Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 6, 2010, Pages 2525-2533

  Bucki, Robert ^a   Leszczyńska, Katarzyna ^b   Byfield, Fitzroy J ^a   Fein, David E ^c   Won, Esther ^a   Cruz, Katrina ^a   Namiot, Andrzej ^b   Kułakowska, Alina ^b   Namiot, Zbigniew ^b   Savage, Paul B ^d   Diamond, Scott L ^c   Janmey, Paul A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIMICROBIAL PEPTIDE HB 71; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; POLYPEPTIDE ANTIBIOTIC AGENT; SPERMINE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCITES FLUID; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; BIOFILM; CEREBROSPINAL FLUID; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE RELEASE; GENE TARGETING; HUMAN; HUMAN CELL; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALIVA; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BACTERIAL INFECTIONS; BIOFILMS; CATHELICIDINS; CATTLE; CELLS, CULTURED; DEXAMETHASONE; DRUG DESIGN; HUMANS; INTERLEUKINS; MACROPHAGES; MICROBIAL SENSITIVITY TESTS; NEUTROPHILS; PHAGOCYTOSIS; PSEUDOMONAS AERUGINOSA; RECEPTORS, GLUCOCORTICOID; SPERMINE; STAPHYLOCOCCUS AUREUS;

EID: 77952667208     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01682-09     Document Type: Article

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