Endocytosis and recycling of the HIV coreceptor CCR5

Journal of Cell Biology

Volumn 151, Issue 6, 2000, Pages 1281-1293

  Signoreta, Nathalie ^a   Pelchen Matthewsa, Annegret ^a   Mackb, Matthias ^b   Proudfootc, Amanda E I ^c   Marsha, Mark ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

^c SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

CCR5; Chemokine receptor; Endocytosis; HIV; Recycling endosome

Indexed keywords

CHEMOKINE RECEPTOR CCR5; G PROTEIN COUPLED RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; ENDOCYTOSIS; ENDOSOME; HALF LIFE TIME; HUMAN IMMUNODEFICIENCY VIRUS; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RECEPTOR INTRINSIC ACTIVITY; STEADY STATE; TRANSCYTOSIS; VIRUS INFECTION;

ANIMALS; ANTI-HIV AGENTS; CELL COMPARTMENTATION; CHO CELLS; CRICETINAE; ENDOCYTOSIS; HUMANS; LIGANDS; RANTES; RECEPTORS, CCR5;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0034638839     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.6.1281     Document Type: Article

References (46)

1. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation
2. Examination of the function of RANTES, MIP-1alpha, and MIP-1beta following interaction with heparin-like glycosaminoglycans
3. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication
4. Molecular mechanism of desensitization of the chemokine receptor CCR-5: Receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
5. HIV blocked by HIV chemokine antagonists
6. Human chemokines: An update
7. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
8. The lymphocyte chemoattractant SDF-1 is a ligand for Lestr/fusin and blocks HIV-1 entry
9. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
10. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor
11. Differential activation of CC chemokine receptors by AOP-RANTES
12. Animal cell mutants defective in glycosaminoglycan biosynthesis
13. Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
14. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain
15. A quantitative analysis of the endocytic pathway in baby hamster kidney cells
16. Glycosaminoglycans mediate cell surface oligomerization of chemokines
17. In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella
18. CD4-chemokine-receptor hybrids in human immunodeficiency virus type 1 (HIV-1) infection
19. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
20. The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification
21. Arrestin/clathin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus
22. Identification of a glycosaminoglycan binding surface on human interleukin-8
23. Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses
24. Use of chemokine receptors by poxviruses
25. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
26. AOP-RANTES prevents CCR5 recycling: A novel inhibitory mechanism of HIV infectivity
27. Three-dimensional structure of endosomes in BHK-21 cells
28. Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor
29. International union of pharmacology. XXII. Nomenclature for chemokine receptors
30. The CXC chemokine SDF-1 is the ligand for Lestr/Fusin and prevents infection by T-cell-line-adapted HIV-1
31. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus
32. Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans
33. Chemokine receptor trafficking and viral replication
34. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist
35. Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors
36. Immunogold labeling of ultrathin cryosections: Application in immunology
37. Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: Implications for chemotaxis
38. Expression of the C-C chemokine receptor 5 in human kidney diseases
39. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions
40. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4
41. Differential regulation of CXCR4 and CCR5 endocytosis
42. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
43. The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivity
44. Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex
45. Chemokine receptors - The new frontier for AIDS research
46. Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway