Retraction Note: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats [J Neuroinflammation. 8, (2001)(101)] DOI: 10.1186/1742-2094-8-101;Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Rao, Jagadeesh S ^a   Kim, Hyung Wook ^a   Kellom, Matthew ^a   Greenstein, Dede ^b   Chen, Mei ^a   Kraft, Andrew D ^c   Harry, Gaylia J ^c   Rapoport, Stanley I ^a   Basselin, Mireille ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CD11B ANTIGEN; CELL PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 EPOXYGENASE; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 IVA; DREBRIN; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; OXYGENASE; PROSTAGLANDIN E2 SYNTHASE; SECRETORY PHOSPHOLIPASE A2; SECRETORY PHOSPHOLIPASE A2 IIA; SYNAPTIC PROTEIN; SYNTHETASE; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; RELA PROTEIN, RAT; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENCEPHALITIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOREACTIVITY; MALE; NERVE CELL LESION; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; TRANSGENIC RAT; ANIMAL; CHEMISTRY; COGNITIVE DEFECT; FISCHER 344 RAT; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; BIOLOGICAL MARKERS; COGNITION DISORDERS; ENCEPHALITIS; HIV-1; HUMANS; INTERLEUKIN-1BETA; MALE; RATS; RATS, INBRED F344; RATS, TRANSGENIC; SIGNAL TRANSDUCTION; SYNAPSES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051634663     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-017-0872-z     Document Type: Erratum

References (80)

1. Foley J, Ettenhofer M, Wright M, Hinkin CH. Emerging issues in the neuropsychology of HIV infection. Curr HIV/AIDS Rep 2008, 5:204-211. 10.1007/s11904-008-0029-x, 18838060.
2. Schouten J, Cinque P, Gisslen M, Reiss P, Portegies P. HIV-1 infection and cognitive impairment in the cART era: a review. AIDS 2011, 25:561-575. 10.1097/QAD.0b013e3283437f9a, 21160410.
3. Paramesparan Y, Garvey LJ, Ashby J, Foster CJ, Fidler S, Winston A. High rates of asymptomatic neurocognitive impairment in vertically acquired HIV-1-infected adolescents surviving to adulthood. J Acquir Immune Defic Syndr 2010, 55:134-136. 10.1097/QAI.0b013e3181d90e8c, 20733406.
4. Simioni S, Cavassini M, Annoni JM, Rimbault Abraham A, Bourquin I, Schiffer V, Calmy A, Chave JP, Giacobini E, Hirschel B, Du Pasquier RA. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS 2010, 24:1243-1250.
5. Lashomb AL, Vigorito M, Chang SL. Further characterization of the spatial learning deficit in the human immunodeficiency virus-1 transgenic rat. J Neurovirol 2009, 15:14-24. 10.1080/13550280802232996, 19085205.
6. Vigorito M, LaShomb AL, Chang SL. Spatial learning and memory in HIV-1 transgenic rats. J Neuroimmune Pharmacol 2007, 2:319-328. 10.1007/s11481-007-9078-y, 18040850.
7. Reid W, Sadowska M, Denaro F, Rao S, Foulke J, Hayes N, Jones O, Doodnauth D, Davis H, Sill A, et al. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc Natl Acad Sci USA 2001, 98:9271-9276. 10.1073/pnas.161290298, 55410, 11481487.
8. Chang SL, Beltran JA, Swarup S. Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model. J Virol 2007, 81:8406-8411. 10.1128/JVI.00155-07, 1951376, 17553897.
9. Basselin M, Ramadan E, Igarashi M, Chang L, Chen M, Kraft AD, Harry GJ, Rapoport SI. Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. J Cereb Blood Flow Metab 31:486-493.
10. Gray F, Haug H, Chimelli L, Geny C, Gaston A, Scaravilli F, Budka H. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Acta Neuropathol 1991, 82:229-233. 10.1007/BF00294450, 1927280.
11. Masliah E, Ge N, Morey M, DeTeresa R, Terry RD, Wiley CA. Cortical dendritic pathology in human immunodeficiency virus encephalitis. Lab Invest 1992, 66:285-291.
12. Masliah E, Heaton RK, Marcotte TD, Ellis RJ, Wiley CA, Mallory M, Achim CL, McCutchan JA, Nelson JA, Atkinson JH, Grant I. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol 1997, 42:963-972. 10.1002/ana.410420618, 9403489.
13. Rothwell NJ. Annual review prize lecture cytokines-killers in the brain?. J Physiol 1999, 514(Pt 1):3-17. 2269053, 9831712.
14. Moolwaney AS, Igwe OJ. Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. Brain Res Mol Brain Res 2005, 137:202-212.
15. Laflamme N, Lacroix S, Rivest S. An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J Neurosci 1999, 19:10923-10930.
16. Blais V, Rivest S. Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries. J Neuropathol Exp Neurol 2001, 60:893-905.
17. Hernandez M, Bayon Y, Sanchez Crespo M, Nieto ML. Signaling mechanisms involved in the activation of arachidonic acid metabolism in human astrocytoma cells by tumor necrosis factor-alpha: phosphorylation of cytosolic phospholipase A2 and transactivation of cyclooxygenase-2. J Neurochem 1999, 73:1641-1649.
18. Griffin DE, Wesselingh SL, McArthur JC. Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Ann Neurol 1994, 35:592-597. 10.1002/ana.410350513, 7910004.
19. Viviani B, Corsini E, Binaglia M, Galli CL, Marinovich M. Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro. Neuroscience 2001, 107:51-58. 10.1016/S0306-4522(01)00332-3, 11744246.
20. Mollace V, Colasanti M, Rodino P, Lauro GM, Nistico G. HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation. Biochem Biophys Res Commun 1994, 203:87-92. 10.1006/bbrc.1994.2152, 7521167.
21. Maccarrone M, Navarra M, Corasaniti MT, Nistico G, Finazzi Agro A. Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade. Biochem J 1998, 333(Pt 1):45-49. 1219553, 9639560.
22. Williams JR, Leaver HA, Ironside JW, Miller EP, Whittle IR, Gregor A. Apoptosis in human primary brain tumours: actions of arachidonic acid. Prostaglandins Leukot Essent Fatty Acids 1998, 58:193-200. 10.1016/S0952-3278(98)90113-2, 9610841.
23. Yagami T, Ueda K, Asakura K, Hata S, Kuroda T, Sakaeda T, Takasu N, Tanaka K, Gemba T, Hori Y. Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. Mol Pharmacol 2002, 61:114-126. 10.1124/mol.61.1.114, 11752212.
24. Fang KM, Chang WL, Wang SM, Su MJ, Wu ML. Arachidonic acid induces both Na+ and Ca2+ entry resulting in apoptosis. J Neurochem 2008, 104:1177-1189. 10.1111/j.1471-4159.2007.05022.x, 17986230.
25. Okuda S, Saito H, Katsuki H. Arachidonic acid: toxic and trophic effects on cultured hippocampal neurons. Neuroscience 1994, 63:691-699. 10.1016/0306-4522(94)90515-0, 7898670.
26. Farooqui AA, Yi Ong W, Lu XR, Halliwell B, Horrocks LA. Neurochemical consequences of kainate-induced toxicity in brain: involvement of arachidonic acid release and prevention of toxicity by phospholipase A(2) inhibitors. Brain Res Brain Res Rev 2001, 38:61-78.
27. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 2004, 27:589-594. 10.1016/j.tins.2004.08.001, 15374669.
28. Kojima N, Kato Y, Shirao T, Obata K. Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs. Brain Res 1988, 464:207-215.
29. Huang SK, Klein DC, Korf HW. Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland. Cell Tissue Res 1992, 267:493-498. 10.1007/BF00319371, 1533347.
30. Aoki C, Sekino Y, Hanamura K, Fujisawa S, Mahadomrongkul V, Ren Y, Shirao T. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. J Comp Neurol 2005, 483:383-402. 10.1002/cne.20449, 15700273.
31. Terry-Lorenzo RT, Inoue M, Connor JH, Haystead TA, Armbruster BN, Gupta RP, Oliver CJ, Shenolikar S. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J Biol Chem 2000, 275:2439-2446. 10.1074/jbc.275.4.2439, 10644697.
32. McCarthy M, Vidaurre I, Geffin R. Maturing neurons are selectively sensitive to human immunodeficiency virus type 1 exposure in differentiating human neuroepithelial progenitor cell cultures. J Neurovirol 2006, 12:333-348. 10.1080/13550280600915347, 17065126.
33. Harigaya Y, Shoji M, Shirao T, Hirai S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J Neurosci Res 1996, 43:87-92. 10.1002/jnr.490430111, 8838578.
34. Julien C, Tremblay C, Bendjelloul F, Phivilay A, Coulombe MA, Emond V, Calon F. Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology. J Neurosci Res 2008, 86:2292-2302. 10.1002/jnr.21667, 18338803.
35. Chuang DM, Chen RW, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, Kanai H, Hough C, Hiroi T, Leeds P. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disord 2002, 4:129-136. 10.1034/j.1399-5618.2002.01179.x, 12071510.
36. Hatanpaa K, Isaacs KR, Shirao T, Brady DR, Rapoport SI. Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J Neuropathol Exp Neurol 1999, 58:637-643. 10.1097/00005072-199906000-00008, 10374754.
37. Counts SE, Nadeem M, Lad SP, Wuu J, Mufson EJ. Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. J Neuropathol Exp Neurol 2006, 65:592-601. 10.1097/00005072-200606000-00007, 16783169.
38. Dwivedi Y, Rizavi HS, Rao JS, Pandey GN. Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in rat brain: focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphate. J Pharmacol Exp Ther 2000, 295:244-254.
39. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
40. Lahiri DK. An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells. Brain Res Mol Brain Res 1998, 58:112-122.
41. Rao JS, Ertley RN, Rapoport SI, Bazinet RP, Lee HJ. Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2. J Neurochem 2007, 102:1918-1927. 10.1111/j.1471-4159.2007.04648.x, 17550430.
42. Ford AL, Goodsall AL, Hickey WF, Sedgwick JD. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J Immunol 1995, 154:4309-4321.
43. Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ. Epoxyeicosanoid signaling in CNS function and disease. Prostaglandins Other Lipid Mediat 2010, 91:68-84. 10.1016/j.prostaglandins.2009.06.004, 2844927, 19545642.
44. Caro AA, Cederbaum AI. Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity. Free Radic Biol Med 2006, 40:364-375. 10.1016/j.freeradbiomed.2005.10.044, 16443151.
45. Morri H, Ozaki M, Watanabe Y. 5'-flanking region surrounding a human cytosolic phospholipase A2 gene. Biochem Biophys Res Commun 1994, 205:6-11. 10.1006/bbrc.1994.2621, 7999086.
46. Antonio V, Brouillet A, Janvier B, Monne C, Bereziat G, Andreani M, Raymondjean M. Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-kappaB and Ets transcription factors. Biochem J 2002, 368:415-424. 10.1042/BJ20020658, 1223003, 12188923.
47. Tanabe T, Tohnai N. Cyclooxygenase isozymes and their gene structures and expression. Prostaglandins Other Lipid Mediat 2002, 68-69:95-114.
48. Hernandez M, Fuentes L, Fernandez Aviles FJ, Crespo MS, Nieto ML. Secretory phospholipase A(2) elicits proinflammatory changes and upregulates the surface expression of fas ligand in monocytic cells: potential relevance for atherogenesis. Circ Res 2002, 90:38-45. 10.1161/hh0102.102978, 11786516.
49. Pereira SG, Oakley F. Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol 2008, 40:1425-1430. 10.1016/j.biocel.2007.05.004, 17693123.
50. Niederberger E, Schmidtko A, Gao W, Kuhlein H, Ehnert C, Geisslinger G. Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. Eur J Pharmacol 2007, 559:55-60. 10.1016/j.ejphar.2006.11.074, 17217946.
51. Dandekar DH, Ganesh KN, Mitra D. HIV-1 Tat directly binds to NFkappaB enhancer sequence: role in viral and cellular gene expression. Nucleic Acids Res 2004, 32:1270-1278. 10.1093/nar/gkh289, 390279, 14981150.
52. Roy A, Fung YK, Liu X, Pahan K. Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 2006, 281:14971-14980. 10.1074/jbc.M600236200, 1963414, 16551637.
53. Perry VH, O'Connor V. The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective. ASN Neuro 2010, 2.
54. Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman HE, Persidsky Y. HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration across blood-brain barrier: implication for viral neuropathogenesis. J Cereb Blood Flow Metab 2007, 27:123-134. 10.1038/sj.jcbfm.9600330, 2232899, 16685256.
55. Flora G, Pu H, Hennig B, Toborek M. Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. Neuromolecular Med 2006, 8:337-352. 10.1385/NMM:8:3:337, 16775385.
56. Flora G, Lee YW, Nath A, Hennig B, Maragos W, Toborek M. Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain. Exp Neurol 2003, 179:60-70. 10.1006/exnr.2002.8048, 12504868.
57. Xiong H, Zeng YC, Lewis T, Zheng J, Persidsky Y, Gendelman HE. HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. J Neurovirol 2000, 6(Suppl 1):S14-23.
58. Kobayashi R, Sekino Y, Shirao T, Tanaka S, Ogura T, Inada K, Saji M. Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant. Neurosci Res 2004, 49:205-217. 10.1016/j.neures.2004.02.014, 15140563.
59. Acquas E, Bachis A, Nosheny RL, Cernak I, Mocchetti I. Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases. Neurotox Res 2004, 5:605-615.
60. Haughey NJ, Mattson MP. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr 2002, 31(Suppl 2):S55-61.
61. Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci 2007, 27:11047-11055. 10.1523/JNEUROSCI.2733-07.2007, 17928446.
62. New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA. HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. J Biol Chem 1998, 273:17852-17858. 10.1074/jbc.273.28.17852, 9651389.
63. Bonavia R, Bajetto A, Barbero S, Albini A, Noonan DM, Schettini G. HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun 2001, 288:301-308. 10.1006/bbrc.2001.5743, 11606043.
64. Gregersen R, Lambertsen K, Finsen B. Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab 2000, 20:53-65. 10.1097/00004647-200001000-00009, 10616793.
65. Hanisch UK. Microglia as a source and target of cytokines. Glia 2002, 40:140-155. 10.1002/glia.10161, 12379902.
66. Taylor DL, Jones F, Kubota ES, Pocock JM. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. J Neurosci 2005, 25:2952-2964. 10.1523/JNEUROSCI.4456-04.2005, 15772355.
67. Beghi E, Citterio A, Cornelio F, Filippini G, Grilli R, Liberati A. Practice guidelines: a more rational approach to diagnosis and treatment and a more effective use of health care resources. Ital J Neurol Sci 1998, 19:120-123. 10.1007/BF02427570, 10935850.
68. Fiore M, Angelucci F, Alleva E, Branchi I, Probert L, Aloe L. Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha. Behav Brain Res 2000, 112:165-175. 10.1016/S0166-4328(00)00180-7, 10862948.
69. Fiore M, Probert L, Kollias G, Akassoglou K, Alleva E, Aloe L. Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain. Brain Behav Immun 1996, 10:126-138. 10.1006/brbi.1996.0013, 8811936.
70. Gemma C, Bickford PC. Interleukin-1beta and caspase-1: players in the regulation of age-related cognitive dysfunction. Rev Neurosci 2007, 18:137-148. 10.1515/REVNEURO.2007.18.2.137, 17593876.
71. Hauss-Wegrzyniak B, Dobrzanski P, Stoehr JD, Wenk GL. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res 1998, 780:294-303. 10.1016/S0006-8993(97)01215-8, 9507169.
72. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, et al. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci 2008, 11:1311-1318. 10.1038/nn.2213, 2597064, 18931664.
73. Lukiw WJ, Bazan NG. Neuroinflammatory signaling upregulation in Alzheimer's disease. Neurochem Res 2000, 25:1173-1184. 10.1023/A:1007627725251, 11059791.
74. Harezlak J, Buchthal S, Taylor M, Schifitto G, Zhong J, Daar E, Alger J, Singer E, Campbell T, Yiannoutsos C, et al. Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment. AIDS Epub Feb 3 2011,
75. Yagami T. Cerebral arachidonate cascade in dementia: Alzheimer's disease and vascular dementia. Curr Neuropharmacol 2006, 4:87-100. 10.2174/157015906775203011, 2430680, 18615138.
76. Sun GY, Xu J, Jensen MD, Simonyi A. Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. J Lipid Res 2004, 45:205-213.
77. Schifitto G, Peterson DR, Zhong J, Ni H, Cruttenden K, Gaugh M, Gendelman HE, Boska M, Gelbard H. Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report. Neurology 2006, 66:919-921. 10.1212/01.wnl.0000204294.28189.03, 16510768.
78. Letendre SL, Woods SP, Ellis RJ, Atkinson JH, Masliah E, van den Brande G, Durelle J, Grant I, Everall I. Lithium improves HIV-associated neurocognitive impairment. AIDS 2006, 20:1885-1888. 10.1097/01.aids.0000244208.49123.1b, 16954730.
79. Basselin M, Ramadan E, Chen M, Rapoport SI. Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. Neurochem Res 2011, 36:139-145. 10.1007/s11064-010-0282-4, 3011042, 20981485.
80. Basselin M, Villacreses NE, Lee HJ, Bell JM, Rapoport SI. Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation. J Neurochem 2007, 102:761-772. 10.1111/j.1471-4159.2007.04593.x, 17488274.