Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

International Journal of Antimicrobial Agents

Volumn 38, Issue 3, 2011, Pages 217-225

  Brogden, Nicole K ^a   Brogden, Kim A ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Antimicrobial peptide congeners; Antimicrobial peptide conjugates; Antimicrobial peptide mimotopes; Cyclotides; Hybrid antimicrobial peptides; Immobilised antimicrobial peptides; Stabilised antimicrobial peptides

Indexed keywords

ANTIINFECTIVE AGENT; BETA DEFENSIN 1; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CECROPIN A; CECROPIN A MELITTIN FUSION PROTEIN; CYCLOTIDE; LYSOZYME; MELITTIN; NISIN; OLIGO ACYL LYSINE; PEPTIDE KLAL; PEPTOID; POLYPEPTIDE ANTIBIOTIC AGENT; SMAP 29 PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; BIOLOGICAL ACTIVITY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STABILITY; DRUG TARGETING; FUNGAL VIRULENCE; HUMAN; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 80051546187     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.05.004     Document Type: Short Survey

References (133)

1. G. Maróti, A. Kereszt, E. Kondorosi, and P. Mergaert Natural roles of antimicrobial peptides in microbes, plants and animals Res Microbiol 162 2011 363 374
2. E.B. Hadley, and R.E. Hancock Strategies for the discovery and advancement of novel cationic antimicrobial peptides Curr Top Med Chem 10 2010 1872 1881
3. D.M. Bowdish, D.J. Davidson, and R.E. Hancock A re-evaluation of the role of host defence peptides in mammalian immunity Curr Protein Pept Sci 6 2005 35 51 (Pubitemid 40259800)
4. K.G. Kohlgraf, A. Ackermann, X. Lu, K. Burnell, M. Belanger, and J.E. Cavanaugh Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice Future Microbiol 5 2010 115 125
5. D. Yang, A. Biragyn, D.M. Hoover, J. Lubkowski, and J.J. Oppenheim Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense Annu Rev Immunol 22 2004 181 215 (Pubitemid 38680422)
6. G. Diamond, and L. Ryan β-Defensins: what are they REALLY doing in the oral cavity? Oral Dis 2011 10.1111/j.1601-0825.2011.01799.x [Epub ahead of print]
7. A.K. Marr, W.J. Gooderham, and R.E. Hancock Antibacterial peptides for therapeutic use: obstacles and realistic outlook Curr Opin Pharmacol 6 2006 468 472 (Pubitemid 44340665)
8. L. Steinstraesser, U. Kraneburg, F. Jacobsen, and S. Al-Benna Host defense peptides and their antimicrobial-immunomodulatory duality Immunobiology 216 2011 322 333
9. R.E. Hancock, and A. Patrzykat Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics Curr Drug Targets Infect Disord 2 2002 79 83 (Pubitemid 34649857)
10. R.E. Hancock, and H.G. Sahl Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Nat Biotechnol 24 2006 1551 1557 (Pubitemid 44967479)
11. C.L. Stevenson Advances in peptide pharmaceuticals Curr Pharm Biotechnol 10 2009 122 137
12. A. Tossi Design and engineering strategies for synthetic antimicrobial peptides D. Drider, S. Rebuffat, Prokaryotic antimicrobial peptides. From genes to applications 2011 Springer New York, NY 81 98
13. K.A. Brogden Perspectives and peptides of the next generation D. Drider, S. Rebuffat, Prokaryotic antimicrobial peptides. From genes to applications 2011 Springer New York, NY 423 439
14. B. Findlay, G.G. Zhanel, and F. Schweizer Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold Antimicrob Agents Chemother 54 2010 4049 4058
15. H.D. Thaker, F. Sgolastra, D. Clements, R.W. Scott, and G.N. Tew Synthetic mimics of antimicrobial peptides from triaryl scaffolds J Med Chem 54 2011 2241 2254
16. E.F. Palermo, and K. Kuroda Structural determinants of antimicrobial activity in polymers which mimic host defense peptides Appl Microbiol Biotechnol 87 2010 1605 1615
17. C.A. Olsen Peptoid-peptide hybrid backbone architectures Chembiochem 11 2010 152 160
18. L. Otvos Jr., C. Snyder, B.A. Condie, P. Bulet, and J.D. Wade Chimeric antimicrobial peptides exhibit multiple modes of action Int J Peptide Res Ther 11 2005 29 42 (Pubitemid 41557306)
19. L. Otvos Jr. Antibacterial peptides and proteins with multiple cellular targets J Pept Sci 11 2005 697 706 (Pubitemid 41684256)
20. D. Takahashi, S.K. Shukla, O. Prakash, and G. Zhang Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity Biochimie 92 2010 1236 1241 Erratum in: Biochimie 2011;93:631
21. N. Mookherjee, L.M. Rehaume, and R.E. Hancock Cathelicidins and functional analogues as antisepsis molecules Expert Opin Ther Targets 11 2007 993 1004 (Pubitemid 47240677)
22. A.E. Garcia, and J.A. Camarero Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics Curr Mol Pharmacol 3 2010 153 163
23. K. Jagadish, and J.A. Camarero Cyclotides, a promising molecular scaffold for peptide-based therapeutics Biopolymers 94 2010 611 616
24. D.J. Craik, and A.C. Conibear The chemistry of cyclotides J Org Chem 76 2011 4805 4817
25. D.C. Ireland, R.J. Clark, N.L. Daly, and D.J. Craik Isolation, sequencing, and structure-activity relationships of cyclotides J Nat Prod 73 2010 1610 1622
26. P. Khare, A. Jain, A. Gulbake, V. Soni, N.K. Jain, and S.K. Jain Bioconjugates: harnessing potential for effective therapeutics Crit Rev Ther Drug Carrier Syst 26 2009 119 155
27. I. Yacoby, and I. Benhar Targeted anti bacterial therapy Infect Disord Drug Targets 7 2007 221 229 (Pubitemid 350028055)
28. F. Costa, I.F. Carvalho, R.C. Montelaro, P. Gomes, and M.C. Martins Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces Acta Biomater 7 2011 1431 1440
29. S.A. Onaizi, and S.S. Leong Tethering antimicrobial peptides: current status and potential challenges Biotechnol Adv 29 2011 67 74
30. H. Takada, and S. Kotani Structural requirements of lipid A for endotoxicity and other biological activities Crit Rev Microbiol 16 1989 477 523
31. A. Tossi, C. Tarantino, and D. Romeo Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity Eur J Biochem 250 1997 549 558 (Pubitemid 28012699)
32. N.P. Chongsiriwatana, T.M. Miller, M. Wetzler, S. Vakulenko, A.J. Karlsson, and S.P. Palecek Short alkylated peptoid mimics of antimicrobial lipopeptides Antimicrob Agents Chemother 55 2011 417 420
33. R. Kapoor, P.R. Eimerman, J.W. Hardy, J.D. Cirillo, C.H. Contag, and A.E. Barron Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis Antimicrob Agents Chemother 55 2011 3058 3062
34. R. Kapoor, M.W. Wadman, M.T. Dohm, A.M. Czyzewski, A.M. Spormann, and A.E. Barron Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms Antimicrob Agents Chemother 55 2011 3054 3057
35. I.S. Radzishevsky, S. Rotem, D. Bourdetsky, S. Navon-Venezia, Y. Carmeli, and A. Mor Improved antimicrobial peptides based on acyl-lysine oligomers Nat Biotechnol 25 2007 657 659 (Pubitemid 46897206)
36. F. Zaknoon, H. Sarig, S. Rotem, L. Livne, A. Ivankin, and D. Gidalevitz Antibacterial properties and mode of action of a short acyl-lysyl oligomer Antimicrob Agents Chemother 53 2009 3422 3429
37. J. Hua, R. Yamarthy, S. Felsenstein, R.W. Scott, K. Markowitz, and G. Diamond Activity of antimicrobial peptide mimetics in the oral cavity: I. Activity against biofilms of Candida albicans Mol Oral Microbiol 25 2010 418 425
38. J. Hua, R.W. Scott, and G. Diamond Activity of antimicrobial peptide mimetics in the oral cavity: II. Activity against periopathogenic biofilms and anti-inflammatory activity Mol Oral Microbiol 25 2010 426 432
39. V. Held-Kuznetsov, S. Rotem, Y.G. Assaraf, and A. Mor Host-defense peptide mimicry for novel antitumor agents FASEB J 23 2009 4299 4307
40. S. Rotem, and A. Mor Antimicrobial peptide mimics for improved therapeutic properties Biochim Biophys Acta 1788 2009 1582 1592
41. K. Lienkamp, and G.N. Tew Synthetic mimics of antimicrobial peptides-a versatile ring-opening metathesis polymerization based platform for the synthesis of selective antibacterial and cell-penetrating polymers Chemistry 15 2009 11784 11800
42. Y. Goldfeder, F. Zaknoon, and A. Mor Experimental conditions that enhance potency of an antibacterial oligo-acyl-lysyl Antimicrob Agents Chemother 54 2010 2590 2595
43. H. Sarig, S. Rotem, L. Ziserman, D. Danino, and A. Mor Impact of self-assembly properties on antibacterial activity of short acyl-lysine oligomers Antimicrob Agents Chemother 52 2008 4308 4314
44. K.L. Piers, M.H. Brown, and R.E. Hancock Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modification Antimicrob Agents Chemother 38 1994 2311 2316 (Pubitemid 24304222)
45. K.L. Piers, M.H. Brown, and R.E.W. Hancock Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria Gene 134 1993 7 13
46. K.L. Piers, and R.E.W. Hancock The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa Mol Microbiol 12 1994 951 958 (Pubitemid 24199675)
47. D. Wade, D. Andreu, S.A. Mitchell, A.M. Silveira, A. Boman, and H.G. Boman Antibacterial peptides designed as analogs or hybrids of cecropins and melittin Int J Pept Protein Res 40 1992 429 436
48. H. Steiner, D. Andreu, and R.B. Merrifield Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects Biochim Biophys Acta 939 1988 260 266 (Pubitemid 18088775)
49. F. Rozgonyi, D. Szabo, B. Kocsis, E. Ostorhazi, G. Abbadessa, and M. Cassone The antibacterial effect of a proline-rich antibacterial peptide A3-APO Curr Med Chem 16 2009 3996 4002
50. D. Szabo, E. Ostorhazi, A. Binas, F. Rozgonyi, B. Kocsis, and M. Cassone The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models Int J Antimicrob Agents 35 2010 357 361
51. X.Q. Qiu, H. Wang, X.F. Lu, J. Zhang, S.F. Li, and G. Cheng An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria Nat Biotechnol 21 2003 1480 1485 (Pubitemid 37522709)
52. X.Q. Qiu, J. Zhang, H. Wang, and G.Y. Wu A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis Antimicrob Agents Chemother 49 2005 1184 1189 (Pubitemid 40327744)
53. R. Eckert, J. He, D.K. Yarbrough, F. Qi, M.H. Anderson, and W. Shi Targeted killing of Streptococcus mutans by a pheromone-guided 'smart' antimicrobial peptide Antimicrob Agents Chemother 50 2006 3651 3657 (Pubitemid 44684877)
54. J. He, M.H. Anderson, W. Shi, and R. Eckert Design and activity of a 'dual-targeted' antimicrobial peptide Int J Antimicrob Agents 33 2009 532 537
55. 1-18 against a multiresistant strain of Acinetobacter baumannii Antimicrob Agents Chemother 46 2002 875 878 (Pubitemid 34157679)
56. D.P. Yevtushenko, R. Romero, B.S. Forward, R.E. Hancock, W.W. Kay, and S. Misra Pathogen-induced expression of a cecropin A-melittin antimicrobial peptide gene confers antifungal resistance in transgenic tobacco J Exp Bot 56 2005 1685 1695 (Pubitemid 40764456)
57. M. Osusky, G. Zhou, L. Osuska, R.E. Hancock, W.W. Kay, and S. Misra Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens Nat Biotechnol 18 2000 1162 1166
58. C.L. Bratt, K.G. Kohlgraf, K. Yohnke, C. Kummet, D.V. Dawson, and K.A. Brogden Communication: antimicrobial activity of SMAP28 with a targeting domain for Porphyromonas gingivalis Probiotics Antimicrob Proteins 2 2009 21 25
59. J.W. Larrick, M. Hirata, Y. Shimomoura, M. Yoshida, H. Zheng, and J. Zhong Antimicrobial activity of rabbit CAP18-derived peptides Antimicrob Agents Chemother 37 1993 2534 2539 (Pubitemid 23357842)
60. J.W. Larrick, M. Hirata, H. Zheng, J. Zhong, D. Bolin, and J.M. Cavaillon A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity J Immunol 152 1994 231 240
61. J.W. Larrick, M. Hirata, J. Zhong, and S.C. Wright Anti-microbial activity of human CAP18 peptides Immunotechnology 1 1995 65 72
62. M. Hirata, Y. Shimomura, M. Yoshida, J.G. Morgan, I. Palings, and D. Wilson Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity Infect Immun 62 1994 1421 1426 (Pubitemid 24110838)
63. S. Tasaka, A. Ishizaka, T. Urano, K. Sayama, F. Sakamaki, and H. Nakamura A derivative of cationic antimicrobial protein attenuates lung injury by suppressing cell adhesion Am J Respir Cell Mol Biol 15 1996 738 744 (Pubitemid 126441446)
64. T. Sawa, K. Kurahashi, M. Ohara, M.A. Gropper, V. Doshi, and J.W. Larrick Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model Antimicrob Agents Chemother 42 1998 3269 3275 (Pubitemid 28553752)
65. S.M. Travis, N.N. Anderson, W.R. Forsyth, C. Espiritu, B.D. Conway, and E.P. Greenberg Bactericidal activity of mammalian cathelicidin-derived peptides Infect Immun 68 2000 2748 2755 (Pubitemid 30253851)
66. J.W. Larrick, J. Lee, S. Ma, X. Li, U. Francke, and S.C. Wright Structural, functional analysis and localization of the human CAP18 gene FEBS Lett 398 1996 74 80 (Pubitemid 26400345)
67. C.D. Ciornei, T. Sigurdardottir, A. Schmidtchen, and M. Bodelsson Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37 Antimicrob Agents Chemother 49 2005 2845 2850 (Pubitemid 40917601)
68. J.W. Larrick, M. Hirata, R.F. Balint, J. Lee, J. Zhong, and S.C. Wright Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein Infect Immun 63 1995 1291 1297
69. L. Bagella, M. Scocchi, and M. Zanetti cDNA sequences of three sheep myeloid cathelicidins FEBS Lett 376 1995 225 228
70. K.A. Brogden, V.C. Kalfa, M.R. Ackermann, D.E. Palmquist, P.B. McCray Jr., and B.F. Tack The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection Antimicrob Agents Chemother 45 2001 331 334 (Pubitemid 32039140)
71. V.C. Kalfa, H.P. Jia, R.A. Kunkle, P.B. McCray Jr., B.F. Tack, and K.A. Brogden Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells Antimicrob Agents Chemother 45 2001 3256 3261 (Pubitemid 32988867)
72. M.M. Mahoney, A.Y. Lee, D.J. Brezinski-Caliguri, and K.M. Huttner Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide FEBS Lett 377 1995 519 522 (Pubitemid 26025745)
73. L. Saiman, S. Tabibi, T.D. Starner, P. San Gabriel, P.L. Winokur, and H.P. Jia Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis Antimicrob Agents Chemother 45 2001 2838 2844 (Pubitemid 32906680)
74. B. Skerlavaj, M. Benincasa, A. Risso, M. Zanetti, and R. Gennaro SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes FEBS Lett 463 1999 58 62 (Pubitemid 30001718)
75. P.L. Weistroffer, S. Joly, R. Srikantha, B.F. Tack, K.A. Brogden, and J.M. Guthmiller SMAP29 congeners demonstrate activity against oral bacteria and reduced toxicity against oral keratinocytes Oral Microbiol Immunol 23 2008 89 95 (Pubitemid 351248603)
76. M.V. Sawai, A.J. Waring, W.R. Kearney, P.B. McCray Jr., W.R. Forsyth, and R.I. Lehrer Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides Protein Eng 15 2002 225 232 (Pubitemid 34429233)
77. R.M. Dawson, and C.Q. Liu Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity Int J Antimicrob Agents 37 2011 432 437
78. R. Saravanan, A. Bhunia, and S. Bhattacharjya Micelle-bound structures and dynamics of the hinge deleted analog of melittin and its diastereomer: implications in cell selective lysis by d-amino acid containing antimicrobial peptides Biochim Biophys Acta 1798 2010 128 139
79. Y.Q. Xiong, A.S. Bayer, L. Elazegui, and M.R. Yeaman A synthetic congener modeled on a microbicidal domain of thrombin-induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule Antimicrob Agents Chemother 50 2006 3786 3792 (Pubitemid 44684894)
80. M.E. Selsted, and A.J. Ouellette Mammalian defensins in the antimicrobial immune response Nat Immunol 6 2005 551 557 (Pubitemid 41710724)
81. R.I. Lehrer Primate defensins Nat Rev Microbiol 2 2004 727 738 (Pubitemid 39200064)
82. B.O. Schroeder, Z. Wu, S. Nuding, S. Groscurth, M. Marcinowski, and J. Beisner Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1 Nature 469 2011 419 423
83. M. De Cecco, E.S. Seo, D.J. Clarke, B.J. McCullough, K. Taylor, and D. Macmillan Conformational preferences of linear β-defensins are revealed by ion mobility-mass spectrometry J Phys Chem B 114 2010 2312 2318
84. D.M. Hoover, Z. Wu, K. Tucker, W. Lu, and J. Lubkowski Antimicrobial characterization of human β-defensin 3 derivatives Antimicrob Agents Chemother 47 2003 2804 2809 (Pubitemid 37040251)
85. Z. Wu, D.M. Hoover, D. Yang, C. Boulegue, F. Santamaria, and J.J. Oppenheim Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3 Proc Natl Acad Sci USA 100 2003 8880 8885 (Pubitemid 36899192)
86. S. Liu, L. Zhou, J. Li, A. Suresh, C. Verma, and Y.H. Foo Linear analogues of human β-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells Chembiochem 9 2008 964 973
87. K. Taylor, D.J. Clarke, B. McCullough, W. Chin, E. Seo, and D. Yang Analysis and separation of residues important for the chemoattractant and antimicrobial activities of β-defensin 3 J Biol Chem 283 2008 6631 6639
88. K.B. Chandrababu, B. Ho, and D. Yang Structure, dynamics, and activity of an all-cysteine mutated human β defensin-3 peptide analogue Biochemistry 48 2009 6052 6061
89. S. Jung, J. Mysliwy, B. Spudy, I. Lorenzen, K. Reiss, and C. Gelhaus Human β-defensin 2 and β-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules Antimicrob Agents Chemother 55 2011 954 960
90. O. Scudiero, S. Galdiero, M. Cantisani, R. Di Noto, M. Vitiello, and M. Galdiero Novel synthetic, salt-resistant analogs of human β-defensins 1 and 3 endowed with enhanced antimicrobial activity Antimicrob Agents Chemother 54 2010 2312 2322
91. N.L. Reynolds, M. De Cecco, K. Taylor, C. Stanton, F. Kilanowski, and J. Kalapothakis Peptide fragments of a β-defensin derivative with potent bactericidal activity Antimicrob Agents Chemother 54 2010 1922 1929
92. Y. Bai, S. Liu, P. Jiang, L. Zhou, J. Li, and C. Tang Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin Biochemistry 48 2009 7229 7239
93. V. Krishnakumari, N. Rangaraj, and R. Nagaraj Antifungal activities of human β-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3 Antimicrob Agents Chemother 53 2009 256 260
94. E. Salvucci, L. Saavedra, and F. Sesma Short peptides derived from the NH2-terminus of subclass IIa bacteriocin enterocin CRL35 show antimicrobial activity J Antimicrob Chemother 59 2007 1102 1108 (Pubitemid 47073320)
95. M.M. Suzuki, M. Matsumoto, A. Yamamoto, M. Ochiai, Y. Horiuchi, and M. Niwa Molecular design of LPS-binding peptides J Microbiol Methods 83 2010 153 155
96. S. Futaki, T. Suzuki, W. Ohashi, T. Yagami, S. Tanaka, and K. Ueda Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery J Biol Chem 276 2001 5836 5840
97. A. Kichler, C. Leborgne, J. Marz, O. Danos, and B. Bechinger Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells Proc Natl Acad Sci USA 100 2003 1564 1568 (Pubitemid 36254487)
98. Y.C. Kim, P.J. Ludovice, and M.R. Prausnitz Transdermal delivery enhanced by antimicrobial peptides J Biomed Nanotechnol 6 2010 612 620
99. M. Pasupuleti, A. Chalupka, M. Morgelin, A. Schmidtchen, and M. Malmsten Tryptophan end-tagging of antimicrobial peptides for increased potency against Pseudomonas aeruginosa Biochim Biophys Acta 1790 2009 800 808
100. L. Catiau, J. Traisnel, V. Delval-Dubois, N.E. Chihib, D. Guillochon, and N. Nedjar-Arroume Minimal antimicrobial peptidic sequence from hemoglobin α-chain: KYR Peptides 32 2011 633 638
101. R.D. Mathison, J.S. Davison, A.D. Befus, and D.A. Gingerich Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein J Inflamm (Lond) 7 2010 49
102. J.P. Tam, Y.A. Lu, J.L. Yang, and K.W. Chiu An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides Proc Natl Acad Sci USA 96 1999 8913 8918 (Pubitemid 29374682)
103. Q. Yu, R.I. Lehrer, and J.P. Tam Engineered salt-insensitive α-defensins with end-to-end circularized structures J Biol Chem 275 2000 3943 3949 (Pubitemid 30094620)
104. M.R. Levengood, and W.A. van der Donk Use of lantibiotic synthetases for the preparation of bioactive constrained peptides Bioorg Med Chem Lett 18 2008 3025 3028 (Pubitemid 351680395)
105. L.D. Kluskens, S.A. Nelemans, R. Rink, L. de Vries, A. Meter-Arkema, and Y. Wang Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog J Pharmacol Exp Ther 328 2009 849 854
106. T. Abraham, S. Marwaha, D.M. Kobewka, R.N. Lewis, E.J. Prenner, and R.S. Hodges The relationship between the binding to and permeabilization of phospholipid bilayer membranes by GS14dK4, a designed analog of the antimicrobial peptide gramicidin S Biochim Biophys Acta 1768 2007 2089 2098 (Pubitemid 47379625)
107. D. Peschen, H.P. Li, R. Fischer, F. Kreuzaler, and Y.C. Liao Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen Nat Biotechnol 22 2004 732 738 (Pubitemid 38702830)
108. M.R. Franzman, K.K. Burnell, F.H. Dehkordi-Vakil, J.M. Guthmiller, D.V. Dawson, and K.A. Brogden Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture Int J Antimicrob Agents 33 2009 14 20
109. E. Leupold, H. Nikolenko, and M. Dathe Apolipoprotein E peptide-modified colloidal carriers: the design determines the mechanism of uptake in vascular endothelial cells Biochim Biophys Acta 1788 2009 442 449
110. L.L. An, Y.H. Yang, X.T. Ma, Y.M. Lin, G. Li, and Y.H. Song LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine Leuk Res 29 2005 535 543 (Pubitemid 40327242)
111. A. Biragyn, M. Surenhu, D. Yang, P.A. Ruffini, B.A. Haines, and E. Klyushnenkova Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens J Immunol 167 2001 6644 6653 (Pubitemid 33081603)
112. R. Bucki, K. Leszczynska, F.J. Byfield, D.E. Fein, E. Won, and K. Cruz Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate Antimicrob Agents Chemother 54 2010 2525 2533
113. A.F. Chu-Kung, R. Nguyen, K.N. Bozzelli, and M. Tirrell Chain length dependence of antimicrobial peptide-fatty acid conjugate activity J Colloid Interface Sci 345 2010 160 167
114. B. Ding, U. Taotofa, T. Orsak, M. Chadwell, and P.B. Savage Synthesis and characterization of peptide-cationic steroid antibiotic conjugates Org Lett 6 2004 3433 3436 (Pubitemid 39406907)
115. A. Guyomard, E. Dé, T. Jouenne, J.J. Malandain, G.M. Muller, and K. Glinel Incorporation of a hydrophobic antibacterial peptide into amphiphilic polyelectrolyte multilayers: a bioinspired approach to prepare biocidal thin coatings Adv Funct Mater 18 2008 758 765 (Pubitemid 351430217)
116. C.N. Cutter, J.L. Willett, and G.R. Siragusa Improved antimicrobial activity of nisin-incorporated polymer films by formulation change and addition of food grade chelator Lett Appl Microbiol 33 2001 325 328 (Pubitemid 32955636)
117. O. Etienne, C. Picart, C. Taddei, Y. Haikel, J.L. Dimarcq, and P. Schaaf Multilayer polyelectrolyte films functionalized by insertion of defensin: a new approach to protection of implants from bacterial colonization Antimicrob Agents Chemother 48 2004 3662 3669 (Pubitemid 39304587)
118. M. Bagheri, M. Beyermann, and M. Dathe Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum Antimicrob Agents Chemother 53 2009 1132 1141
119. S.L. Haynie, G.A. Crum, and B.A. Doele Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin Antimicrob Agents Chemother 39 1995 301 307
120. K. Glinel, A.M. Jonas, T. Jouenne, J. Leprince, L. Galas, and W.T. Huck Antibacterial and antifouling polymer brushes incorporating antimicrobial peptide Bioconjug Chem 20 2009 71 77
121. G. Gao, D. Lange, K. Hilpert, J. Kindrachuk, Y. Zou, and J.T. Cheng The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides Biomaterials 32 2011 3899 3909
122. S. Rotem, N. Raz, Y. Kashi, and A. Mor Bacterial capture by peptide-mimetic oligoacyllysine surfaces Appl Environ Microbiol 76 2011 3301 3307
123. N.P. Guerra, A.B. Araujo, A.M. Barrera, A.T. Agrasar, C.L. Macias, and J. Carballo Antimicrobial activity of nisin adsorbed to surfaces commonly used in the food industry J Food Prot 68 2005 1012 1019 (Pubitemid 40641226)
124. A. Hequet, V. Humblot, J.M. Berjeaud, and C.M. Pradier Optimized grafting of antimicrobial peptides on stainless steel surface and biofilm resistance tests Colloids Surf B Biointerfaces 84 2011 301 309
125. H.R. Luckarift, M.B. Dickerson, K.H. Sandhage, and J.C. Spain Rapid, room-temperature synthesis of antibacterial bionanocomposites of lysozyme with amorphous silica or titania Small 2 2006 640 643
126. I. Izquierdo-Barba, M. Vallet-Regi, N. Kupferschmidt, O. Terasaki, A. Schmidtchen, and M. Malmsten Incorporation of antimicrobial compounds in mesoporous silica film monolith Biomaterials 30 2009 5729 5736
127. N.V. Kulagina, M.E. Lassman, F.S. Ligler, and C.R. Taitt Antimicrobial peptides for detection of bacteria in biosensor assays Anal Chem 77 2005 6504 6508 (Pubitemid 41436994)
128. N.V. Kulagina, K.M. Shaffer, G.P. Anderson, F.S. Ligler, and C.R. Taitt Antimicrobial peptide-based array for Escherichia coli and Salmonella screening Anal Chim Acta 575 2006 9 15 (Pubitemid 44109671)
129. C.R. Taitt, S.H. North, and N.V. Kulagina Antimicrobial peptide arrays for detection of inactivated biothreat agents Methods Mol Biol 570 2009 233 255
130. K.A. Brogden Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 3 2005 238 250 (Pubitemid 40298223)
131. M. Yoshinari, T. Kato, K. Matsuzaka, T. Hayakawa, T. Inoue, and Y. Oda Adsorption behavior of antimicrobial peptide histatin 5 on PMMA J Biomed Mater Res B Appl Biomater 77 2006 47 54
132. S. Makihira, T. Shuto, H. Nikawa, K. Okamoto, Y. Mine, and Y. Takamoto Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1 Int J Mol Sci 11 2010 1458 1470
133. M. Yoshinari, T. Kato, K. Matsuzaka, T. Hayakawa, and K. Shiba Prevention of biofilm formation on titanium surfaces modified with conjugated molecules comprised of antimicrobial and titanium-binding peptides Biofouling 26 2010 103 110