메뉴 건너뛰기




Volumn 9, Issue 4, 2009, Pages 507-517

Bevacizumab: Current indications and future development for management of solid tumors

Author keywords

Advanced solid tumors; Angiogenesis; Bevacizumab; Chemotherapy; Metastatic; Targeted therapy; Vascular endothelial growth factor; VEGF

Indexed keywords

ALPHA2A INTERFERON; ANTHRACYCLINE; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CELECOXIB; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; INTERFERON; INTERLEUKIN 2; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PLACEBO; SORAFENIB; SUNITINIB; TAXANE DERIVATIVE; TEMOZOLOMIDE;

EID: 67649298020     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590902817817     Document Type: Review
Times cited : (72)

References (109)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285(21):1182-1186
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82(1):4-6
    • (1990) J Natl Cancer Inst , vol.82 , Issue.1 , pp. 4-6
    • Folkman, J.1
  • 3
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • DOI 10.1038/74651
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000;6(4):389-395 (Pubitemid 30208155)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 389-395
    • Carmeliet, P.1
  • 4
    • 0032146088 scopus 로고    scopus 로고
    • Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis
    • DOI 10.1016/S0959-8049(98)00069-0, PII S0959804998000690
    • Fujimoto K, Hosotani R, Wada M, et al. Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis. Eur J Cancer 1998;34(9):1439-1447 (Pubitemid 28370938)
    • (1998) European Journal of Cancer , vol.34 , Issue.9 , pp. 1439-1447
    • Fujimoto, K.1    Hosotani, R.2    Wada, M.3    Lee, J.-U.4    Koshiba, T.5    Miyamoto, Y.6    Tsuji, S.7    Nakajima, S.8    Doi, R.9    Imamura, M.10
  • 5
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23(5):1011-1027 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 6
    • 0034075041 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
    • DOI 10.1016/S0959-8049(00)00003-4, PII S0959804900000034
    • Lee JC, Chow NH, Wang ST, Huang SM. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 2000;36(6):748-753 (Pubitemid 30179746)
    • (2000) European Journal of Cancer , vol.36 , Issue.6 , pp. 748-753
    • Lee, J.-C.1    Chow, N.-H.2    Wang, S.-T.3    Huang, S.-M.4
  • 7
    • 0029857184 scopus 로고    scopus 로고
    • Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer
    • Takahashi Y, Cleary KR, Mai M, et al. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin Cancer Res 1996;2(10):1679-1684 (Pubitemid 26356351)
    • (1996) Clinical Cancer Research , vol.2 , Issue.10 , pp. 1679-1684
    • Takahashi, Y.1    Cleary, K.R.2    Mai, M.3    Kitadai, Y.4    Bucana, C.D.5    Ellis, L.M.6
  • 8
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995;55(18):3964-3968
    • (1995) Cancer Res , vol.55 , Issue.18 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3
  • 9
    • 0034125067 scopus 로고    scopus 로고
    • Molecular basis of angiogenesis. Role of VEGF and VE-cadherin
    • discussion 62-64
    • Carmeliet P, Collen D. Molecular basis of angiogenesis. Role of VEGF and VE-cadherin. Ann NY Acad Sci 2000;902:249-62; discussion 62-64
    • (2000) Ann NY Acad Sci , vol.902 , pp. 249-262
    • Carmeliet, P.1    Collen, D.2
  • 10
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • DOI 10.1200/JCO.2002.10.088
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20(21):4368-4380 (Pubitemid 35266299)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 11
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9(6):669-676 (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    Lecouter, J.3
  • 12
    • 45849106868 scopus 로고    scopus 로고
    • Bevacizumab and oxaliplatin-based chemotherapy in metastatic colorectal cancer
    • Beatty GL, Giantonio BJ. Bevacizumab and oxaliplatin-based chemotherapy in metastatic colorectal cancer. Expert Rev Anticancer Ther 2008;8(5):683-688
    • (2008) Expert Rev Anticancer Ther , vol.8 , Issue.5 , pp. 683-688
    • Beatty, G.L.1    Giantonio, B.J.2
  • 13
    • 24744466384 scopus 로고    scopus 로고
    • Bevacizumab-current status and future directions
    • Midgley R, Kerr D. Bevacizumab-current status and future directions. Ann Oncol 2005;16(7):999-1004
    • (2005) Ann Oncol , vol.16 , Issue.7 , pp. 999-1004
    • Midgley, R.1    Kerr, D.2
  • 14
    • 34247606548 scopus 로고    scopus 로고
    • Bevacizumab in the management of solid tumors
    • DOI 10.1586/14737140.7.4.433
    • Panares RL, Garcia AA. Bevacizumab in the management of solid tumors. Expert Rev Anticancer Ther 2007;7(4):433-445 (Pubitemid 46681799)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.4 , pp. 433-445
    • Panares, R.L.1    Garcia, A.A.2
  • 15
    • 0032806309 scopus 로고    scopus 로고
    • Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin
    • Borgstrom P, Gold DP, Hillan KJ, Ferrara N. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res 1999;19(5B):4203-4214
    • (1999) Anticancer Res , vol.19 , Issue.5 B , pp. 4203-4214
    • Borgstrom, P.1    Gold, D.P.2    Hillan, K.J.3    Ferrara, N.4
  • 16
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • DOI 10.1038/362841a0
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362(6423):841-844 (Pubitemid 23132159)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 17
    • 0032848409 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre- Clinical model
    • DOI 10.1016/S0022-5347(01)61829-9
    • Melnyk O, Zimmerman M, Kim KJ, Shuman M. Neutralizing anti-vascular endothelial growth factor antibody inhibits further growth of established prostate cancer and metastases in a pre-clinical model. J Urol 1999;161(3):960-963 (Pubitemid 29422416)
    • (1999) Journal of Urology , vol.161 , Issue.3 , pp. 960-963
    • Melnyk, O.1    Zimmerman, M.2    Kim, K.J.3    Shuman, M.4
  • 18
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997;57(20):4593-4599 (Pubitemid 27441066)
    • (1997) Cancer Research , vol.57 , Issue.20 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 19
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005;65(3):671-680 (Pubitemid 40216420)
    • (2005) Cancer Research , vol.65 , Issue.3 , pp. 671-680
    • Gerber, H.-P.1    Ferrara, N.2
  • 22
    • 33748999448 scopus 로고    scopus 로고
    • Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: Updated results from a large observational registry in the US (BRiTE)
    • Hedrick E, Kozloff M, Hainsworth J, et al. Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: Updated results from a large observational registry in the US (BRiTE). In: 2006 ASCO Annual Meeting; 2006: J Clin Oncol 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006:3536
    • (2006) 2006 ASCO Annual Meeting; 2006: J Clin Oncol 2006 ASCO Annual Meeting Proceedings Part I , vol.24 , Issue.18 S JUNE 20 SUPPL. , pp. 3536
    • Hedrick, E.1    Kozloff, M.2    Hainsworth, J.3
  • 23
    • 67649287188 scopus 로고    scopus 로고
    • Preliminary safety of bevacizumab with first-line FOLFOX, CAPOX, FOLFIRI, and capecitabine for mCRC: First BEATrial
    • Abstract 346
    • VanCutsem E, Michael M, Berry S, et al. Preliminary safety of bevacizumab with first-line FOLFOX, CAPOX, FOLFIRI, and capecitabine for mCRC: first BEATrial. 2007 Gastrointestinal Cancers Symposium (Abstract 346); 2007
    • (2007) 2007 Gastrointestinal Cancers Symposium
    • Vancutsem, E.1    Michael, M.2    Berry, S.3
  • 25
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21(1):60-65
    • (2003) J Clin Oncol , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 28
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treated with bevacizumab combination therapy
    • DOI 10.1159/000088481
    • Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy. Oncology 2005;69(Suppl 3):25-33 (Pubitemid 41680950)
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 29
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • DOI 10.1200/JCO.2006.09.6305
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25(12):1539-1544 • A Phase III study comparing bevacizumab plus FOLFOX with FOLFOX alone and bevacizumab alone. (Pubitemid 46733080)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6    Schwartz, M.A.7    Benson III, A.B.8
  • 31
    • 56649123212 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis
    • Nalluri SR, Chu D, Keresztes R, et al. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA 2008;300(19):2277-2285
    • (2008) JAMA , vol.300 , Issue.19 , pp. 2277-2285
    • Nalluri, S.R.1    Chu, D.2    Keresztes, R.3
  • 33
    • 40149096054 scopus 로고    scopus 로고
    • Management of bevacizumab-associated bowel perforation: A case series and review of the literature
    • DOI 10.1093/annonc/mdm508
    • Badgwell BD, Camp ER, Feig B, et al. Management of bevacizumab-associated bowel perforation: a case series and review of the literature. Ann Oncol 2008;19(3):577-582 (Pubitemid 351325682)
    • (2008) Annals of Oncology , vol.19 , Issue.3 , pp. 577-582
    • Badgwell, B.D.1    Camp, E.R.2    Feig, B.3    Wolff, R.A.4    Eng, C.5    Ellis, L.M.6    Cormier, J.N.7
  • 34
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: Results from the eastern cooperative oncology group study E2200
    • DOI 10.1093/annonc/mdl161
    • Giantonio BJ, Levy DE, O'Dwyer PJ, et al. A Phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the Eastern Cooperative Oncology Group study E2200. Ann Oncol 2006;17(9):1399-1403 (Pubitemid 44400378)
    • (2006) Annals of Oncology , vol.17 , Issue.9 , pp. 1399-1403
    • Giantonio, B.J.1    Levy, D.E.2    O'Dwyer, P.J.3    Meropol, N.J.4    Catalano, P.J.5    Benson III, A.B.6
  • 35
    • 7444224685 scopus 로고    scopus 로고
    • Integrating the anti-VEGF - A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer
    • Hurwitz H. Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer. Clin Colorectal Cancer 2004;4(Suppl 2):S62-8 (Pubitemid 39440145)
    • (2004) Clinical Colorectal Cancer , vol.4 , Issue.SUPPL. 2
    • Hurwitz, H.1
  • 36
    • 54249108586 scopus 로고    scopus 로고
    • Initial safety report of NSABP C-08, a randomized Phase III study of modified 5-fluorouracil (5-FU)/leucovorin (LCV) and oxaliplatin (OX) (mFOLFOX6) with or without bevacizumab (bev) in the adjuvant treatment of patients with stage II/III colon cancer
    • abstract 4006.
    • Allegra CJ, Yothers G, O'Connell MJ, et al. Initial safety report of NSABP C-08, a randomized Phase III study of modified 5-fluorouracil (5-FU)/leucovorin (LCV) and oxaliplatin (OX) (mFOLFOX6) with or without bevacizumab (bev) in the adjuvant treatment of patients with stage II/III colon cancer [abstract 4006]. 2008 ASCO annual meeting; J Clin Oncol 2008;26(May 20 Suppl)
    • (2008) 2008 ASCO Annual Meeting; J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3
  • 37
    • 33947311852 scopus 로고    scopus 로고
    • What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?
    • Han ES, Monk BJ. What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer? Gynecol Oncol 2007;105(1):3-6
    • (2007) Gynecol Oncol , vol.105 , Issue.1 , pp. 3-6
    • Han, E.S.1    Monk, B.J.2
  • 40
    • 39149108869 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
    • DOI 10.1200/JCO.2007.15.5390
    • Fuchs CS, Marshall J, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol 2008;26(4):689-690 (Pubitemid 351264373)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.4 , pp. 689-690
    • Fuchs, C.S.1    Marshall, J.2    Barrueco, J.3
  • 43
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized Phase III study
    • A Phase III trial involving use of bevacizumab in first line treatment of metastatic colorectal cancer
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized Phase III study. J Clin Oncol 2008;26(12):2013-2019 • A Phase III trial involving use of bevacizumab in first line treatment of metastatic colorectal cancer.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 44
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • A large observational study involving the use of bevacizumab in first line and second line treatment of metastatic colorectal cancer
    • Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 2008;26(33):5326-5334 • A large observational study involving the use of bevacizumab in first line and second line treatment of metastatic colorectal cancer.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 46
    • 46049113331 scopus 로고    scopus 로고
    • An updated analysis of safety and efficacy of oxaliplatin (Ox)/bevacizumab (bev) +/- Panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE)
    • Abstract 273
    • Hecht JR, Mitchell E, Chidiac T, et al. An updated analysis of safety and efficacy of oxaliplatin (Ox)/bevacizumab (bev) +/- panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE). 2008 Gastrointestinal Cancers Symposium (Abstract 273); 2008
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 47
    • 49149109102 scopus 로고    scopus 로고
    • Randomized Phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG)
    • abstract LBA4011
    • Punt CJ, Tol J, Rodenburg CJ, et al. Randomized Phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG) [abstract LBA4011]. 2008 ASCO Annual Meeting; J Clin Oncol 2008;26(May 20 Suppl)
    • (2008) 2008 ASCO Annual Meeting; J Clin Oncol , Issue.26 MAY 20 SUPPL.
    • Punt, C.J.1    Tol, J.2    Rodenburg, C.J.3
  • 48
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359(17):1757-1765
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 51
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of Eastern Cooperative Oncology Group Trial 4599
    • Ramalingam SS, Dahlberg SE, Langer CJ, et al. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. J Clin Oncol 2008;26(1):60-65
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 52
    • 35548962413 scopus 로고    scopus 로고
    • Randomised, double-blind multicentre Phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704
    • abstract LBA7514
    • Manegold C, von Pawel J, Zatloukal P, et al. Randomised, double-blind multicentre Phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704 [abstract LBA7514]. 2007 ASCO Annual Meeting; 2007: J Clin Oncol 2007;25(18S) (June 20 Supplement)
    • (2007) 2007 ASCO Annual Meeting; 2007: J Clin Oncol , vol.25 , Issue.18 S JUNE 20 SUPPL.
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 53
    • 15844380285 scopus 로고    scopus 로고
    • Lung cancer in women: Analysis of the national Surveillance, Epidemiology, and End Results database
    • DOI 10.1378/chest.127.3.768
    • Fu JB, Kau TY, Severson RK, Kalemkerian GP. Lung cancer in women: analysis of the national surveillance, epidemiology, and end results database. Chest 2005;127(3):768-777 (Pubitemid 40775504)
    • (2005) Chest , vol.127 , Issue.3 , pp. 768-777
    • Fu, J.B.1    Kau, T.Y.2    Severson, R.K.3    Kalemkerian, G.P.4
  • 54
    • 1342268525 scopus 로고    scopus 로고
    • American society of clinical oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
    • Pfister DG, Johnson DH, Azzoli CG, et al. American society of clinical oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 2004;22(2):330-353
    • (2004) J Clin Oncol , vol.22 , Issue.2 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 55
    • 8444234397 scopus 로고    scopus 로고
    • Treatment of brain metastases from lung cancer: Chemotherapy
    • DOI 10.1016/j.lungcan.2004.07.967, PII S0169500204800333, Trends in Diagnostic and Therapy of Lung Cancer
    • Schuette W. Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer 2004;45(Suppl 2):S253-7 (Pubitemid 39488196)
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Schuette, W.1
  • 56
    • 34247231012 scopus 로고    scopus 로고
    • The proportion of patients with metastatic non-small cell lung cancer potentially eligible for treatment with bevacizumab: A single institutional survey
    • PII 0124389420060600000023
    • Velcheti V, Viswanathan A, Govindan R. The proportion of patients with metastatic non-small cell lung cancer potentially eligible for treatment with bevacizumab: a single institutional survey. J Thorac Oncol 2006;1(5):501 (Pubitemid 47181431)
    • (2006) Journal of Thoracic Oncology , vol.1 , Issue.5 , pp. 501
    • Velcheti, V.1    Viswanathan, A.2    Govindan, R.3
  • 57
    • 36148992949 scopus 로고    scopus 로고
    • The role of bevacizumab in the treatment of non-small cell lung cancer: Current indications and future developments
    • DOI 10.1634/theoncologist.12-10-1183
    • Gridelli C, Maione P, Rossi A, De Marinis F. The role of bevacizumab in the treatment of non-small cell lung cancer: current indications and future developments. Oncologist 2007;12(10):1183-1193 (Pubitemid 350106349)
    • (2007) Oncologist , vol.12 , Issue.10 , pp. 1183-1193
    • Gridelli, C.1    Maione, P.2    Rossi, A.3    De Marinis, F.4
  • 58
    • 15544391142 scopus 로고    scopus 로고
    • Angiogenesis of breast cancer
    • DOI 10.1200/JCO.2005.12.017
    • Schneider BP, Miller KD. Angiogenesis of breast cancer. J Clin Oncol 2005;23(8):1782-1790 (Pubitemid 46211430)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.8 , pp. 1782-1790
    • Schneider, B.P.1    Miller, K.D.2
  • 59
    • 34248576452 scopus 로고    scopus 로고
    • Bevacizumab for Advanced Breast Cancer
    • DOI 10.1016/j.hoc.2007.03.006, PII S0889858807000202, Current and Emerging Systemic Treatment Strategies for Breast Cancer
    • Traina TA, Rugo HS, Dickler M. Bevacizumab for advanced breast cancer. Hematol Oncol Clin North Am 2007;21(2):303-319 (Pubitemid 46754733)
    • (2007) Hematology/Oncology Clinics of North America , vol.21 , Issue.2 , pp. 303-319
    • Traina, T.A.1    Rugo, H.S.2    Dickler, M.3
  • 62
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357(26):2666- 2676
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 63
    • 0037303885 scopus 로고    scopus 로고
    • E2100: A Phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer
    • Miller KD. E2100: a Phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer 2003;3(6):421-422
    • (2003) Clin Breast Cancer , vol.3 , Issue.6 , pp. 421-422
    • Miller, K.D.1
  • 65
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
    • Klauber N, Parangi S, Flynn E, et al. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res 1997;57(1):81-86 (Pubitemid 27021522)
    • (1997) Cancer Research , vol.57 , Issue.1 , pp. 81-86
    • Klauber, N.1    Parangi, S.2    Flynn, E.3    Hamel, E.4    D'Amato, R.J.5
  • 66
    • 54249120945 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, Phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO
    • abstract LBA1011
    • Miles D, Chan A, Romieu G, et al. Randomized, double-blind, placebo-controlled, Phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO [abstract LBA1011]. J Clin Oncol 2008;26(May 20 Suppl)
    • (2008) J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Miles, D.1    Chan, A.2    Romieu, G.3
  • 67
    • 34447502449 scopus 로고    scopus 로고
    • Experience with bevacizumab in the management of epithelial ovarian cancer
    • DOI 10.1200/JCO.2007.12.1509
    • Burger RA. Experience with bevacizumab in the management of epithelial ovarian cancer. J Clin Oncol 2007;25(20):2902-2908 (Pubitemid 47123154)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.20 , pp. 2902-2908
    • Burger, R.A.1
  • 68
    • 35848943469 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of ovarian cancer
    • DOI 10.1586/14737140.7.10.1339
    • Han ES, Monk BJ. Bevacizumab in the treatment of ovarian cancer. Expert Rev Anticancer Ther 2007;7(10):1339-1345 (Pubitemid 351826900)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.10 , pp. 1339-1345
    • Han, E.S.1    Monk, B.J.2
  • 69
    • 41849092178 scopus 로고    scopus 로고
    • Angiogenesis as a strategic target for ovarian cancer therapy
    • Spannuth WA, Sood AK, Coleman RL. Angiogenesis as a strategic target for ovarian cancer therapy. Nat Clin Pract Oncol 2008;5(4):194-204
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.4 , pp. 194-204
    • Spannuth, W.A.1    Sood, A.K.2    Coleman, R.L.3
  • 70
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group study
    • DOI 10.1200/JCO.2007.11.5345
    • Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007;25(33):5165-5171 (Pubitemid 350237599)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.33 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 72
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia
    • Garcia AA, Hirte H, Fleming G, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital Phase II consortia. J Clin Oncol 2008;26(1):76-82
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 73
    • 33947288597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: Current status and future directions
    • DOI 10.1158/1078-0432.CCR-06-1989
    • Rini BI. Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and future directions. Clin Cancer Res 2007;13(4):1098-1106 (Pubitemid 46424048)
    • (2007) Clinical Cancer Research , vol.13 , Issue.4 , pp. 1098-1106
    • Rini, B.I.1
  • 77
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park YN, Kim YB, Yang KM, Park C. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 2000;124(7):1061-1065 (Pubitemid 30602050)
    • (2000) Archives of Pathology and Laboratory Medicine , vol.124 , Issue.7 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.-B.2    Yang, K.M.3    Park, C.4
  • 78
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in human hepatocellular carcinoma
    • DOI 10.1002/hep.510280111
    • Yamaguchi R, Yano H, Iemura A, et al. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998;28(1):68-77 (Pubitemid 28299987)
    • (1998) Hepatology , vol.28 , Issue.1 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3    Ogasawara, S.4    Haramaki, M.5    Kojiro, M.6
  • 79
    • 33749261599 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma
    • DOI 10.1016/j.canlet.2006.01.008, PII S0304383506000280
    • Pang R, Poon RT. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma. Cancer Lett 2006;242(2):151-167 (Pubitemid 44485315)
    • (2006) Cancer Letters , vol.242 , Issue.2 , pp. 151-167
    • Pang, R.1    Poon, R.T.P.2
  • 80
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • Semela D, Dufour JF. Angiogenesis and hepatocellular carcinoma. J Hepatol 2004;41(5):864-880
    • (2004) J Hepatol , vol.41 , Issue.5 , pp. 864-880
    • Semela, D.1    Dufour, J.F.2
  • 81
    • 32944480899 scopus 로고    scopus 로고
    • Opportunities for targeted therapies in hepatocellular carcinoma
    • DOI 10.1200/JCO.2004.00.1537
    • Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005;23(31):8093-8108 (Pubitemid 46657412)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.31 , pp. 8093-8108
    • Thomas, M.B.1    Abbruzzese, J.L.2
  • 82
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359(4):378-390
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 83
    • 38049092474 scopus 로고    scopus 로고
    • Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary results of a Phase II study with circulating endothelial cell (CEC) monitoring
    • Malka D, Dromain C, Farace F, et al. Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): Preliminary results of a Phase II study with circulating endothelial cell (CEC) monitoring. In: 2007 ASCO Annual Meeting; 2007: J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007:4570
    • (2007) 2007 ASCO Annual Meeting; 2007: J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I , vol.25 , Issue.18 S JUNE 20 SUPPL. , pp. 4570
    • Malka, D.1    Dromain, C.2    Farace, F.3
  • 84
    • 33750917456 scopus 로고    scopus 로고
    • Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein
    • Schwartz JD, Schwartz M, Lehrer D, et al. Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein. In: 2006 ASCO Annual Meeting; 2006: J Clin Oncol 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006:4144
    • (2006) 2006 ASCO Annual Meeting; 2006: J Clin Oncol 2006 ASCO Annual Meeting Proceedings Part I. , vol.24 , Issue.18 S JUNE 20 SUPPL. , pp. 4144
    • Schwartz, J.D.1    Schwartz, M.2    Lehrer, D.3
  • 86
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008;26(18):2992-2998
    • (2008) J Clin Oncol , vol.26 , Issue.18 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3
  • 87
    • 0037389767 scopus 로고    scopus 로고
    • Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
    • Lamszus K, Ulbricht U, Matschke J, et al. Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin Cancer Res 2003;9(4):1399-1405 (Pubitemid 36418393)
    • (2003) Clinical Cancer Research , vol.9 , Issue.4 , pp. 1399-1405
    • Lamszus, K.1    Ulbricht, U.2    Matschke, J.3    Brockmann, M.A.4    Fillbrandt, R.5    Westphal, M.6
  • 89
    • 0035688408 scopus 로고    scopus 로고
    • Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograt
    • DOI 10.1023/A:1013329832067
    • Stefanik DF, Fellows WK, Rizkalla LR, et al. Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograft. J Neurooncol 2001;55(2):91-100 (Pubitemid 34065325)
    • (2001) Journal of Neuro-Oncology , vol.55 , Issue.2 , pp. 91-100
    • Stefanik, D.F.1    Fellows, W.K.2    Rizkalla, L.R.3    Rizkalla, W.M.4    Stefanik, P.P.5    Deleo, A.B.6    Welch, W.C.7
  • 90
    • 43049124382 scopus 로고    scopus 로고
    • Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors
    • DOI 10.1002/cncr.23401
    • Bokstein F, Shpigel S, Blumenthal DT. Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors. Cancer 2008;112(10):2267-2273 (Pubitemid 351628638)
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2267-2273
    • Bokstein, F.1    Shpigel, S.2    Blumenthal, D.T.3
  • 91
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007;13(4):1253-1259
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 92
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007;25(30):4722-4729
    • (2007) J Clin Oncol , vol.25 , Issue.30 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 94
    • 43249128897 scopus 로고    scopus 로고
    • Phase I study of bevacizumab added to fluorouracil- And hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer
    • Seiwert TY, Haraf DJ, Cohen EE, et al. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol 2008;26(10):1732-1741
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1732-1741
    • Seiwert, T.Y.1    Haraf, D.J.2    Cohen, E.E.3
  • 95
    • 41649114168 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in advanced carcinoid tumor: A random assignment Phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b
    • Yao JC, Phan A, Hoff PM, et al. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment Phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b. J Clin Oncol 2008;26(8):1316-1323
    • (2008) J Clin Oncol , vol.26 , Issue.8 , pp. 1316-1323
    • Yao, J.C.1    Phan, A.2    Hoff, P.M.3
  • 98
    • 34247468303 scopus 로고    scopus 로고
    • The potential of antiangiogenic therapy in non-small cell lung cancer
    • DOI 10.1158/1078-0432.CCR-06-2186
    • Giaccone G. The potential of antiangiogenic therapy in non-small cell lung cancer. Clin Cancer Res 2007;13(7):1961-1970 (Pubitemid 46649861)
    • (2007) Clinical Cancer Research , vol.13 , Issue.7 , pp. 1961-1970
    • Giaccone, G.1
  • 99
    • 36348951548 scopus 로고    scopus 로고
    • New approaches in angiogenic targeting for colorectal cancer
    • Prat A, Casado E, Cortes J. New approaches in angiogenic targeting for colorectal cancer. World J Gastroenterol 2007;13(44):5857-5866 (Pubitemid 350148502)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.44 , pp. 5857-5866
    • Prat, A.1    Casado, E.2    Cortes, J.3
  • 100
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A, et al. Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 2008;26(29):4714-4719
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 101
    • 33846821872 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • DOI 10.1200/JCO.2006.08.5415
    • Motzer RJ, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol 2006;24(35):5601-5608 (Pubitemid 46631341)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.35 , pp. 5601-5608
    • Motzer, R.J.1    Bukowski, R.M.2
  • 102
    • 44449178477 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Key to diagnosis and choice of therapy
    • Rutkowski P, Debiec-Rychter M, Ruka W. Gastrointestinal stromal tumors: key to diagnosis and choice of therapy. Mol Diagn Ther 2008;12(3):131-143 (Pubitemid 351754587)
    • (2008) Molecular Diagnosis and Therapy , vol.12 , Issue.3 , pp. 131-143
    • Rutkowski, P.1    Debiec-Rychter, M.2    Ruka, W.3
  • 105
    • 67649247403 scopus 로고    scopus 로고
    • A Phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs) abstract 3557
    • Rixe O, Verslype C, Khayat D, et al. A Phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs) [abstract 3557]. In: 2008 ASCO Annual Meeting; 2008: J Clin Oncol 2008;26(May 20 Suppl)
    • (2008) 2008 ASCO Annual Meeting; 2008: J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Rixe, O.1    Verslype, C.2    Khayat, D.3
  • 106
    • 67649262706 scopus 로고    scopus 로고
    • Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial
    • abstract 4027
    • Tang P, Cohen SJ, Bjarnason GA, et al. Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial [abstract 4027]. In: 2008 ASCO Annual Meeting; 2008: J Clin Oncol 2008;26(May 20 Suppl)
    • (2008) 2008 ASCO Annual Meeting; 2008: J Clin Oncol , vol.26 , Issue.MAY 20 SUPPL.
    • Tang, P.1    Cohen, S.J.2    Bjarnason, G.A.3
  • 109
    • 44849140532 scopus 로고    scopus 로고
    • Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer
    • DOI 10.1097/JTO.0b013e318174e95a, PII 0124389420080600100005
    • Natale RB. Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer. J Thorac Oncol 2008;3(6 Suppl 2):S128-30 (Pubitemid 351790696)
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.6 SUPPL. 2
    • Natale, R.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.