Neuroprotective effects of lithium in cultured cells and animal models of diseases

Bipolar Disorders

Volumn 4, Issue 2, 2002, Pages 129-136

  Chuang, De Maw ^a   Chen, Ren Wu ^a   Chalecka Franaszek, Elzbieta ^a,b   Ren, Ming ^a   Hashimoto, Ryota ^a   Senatorov, Vladimir ^a   Kanai, Hirohiko ^a   Hough, Christopher ^b   Hiroi, Toyoko ^a   Leeds, Peter ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Disease; Excitotoxicity; Huntington's; Lithium; Neuroprotection stroke

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMYLOID BETA PROTEIN; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CERAMIDE DERIVATIVE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXCITOTOXIN; GLUTAMIC ACID; GROWTH FACTOR; IBOTENIC ACID; LITHIUM; METHAMPHETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OUABAIN; PHENYTOIN; POTASSIUM; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P53; QUINOLINIC ACID; SODIUM; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THAPSIGARGIN; UNINDEXED DRUG; VALINOMYCIN; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL CULTURE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DISEASE MODEL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUNTINGTON CHOREA; MANIC DEPRESSIVE PSYCHOSIS; NERVE CELL STIMULATION; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; REVIEW; STROKE;

ANIMALS; BIPOLAR DISORDER; CELLS, CULTURED; CEREBROVASCULAR ACCIDENT; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; GLUTAMIC ACID; LITHIUM CARBONATE; NEURONS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0036116367     PISSN: 13985647     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-5618.2002.01179.x     Document Type: Review

References (65)

1. Anti-bipolar therapy: Mechanism of actions of lithium
2. Lithium at 50: Have the neuroprotective effects of this unique cation been overlooked?
3. A protective effect of lithium on rat behaviour altered by ibotenic acid lesions of the basal forebrain cholinergic system
4. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx
5. Subgenual prefrontal cortex abnormalities in mood disorders
6. Glial reduction in the subgenual prefrontal cortex in mood disorders
7. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression
8. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: Involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation
9. Valproic acid protects against glutamate-induced excitotoxicity in mature cerebellar granule cells
10. Lithium protects rat cerebellar granule cells against apoptosis induced by anti-convulsants, Phenytoin and carbamazepine
11. β-Amyloid peptide-induced death of PC 12 cells and cerebellar neurons is inhibited by long-term lithium treatment
12. Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons
13. Tumor-suppressor p53 is a regulator of Bcl-2 and Bax gene-expression in-vitro and in-vitro
14. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
15. Mechanisms controlling cellular suicide: Role Bcl-2 caspases
16. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
17. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
18. Long-term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression
19. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
20. JNK and p38 stress kinases-degenerative effectors of signal transduction-cascades in the nervous system
21. Serine/threonine phosphorylation in cytokine signal transduction
22. Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
23. Regulation of c-Jun N-terminal kinase (JNK) and p38 kinase in cultured brain neurons: Role of glutamate and lithium
24. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
25. AP-1 function and regulation
26. Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: Modulation by lithium
27. Lithium increases transcription factor binding to AP-1 and cyclic AMP-responsive element in cultured neurons and rat brain
28. Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY 5Y cells
29. Lithium stimulates gene expression through the AP-1 transcription factor pathway
30. Regulation of neuronal survival by the serine-threonine protein kinase Akt
31. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
32. The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
33. CREB couples neurotrophin signals to survival messages
34. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
35. Effects of chronic lithium treatment on ornithine decarboxylase induction and excitotoxic neuropathology in the rat
36. Lithium delays the radiation-induced apoptotic process in external granule cells of mouse cerebellum
37. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats
38. Acute lithium protects against brain injury in an ischemia/reperfusion model of rats
39. Ischemic cell death in brain neurons
40. Further studies on the neuroprotective effects of lithium against brain injury in a rat ischemia/reperfusion model
41. Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
42. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
43. Nuclear factor kappa B nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum
44. Lithium suppresses excitotoxicity-induced striatal lesions in rats, an animal model of Huntington's disease
45. Co-stimulation of cyclic AMP-linked metabotropic glutamate receptors in rat striataum attenuates excitotoxin-induced NF-kB activation and apoptosis
46. Prostaglandin A1 protects striatal neurons against excitotoxic injury in rat striatum
47. + protection of cerebellar granule cells switched to non-depolarizing medium
48. +
49. HIV-1 Tat-mediated activation of glycogen synthase kinase-3β contributes to Tat-mediated neurotoxicity
50. 2-ceramide in cerebellar granule neurons
51. LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons
52. Lithium protects cultured neurons against β-amyloid-induced neurodegeneration
53. Lithium chloride promotes short-term survival of PC 12 cells after serum and NGF deprivation
54. Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase-3b in cellular and animal models of neuronal degeneration
55. Neuroprotective effects of mood-stabilizing drugs in rat PC 12 pheochromocytoma cells
56. Lithium protects against ouabain-induced cell death
57. A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: Caspase-3 dependency
58. Glycogen synthase kinase-3β facilitates staurosporine- and heat shock-induced apoptosis: Protection by lithium
59. Lithium treatment in ovo: Effects on embryonic heart rate, natural death of ciliary ganglionic neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO
60. A neuroprotective role of lithium for motor neurons in vivo
61. NMDA receptor-mediated K + efflux and neuronal apoptosis
62. Intracellular K + suppresses the activation of apoptosis in lymphocytes
63. Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex
64. Lithium-induced increase in human brain grey matter
65. Lithium increases N-acetyl-aspartate in the human brain: In vivo evidence in support of bcl-2′s neuroprotective effects?