:DC%2BC3cXhtVeit77K
191. F Balkwill 2004 The significance of cancer cell expression of the chemokine receptor CXCR4 Semin Cancer Biol 14 3 171 179 15246052 1:CAS:528:DC%2BD2cXjvVemsb0%3D (Pubitemid 38586742)
192. F Bertolini C Dell'Agnola P Mancuso C Rabascio A Burlini S Monestiroli A Gobbi G Pruneri G Martinelli 2002 CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma Cancer Res 62 11 3106 3112 12036921 1:CAS:528:DC%2BD38XksVyqsrg%3D (Pubitemid 34602402)
193. JB Rubin AL Kung RS Klein JA Chan Y Sun K Schmidt MW Kieran AD Luster RA Segal 2003 A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors Proc Natl Acad Sci U S A 100 23 13513 13518 14595012 1:CAS:528:DC%2BD3sXptFOit78%3D (Pubitemid 37444773)
194. HE Wiley EB Gonzalez W Maki MT Wu ST Hwang 2001 Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma J Natl Cancer Inst 93 21 1638 1643 11698568 1:CAS:528:DC%2BD3MXptVegt7c%3D (Pubitemid 33094871)
195. N Cabioglu MS Yazici B Arun KR Broglio GN Hortobagyi JE Price A Sahin 2005 CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer Clin Cancer Res 11 16 5686 5693 16115904 1:CAS:528:DC%2BD2MXos1CjsL4%3D (Pubitemid 41170291)
196. JL Wilson J Burchell MJ Grimshaw 2006 Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1 Cancer Res 66 24 11802 11807 17178876 1:CAS:528:DC%2BD28Xhtlagu7zK (Pubitemid 46094191)
197. LL Cavanagh UH Von Andrian 2002 Travellers in many guises: the origins and destinations of dendritic cells Immunol Cell Biol 80 5 448 462 12225381
198. K Mashino N Sadanaga H Yamaguchi F Tanaka M Ohta K Shibuta H Inoue M Mori 2002 Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma Cancer Res 62 10 2937 2941 12019175 1:CAS:528:DC%2BD38XjvFSmtLs%3D (Pubitemid 34525782)
199. Y Ding Y Shimada M Maeda A Kawabe J Kaganoi I Komoto Y Hashimoto M Miyake H Hashida M Imamura 2003 Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma Clin Cancer Res 9 9 3406 3412 12960129 1:CAS:528:DC%2BD3sXotFCktr4%3D (Pubitemid 37082736)
200. T Ishida A Utsunomiya S Iida H Inagaki Y Takatsuka S Kusumoto G Takeuchi S Shimizu M Ito H Komatsu A Wakita T Eimoto K Matsushima R Ueda 2003 Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome Clin Cancer Res 9 10 Pt 1 3625 3634 14506150 1:CAS:528:DC%2BD3sXosVOlu7w%3D (Pubitemid 37169227)
201. B Homey W Wang H Soto ME Buchanan A Wiesenborn D Catron A Muller TK McClanahan MC Dieu-Nosjean R Orozco T Ruzicka P Lehmann E Oldham A Zlotnik 2000 Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) J Immunol 164 7 3465 3470 10725697 1:CAS:528:DC%2BD3cXitFOqsr4%3D (Pubitemid 30169794)
202. O Simonetti G Goteri G Lucarini A Filosa T Pieramici C Rubini G Biagini A Offidani 2006 Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape Eur J Cancer 42 8 1181 1187 16644201 1:CAS:528:DC%2BD28Xks1erurg%3D
203. T Murakami AR Cardones SE Finkelstein NP Restifo BA Klaunberg FO Nestle SS Castillo PA Dennis ST Hwang 2003 Immune evasion by murine melanoma mediated through CC chemokine receptor-10 J Exp Med 198 9 1337 1347 14581607 1:CAS:528:DC%2BD3sXovVKiur0%3D (Pubitemid 37392479)
204. H Harasawa Y Yamada K Hieshima Z Jin T Nakayama O Yoshie K Shimizu H Hasegawa T Hayashi Y Imaizumi S Ikeda H Soda S Atogami Y Takasaki K Tsukasaki M Tomonaga K Murata K Sugahara K Tsuruda S Kamihira 2006 Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma Leuk Lymphoma 47 10 2163 2173 17071491 1:CAS:528:DC%2BD28XhtlCiu7%2FO (Pubitemid 44650094)
205. M Kleinhans A Tun-Kyi M Gilliet ME Kadin R Dummer G Burg FO Nestle 2003 Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma Blood 101 4 1487 1493 12393570 1:CAS:528:DC%2BD3sXht1agu7s%3D (Pubitemid 36182525)
206. M Martins-Green C Tilley R Schwarz C Hatier MJ Bissell 1991 Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene Cell Regul 2 9 739 752 1742344 1:STN:280:DyaK38%2FnsFOgtw%3D%3D
207. Y Cao C Chen JA Weatherbee M Tsang J Folkman 1995 gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice J Exp Med 182 6 2069 2077 7500052 1:CAS:528: DyaK2MXpslylsr0%3D (Pubitemid 3007462)
208. J Luan R Shattuck-Brandt H Haghnegahdar JD Owen R Strieter M Burdick C Nirodi D Beauchamp KN Johnson A Richmond 1997 Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression J Leukoc Biol 62 5 588 597 9365113 1:CAS:528:DyaK2sXnt1Oku7w%3D (Pubitemid 27519769)
209. DA Arenberg MP Keane B DiGiovine SL Kunkel SB Morris YY Xue MD Burdick MC Glass MD Iannettoni RM Strieter 1998 Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer J Clin Invest 102 3 465 472 9691082 1:CAS:528:DyaK1cXlt1egtbw%3D (Pubitemid 28376148)
210. E Van Coillie I Van Aelst A Wuyts R Vercauteren R Devos C De Wolf-Peeters J Van Damme G Opdenakker 2001 Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle Am J Pathol 159 4 1405 1414 11583968 (Pubitemid 32947970)
211. SK Ahuja PM Murphy 1996 The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor J Biol Chem 271 34 20545 20550 8702798 1:CAS:528:DyaK28Xlt1ynsr4%3D (Pubitemid 26281830)
212. AE Koch PJ Polverini SL Kunkel LA Harlow LA DiPietro VM Elner SG Elner RM Strieter 1992 Interleukin-8 as a macrophage-derived mediator of angiogenesis Science 258 5089 1798 1801 1281554 1:CAS:528:DyaK3sXlslyktg%3D%3D (Pubitemid 23087348)
213. R Salcedo HA Young ML Ponce JM Ward HK Kleinman WJ Murphy JJ Oppenheim 2001 Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells J Immunol 166 12 7571 7578 11390513 1:CAS:528: DC%2BD3MXksVOmsL0%3D (Pubitemid 32525638)
214. AD Luster SM Greenberg P Leder 1995 The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation J Exp Med 182 1 219 231 7790818 1:CAS:528:DyaK2MXmsVCksb4%3D
215. TD Shellenberger M Wang M Gujrati A Jayakumar RM Strieter MD Burdick CG Ioannides CL Efferson AK El-Naggar D Roberts GL Clayman MJ Frederick 2004 BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells Cancer Res 64 22 8262 8270 15548693 1:CAS:528:DC%2BD2cXpvVGlu74%3D (Pubitemid 39496830)