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Volumn 250, Issue 2, 1997, Pages 549-558

Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity

Author keywords

Amphipathic; Antibacterial peptide; Cathelicidin; Membrane permeabilization; helix

Indexed keywords

ANTIINFECTIVE AGENT; SYNTHETIC PEPTIDE;

EID: 0031451521     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.0549a.x     Document Type: Article
Times cited : (128)

References (59)
  • 2
    • 0025724956 scopus 로고
    • Interaction with phospholipid bilayers, ion channel formation, and antimicrobial activity of basic amphipathic α-helical model peptides of various chain lengths
    • Agawa, Y., Lee, S., Ono, S., Aoyagi, H., Ohno, M., Taniguchi, T., Anzai, K. & Kirino, Y. (1991) Interaction with phospholipid bilayers, ion channel formation, and antimicrobial activity of basic amphipathic α-helical model peptides of various chain lengths. J. Biol. Chem. 266, 20218-20222.
    • (1991) J. Biol. Chem. , vol.266 , pp. 20218-20222
    • Agawa, Y.1    Lee, S.2    Ono, S.3    Aoyagi, H.4    Ohno, M.5    Taniguchi, T.6    Anzai, K.7    Kirino, Y.8
  • 3
    • 0021949580 scopus 로고
    • N-terminal analogues of cecropin A: Synthesis, antibacterial activity, and conformational properties
    • Andreu, D., Merrifield, R. B., Steiner, H. & Boman, H. G. (1985) N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties, Biochemistry 24, 1683-1688.
    • (1985) Biochemistry , vol.24 , pp. 1683-1688
    • Andreu, D.1    Merrifield, R.B.2    Steiner, H.3    Boman, H.G.4
  • 4
    • 0028834275 scopus 로고
    • cDNA sequences of three sheep myeloid cathelicidins
    • Bagella, L., Scocchi, M. & Zanetti, M. (1995) cDNA sequences of three sheep myeloid cathelicidins, FEBS Lett. 376, 225-228.
    • (1995) FEBS Lett. , vol.376 , pp. 225-228
    • Bagella, L.1    Scocchi, M.2    Zanetti, M.3
  • 5
    • 0029047938 scopus 로고
    • Amphibian skin: A promising resource for antimicrobial peptides
    • Barra, D. & Simmaco, M. (1995) Amphibian skin: a promising resource for antimicrobial peptides, Trends Biotechnol. 13, 205-209.
    • (1995) Trends Biotechnol. , vol.13 , pp. 205-209
    • Barra, D.1    Simmaco, M.2
  • 6
    • 0027488740 scopus 로고
    • Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy
    • Bechinger, B., Zasloff, M. & Opella, S. J. (1993) Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy. Protein Sci. 2, 2077-2084.
    • (1993) Protein Sci. , vol.2 , pp. 2077-2084
    • Bechinger, B.1    Zasloff, M.2    Opella, S.J.3
  • 8
    • 0027043261 scopus 로고
    • Design of model amphipathic peptides having potent antimicrobial activities
    • Blondelle, S. E. & Houghten, R. A. (1992) Design of model amphipathic peptides having potent antimicrobial activities. Biochemistry 31, 12688-12694.
    • (1992) Biochemistry , vol.31 , pp. 12688-12694
    • Blondelle, S.E.1    Houghten, R.A.2
  • 9
    • 0030049034 scopus 로고    scopus 로고
    • Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial chemistry
    • Blondelle, S. E., Takahashi, E., Houghten, R. A. & Perez-Paya, E. (1996) Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial chemistry, Biochem, J. 313, 141-147.
    • (1996) Biochem, J. , vol.313 , pp. 141-147
    • Blondelle, S.E.1    Takahashi, E.2    Houghten, R.A.3    Perez-Paya, E.4
  • 10
    • 0030021761 scopus 로고    scopus 로고
    • Novel antimicrobial compounds identified using synthetic combinatorial library technology
    • Blondelle, S. E. & Houghten, R. A. (1996) Novel antimicrobial compounds identified using synthetic combinatorial library technology, Trends Biotechnol. 14, 60-65.
    • (1996) Trends Biotechnol. , vol.14 , pp. 60-65
    • Blondelle, S.E.1    Houghten, R.A.2
  • 11
    • 0024841875 scopus 로고
    • Antibacterial and antimalarial properties of peptides that are cecropin-mellitin hybrids
    • Boman, H. G., Wade, D., Boman, I. A., Wahlin, B. & Merrifield, R. B. (1989) Antibacterial and antimalarial properties of peptides that are cecropin-mellitin hybrids. FEBS Lett. 259, 103-106.
    • (1989) FEBS Lett. , vol.259 , pp. 103-106
    • Boman, H.G.1    Wade, D.2    Boman, I.A.3    Wahlin, B.4    Merrifield, R.B.5
  • 13
    • 0028933794 scopus 로고
    • Peptides antibiotics and their role in innate immunity
    • Boman, H. G. (1995) Peptides antibiotics and their role in innate immunity. Annu. Rev. Immun. 13, 61-92.
    • (1995) Annu. Rev. Immun. , vol.13 , pp. 61-92
    • Boman, H.G.1
  • 14
    • 0024418033 scopus 로고
    • Protein estimation by the product of integrated peak area and flow rate
    • Buck, M. A., Olah, T. A., Weitzmann, C. J. & Cooperman, B. S. (1989) Protein estimation by the product of integrated peak area and flow rate. Anal. Biochem. 182, 295-299.
    • (1989) Anal. Biochem. , vol.182 , pp. 295-299
    • Buck, M.A.1    Olah, T.A.2    Weitzmann, C.J.3    Cooperman, B.S.4
  • 15
    • 0016169865 scopus 로고
    • Determination of the helix and β form of proteins in aqueous solution by circular dichroism
    • Chen, Y. H., Yang, J. T., Chau, K. H. (1974) Determination of the helix and β form of proteins in aqueous solution by circular dichroism, Biochemistry 13, 3350-3355.
    • (1974) Biochemistry , vol.13 , pp. 3350-3355
    • Chen, Y.H.1    Yang, J.T.2    Chau, K.H.3
  • 16
    • 0023735907 scopus 로고
    • Synthetic magainin analogues with improved antimicrobial activity
    • Chen, H.-C., Brown, J. H., Morell, J. L. & Huang, C. M. (1988) Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett. 236, 462-466.
    • (1988) FEBS Lett. , vol.236 , pp. 462-466
    • Chen, H.-C.1    Brown, J.H.2    Morell, J.L.3    Huang, C.M.4
  • 17
    • 0029128705 scopus 로고
    • The solution structure of the active domain of CAP18 - A lipopolysaccharide binding protein from rabbit leukocytes
    • Chen, H.-C., Brock, R., Luh, F., Chou, P.-J., Larrick, J. W., Huang, R.-F. & Huang, T. (1995) The solution structure of the active domain of CAP18 - a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett. 370, 46-52.
    • (1995) FEBS Lett. , vol.370 , pp. 46-52
    • Chen, H.-C.1    Brock, R.2    Luh, F.3    Chou, P.-J.4    Larrick, J.W.5    Huang, R.-F.6    Huang, T.7
  • 19
    • 0028177259 scopus 로고
    • Application to the de novo design of ideally amphipathic Leu. Lys peptides with hemolytic activity higher than that of mellitin
    • Cornut, I., Büttner, K., Dasseux, J.-L. & Dufourcq, J. (1994) Application to the de novo design of ideally amphipathic Leu. Lys peptides with hemolytic activity higher than that of mellitin. FEBS Lett. 349, 29-33.
    • (1994) FEBS Lett. , vol.349 , pp. 29-33
    • Cornut, I.1    Büttner, K.2    Dasseux, J.-L.3    Dufourcq, J.4
  • 20
    • 0024104215 scopus 로고
    • The magainins: Sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity
    • Cuervo, J. H., Rodriguez, B. & Houghten, R. A. (1988) The magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity. Peptide Res. 1, 81-86.
    • (1988) Peptide Res. , vol.1 , pp. 81-86
    • Cuervo, J.H.1    Rodriguez, B.2    Houghten, R.A.3
  • 21
    • 0029028865 scopus 로고
    • Maturation pathway of nisin and other lantibiotics: Post-translationally modified antimicrobial peptides exported by gram-positive bacteria
    • de Vos, M. W., Kuipers, O. P., van der Meer, J. R. & Siezen, R. J. (1995) Maturation pathway of nisin and other lantibiotics: post-translationally modified antimicrobial peptides exported by gram-positive bacteria, Mol. Microbiol. 17, 427-437.
    • (1995) Mol. Microbiol. , vol.17 , pp. 427-437
    • De Vos, M.W.1    Kuipers, O.P.2    Van Der Meer, J.R.3    Siezen, R.J.4
  • 22
    • 0021691817 scopus 로고
    • Analysis of membrane and surface protein sequences with the Hydrophobic moment plot
    • Eisenberg, D., Schwarz, E., Komaromy, M. & Wall, R. (1984) Analysis of membrane and surface protein sequences with the Hydrophobic moment plot, J. Mol. Biol. 179, 125-142.
    • (1984) J. Mol. Biol. , vol.179 , pp. 125-142
    • Eisenberg, D.1    Schwarz, E.2    Komaromy, M.3    Wall, R.4
  • 23
    • 0024508874 scopus 로고
    • The chemical synthesis of cecropin D and an analogue with enhanced antibacterial activity
    • Fink, J., Merrifield, R. B., Boman, A. & Boman, H. G. (1989) The chemical synthesis of cecropin D and an analogue with enhanced antibacterial activity. J. Biol. Chem. 264, 6260-6267.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6260-6267
    • Fink, J.1    Merrifield, R.B.2    Boman, A.3    Boman, H.G.4
  • 24
    • 0031009432 scopus 로고    scopus 로고
    • Identification of CRAMP, a cathelin related antimicrobial peptide expressed in embryonic and adult mouse
    • Gallo, R. L., Kim, K. J., Bernfield, M., Kozak, C. A., Zanetti, M. Merluzzi, L. & Gennaro, R. (1997) Identification of CRAMP, a cathelin related antimicrobial peptide expressed in embryonic and adult mouse, J. Biol. Chem. 272, 13088-13093.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13088-13093
    • Gallo, R.L.1    Kim, K.J.2    Bernfield, M.3    Kozak, C.A.4    Zanetti, M.5    Merluzzi, L.6    Gennaro, R.7
  • 25
    • 0024460671 scopus 로고
    • Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils
    • Gennaro, R., Skerlavaj, B. & Romeo, D. (1989) Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils. Infect. Immun. 57, 3142-3146.
    • (1989) Infect. Immun. , vol.57 , pp. 3142-3146
    • Gennaro, R.1    Skerlavaj, B.2    Romeo, D.3
  • 26
    • 0021185399 scopus 로고
    • Alterations in outer membrane permeability
    • Hancock, R. E. W. (1984) Alterations in outer membrane permeability. Annu. Rev. Microbiol. 38, 237-264.
    • (1984) Annu. Rev. Microbiol. , vol.38 , pp. 237-264
    • Hancock, R.E.W.1
  • 27
    • 0014561151 scopus 로고
    • Phosphotransferase system of Staphylococcus aureus: Its requirement for the accumulation and metabolism of galactosides
    • Hengstenberg, W., Penberthy, W. K., Hill, K. L. & Morse, M. L. (1969) Phosphotransferase system of Staphylococcus aureus: its requirement for the accumulation and metabolism of galactosides, J. Bacteriol. 99, 383-388.
    • (1969) J. Bacteriol. , vol.99 , pp. 383-388
    • Hengstenberg, W.1    Penberthy, W.K.2    Hill, K.L.3    Morse, M.L.4
  • 31
    • 0029594533 scopus 로고
    • Membrane thinning caused by magainin 2
    • Ludtke, S. J., He, K. & Huang, H. (1995) Membrane thinning caused by magainin 2, Biochemistry 34, 16764-16769.
    • (1995) Biochemistry , vol.34 , pp. 16764-16769
    • Ludtke, S.J.1    He, K.2    Huang, H.3
  • 33
    • 0029584314 scopus 로고
    • Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide
    • Mahoney, M. M., Lee, A. Y., Brezinski-Caliguri, D. J. & Huttner, K. M. (1995) Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide, FEBS Lett. 377, 519-522.
    • (1995) FEBS Lett. , vol.377 , pp. 519-522
    • Mahoney, M.M.1    Lee, A.Y.2    Brezinski-Caliguri, D.J.3    Huttner, K.M.4
  • 34
    • 0028920870 scopus 로고
    • Structure-activity on magainins and other host defense peptides
    • Maloy, W. L. & Kari, U. P. (1995) Structure-activity on magainins and other host defense peptides. Biopolymers 37, 105-122.
    • (1995) Biopolymers , vol.37 , pp. 105-122
    • Maloy, W.L.1    Kari, U.P.2
  • 35
    • 0029051685 scopus 로고
    • Defensins and other endogenous peptide antibiotics of vertebrates
    • Martin, E., Ganz, T. & Lehrer, R. I. (1995) Defensins and other endogenous peptide antibiotics of vertebrates, J. leukocyte Biol. 58, 128-136.
    • (1995) J. Leukocyte Biol. , vol.58 , pp. 128-136
    • Martin, E.1    Ganz, T.2    Lehrer, R.I.3
  • 36
    • 0028208901 scopus 로고
    • Orientational and aggregational states of magainin 2 in phospholipid bilayers
    • Matsuzaki, K., Murase, O., Tokuda, H., Funakoshi, S., Fujii, N. & Miyajima, K. (1994) Orientational and aggregational states of magainin 2 in phospholipid bilayers, Biochemistry 33, 3342-3349.
    • (1994) Biochemistry , vol.33 , pp. 3342-3349
    • Matsuzaki, K.1    Murase, O.2    Tokuda, H.3    Funakoshi, S.4    Fujii, N.5    Miyajima, K.6
  • 37
    • 0028924198 scopus 로고
    • Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2
    • Matsuzaki, K., Sugishita, K., Fujii, N. & Miyajima, K. (1995) Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2, Biochemistry 34, 3423-3429.
    • (1995) Biochemistry , vol.34 , pp. 3423-3429
    • Matsuzaki, K.1    Sugishita, K.2    Fujii, N.3    Miyajima, K.4
  • 38
    • 0029775069 scopus 로고    scopus 로고
    • An antimicrobial peptide, mugainin 2, induces rapid flip-flop of phospholipids coupled with pore formation and peptide translocation
    • Matsuzaki, K., Murase, O., Fujii, N. & Miyajima, K. (1996) An antimicrobial peptide, mugainin 2, induces rapid flip-flop of phospholipids coupled with pore formation and peptide translocation, Biochemistry 35, 11361-11368.
    • (1996) Biochemistry , vol.35 , pp. 11361-11368
    • Matsuzaki, K.1    Murase, O.2    Fujii, N.3    Miyajima, K.4
  • 39
    • 0028174888 scopus 로고
    • 2-terminal α-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity
    • 2-terminal α-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity, j. Biol. Chem. 269, 1934-1939.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1934-1939
    • Mor, A.1    Nicolas, P.2
  • 40
    • 0028829183 scopus 로고
    • Peptides as weapons against microorganisms in the chemical defence system of vertebrates
    • Nicolas, P. & Mor, A. (1995) Peptides as weapons against microorganisms in the chemical defence system of vertebrates, Annu. Rev. Microbiol. 49, 277-304.
    • (1995) Annu. Rev. Microbiol. , vol.49 , pp. 277-304
    • Nicolas, P.1    Mor, A.2
  • 41
    • 0029069628 scopus 로고
    • Comparison of the effects of hydrophobicity, amphiphilicity, and α-helicity on the activities of antimicrobial peptides
    • Pathak, N., Salas-Auvert, R., Ruche, G., Janna, M.-H., McCarthy, D. & Harrison, R. G. (1995) Comparison of the effects of hydrophobicity, amphiphilicity, and α-helicity on the activities of antimicrobial peptides, Proteins 22, 182-186.
    • (1995) Proteins , vol.22 , pp. 182-186
    • Pathak, N.1    Salas-Auvert, R.2    Ruche, G.3    Janna, M.-H.4    McCarthy, D.5    Harrison, R.G.6
  • 42
    • 0026969265 scopus 로고
    • Interaction of antimicrobial dermaseptin and its fluorescently labelled analogues with phospholipid membranes
    • Pouny, Y., Rapaport, D., Mor, A., Nicolas, P. & Shai, Y. (1992) Interaction of antimicrobial dermaseptin and its fluorescently labelled analogues with phospholipid membranes. Biochemistry 31, 12416-12423.
    • (1992) Biochemistry , vol.31 , pp. 12416-12423
    • Pouny, Y.1    Rapaport, D.2    Mor, A.3    Nicolas, P.4    Shai, Y.5
  • 43
    • 0027265032 scopus 로고
    • Interactions of basic amphiphilic peptides with dimyristoylphosphatidylcholine small unilamellar vesicles: Optical, NMR, electron microscopy studies and conformational calculations
    • Reynaud, J. A., Grivet, J. P., Sy, D. & Trudelle, Y. (1993) Interactions of basic amphiphilic peptides with dimyristoylphosphatidylcholine small unilamellar vesicles: optical, NMR, electron microscopy studies and conformational calculations, Biochemistry 32, 4997-5008.
    • (1993) Biochemistry , vol.32 , pp. 4997-5008
    • Reynaud, J.A.1    Grivet, J.P.2    Sy, D.3    Trudelle, Y.4
  • 44
    • 0027291015 scopus 로고
    • Prediction ot protein secondary structure at better than 70% accuracy
    • Rost, B. & Sander, C. (1993) Prediction ot protein secondary structure at better than 70% accuracy, J. Mol. Biol. 232, 584-599.
    • (1993) J. Mol. Biol. , vol.232 , pp. 584-599
    • Rost, B.1    Sander, C.2
  • 45
    • 0028339191 scopus 로고
    • Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: Facets of their conformational features, structure-function correlations and membrane perturbing abilities
    • Saberwal, G. & Nagaraj, R. (1994) Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane perturbing abilities, Biochim. Biophys. Acta 1197, 109-131.
    • (1994) Biochim. Biophys. Acta , vol.1197 , pp. 109-131
    • Saberwal, G.1    Nagaraj, R.2
  • 46
    • 0028696530 scopus 로고
    • Gene-encoded antibiotics made in bacteria
    • Sahl, H. G. (1994) Gene-encoded antibiotics made in bacteria, Ciba Found. Symp. 186, 27-42.
    • (1994) Ciba Found. Symp. , vol.186 , pp. 27-42
    • Sahl, H.G.1
  • 47
    • 0001993847 scopus 로고
    • Laboratory studies with antifungal agents: Susceptibility tests and bioassays
    • (Lennette, E., Balows, A., Hausler, W. & Shadomy H., eds) American Society for Microbiology, Washington DC
    • Shadomy, S., Espinel-Ingroff, A. & Cartwright, R. (1985) Laboratory studies with antifungal agents: susceptibility tests and bioassays, in Manual of clinical microbiology (Lennette, E., Balows, A., Hausler, W. & Shadomy H., eds) pp. 991-998, American Society for Microbiology, Washington DC.
    • (1985) Manual of Clinical Microbiology , pp. 991-998
    • Shadomy, S.1    Espinel-Ingroff, A.2    Cartwright, R.3
  • 48
    • 0021009230 scopus 로고
    • Chemical structure of the lipid A component of the lipopolysaccharide from Proteus mirabilis Re-mutant
    • Sidorczyk, Z., Zähringer, U. & Rietschel, E. Th. (1983) Chemical structure of the lipid A component of the lipopolysaccharide from Proteus mirabilis Re-mutant, Eur. J. Biochem. 137, 15-22.
    • (1983) Eur. J. Biochem. , vol.137 , pp. 15-22
    • Sidorczyk, Z.1    Zähringer, U.2    Rietschel, E.Th.3
  • 49
    • 0025066842 scopus 로고
    • Rapid membrane permeabilzation and inhibition of vital functions of gram-negative bacteria by bactenecins
    • Skerlavaj, B., Romeo, D. & Gennaro, R. (1990) Rapid membrane permeabilzation and inhibition of vital functions of gram-negative bacteria by bactenecins, Infect. Immun. 58, 3724-3730.
    • (1990) Infect. Immun. , vol.58 , pp. 3724-3730
    • Skerlavaj, B.1    Romeo, D.2    Gennaro, R.3
  • 50
    • 0029961492 scopus 로고    scopus 로고
    • Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell-lyric activities
    • Skerlavaj, B., Gennaro, R., Bagella, L., Merluzzi, L., Risso, A. & Zanetti, M. (1996) Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell-lyric activities, J. Biol. Chem. 271, 28 375-28 381.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28375-28381
    • Skerlavaj, B.1    Gennaro, R.2    Bagella, L.3    Merluzzi, L.4    Risso, A.5    Zanetti, M.6
  • 51
    • 0028009472 scopus 로고
    • Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA
    • Storici, P., Scocchi, M., Tossi, A., Gennaro, R. & Zanetti, M. (1994) Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA. FEBS Lett. 337, 303-307.
    • (1994) FEBS Lett. , vol.337 , pp. 303-307
    • Storici, P.1    Scocchi, M.2    Tossi, A.3    Gennaro, R.4    Zanetti, M.5
  • 52
    • 0030057777 scopus 로고    scopus 로고
    • Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides
    • Storici, P., Tossi, A., Lenarcic, B. & Romeo, D. (1996) Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides. Eur. J. Biochem. 238, 769-776.
    • (1996) Eur. J. Biochem. , vol.238 , pp. 769-776
    • Storici, P.1    Tossi, A.2    Lenarcic, B.3    Romeo, D.4
  • 53
    • 0028294292 scopus 로고
    • Identification and characterization of a primary antibacterial domain in CAP18. a lipopolysaccharide binding protein from rabbit leukocytes
    • Tossi, A., Scocchi, M. Skerlavaj, B. & Gennaro, R. (1994) Identification and characterization of a primary antibacterial domain in CAP18. a lipopolysaccharide binding protein from rabbit leukocytes. FEBS Lett. 339, 108-112.
    • (1994) FEBS Lett. , vol.339 , pp. 108-112
    • Tossi, A.1    Scocchi, M.2    Skerlavaj, B.3    Gennaro, R.4
  • 54
    • 0028904007 scopus 로고
    • PMAP-37, a novel antibacterial peptide from pig myeloid cells cDNA cloning, chemical synthesis and activity
    • Tossi, A., Scocchi, M., Zanetti, M., Storici, P. & Gennaro, R. (1995) PMAP-37, a novel antibacterial peptide from pig myeloid cells cDNA cloning, chemical synthesis and activity, Eur. J. Biochem. 228, 941-946.
    • (1995) Eur. J. Biochem. , vol.228 , pp. 941-946
    • Tossi, A.1    Scocchi, M.2    Zanetti, M.3    Storici, P.4    Gennaro, R.5
  • 55
    • 0030629279 scopus 로고    scopus 로고
    • An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides
    • Tossi, A., Scocchi, M., Zanetti, M., Gennaro, R., Storici, P. & Romeo D. (1997) An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides, Methods Mol. Biol. 78, 133-150.
    • (1997) Methods Mol. Biol. , vol.78 , pp. 133-150
    • Tossi, A.1    Scocchi, M.2    Zanetti, M.3    Gennaro, R.4    Storici, P.5    Romeo, D.6
  • 56
    • 0001479670 scopus 로고
    • A simple ultraviolet spectrophotometric method for the determination protein concentration
    • Waddell, W. J. (1956) A simple ultraviolet spectrophotometric method for the determination protein concentration, J. Lab. Clin. Med. 48, 311-314.
    • (1956) J. Lab. Clin. Med. , vol.48 , pp. 311-314
    • Waddell, W.J.1
  • 57
    • 0028844134 scopus 로고
    • Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
    • Zanetti, M., Gennaro, R. & Romeo, D. (1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain, FEBS Lett. 374, 1-5.
    • (1995) FEBS Lett. , vol.374 , pp. 1-5
    • Zanetti, M.1    Gennaro, R.2    Romeo, D.3
  • 58
    • 0023854883 scopus 로고
    • Antimicrobial activity of synthetic magainin peptides and several analogues
    • Zasloff, M., Martin, B. & Chen, H.-C. (1988) Antimicrobial activity of synthetic magainin peptides and several analogues, Proc. Natl Acad. Sci. USA 85, 910-913.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 910-913
    • Zasloff, M.1    Martin, B.2    Chen, H.-C.3


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