The angiostatic activity of interferon-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan

Molecular Therapy

Volumn 9, Issue 6, 2004, Pages 846-855

  Yang, Jinming ^a   Richmond, Ann ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOSAMINOGLYCAN; HEPARIN; MUTANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DATA ANALYSIS; DENSITY; DRUG RECEPTOR BINDING; EXPRESSION VECTOR; FEMALE; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INOCULATION; MELANOMA; MELANOMA CELL; MICROVASCULATURE; MOLECULAR CLONING; MOUSE; NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PROTEIN SECRETION; TUMOR CELL; TUMOR CELL LINE; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIGENS, CD31; BINDING, COMPETITIVE; CAPILLARIES; CELL LINE, TUMOR; CHEMOKINES, CXC; GLYCOSAMINOGLYCANS; HUMANS; MELANOMA; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BINDING; RECEPTORS, CHEMOKINE; TRANSFECTION;

MUS MUSCULUS; VECTORS;

EID: 3042855031     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.01.010     Document Type: Article

References (35)

1. Luster A.D. Unkeless J.C. Ravetch J.V. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins Nature 315 1985 672-676
2. Zaks-Zilberman M. Zaks T.Z. Vogel S.N. Induction of proinflammatory and chemokine genes by lipopolysaccharide and paclitaxel (Taxol) in murine and human breast cancer cell lines Cytokine 15 2001 156-165
3. Luster A.D. Ravetch J.V. Biochemical characterization of a gamma interferon-inducible cytokine (IP-10) J. Exp. Med. 166 1987 1084-1097
4. Taub D.D. et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells J. Exp. Med. 177 1993 1809-1814
5. Hancock W.W. Gao W. Csizmadia V. Faia K.L. Shemmeri N. Luster A.D. Donor-derived IP-10 initiates development of acute allograft rejection J. Exp. Med. 193 2001 975-980
6. Mach F. et al. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells J. Clin. Invest. 104 1999 1041-1050
7. Balashov K.E. Rottman J.B. Weiner H.L. Hancock W.W. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions Proc. Natl. Acad. Sci. USA 96 1999 6873-6878
8. Zhao D.X. Hu Y. Miller G.G. Luster A.D. Mitchell R.N. Libby P. Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection J. Immunol. 169 2002 1556-1560
9. Luster A.D. Greenberg S.M. Leder P. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation J. Exp. Med. 182 1995 219-231
10. Vlodavsky I. Goldshmidt O. Properties and function of heparanase in cancer metastasis and angiogenesis Haemostasis 31 Suppl. 1 2001 60-63
11. Vlodavsky I. et al. Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development Semin. Cancer Biol. 12 2002 121-129
12. Vlodavsky I. et al. Molecular properties and involvement of heparanase in cancer progression and normal development Biochimie 83 2001 831-839
13. Marchisone C. Del Grosso F. Masiello L. Prat M. Santi L. Noonan D.M. Phenotypic alterations in Kaposi's sarcoma cells by antisense reduction of perlecan Pathol. Oncol. Res. 6 2000 10-17
14. Angiolillo A.L. et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo J. Exp. Med. 182 1995 155-162
15. Arenberg D.A. et al. Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases J. Exp. Med. 184 1996 981-992
16. Pertl U. et al. IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy J. Immunol. 166 2001 6944-6951
17. Feldman A.L. et al. Retroviral gene transfer of interferon-inducible protein 10 inhibits growth of human melanoma xenografts Int. J. Cancer 99 2002 149-153
18. Romagnani P. et al. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity J. Clin. Invest. 107 2001 53-63
19. Soejima K. Rollins B.J. A functional IFN-gamma-inducible protein-10/CXCL10-specific receptor expressed by epithelial and endothelial cells that is neither CXCR3 nor glycosaminoglycan J. Immunol. 167 2001 6576-6582
20. Proost P. et al. Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties Blood 98 2001 3554-3561
21. Clark-Lewis I. Mattioli I. Gong J.H. Loetscher P. Structure-function relationship between the human chemokine receptor CXCR3 and its ligands J. Biol. Chem. 278 2003 289-295
22. Campanella G.S. Lee E.M. Sun J. Luster A.D. CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10) J. Biol. Chem. 278 2003 17066-17074
23. Hileman R.E. Fromm J.R. Weiler J.M. Linhardt R.J. Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins Bioessays 20 1998 156-167
24. Proudfoot A.E. et al. The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity J. Biol. Chem. 276 2001 10620-10626
25. Strieter R.M. Kunkel S.L. Arenberg D.A. Burdick M.D. Polverini P.J. Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis Biochem. Biophys. Res. Commun. 210 1995 51-57
26. Luster A.D. Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo J. Exp. Med. 178 1993 1057-1065
27. Loetscher P. Seitz M. Baggiolini M. Moser B. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes J. Exp. Med. 184 1996 569-577
28. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm Cell 76 1994 301-314
29. Wang D. Sai J. Richmond A. Cell surface heparan sulfate participates in CXCL1-induced signaling Biochemistry 42 2003 1071-1077
30. Webb L.M. Ehrengruber M.U. Clark-Lewis I. Baggiolini M. Rot A. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8 Proc. Natl. Acad. Sci. USA 90 1993 7158-7162
31. Lasagni L. et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4 J. Exp. Med. 197 2003 1537-1549
32. Arenberg D.A. Zlotnick A. Strom S.R. Burdick M.D. Strieter R.M. The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model Cancer Immunol. Immunother. 49 2001 587-592
33. Salcedo R. et al. Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells FASEB J. 14 2000 2055-2064
34. Yang J. Richmond A. Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells Cancer Res. 61 2001 4901-4909
35. Van Riper G. Siciliano S. Fischer P.A. Meurer R. Springer M.S. Rosen H. Characterization and species distribution of high affinity GTP-coupled receptors for human RANTES and monocyte chemoattractant protein 1 J. Exp. Med. 177 1993 851-856