HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: Relevance for HIV-1-associated dementia

Journal of NeuroVirology

Volumn 6, Issue SUPPL. 1, 2000, Pages

  Xiong, Huangui ^a   Zeng, Yong Chun ^a   Lewis, Travis ^a   Zheng, Jialin ^a   Persidsky, Yuri ^a   Gendelman, Howard E ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Chemokines; Cytokines; HIV 1; HIV 1 associated dementia; Neurotoxicity; Viral structural and regulatory proteins

Indexed keywords

ARACHIDONIC ACID; CHEMOKINE; CYTOKINE; NITRIC OXIDE; THROMBOCYTE ACTIVATING FACTOR; VIRUS PROTEIN;

CONFERENCE PAPER; DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MICROGLIA; MONONUCLEAR PHAGOCYTE; NERVE CELL NECROSIS; PRIORITY JOURNAL;

AIDS DEMENTIA COMPLEX; ANIMALS; BRAIN; CELL DEATH; CHEMOKINES; CYTOKINES; GENE PRODUCTS, TAT; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MACROPHAGES; MICROGLIA; NEURONS; RECEPTORS, CHEMOKINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034041752     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (96)

1. Barbour B, Szatkowski M, Ingledew N, Attwell D (1989). Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 342: 918-920.
2. Bashir ZT, Bortolotto ZA, Davies CH, Berretta N, Irving AJ, Seal AJ, Henley JM, Jane DE, Watkins JC, Collingridge GL (1993). Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363: 347-350.
3. Bellinger FP, Madamba SG, Campbell IL, Siggins GR (1995). Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neurosci Lett 198: 95-98.
4. Bennett BA, Rusyniak DE, Hollingsworth CK (1995). Hiv-1 gp120-induced neurotoxicity to midbrain dopamine cultures. Brain Res 705: 168-176.
5. Bubien JK, Benveniste EN, Benos DJ (1995). HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes. Am J Physiol 268: C1440-C1449.
6. Cheng J, Nath A, Knudsen B, Hochman S, Geiger JD, Ma M, Magnuson DSK (1998). Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience 82: 97-106.
7. Coan EJ, Saywood W, Collingridge GL (1987). MK-801 blocks NMDA receptor-mediated synaptic transmission and long-term potentiation in rat hippocampal slices. Neurosci Lett 80: 111-114.
8. Collingridge GL, Kehl SL, McLennan H (1983). Excitatory amino acids in synaptic transmission in the Schaffer-commissural pathway of rat hippocampus. J Physiol 334: 33-46.
9. Conant K, Garzino-Demo A, Nath A, McArthur J, Halliday W, Power C, Gallo R, Major E (1998). Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 95: 3117-3121.
10. Cunningham AJ, Murray CA, O'Neill LAJ, Lynch MA, O'Connor JJ (1996). Interleukin-1β (IL-1β) and tumor necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci Lett 203: 17-20.
11. + voltage-gated current from Jurkat E6.1 T cells by up-phosphorylation. FEBS Lett 443: 187-191.
12. Dreyer EB, Lipton SA (1995). The coat protein gp120 of HIV-1 inhibits astrocytes uptake of excitatory amino acids via macrophage arachidonic acid. Eur J Neurosci 7: 2502-2507.
13. Dreyer EB, Kaiser PK, Offermann JT, Lipton SA (1990). HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 248: 364-367.
14. Ensoli B, Buonaguro L, Barillari G, Fiorelli V, Gendelman R, Morgan RA, Wingfield P, Gallo RC (1993). Release, uptake and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 67: 277-287.
15. Epstein LG, Gendelman HE (1993). Human Immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 33: 429-436.
16. Esser R, von Briesen H, Brugger M, Ceska M, Glienke W, Muller S, Rehm A, Rubsamen-Waigmann H, Andreesen R (1991). Secretory repertoire of HIV-infected human monocytes/macrophages. Pathobiology 59: 219-222.
17. Everall IP, Luthbert PJ, Lantos PL (1991). Neuronal loss in the frontal cortex in HIV infection. Lancet 337: 1119-1121.
18. Everall IP, Glass JD, McArthur J, Spargo E, Lantos L (1994). Neuronaldensity in superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol 88: 538-544.
19. Gendelman HE, Lipton SA, Tardieu M, Epstein L (1994). The neuropathogenesis of HIV-1 infection. J Leukoc Biol 56: 389-398.
20. Gendelman HE, Persidsky Y, Ghorpade A, Limoges J, Stins M, Fiala M, Morrisett R (1997). The neuropathogenesis of HIV-1 dementia. AIDS 97 11: S35-S45.
21. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Volsky DJ, Epstein LG, Gendelman HE (1992). Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176: 1703-1718.
22. Glabinski AR, Ransohoff RM (1999). Chemokines and chemokine receptors in CNS pathology. J Neurovirol 5: 3-12.
23. Glass JD, Fedor H, Wesselingh SL, McArthur JC (1995). Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlation with dementia. Ann Neurol 38: 755-762.
24. Glowa JR, Panlilio LV, Brenneman DE, Gozes I, Fridkin M, Hill JM (1992). Learning impairment following intracerebral administration of the HIV envelope gp120 or a VIP antagonist. Brain Res 570: 49-53.
25. Guilian D, Wendt E, Vaca K, Noon C (1993). The envelope glycoprotein of HIV-1 stimulates monocytes release of neurotoxins. Proc Natl Acad Sci USA 90: 2769-2773.
26. Haas HS, Schauenstein K (1997). Neuroimmunomodulation via limbic structure - the neuroanatomy of psychoimmunology. Prog Neurobiol 51: 195-222.
27. Hesselgesser J, Horuk R (1999). Chemokine and chemokine receptor expression in the central nervous system. J Neurovirol 5: 13-26.
28. Hill JM, Mervis RF, Avidor R, Moody TW, Brenneman DE (1993). HIV envelope protein-induced neuronal damage and retardation of behavioral development in rat neonates. Brain Res 603: 222-233.
29. Horuk R, Martin AW, Wang ZX, Schweitzer L, Gerassimides A, Guo H, Lu ZH, Hesselgesser J, Perez HD, Kim J, Parker J, Hadley TJ, Peiper SC (1997). Expression of chemokine receptors by subsets of neurons in the normal central nervous system. J Immunol 158: 2882-2890.
30. Katsuki H, Nakai S, Hirai Y, Akaji K, Kiso Y, Satoh M (1990). Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur J Pharmacol 181: 323-326.
31. Kauer JA, Malenka RC, Nicoll RA (1998). NMDA application potentiates synaptic transmission in the hippocampus. Nature 334: 250-252.
32. Kaul M, Lipton SA (1999). Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci USA 96: 8212-8216.
33. Ketzler S, Weis S, Haug H, Budka H (1990). Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropath. Berlin 80: 92-94.
34. Krucker T, Toggas SM, Mucke L, Siggins GR (1998). Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience 83: 691-700.
35. 2+]I homeostasis and induce neurotoxicity in human embryonic neurons. Eur J Neurosci 7: 2285-2293.
36. Lavi E, Strizki JM, Ulrich AM, Zhang W, Fu L, Wang Q, O'Connor M, Hoxie JA, Gonzalez-Scarano F (1997). CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol 151: 1035-1042.
37. Li AJ, Katafuchi T, Oda S, Hori T, Oomura Y (1997). Interleukin-6 inhibits long-term potentiation in rat hippocampal slices. Brain Res 748: 30-38.
38. Lipton SA (1992). Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 42: 1403-1405.
39. Lipton SA (1991). Calcium channel antagonists and human immunodeficency virus coat protein mediated neuronal injury. Ann Neurol 30: 110-114.
40. 2+, N-methyl-D-aspartate receptors, and AIDS-related neuronal injury. Int Rev Neurobio 36: 1-27.
41. Lipton SA (1998). Neuronal injury associated with HIV-1: Approaches to treatment. Annu Rev Pharmacol Toxicol 38: 159-177.
42. Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB (1991). Synergistiac effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 7: 111-118.
43. Lo TM, Fallert CJ, Piser TM, Thayer SA (1992). HTV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons. Brain Res 594: 189-196.
44. Luk WP, Zhang Y, White TD, Lue FA, Wu C, Jiang CG, Zhang L, Moldofsky H (1999). Adenosine: a mediator of interleukin-1 beta-mediated hippocampal synaptic inhibition. J Neurosci 19: 4238-4244.
45. Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F (1983). Intracellular injection of EGTA block induction of hippocampal long-term potentiation. Nature 305: 719-721.
46. Lynch MA (1998). Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1 beta? Prog Neurobiol 56: 571-589.
47. Magnuson DSK, Knudson BE, Geiger JD, Brownstone RM, Nath A (1995). Human immunodeficiency virus type 1 Tat activates non N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 37: 373-380.
48. Malenka RC, Kauer JA, Zucker RS, Nicoll RA (1988). Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission. Science 242: 81-84.
49. Masliah E, Achim CL, Ge N, DeTheresa R, Terry RD, Wiley CA (1992). Spectrum of human immunodeficiency virus-associated neorcortical damage. Ann Neurol 32: 321-329.
50. McArthur JC, Grant I (1998) HIV neurocognitive disorders. In: The Neurology of AIDS. Gendelman H, Lipton S, Epstein L, Swindells S, (eds). Chapman and Hall: New York, pp 499-524.
51. 2+]I and the toxic actions of HIV coat protein gp120. Eur J Neurosci 11: 1167-1178.
52. Mehler MF, Rozental R, Dougherty M, Spray DC, Kessler J (1993). Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 362: 62-65.
53. Meltzer MS, Skillman DR, Gomatos PJ, Kalter DC, Gendelman HE (1990). Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. Annu Rev Immunol 8: 169-194.
54. Meltzer MS, Gendelman HE (1992). Mononuclear phagocytes as targets, tissue reservoirs, and immunoregulatory cells in human immunodeficiency virus disease. Curr Top Microbiol Immunol 181: 239-263.
55. Meucci O, Miller RJ (1996). gp120-induced neurotoxicity in hippocampal pyramidal neuron culture: protective action of TGF-β1. J Neurosci 16: 4080-4088.
56. Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl. Acad. Sci. USA 95: 14500-14505.
57. Michaels J, Price RW, Rosenblum MK (1988). Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion. Acta Neuropathol 76: 373-379.
58. A receptor function in brain. Mol Pharmacol 39: 105-108.
59. Mrak RE, Sheng JG, Griffin WST (1995). Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol 26: 816-823.
60. Muller WEG, Schroder HC, Ushijima H, Dapper J. Bormann J (1992). Gp120 of HIV-1 induces apoptosis in rat cortical cell culture: prevention by memantine. Eur J Pharmacol 226: 209-214.
61. Murray CA, MaGahon B, McBennett S, Lynch MA (1997). Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats. Neurobiol Aging 18: 343-348.
62. Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD (1996). Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 70: 1475-1480.
63. Patterson PH, Nawa H (1993). Neuronal differentiation factors / cytokines and synaptic plasticity. Cell 72. Neuron 10 (Suppl.): 23-137.
64. Persidsky Y, Ghorpade A, Rasmussen J, Limoges J, Liu XJ, Stins M, Fiala M, Way D, Kim KS, Witte MH, Weinand M, Carhart L, Gendelman HE (1999). Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol 155: 1599-1611.
65. Persidsky Y, Stins M, Way D, Witte M, Weinand M, Kim K, Bock P, Gendelman, Fiala M (1997). A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol 158: 3499-3510.
66. Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T. Tyor TW, Patil A, Nottet HSLM, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE (1996). Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol 149: 1027-1053.
67. Plata-Salaman CR, Ffrench-Mullen JMH (1992). Interleukin-1β decrease calcium currents in CA1 hippocampal neurons at pathophysiological concentrations. Brain Res Bull 29: 221-223.
68. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P (1988). The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239: 586-592.
69. Reyes E, Mohar A, Mallory M, Miller A, Masliah E (1994). Hippocampal involvement associated with human immunodeficiency virus encephalitis in Mexico. Arch Pathol Lab Med 118: 1130-1134.
70. Rothwell NJ (1999). Cytokines - killers in the brain? J Physiol (Lond) 514: 3-17.
71. Rothwell NJ, Hopkins SJ (1995). Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci 18: 130-136.
72. Rothwell NJ, Relton JK (1993). Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci Biobehav Rev 17: 217-227.
73. Sabatier JM, Vives E, Mabrouk K, Benjouad A, Rochat H, Duval A, Hue B, Bahraoui E (1991). Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J Virol 65: 961-967.
74. Savio T, Lavi G (1993). Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: a study with rat cerebellar granule cell cultures. J Neurosci Res 34: 265-272.
75. Sanders VJ, Pittman CA, White MG, Wiley CA, Achim CL (1998). Chemokines and receptors in HIV encephalitis. AIDS 12: 1021-1026.
76. Schmidtmayerova H, Nottet H, Nuovo G, Raabe T, Flanagan C, Dubrovsky L, Gendelman H, Cerami A, Bukrinsky M, Sherry B (1996). Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 93: 700-704.
77. Seisjo BK (1988). Historical review: calium, ischemia and death of brain cells. Ann NY Acad Sci 522: 638-661.
78. Starling I, Wright A, Arbuthnott, Harkiss G (1999). Acute in vivo neurotoxicity of peptides from maedi visna virus transactivating protein Tat. Brain Res 830: 285-291.
79. Srijbos PJ, Zamani MR, Rothwell NJ, Arbuthnott G, Harkiss G (1995). Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus. Neurosci Lett 197: 215-218.
80. Sweetnam PM, Saab OH, Wroblewski JT, Price CH, Karbon EW, Ferkany JW (1993). The envelope glycoprotein of HIV-1 alters NMDA receptor function. Eur J Neurosci 5: 276-283.
81. Tancredi V, D'Areangelo G, Grassi F, Tarroni P, Palmieri G, Santoni A, Eusebi F (1992). Tumor necrosis factor alters synaptic transmission in the rat hippocampal slices. Neurosci Lett 146: 176-178.
82. Tancredi V, Zona C, Velloti F, Eusebi F, Santoni A (1990). Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res 525: 149-151.
83. Toggas SM, Masliah E, Rockenstein EM, Rail GF, Abraham CR, Mucke L (1994). Central nervous system damage produced by expression of the HIV-1 coat protein p120 in transgenic mice. Nature 367: 188-193.
84. Volterra A, Trotti D, Cassutti P, Tromba C, Salvaggio A, Melcangi RC, Racagni G (1992). High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes. J Neurochem 59: 600-606.
85. Wahl LM, Corcoran ML, Pyle SW, Arthur LO, Arel-Belan A, Farrar WL (1989). Human immunodeficiency virus glycoprotein (gp120) induction of monocytes arachidonic acid metabolites and interleukin 1. Proc Natl. Acad. Sci. USA 86: 621-625.
86. Wieraszko A, Li G, Kornecki E, Hohan MV, Ehrlich YH (1993). Long-term potentiation in the hippocampus induced by platelet-activating factor. Neuron 10: 553-557.
87. Wiley CA, Masliah E, Morey M, Lemere C, DeTheresa R, Grafe M, Hansen L, Terry R (1991). Neocortical damage during HIV infection. Ann Neurol 29: 651-657.
88. Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. Neuroreport 7: 1045-1049.
89. Xiong H, Zheng J, Thylin M, Gendelman HE (1999a). Unraveling the mechanisms of neurotoxicity in HIV type 1-associated dementia: Implication of neuronal synaptic transmission by macrophage secretory products. AIDS Res Hum Retrov 15: 57-63.
90. Xiong H, Zeng YC, Zheng J, Thylin M, Gendelman HE (1999b). Soluble HIV-1 infected macrophage secretory products mediate blockade of long-term potentiation: a mechanism for cognitive dysfunction in HIV-1-associated dementia. J Neurovirol 5: 519-528.
91. Young AB, Greenamyre JT, Hollingsworth A, Albin R, D'Amato C, Shoulson I, Penny JB (1988). NMDA receptor losses in putmen from patients with Huntington's disease. Science 241: 981-983.
92. Yu B, Shinnick-Gallagher P (1994). Interleukin 1β inhibits synaptic transmission and induces membrane hyperpolarization in amygdala neurons. J Pharmacol Expl Ther 271: 590-600.
93. Zeise ML, Madamba S, Siggins GR (1992). Interleukin-1β increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro. Regul Peptides 39: 1-7.
94. Zheng J, Gendelman HE (1997). The HIV-1 associated dementia complex: a metabolic encephalopathy fueled by viral replication in mononuclear phagocytes. Curr Opin Neurobiol 10: 319-332.
95. Zheng J, Ghorpade A, Niemann D, Cotter RL, Thylin MR, Epstein L, Swartz JM, Shepard EB, Liu XJ, Nukuna A, Gendelman HE (1999a). Lymphotropic virons affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type-1 associated dementia. J Virol 73: 8256-8267.
96. Zheng J, Thylin MR, Ghorpade A, Xiong H, Persidsky Y, Cotter RL, Niemann D, Che M, Zeng YC, Gelbard HA, Shepard EB, Swartz JM, Gendelman HE (1999b). Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. J Neuroimmunol 98: 185-200.